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Items: 1 to 50 of 159

1.

A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria.

Sakaki K, Ohishi K, Shimizu T, Kobayashi I, Mori N, Matsuda K, Tomita T, Watanabe H, Tanaka K, Kuzuyama T, Nishiyama M.

Nat Chem Biol. 2020 Feb 10. doi: 10.1038/s41589-019-0461-9. [Epub ahead of print]

PMID:
32042199
2.

Recent advances in the biosynthesis of nucleoside antibiotics.

Shiraishi T, Kuzuyama T.

J Antibiot (Tokyo). 2019 Dec;72(12):913-923. doi: 10.1038/s41429-019-0236-2. Epub 2019 Sep 25. Review.

PMID:
31554958
3.

An Unusual Skeletal Rearrangement in the Biosynthesis of the Sesquiterpene Trichobrasilenol from Trichoderma.

Murai K, Lauterbach L, Teramoto K, Quan Z, Barra L, Yamamoto T, Nonaka K, Shiomi K, Nishiyama M, Kuzuyama T, Dickschat JS.

Angew Chem Int Ed Engl. 2019 Oct 14;58(42):15046-15050. doi: 10.1002/anie.201907964. Epub 2019 Sep 9.

PMID:
31418991
4.

An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces.

Kobayashi M, Tomita T, Shin-Ya K, Nishiyama M, Kuzuyama T.

Angew Chem Int Ed Engl. 2019 Sep 16;58(38):13349-13353. doi: 10.1002/anie.201906864. Epub 2019 Aug 13.

PMID:
31350791
5.

Biochemical characterization of archaeal homocitrate synthase from Sulfolobus acidocaldarius.

Suzuki T, Akiyama N, Yoshida A, Tomita T, Lassak K, Haurat MF, Okada T, Takahashi K, Albers SV, Kuzuyama T, Nishiyama M.

FEBS Lett. 2020 Jan;594(1):126-134. doi: 10.1002/1873-3468.13550. Epub 2019 Aug 1.

PMID:
31330039
6.

Comprehensive Derivatization of Thioviridamides by Heterologous Expression.

Kudo K, Koiwai H, Kagaya N, Nishiyama M, Kuzuyama T, Shin-Ya K, Ikeda H.

ACS Chem Biol. 2019 Jun 21;14(6):1135-1140. doi: 10.1021/acschembio.9b00330. Epub 2019 Jun 11.

PMID:
31184470
7.

The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics.

Romo AJ, Shiraishi T, Ikeuchi H, Lin GM, Geng Y, Lee YH, Liem PH, Ma T, Ogasawara Y, Shin-Ya K, Nishiyama M, Kuzuyama T, Liu HW.

J Am Chem Soc. 2019 Sep 11;141(36):14152-14159. doi: 10.1021/jacs.9b03021. Epub 2019 Sep 3.

8.

Glutamate Dehydrogenase from Thermus thermophilus Is Activated by AMP and Leucine as a Complex with Catalytically Inactive Adenine Phosphoribosyltransferase Homolog.

Tomita T, Matsushita H, Yoshida A, Kosono S, Yoshida M, Kuzuyama T, Nishiyama M.

J Bacteriol. 2019 Jun 21;201(14). pii: e00710-18. doi: 10.1128/JB.00710-18. Print 2019 Jul 15.

9.

Protein acetylation on 2-isopropylmalate synthase from Thermus thermophilus HB27.

Yoshida A, Yoshida M, Kuzuyama T, Nishiyama M, Kosono S.

Extremophiles. 2019 Jul;23(4):377-388. doi: 10.1007/s00792-019-01090-y. Epub 2019 Mar 27.

PMID:
30919057
10.
11.

Structural and Mechanistic Insight into Terpene Synthases that Catalyze the Irregular Non-Head-to-Tail Coupling of Prenyl Substrates.

Kobayashi M, Kuzuyama T.

