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Determining the development of persisters in extensively-drug resistant Acinetobacter baumannii upon exposure to polymyxin B-based antibiotic combinations using flow cytometry.

Wong FH, Cai Y, Leck H, Lim TP, Teo JQ, Lee W, Koh TH, Tan TT, Tan KW, Kwa AL.

Antimicrob Agents Chemother. 2019 Dec 9. pii: AAC.01712-19. doi: 10.1128/AAC.01712-19. [Epub ahead of print]


Quantification of Human MAIT Cell-Mediated Cellular Cytotoxicity and Antimicrobial Activity.

Sia WR, Boulouis C, Gulam MY, Kwa ALH, Sandberg JK, Leeansyah E.

Methods Mol Biol. 2020;2098:149-165. doi: 10.1007/978-1-0716-0207-2_10.


Ten-year narrative review on antimicrobial resistance in Singapore.

Chua AQ, Kwa AL, Tan TY, Legido-Quigley H, Hsu LY.

Singapore Med J. 2019 Aug;60(8):387-396. doi: 10.11622/smedj.2019088.


Antecedent Carbapenem Exposure as a Risk Factor for Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae and Carbapenemase-Producing Enterobacteriaceae.

Marimuthu K, Ng OT, Cherng BPZ, Fong RKC, Pada SK, De PP, Ooi ST, Smitasin N, Thoon KC, Krishnan PU, Ang MLT, Chan DSG, Kwa ALH, Deepak RN, Chan YK, Chan YFZ, Huan X, Zaw Linn K, Tee NWS, Tan TY, Koh TH, Lin RTP, Hsu LY, Sengupta S, Paterson DL, Perencevich E, Harbarth S, Teo J, Venkatachalam I; CaPES Study Group.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00845-19. doi: 10.1128/AAC.00845-19. Print 2019 Oct.


In vitro Pharmacodynamics and PK/PD in Animals.

Lee W, Cai Y, Lim TP, Teo J, Chua SC, Kwa AL.

Adv Exp Med Biol. 2019;1145:105-116. doi: 10.1007/978-3-030-16373-0_8. Review.


Empiric Meropenem-based versus Ceftazidime-based Therapy for Severe Community-Acquired Pneumonia in a Retrospective Cohort Study.

Chua NG, Liew YX, Lee W, Tang SS, Zhou YP, Patel K, Kwa AL, Chlebicki MP.

Ann Acad Med Singapore. 2019 Mar;48(3):98-103. No abstract available.


Risk factors and outcomes associated with the isolation of polymyxin B and carbapenem-resistant Enterobacteriaceae spp.: A case-control study.

Teo JQ, Chang CW, Leck H, Tang CY, Lee SJ, Cai Y, Ong RT, Koh TH, Tan TT, Kwa AL.

Int J Antimicrob Agents. 2019 May;53(5):657-662. doi: 10.1016/j.ijantimicag.2019.03.011. Epub 2019 Mar 14.


Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use.

Schuetz P, Beishuizen A, Broyles M, Ferrer R, Gavazzi G, Gluck EH, González Del Castillo J, Jensen JU, Kanizsai PL, Kwa ALH, Krueger S, Luyt CE, Oppert M, Plebani M, Shlyapnikov SA, Toccafondi G, Townsend J, Welte T, Saeed K.

Clin Chem Lab Med. 2019 Aug 27;57(9):1308-1318. doi: 10.1515/cclm-2018-1181.


Do antimicrobial stewardship programme interventions reduce the rate of and protect against Clostridium difficile infection?

Chia BY, Teo JQ, Lee W, Liew YX, Ee RP, Chlebicki MP, Oon LL, Kwa AL.

J Glob Antimicrob Resist. 2019 Jun;17:312-315. doi: 10.1016/j.jgar.2019.01.018. Epub 2019 Jan 22.


Molecular mechanisms of azole resistance in Candida bloodstream isolates.

