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Items: 39


Identification of ADAM12 as a Novel Basigin Sheddase.

Albrechtsen R, Wewer Albrechtsen NJ, Gnosa S, Schwarz J, Dyrskjøt L, Kveiborg M.

Int J Mol Sci. 2019 Apr 22;20(8). pii: E1957. doi: 10.3390/ijms20081957.


PACS-2 functions in colorectal cancer.

Kveiborg M, Thomas G.

Aging (Albany NY). 2018 Jun 22;10(6):1190-1191. doi: 10.18632/aging.101489. No abstract available.


Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface.

Mygind KJ, Störiko T, Freiberg ML, Samsøe-Petersen J, Schwarz J, Andersen OM, Kveiborg M.

J Biol Chem. 2018 May 25;293(21):8077-8088. doi: 10.1074/jbc.RA117.001077. Epub 2018 Apr 5.


The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms.

Andersen AP, Samsøe-Petersen J, Oernbo EK, Boedtkjer E, Moreira JMA, Kveiborg M, Pedersen SF.

Int J Cancer. 2018 Jun 15;142(12):2529-2542. doi: 10.1002/ijc.31276. Epub 2018 Feb 7.


Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the ApcMin model of colorectal cancer.

Dombernowsky SL, Schwarz J, Samsøe-Petersen J, Albrechtsen R, Jensen KB, Thomas G, Kveiborg M.

Oncotarget. 2017 Nov 26;8(65):108303-108315. doi: 10.18632/oncotarget.22661. eCollection 2017 Dec 12.


Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration.

Mygind KJ, Schwarz J, Sahgal P, Ivaska J, Kveiborg M.

J Cell Sci. 2018 Jan 4;131(1). pii: jcs205393. doi: 10.1242/jcs.205393.


The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.

Dombernowsky SL, Samsøe-Petersen J, Petersen CH, Instrell R, Hedegaard AM, Thomas L, Atkins KM, Auclair S, Albrechtsen R, Mygind KJ, Fröhlich C, Howell M, Parker P, Thomas G, Kveiborg M.

Nat Commun. 2015 Jun 25;6:7518. doi: 10.1038/ncomms8518.


The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines.

Kirkegaard T, Yde CW, Kveiborg M, Lykkesfeldt AE.

Int J Oncol. 2014 Jul;45(1):393-400. doi: 10.3892/ijo.2014.2434. Epub 2014 May 9.


ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth.

Albrechtsen R, Kveiborg M, Stautz D, Vikeså J, Noer JB, Kotzsh A, Nielsen FC, Wewer UM, Fröhlich C.

J Cell Sci. 2013 Oct 15;126(Pt 20):4707-20. doi: 10.1242/jcs.129510. Epub 2013 Sep 4.


ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.

Fröhlich C, Klitgaard M, Noer JB, Kotzsch A, Nehammer C, Kronqvist P, Berthelsen J, Blobel C, Kveiborg M, Albrechtsen R, Wewer UM.

Biochem J. 2013 May 15;452(1):97-109. doi: 10.1042/BJ20121558.


Cell-surface metalloprotease ADAM12 is internalized by a clathrin- and Grb2-dependent mechanism.

Stautz D, Leyme A, Grandal MV, Albrechtsen R, van Deurs B, Wewer U, Kveiborg M.

Traffic. 2012 Nov;13(11):1532-46. doi: 10.1111/j.1600-0854.2012.01405.x. Epub 2012 Sep 10.


Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12.

Stautz D, Wewer UM, Kveiborg M.

PLoS One. 2012;7(5):e37628. doi: 10.1371/journal.pone.0037628. Epub 2012 May 25.


Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus.

Rowe GC, Vialou V, Sato K, Saito H, Yin M, Green TA, Lotinun S, Kveiborg M, Horne WC, Nestler EJ, Baron R.

J Bone Miner Res. 2012 Aug;27(8):1649-58. doi: 10.1002/jbmr.1618.


ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.

Fröhlich C, Nehammer C, Albrechtsen R, Kronqvist P, Kveiborg M, Sehara-Fujisawa A, Mercurio AM, Wewer UM.

Mol Cancer Res. 2011 Nov;9(11):1449-61. doi: 10.1158/1541-7786.MCR-11-0100. Epub 2011 Aug 29.


PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways.

Kveiborg M, Instrell R, Rowlands C, Howell M, Parker PJ.

PLoS One. 2011 Feb 28;6(2):e17168. doi: 10.1371/journal.pone.0017168.


Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity.

Albrechtsen R, Stautz D, Sanjay A, Kveiborg M, Wewer UM.

Exp Cell Res. 2011 Jan 15;317(2):195-209. doi: 10.1016/j.yexcr.2010.10.003. Epub 2010 Oct 14.


Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).

Kveiborg M, Jacobsen J, Lee MH, Nagase H, Wewer UM, Murphy G.

Biochem J. 2010 Aug 15;430(1):79-86. doi: 10.1042/BJ20100649.


ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity.

