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BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers.

Kuznetsov JN, Aguero TH, Owens DA, Kurtenbach S, Field MG, Durante MA, Rodriguez DA, King ML, Harbour JW.

Sci Adv. 2019 Sep 18;5(9):eaax1738. doi: 10.1126/sciadv.aax1738. eCollection 2019 Sep.


BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas.

Field MG, Kuznetsov JN, Bussies PL, Cai LZ, Alawa KA, Decatur CL, Kurtenbach S, Harbour JW.

Clin Cancer Res. 2019 Sep 15;25(18):5663-5673. doi: 10.1158/1078-0432.CCR-19-0366. Epub 2019 Jul 8.


Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts.

Leclerc GM, Leclerc GJ, Kuznetsov JN, DeSalvo J, Barredo JC.

PLoS One. 2013 Aug 23;8(8):e74420. doi: 10.1371/journal.pone.0074420. eCollection 2013.


Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia.

DeSalvo J, Kuznetsov JN, Du J, Leclerc GM, Leclerc GJ, Lampidis TJ, Barredo JC.

Mol Cancer Res. 2012 Jul;10(7):969-78. doi: 10.1158/1541-7786.MCR-12-0125. Epub 2012 Jun 12.


AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.

Kuznetsov JN, Leclerc GJ, Leclerc GM, Barredo JC.

Mol Cancer Ther. 2011 Mar;10(3):437-47. doi: 10.1158/1535-7163.MCT-10-0777. Epub 2011 Jan 24.

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