Teo JQ, Lee SJ, Tan AL, Lim RS, Cai Y, Lim TP, Kwa AL.

BMC Infect Dis. 2019 Jan 17;19(1):63. doi: 10.1186/s12879-019-3672-5.


Discontinuation of antibiotic therapy within 24 hours of treatment initiation for patients with no clinical evidence of bacterial infection: a 5-year safety and outcome study from Singapore General Hospital Antimicrobial Stewardship Program.

Loo LW, Liew YX, Lee W, Lee LW, Chlebicki P, Kwa AL.

Int J Antimicrob Agents. 2019 May;53(5):606-611. doi: 10.1016/j.ijantimicag.2019.01.008. Epub 2019 Jan 11.


Management of complicated skin and soft tissue infections with a special focus on the role of newer antibiotics.

Leong HN, Kurup A, Tan MY, Kwa ALH, Liau KH, Wilcox MH.

Infect Drug Resist. 2018 Oct 25;11:1959-1974. doi: 10.2147/IDR.S172366. eCollection 2018. Review.


Correction to: Candidemia in a major regional tertiary referral hospital - epidemiology, practice patterns and outcomes.

Teo JQ, Candra SR, Lee SJ, Chia SY, Leck H, Tan AL, Neo HP, Leow KW, Cai Y, Ee PLR, Lim TP, Lee W, Kwa AL.

Antimicrob Resist Infect Control. 2018 Nov 7;7:130. doi: 10.1186/s13756-018-0413-2. eCollection 2018.


Integrated pharmacokinetic-pharmacodynamic modeling to evaluate empiric carbapenem therapy in bloodstream infections.

Lim TP, Wang R, Poh GQ, Koh TH, Tan TY, Lee W, Teo JQ, Cai Y, Tan TT, Ee PLR, Kwa AL.

Infect Drug Resist. 2018 Sep 27;11:1591-1596. doi: 10.2147/IDR.S168191. eCollection 2018.


Antimicrobial stewardship for acute-care hospitals: An Asian perspective.

Apisarnthanarak A, Kwa AL, Chiu CH, Kumar S, Thu LTA, Tan BH, Zong Z, Chuang YC, Karuniawati A, Tayzon MF, So TM, Peterson LR.

Infect Control Hosp Epidemiol. 2018 Oct;39(10):1237-1245. doi: 10.1017/ice.2018.188. Epub 2018 Sep 19. Review.


Rapid Antibiotic Combination Testing for Carbapenem-Resistant Gram-Negative Bacteria within Six Hours Using ATP Bioluminescence.

Cai Y, Seah CL, Leck H, Lim TP, Teo JQ, Lee W, Tan TT, Koh TH, Ee PLR, Kwa AL.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00183-18. doi: 10.1128/AAC.00183-18. Print 2018 Sep.


Optimisation of antimicrobial dosing based on pharmacokinetic and pharmacodynamic principles.

Hoo GSR, Liew YX, Kwa AL.

Indian J Med Microbiol. 2017 Jul-Sep;35(3):340-346. doi: 10.4103/ijmm.IJMM_17_278. Review.


NLRP3 inflammasome pathway has a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection.

Dikshit N, Kale SD, Khameneh HJ, Balamuralidhar V, Tang CY, Kumar P, Lim TP, Tan TT, Kwa AL, Mortellaro A, Sukumaran B.

Mucosal Immunol. 2018 Jan;11(1):257-272. doi: 10.1038/mi.2017.50. Epub 2017 Jun 14.


Prevalence of Healthcare-Associated Infections and Antimicrobial Use Among Adult Inpatients in Singapore Acute-Care Hospitals: Results From the First National Point Prevalence Survey.

Cai Y, Venkatachalam I, Tee NW, Tan TY, Kurup A, Wong SY, Low CY, Wang Y, Lee W, Liew YX, Ang B, Lye DC, Chow A, Ling ML, Oh HM, Cuvin CA, Ooi ST, Pada SK, Lim CH, Tan JWC, Chew KL, Nguyen VH, Fisher DA, Goossens H, Kwa AL, Tambyah PA, Hsu LY, Marimuthu K.