Chembiochem. 2019 Jan 2;20(1):29-33. doi: 10.1002/cbic.201800510. Epub 2018 Nov 22. Review.

PMID:
30277292
12.

Discovery of an Antibacterial Isoindolinone-Containing Tetracyclic Polyketide by Cryptic Gene Activation and Characterization of Its Biosynthetic Gene Cluster.

Thong WL, Shin-Ya K, Nishiyama M, Kuzuyama T.

ACS Chem Biol. 2018 Sep 21;13(9):2615-2622. doi: 10.1021/acschembio.8b00553. Epub 2018 Aug 17.

PMID:
30080389
13.

Biochemical and Structural Analysis of FomD That Catalyzes the Hydrolysis of Cytidylyl ( S)-2-Hydroxypropylphosphonate in Fosfomycin Biosynthesis.

Sato S, Miyanaga A, Kim SY, Kuzuyama T, Kudo F, Eguchi T.

Biochemistry. 2018 Aug 14;57(32):4858-4866. doi: 10.1021/acs.biochem.8b00690. Epub 2018 Jul 25.

PMID:
30010320
14.

Discovery of Unprecedented Hydrazine-Forming Machinery in Bacteria.

Matsuda K, Tomita T, Shin-Ya K, Wakimoto T, Kuzuyama T, Nishiyama M.

J Am Chem Soc. 2018 Jul 25;140(29):9083-9086. doi: 10.1021/jacs.8b05354. Epub 2018 Jul 17.

PMID:
30001119
15.

C-Methylation Catalyzed by Fom3, a Cobalamin-Dependent Radical S-adenosyl-l-methionine Enzyme in Fosfomycin Biosynthesis, Proceeds with Inversion of Configuration.

Sato S, Kudo F, Kuzuyama T, Hammerschmidt F, Eguchi T.

Biochemistry. 2018 Aug 21;57(33):4963-4966. doi: 10.1021/acs.biochem.8b00614. Epub 2018 Jul 12.

PMID:
29966085
16.

Identification and heterologous expression of the actinoallolide biosynthetic gene cluster.

Inahashi Y, Shiraishi T, Také A, Matsumoto A, Takahashi Y, Ōmura S, Kuzuyama T, Nakashima T.

J Antibiot (Tokyo). 2018 Aug;71(8):749-752. doi: 10.1038/s41429-018-0057-8. Epub 2018 Apr 20.

PMID:
29679043
17.

Distinct roles for U-type proteins in iron-sulfur cluster biosynthesis revealed by genetic analysis of the Bacillus subtilis sufCDSUB operon.

Yokoyama N, Nonaka C, Ohashi Y, Shioda M, Terahata T, Chen W, Sakamoto K, Maruyama C, Saito T, Yuda E, Tanaka N, Fujishiro T, Kuzuyama T, Asai K, Takahashi Y.

Mol Microbiol. 2018 Mar;107(6):688-703. doi: 10.1111/mmi.13907. Epub 2018 Jan 18.

18.

Structure and Mechanism of the Monoterpene Cyclolavandulyl Diphosphate Synthase that Catalyzes Consecutive Condensation and Cyclization.

Tomita T, Kobayashi M, Karita Y, Yasuno Y, Shinada T, Nishiyama M, Kuzuyama T.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14913-14917. doi: 10.1002/anie.201708474. Epub 2017 Oct 11.

PMID:
28922556
19.

Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme.

Cho SH, Kim SY, Tomita T, Shiraishi T, Park JS, Sato S, Kudo F, Eguchi T, Funa N, Nishiyama M, Kuzuyama T.

ACS Chem Biol. 2017 Aug 18;12(8):2209-2215. doi: 10.1021/acschembio.7b00419. Epub 2017 Jul 20.

PMID:
28727444
20.

Crystal structure of LysK, an enzyme catalyzing the last step of lysine biosynthesis in Thermus thermophilus, in complex with lysine: Insight into the mechanism for recognition of the amino-group carrier protein, LysW.

