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Items: 15

1.

CYP3A4 induction in the liver and intestine of PXR/CYP3A-humanized mice: approaches by mass spectrometry imaging and portal blood analysis.

Kobayashi K, Kuze J, Abe S, Takehara S, Minegishi G, Igarashi K, Kitajima S, Kanno J, Yamamoto T, Oshimura M, Kazuki Y.

Mol Pharmacol. 2019 Aug 27. pii: mol.119.117333. doi: 10.1124/mol.119.117333. [Epub ahead of print]

2.

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.

Kazuki Y, Kobayashi K, Hirabayashi M, Abe S, Kajitani N, Kazuki K, Takehara S, Takiguchi M, Satoh D, Kuze J, Sakuma T, Kaneko T, Mashimo T, Osamura M, Hashimoto M, Wakatsuki R, Hirashima R, Fujiwara R, Deguchi T, Kurihara A, Tsukazaki Y, Senda N, Yamamoto T, Scheer N, Oshimura M.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3072-3081. doi: 10.1073/pnas.1808255116. Epub 2019 Feb 4.

3.

Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates.

Takenaka T, Kazuki K, Harada N, Kuze J, Chiba M, Iwao T, Matsunaga T, Abe S, Oshimura M, Kazuki Y.

Drug Metab Pharmacokinet. 2017 Feb;32(1):61-68. doi: 10.1016/j.dmpk.2016.08.004. Epub 2016 Aug 26.

PMID:
28139373
4.

Application of a Human Intestinal Epithelial Cell Monolayer to the Prediction of Oral Drug Absorption in Humans as a Superior Alternative to the Caco-2 Cell Monolayer.

Takenaka T, Harada N, Kuze J, Chiba M, Iwao T, Matsunaga T.

J Pharm Sci. 2016 Feb;105(2):915-924. doi: 10.1016/j.xphs.2015.11.035.

PMID:
26869436
5.

Human small intestinal epithelial cells differentiated from adult intestinal stem cells as a novel system for predicting oral drug absorption in humans.

Takenaka T, Harada N, Kuze J, Chiba M, Iwao T, Matsunaga T.

Drug Metab Dispos. 2014 Nov;42(11):1947-54. doi: 10.1124/dmd.114.059493. Epub 2014 Sep 8.

PMID:
25200868
6.

Utility of cryopreserved hepatocytes suspended in serum to predict hepatic clearance in dogs and monkeys.

Shibata Y, Kuze J, Chiba M.

Drug Metab Pharmacokinet. 2014;29(2):168-76. Epub 2013 Sep 17.

7.

Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam.

Kuze J, Mutoh T, Takenaka T, Oda N, Hanioka N, Narimatsu S.

Xenobiotica. 2013 Jul;43(7):598-606. doi: 10.3109/00498254.2012.751517. Epub 2013 Jan 3.

PMID:
23282066
8.

Separate evaluation of intestinal and hepatic metabolism of three benzodiazepines in rats with cannulated portal and jugular veins: comparison with the profile in non-cannulated mice.

Kuze J, Mutoh T, Takenaka T, Morisaki K, Nakura H, Hanioka N, Narimatsu S.

Xenobiotica. 2009 Nov;39(11):871-80. doi: 10.3109/00498250903215382.

PMID:
19845438
9.

[Social relationaship factors and risk of care requirement in Japanese elderly].

Yoshii K, Kondo K, Kuze J, Higuchi K.

Nihon Koshu Eisei Zasshi. 2005 Jun;52(6):456-67. Japanese.

PMID:
16038414
10.

Binocular rivalry alternation rate declines with age.

Ukai K, Ando H, Kuze J.

Percept Mot Skills. 2003 Oct;97(2):393-7.

PMID:
14620224
11.

N3-phenacyluridine, a novel hypnotic compound, interacts with the benzodiazepine receptor.

Kimura T, Kuze J, Watanabe K, Kondo S, Ho IK, Yamamoto I.

Eur J Pharmacol. 1996 Sep 12;311(2-3):265-9.

PMID:
8891608
12.

Central nervous system depressant effects of N3-substituted derivatives of deoxyuridine in mice.

Kimura T, Kuze J, Teraoka S, Watanabe K, Tateoka Y, Kondo S, Ho IK, Yamamoto I.

Biol Pharm Bull. 1996 Jan;19(1):142-5.

PMID:
8820928
13.

The potent depressant effects of N3-phenacyluridine in mice.

Yamamoto I, Kuze J, Kimura T, Watanabe K, Kondo S, Ho IK.

Biol Pharm Bull. 1994 Apr;17(4):514-6.

PMID:
8069259
14.

Sedative and hypnotic activities of pyrimidine nucleoside derivatives.

Kimura T, Teraoka S, Kuze J, Watanabe K, Kondo S, Ho IK, Yamamoto I.

Nucleic Acids Symp Ser. 1993;(29):51-2.

PMID:
8247791
15.

The nucleoside derivatives possessing sedative and hypnotic effects.

Kimura T, Kuze J, Watanabe K, Yamamoto I, Ueda T, Katagiri N, Kaneko C, Tateoka Y, Kondo S.

Nucleic Acids Symp Ser. 1991;(25):95-6.

PMID:
1842113

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