Clin Infect Dis. 2017 May 15;64(suppl_2):S61-S67. doi: 10.1093/cid/cix103.


Candidemia in a major regional tertiary referral hospital - epidemiology, practice patterns and outcomes.

Teo JQ, Candra SR, Lee SJ, Chia SY, Leck H, Tan AL, Neo HP, Leow KW, Cai Y, Ee PLR, Lim TP, Lee W, Kwa AL.

Antimicrob Resist Infect Control. 2017 Mar 11;6:27. doi: 10.1186/s13756-017-0184-1. eCollection 2017. Erratum in: Antimicrob Resist Infect Control. 2018 Nov 7;7:130.


Evaluating Polymyxin B-Based Combinations against Carbapenem-Resistant Escherichia coli in Time-Kill Studies and in a Hollow-Fiber Infection Model.

Cai Y, Lim TP, Teo JQ, Sasikala S, Chan EC, Hong YJ, Lee W, Tan TY, Tan TT, Koh TH, Hsu LY, Kwa AL.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01509-16. doi: 10.1128/AAC.01509-16. Print 2017 Jan.


Carbapenem Resistance in Gram-Negative Bacteria: The Not-So-Little Problem in the Little Red Dot.

Teo JQ, Cai Y, Lim TP, Tan TT, Kwa AL.

Microorganisms. 2016 Feb 16;4(1). pii: E13. doi: 10.3390/microorganisms4010013. Review.


mcr-1 in Multidrug-Resistant blaKPC-2-Producing Clinical Enterobacteriaceae Isolates in Singapore.

Teo JQ, Ong RT, Xia E, Koh TH, Khor CC, Lee SJ, Lim TP, Kwa AL.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6435-7. doi: 10.1128/AAC.00804-16. Print 2016 Oct. No abstract available.


In Vitro Activity of Polymyxin B in Combination with Various Antibiotics against Extensively Drug-Resistant Enterobacter cloacae with Decreased Susceptibility to Polymyxin B.

Cai Y, Lim TP, Teo J, Sasikala S, Lee W, Hong Y, Chan EC, Tan TY, Tan TT, Koh TH, Hsu LY, Kwa AL.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5238-46. doi: 10.1128/AAC.00270-16. Print 2016 Sep.


Physicochemical Stability Study of Polymyxin B in Various Infusion Solutions for Administration to Critically Ill Patients.

Lim TP, Hee DK, Lee W, Teo JQ, Cai Y, Chia SY, Leaw JY, Lee SJ, Lee LS, Kwa AL.

Ann Pharmacother. 2016 Sep;50(9):790-2. doi: 10.1177/1060028016649598. Epub 2016 May 19. No abstract available.


Clinical Efficacy of Polymyxin Monotherapy versus Nonvalidated Polymyxin Combination Therapy versus Validated Polymyxin Combination Therapy in Extensively Drug-Resistant Gram-Negative Bacillus Infections.

Cai B, Cai Y, Liew YX, Chua NG, Teo JQ, Lim TP, Kurup A, Ee PL, Tan TT, Lee W, Kwa AL.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4013-22. doi: 10.1128/AAC.03064-15. Print 2016 Jul.


Risk of swallowing-related chest infections in patients with nasopharyngeal carcinoma treated with definitive intensity-modulated radiotherapy.

Xiong J, Krishnaswamy G, Raynor S, Loh KS, Kwa AL, Lim CM.

Head Neck. 2016 Apr;38 Suppl 1:E1660-5. doi: 10.1002/hed.24296. Epub 2016 Feb 18.


A multidisciplinary antimicrobial stewardship programme safely decreases the duration of broad-spectrum antibiotic prescription in Singaporean adult renal patients.

Cai Y, Shek PY, Teo I, Tang SS, Lee W, Liew YX, Chlebicki P, Kwa AL.