Fujita S, Cho SH, Yoshida A, Hasebe F, Tomita T, Kuzuyama T, Nishiyama M.

Biochem Biophys Res Commun. 2017 Sep 16;491(2):409-415. doi: 10.1016/j.bbrc.2017.07.088. Epub 2017 Jul 15.

PMID:
28720495
21.

Methylcobalamin-Dependent Radical SAM C-Methyltransferase Fom3 Recognizes Cytidylyl-2-hydroxyethylphosphonate and Catalyzes the Nonstereoselective C-Methylation in Fosfomycin Biosynthesis.

Sato S, Kudo F, Kim SY, Kuzuyama T, Eguchi T.

Biochemistry. 2017 Jul 18;56(28):3519-3522. doi: 10.1021/acs.biochem.7b00472. Epub 2017 Jul 7.

PMID:
28678474
22.

Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer.

Kudo K, Ozaki T, Shin-Ya K, Nishiyama M, Kuzuyama T.

J Am Chem Soc. 2017 May 24;139(20):6799-6802. doi: 10.1021/jacs.7b02071. Epub 2017 May 12.

PMID:
28497964
23.

Crystal structure of the 2-iminoglutarate-bound complex of glutamate dehydrogenase from Corynebacterium glutamicum.

Tomita T, Yin L, Nakamura S, Kosono S, Kuzuyama T, Nishiyama M.

FEBS Lett. 2017 Jun;591(11):1611-1622. doi: 10.1002/1873-3468.12667. Epub 2017 May 25.

24.

Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol.

Tomita T, Kim SY, Teramoto K, Meguro A, Ozaki T, Yoshida A, Motoyoshi Y, Mori N, Ishigami K, Watanabe H, Nishiyama M, Kuzuyama T.

ACS Chem Biol. 2017 Jun 16;12(6):1621-1628. doi: 10.1021/acschembio.7b00154. Epub 2017 May 2.

PMID:
28463490
25.

Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms.

Nara A, Hashimoto T, Komatsu M, Nishiyama M, Kuzuyama T, Ikeda H.

J Antibiot (Tokyo). 2017 May;70(5):616-624. doi: 10.1038/ja.2017.33. Epub 2017 Mar 15.

PMID:
28293034
26.

Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces.

Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T, Nishiyama M.

Nat Chem Biol. 2016 Nov;12(11):967-972. doi: 10.1038/nchembio.2181. Epub 2016 Sep 26.

PMID:
28288097
27.

Biosynthetic studies on terpenoids produced by Streptomyces.

Kuzuyama T.

J Antibiot (Tokyo). 2017 Jul;70(7):811-818. doi: 10.1038/ja.2017.12. Epub 2017 Feb 15. Review.

28.

Genome Mining of Amino Group Carrier Protein-Mediated Machinery: Discovery and Biosynthetic Characterization of a Natural Product with Unique Hydrazone Unit.

Matsuda K, Hasebe F, Shiwa Y, Kanesaki Y, Tomita T, Yoshikawa H, Shin-Ya K, Kuzuyama T, Nishiyama M.

ACS Chem Biol. 2017 Jan 20;12(1):124-131. doi: 10.1021/acschembio.6b00818. Epub 2016 Nov 30.

PMID:
28103675
29.

Structure and function of an ancestral-type β-decarboxylating dehydrogenase from Thermococcus kodakarensis.

Shimizu T, Yin L, Yoshida A, Yokooji Y, Hachisuka SI, Sato T, Tomita T, Nishida H, Atomi H, Kuzuyama T, Nishiyama M.

Biochem J. 2017 Jan 1;474(1):105-122. doi: 10.1042/BCJ20160699. Epub 2016 Nov 9.

PMID:
27831491
30.

Novel stand-alone RAM domain protein-mediated catalytic control of anthranilate phosphoribosyltransferase in tryptophan biosynthesis in Thermus thermophilus.