Stautz D, Sanjay A, Hansen MT, Albrechtsen R, Wewer UM, Kveiborg M.

Exp Cell Res. 2010 Jan 1;316(1):55-67. doi: 10.1016/j.yexcr.2009.09.017. Epub 2009 Sep 19.


Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity.

Sabatakos G, Rowe GC, Kveiborg M, Wu M, Neff L, Chiusaroli R, Philbrick WM, Baron R.

J Bone Miner Res. 2008 May;23(5):584-95. doi: 10.1359/jbmr.080110.


Cellular roles of ADAM12 in health and disease.

Kveiborg M, Albrechtsen R, Couchman JR, Wewer UM.

Int J Biochem Cell Biol. 2008;40(9):1685-702. doi: 10.1016/j.biocel.2008.01.025. Epub 2008 Feb 1. Review.


ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation.

Kveiborg M, Albrechtsen R, Rudkjaer L, Wen G, Damgaard-Pedersen K, Wewer UM.

J Bone Miner Res. 2006 Aug;21(8):1288-96.


ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme.

Wewer UM, Mörgelin M, Holck P, Jacobsen J, Lydolph MC, Johnsen AH, Kveiborg M, Albrechtsen R.

J Biol Chem. 2006 Apr 7;281(14):9418-22. Epub 2006 Feb 2.


Hierarchy of ADAM12 binding to integrins in tumor cells.

Thodeti CK, Fröhlich C, Nielsen CK, Holck P, Sundberg C, Kveiborg M, Mahalingam Y, Albrechtsen R, Couchman JR, Wewer UM.

Exp Cell Res. 2005 Oct 1;309(2):438-50.


A role for ADAM12 in breast tumor progression and stromal cell apoptosis.

Kveiborg M, Fröhlich C, Albrechtsen R, Tischler V, Dietrich N, Holck P, Kronqvist P, Rank F, Mercurio AM, Wewer UM.

Cancer Res. 2005 Jun 1;65(11):4754-61.


Regulation of ADAM12 cell-surface expression by protein kinase C epsilon.

Sundberg C, Thodeti CK, Kveiborg M, Larsson C, Parker P, Albrechtsen R, Wewer UM.

J Biol Chem. 2004 Dec 3;279(49):51601-11. Epub 2004 Sep 13.


DeltaFosB induces osteosclerosis and decreases adipogenesis by two independent cell-autonomous mechanisms.

Kveiborg M, Sabatakos G, Chiusaroli R, Wu M, Philbrick WM, Horne WC, Baron R.

Mol Cell Biol. 2004 Apr;24(7):2820-30.


ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function.

Kawaguchi N, Sundberg C, Kveiborg M, Moghadaszadeh B, Asmar M, Dietrich N, Thodeti CK, Nielsen FC, Möller P, Mercurio AM, Albrechtsen R, Wewer UM.

J Cell Sci. 2003 Oct 1;116(Pt 19):3893-904. Epub 2003 Aug 12.


The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels.

Kveiborg M, Chiusaroli R, Sims NA, Wu M, Sabatakos G, Horne WC, Baron R.

Endocrinology. 2002 Nov;143(11):4304-9.


Evidence of a normal mean telomere fragment length in patients with Ullrich-Turner syndrome.

Kveiborg M, Gravholt CH, Kassem M.

Eur J Hum Genet. 2001 Nov;9(11):877-9.


Treatment with 1,25-dihydroxyvitamin D3 reduces impairment of human osteoblast functions during cellular aging in culture.

Kveiborg M, Rattan SI, Clark BF, Eriksen EF, Kassem M.

J Cell Physiol. 2001 Feb;186(2):298-306.


Changes in the insulin-like growth factor-system may contribute to in vitro age-related impaired osteoblast functions.

Kveiborg M, Flyvbjerg A, Rattan SI, Kassem M.

Exp Gerontol. 2000 Oct;35(8):1061-74.


CBFA1 and topoisomerase I mRNA levels decline during cellular aging of human trabecular osteoblasts.

Christiansen M, Kveiborg M, Kassem M, Clark BF, Rattan SI.

J Gerontol A Biol Sci Med Sci. 2000 Apr;55(4):B194-200.


[Biological action mechanisms and effects of calcitriol].

Kveiborg M, Mosekilde L, Eriksen EF, Kassem MS.

Ugeskr Laeger. 1999 Oct 11;161(41):5669-74. Review. Danish.


Telomere shortening during aging of human osteoblasts in vitro and leukocytes in vivo: lack of excessive telomere loss in osteoporotic patients.

Kveiborg M, Kassem M, Langdahl B, Eriksen EF, Clark BF, Rattan SI.

Mech Ageing Dev. 1999 Jan 15;106(3):261-71.


Cloning and identification of genes that associate with mammalian replicative senescence.

Gonos ES, Derventzi A, Kveiborg M, Agiostratidou G, Kassem M, Clark BF, Jat PS, Rattan SI.

Exp Cell Res. 1998 Apr 10;240(1):66-74.


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