Int J Antimicrob Agents. 2016 Jan;47(1):91-6. doi: 10.1016/j.ijantimicag.2015.10.021. Epub 2015 Nov 26.


Intravenous ceftaroline 200 mg administered every 8 h is safe and adequate for meticillin-resistant Staphylococcus aureus bloodstream infections in end-stage renal failure patients on haemodialysis: a case study.

Chung SJ, Lim TP, Kwa AL.

Int J Antimicrob Agents. 2015 Dec;46(6):720-1. doi: 10.1016/j.ijantimicag.2015.09.012. Epub 2015 Oct 23. No abstract available.


Cost effectiveness of an antimicrobial stewardship programme.

Liew YX, Lee W, Kwa AL, Chlebicki MP.

Int J Antimicrob Agents. 2015 Nov;46(5):594-5. doi: 10.1016/j.ijantimicag.2015.08.008. Epub 2015 Sep 21. No abstract available.


Polymyxin B versus colistin: an update.

Cai Y, Lee W, Kwa AL.

Expert Rev Anti Infect Ther. 2015;13(12):1481-97. doi: 10.1586/14787210.2015.1093933. Epub 2015 Oct 21. Review.


Using an Adenosine Triphosphate Bioluminescent Assay to Determine Effective Antibiotic Combinations against Carbapenem-Resistant Gram Negative Bacteria within 24 Hours.

Cai Y, Leck H, Lim TP, Teo J, Lee W, Hsu LY, Koh TH, Tan TT, Tan TY, Kwa AL.

PLoS One. 2015 Oct 13;10(10):e0140446. doi: 10.1371/journal.pone.0140446. eCollection 2015.


Impact of Antimicrobial Stewardship Program (ASP) on Outcomes in Patients with Acute Bacterial Skin and Skin Structure Infections (ABSSSIs) in an Acute-Tertiary Care Hospital.

Loo LW, Liew YX, Lee W, Chlebicki P, Kwa AL.

Infect Dis Ther. 2015 Sep;4(Suppl 1):15-25. doi: 10.1007/s40121-015-0085-7. Epub 2015 Sep 11.


Candida Surveillance in Surgical Intensive Care Unit (SICU) in a Tertiary Institution.

Liew YX, Teo J, Too IA, Ngan CC, Tan AL, Chlebicki MP, Kwa AL, Lee W.

BMC Infect Dis. 2015 Jul 3;15:256. doi: 10.1186/s12879-015-0997-6.


In vitro pharmacodynamics of various antibiotics in combination against extensively drug-resistant Klebsiella pneumoniae.

Lim TP, Cai Y, Hong Y, Chan EC, Suranthran S, Teo JQ, Lee WH, Tan TY, Hsu LY, Koh TH, Tan TT, Kwa AL.

Antimicrob Agents Chemother. 2015 May;59(5):2515-24. doi: 10.1128/AAC.03639-14. Epub 2015 Feb 17.


Extensively drug-resistant Acinetobacter baumannii in a Thai hospital: a molecular epidemiologic analysis and identification of bactericidal Polymyxin B-based combinations.

Teo J, Lim TP, Hsu LY, Tan TY, Sasikala S, Hon PY, Kwa AL, Apisarnthanarak A.

Antimicrob Resist Infect Control. 2015 Jan 29;4(1):2. doi: 10.1186/s13756-015-0043-x. eCollection 2015.


Role of antibiotic prophylaxis in necrotizing pancreatitis: a meta-analysis.

Lim CL, Lee W, Liew YX, Tang SS, Chlebicki MP, Kwa AL.

J Gastrointest Surg. 2015 Mar;19(3):480-91. doi: 10.1007/s11605-014-2662-6. Epub 2015 Jan 22. Review.


Prospective audit and feedback in antimicrobial stewardship: is there value in early reviewing within 48 h of antibiotic prescription?

Liew YX, Lee W, Tay D, Tang SS, Chua NG, Zhou Y, Kwa AL, Chlebicki MP.