Kubota T, Matsushita H, Tomita T, Kosono S, Yoshida M, Kuzuyama T, Nishiyama M.

Extremophiles. 2017 Jan;21(1):73-83. doi: 10.1007/s00792-016-0884-0. Epub 2016 Oct 19.

PMID:
27757697
31.

Characterization of two β-decarboxylating dehydrogenases from Sulfolobus acidocaldarius.

Takahashi K, Nakanishi F, Tomita T, Akiyama N, Lassak K, Albers SV, Kuzuyama T, Nishiyama M.

Extremophiles. 2016 Nov;20(6):843-853. Epub 2016 Sep 2.

PMID:
27590116
32.

Mechanistic insights into Diels-Alder reactions in natural product biosynthesis.

Hashimoto T, Kuzuyama T.

Curr Opin Chem Biol. 2016 Dec;35:117-123. doi: 10.1016/j.cbpa.2016.09.015. Epub 2016 Sep 30. Review.

PMID:
27697700
33.

Determinants of dual substrate specificity revealed by the crystal structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate·Mg(2+)·NADH.

Takahashi K, Tomita T, Kuzuyama T, Nishiyama M.

Biochem Biophys Res Commun. 2016 Sep 30;478(4):1688-93. doi: 10.1016/j.bbrc.2016.09.004. Epub 2016 Sep 4.

PMID:
27601325
34.

Lysine Biosynthesis of Thermococcus kodakarensis with the Capacity to Function as an Ornithine Biosynthetic System.

Yoshida A, Tomita T, Atomi H, Kuzuyama T, Nishiyama M.

J Biol Chem. 2016 Oct 7;291(41):21630-21643. Epub 2016 Aug 26.

35.

Aspartate kinase involved in 4-hydroxy-3-nitrosobenzamide biosynthesis in Streptomyces murayamaensis.

Tsujimoto M, Yoshida A, Shimizu T, Tomita T, Ohnishi Y, Kuzuyama T, Nishiyama M.

Biosci Biotechnol Biochem. 2016 Nov;80(11):2255-2263. doi: 10.1080/09168451.2016.1214534. Epub 2016 Aug 2.

PMID:
27485103
36.

Biosynthesis of Trehangelin in Polymorphospora rubra K07-0510: Identification of Metabolic Pathway to Angelyl-CoA.

Inahashi Y, Shiraishi T, Palm K, Takahashi Y, Ōmura S, Kuzuyama T, Nakashima T.

Chembiochem. 2016 Aug 3;17(15):1442-7. doi: 10.1002/cbic.201600208. Epub 2016 Jun 17.

PMID:
27311629
37.

Biosynthesis of the antituberculous agent caprazamycin: Identification of caprazol-3"-phosphate, an unprecedented caprazamycin-related metabolite.

Shiraishi T, Hiro N, Igarashi M, Nishiyama M, Kuzuyama T.

J Gen Appl Microbiol. 2016 Jul 14;62(3):164-6. doi: 10.2323/jgam.2016.01.002. Epub 2016 May 23. No abstract available.

38.

Crystal Structure of the LysY·LysW Complex from Thermus thermophilus.

Shimizu T, Tomita T, Kuzuyama T, Nishiyama M.

J Biol Chem. 2016 May 6;291(19):9948-59. doi: 10.1074/jbc.M115.707034. Epub 2016 Mar 9.

39.

Methylbenzene-Containing Polyketides from a Streptomyces that Spontaneously Acquired Rifampicin Resistance: Structural Elucidation and Biosynthesis.

Thong WL, Shin-ya K, Nishiyama M, Kuzuyama T.

J Nat Prod. 2016 Apr 22;79(4):857-64. doi: 10.1021/acs.jnatprod.5b00922. Epub 2016 Feb 24.

PMID:
26905826
40.