Int J Antimicrob Agents. 2015 Feb;45(2):168-73. doi: 10.1016/j.ijantimicag.2014.10.018. Epub 2014 Nov 25.


Polymyxin B with dual carbapenem combination therapy against carbapenemase-producing Klebsiella pneumoniae.

Chua NG, Zhou YP, Tan TT, Lingegowda PB, Lee W, Lim TP, Teo J, Cai Y, Kwa AL.

J Infect. 2015 Mar;70(3):309-11. doi: 10.1016/j.jinf.2014.10.001. Epub 2014 Oct 7. No abstract available.


Echinocandin-induced eosinophilia: a case report.

Chua NG, Zhou YP, Lingegowda PB, Kwa AL, Lee W.

Scand J Infect Dis. 2014 Nov;46(11):809-12. doi: 10.3109/00365548.2014.938692. Epub 2014 Aug 14.


Nonattenuated Polymyxin B Used for the Treatment of Extreme-Drug Resistant Acinetobacter baumannii-Related Infections in Patients with Preexisting End Stage Renal Failure.

Zhou YP, Chua NG, Chlebicki MP, Lee WH, Kwa AL.

Case Rep Infect Dis. 2014;2014:573279. doi: 10.1155/2014/573279. Epub 2014 Jun 3.


A procalcitonin-based guideline promotes shorter duration of antibiotic use safely in acute pancreatitis.

Cai Y, Ee J, Liew YX, Lee W, Chlebicki MP, Goh YC, Kwa AL.

J Infect. 2014 Oct;69(4):412-5. doi: 10.1016/j.jinf.2014.06.008. Epub 2014 Jun 23. No abstract available.


Prolonged infusion versus intermittent boluses of ╬▓-lactam antibiotics for treatment of acute infections: a meta-analysis.

Teo J, Liew Y, Lee W, Kwa AL.

Int J Antimicrob Agents. 2014 May;43(5):403-11. doi: 10.1016/j.ijantimicag.2014.01.027. Epub 2014 Mar 1. Review.


Evaluation of Ertapenem use with impact assessment on extended-spectrum beta-lactamases (ESBL) production and gram-negative resistance in Singapore General Hospital (SGH).

Lim CL, Lee W, Lee AL, Liew LT, Nah SC, Wan CN, Chlebicki MP, Kwa AL.

BMC Infect Dis. 2013 Nov 6;13:523. doi: 10.1186/1471-2334-13-523.


Outcomes of appropriate empiric combination versus monotherapy for Pseudomonas aeruginosa bacteremia.

Bowers DR, Liew YX, Lye DC, Kwa AL, Hsu LY, Tam VH.

Antimicrob Agents Chemother. 2013 Mar;57(3):1270-4. doi: 10.1128/AAC.02235-12. Epub 2012 Dec 21.


Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated drug clearance of rifampicin.

New LS, Lim TP, Oh JW, Cheah GJ, Kwa AL, Chan EC.

Anal Bioanal Chem. 2013 Feb;405(4):1407-15. doi: 10.1007/s00216-012-6549-7. Epub 2012 Nov 24.


Risk factors for extreme-drug resistant Pseudomonas aeruginosa infections in patients with hematologic malignancies.

Liew YX, Tan TT, Lee W, Ng JL, Chia DQ, Wong GC, Kwa AL.

Am J Infect Control. 2013 Feb;41(2):140-4. doi: 10.1016/j.ajic.2012.02.025. Epub 2012 Jul 15.


The presence of an FKS mutation rather than MIC is an independent risk factor for failure of echinocandin therapy among patients with invasive candidiasis due to Candida glabrata.

Shields RK, Nguyen MH, Press EG, Kwa AL, Cheng S, Du C, Clancy CJ.

Antimicrob Agents Chemother. 2012 Sep;56(9):4862-9. doi: 10.1128/AAC.00027-12. Epub 2012 Jul 2.

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