"Cation-Stitching Cascade": exquisite control of terpene cyclization in cyclooctatin biosynthesis.

Sato H, Teramoto K, Masumoto Y, Tezuka N, Sakai K, Ueda S, Totsuka Y, Shinada T, Nishiyama M, Wang C, Kuzuyama T, Uchiyama M.

Sci Rep. 2015 Dec 18;5:18471. doi: 10.1038/srep18471.

41.

Novel features of the ISC machinery revealed by characterization of Escherichia coli mutants that survive without iron-sulfur clusters.

Tanaka N, Kanazawa M, Tonosaki K, Yokoyama N, Kuzuyama T, Takahashi Y.

Mol Microbiol. 2016 Mar;99(5):835-48. doi: 10.1111/mmi.13271. Epub 2015 Dec 1.

42.

Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes.

Ye Y, Minami A, Mandi A, Liu C, Taniguchi T, Kuzuyama T, Monde K, Gomi K, Oikawa H.

J Am Chem Soc. 2015 Sep 16;137(36):11846-53. doi: 10.1021/jacs.5b08319. Epub 2015 Sep 4.

PMID:
26332841
43.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

44.

An unusual terpene cyclization mechanism involving a carbon-carbon bond rearrangement.

Meguro A, Motoyoshi Y, Teramoto K, Ueda S, Totsuka Y, Ando Y, Tomita T, Kim SY, Kimura T, Igarashi M, Sawa R, Shinada T, Nishiyama M, Kuzuyama T.

Angew Chem Int Ed Engl. 2015 Mar 27;54(14):4353-6. doi: 10.1002/anie.201411923. Epub 2015 Feb 16.

PMID:
25689152
45.

Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides.

Hashimoto T, Hashimoto J, Teruya K, Hirano T, Shin-ya K, Ikeda H, Liu HW, Nishiyama M, Kuzuyama T.

J Am Chem Soc. 2015 Jan 21;137(2):572-5. doi: 10.1021/ja510711x. Epub 2015 Jan 5.

46.

Terpene synthases are widely distributed in bacteria.

Yamada Y, Kuzuyama T, Komatsu M, Shin-Ya K, Omura S, Cane DE, Ikeda H.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):857-62. doi: 10.1073/pnas.1422108112. Epub 2014 Dec 22.

47.

Structural insight into amino group-carrier protein-mediated lysine biosynthesis: crystal structure of the LysZ·LysW complex from Thermus thermophilus.

Yoshida A, Tomita T, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M.

J Biol Chem. 2015 Jan 2;290(1):435-47. doi: 10.1074/jbc.M114.595983. Epub 2014 Nov 12.

48.

Identification of the biosynthetic gene cluster for the herbicide phosphonothrixin in Saccharothrix sp. ST-888.

Lin J, Nishiyama M, Kuzuyama T.

J Antibiot (Tokyo). 2015 May;68(5):357-9. doi: 10.1038/ja.2014.149. Epub 2014 Oct 29. No abstract available.

PMID:
25351949
49.

Crystallization and preliminary X-ray diffraction analysis of cyclolavandulyl diphosphate synthase, a new member of the cis-isoprenyl diphosphate synthase superfamily.

Tomita T, Ozaki T, Matsuda K, Nishiyama M, Kuzuyama T.

Acta Crystallogr F Struct Biol Commun. 2014 Oct;70(Pt 10):1410-3. doi: 10.1107/S2053230X14018883. Epub 2014 Sep 25.

50.

Genome-wide comprehensive analysis of transcriptional regulation by ArgR in Thermus thermophilus.

Iwanaga N, Ide K, Nagashima T, Tomita T, Agari Y, Shinkai A, Kuramitsu S, Okada-Hatakeyema M, Kuzuyama T, Nishiyama M.

Extremophiles. 2014 Nov;18(6):995-1008. doi: 10.1007/s00792-014-0669-2. Epub 2014 Jul 29.

PMID:
25069875

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