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Items: 1 to 50 of 175


Highlight article: Vincristine-induced anemia in hereditary spherocytosis.

Michlitsch J, Larkin S, Vichinsky E, Kuypers FA.

Exp Biol Med (Maywood). 2019 Jul;244(10):850-854. doi: 10.1177/1535370219853791. Epub 2019 Jun 4. No abstract available.


Image-Based Flow Cytometry and Angle-Resolved Light Scattering to Define the Sickling Process.

Goktas P, Sukharevsky IO, Larkin S, Kuypers FA, Yalcin O, Altintas A.

Cytometry A. 2019 May;95(5):488-498. doi: 10.1002/cyto.a.23756. Epub 2019 Apr 13.


ACBD6 protein controls acyl chain availability and specificity of the N-myristoylation modification of proteins.

Soupene E, Kuypers FA.

J Lipid Res. 2019 Mar;60(3):624-635. doi: 10.1194/jlr.M091397. Epub 2019 Jan 14.


Hereditary elliptocytosis: Variable clinical severity caused by 3 variants in the α-spectrin gene.

Franck P, Postma C, Spaans A, Veuger M, de Kort G, Hudig C, Wijermans P, Kuypers F.

Int J Lab Hematol. 2018 Aug;40(4):e66-e70. doi: 10.1111/ijlh.12837. Epub 2018 May 5. No abstract available.


Featured Article: Depletion of HDL3 high density lipoprotein and altered functionality of HDL2 in blood from sickle cell patients.

Soupene E, Larkin SK, Kuypers FA.

Exp Biol Med (Maywood). 2017 Jun;242(12):1244-1253. doi: 10.1177/1535370217706966. Epub 2017 Apr 24.


Simvastatin reduces vaso-occlusive pain in sickle cell anaemia: a pilot efficacy trial.

Hoppe C, Jacob E, Styles L, Kuypers F, Larkin S, Vichinsky E.

Br J Haematol. 2017 May;177(4):620-629. doi: 10.1111/bjh.14580. Epub 2017 Mar 28.


Erythrocytes from hereditary xerocytosis patients heterozygous for KCNN4 V282M exhibit increased spontaneous Gardos channel-like activity inhibited by senicapoc.

Rivera A, Vandorpe DH, Shmukler BE, Gallagher DR, Fikry CC, Kuypers FA, Brugnara C, Snyder LM, Alper SL.

Am J Hematol. 2017 Jun;92(6):E108-E110. doi: 10.1002/ajh.24716. Epub 2017 Apr 29. No abstract available.


Targeting tumor hypoxia with the epigenetic anticancer agent, RRx-001: a superagonist of nitric oxide generation.

Fens MH, Cabrales P, Scicinski J, Larkin SK, Suh JH, Kuypers FA, Oronsky N, Lybeck M, Oronsky A, Oronsky B.

Med Oncol. 2016 Aug;33(8):85. doi: 10.1007/s12032-016-0798-9. Epub 2016 Jul 4.


Featured Article: Alterations of lecithin cholesterol acyltransferase activity and apolipoprotein A-I functionality in human sickle blood.

Soupene E, Borja MS, Borda M, Larkin SK, Kuypers FA.

Exp Biol Med (Maywood). 2016 Nov;241(17):1933-1942. Epub 2016 Jun 27.


A look inside the mechanistic black box: Are red blood cells the critical effectors of RRx-001 cytotoxicity?

Cabrales P, Scicinski J, Reid T, Kuypers F, Larkin S, Fens M, Oronsky A, Oronsky B.

Med Oncol. 2016 Jul;33(7):63. doi: 10.1007/s12032-016-0775-3. Epub 2016 May 26.


Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA.

Soupene E, Kao J, Cheng DH, Wang D, Greninger AL, Knudsen GM, DeRisi JL, Kuypers FA.

J Lipid Res. 2016 Feb;57(2):288-98. doi: 10.1194/jlr.M065003. Epub 2015 Nov 30.


Sub-population analysis of deformability distribution in heterogeneous red blood cell population.

Lee DW, Doh I, Kuypers FA, Cho YH.

Biomed Microdevices. 2015 Dec;17(6):102. doi: 10.1007/s10544-015-0007-1.


Ligand binding to the ACBD6 protein regulates the acyl-CoA transferase reactions in membranes.

Soupene E, Kuypers FA.

J Lipid Res. 2015 Oct;56(10):1961-71. doi: 10.1194/jlr.M061937. Epub 2015 Aug 19.


From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria.

Yalcin O, Oronsky B, Carvalho LJ, Kuypers FA, Scicinski J, Cabrales P.

Malar J. 2015 May 28;14:218. doi: 10.1186/s12936-015-0720-5.


Dysregulated arginine metabolism and cardiopulmonary dysfunction in patients with thalassaemia.

Morris CR, Kim HY, Klings ES, Wood J, Porter JB, Trachtenberg F, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Hassell K, Taher A, Neufeld EJ, Thompson AA, Larkin S, Suh JH, Vichinsky EP, Kuypers FA; Thalassemia Clinical Research Network.

Br J Haematol. 2015 Jun;169(6):887-98. doi: 10.1111/bjh.13452. Epub 2015 Apr 24.


Remodeling of host phosphatidylcholine by Chlamydia acyltransferase is regulated by acyl-CoA binding protein ACBD6 associated with lipid droplets.

Soupene E, Wang D, Kuypers FA.

Microbiologyopen. 2015 Apr;4(2):235-251. doi: 10.1002/mbo3.234. Epub 2015 Jan 21.


Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance.

Tang HY, Ho HY, Wu PR, Chen SH, Kuypers FA, Cheng ML, Chiu DT.

Antioxid Redox Signal. 2015 Mar 20;22(9):744-59. doi: 10.1089/ars.2014.6142. Epub 2015 Feb 10.


Microparticles as biomarkers of osteonecrosis of the hip in sickle cell disease.

Marsh A, Schiffelers R, Kuypers F, Larkin S, Gildengorin G, van Solinge W, Hoppe C.

Br J Haematol. 2015 Jan;168(1):135-8. doi: 10.1111/bjh.13110. Epub 2014 Sep 6.


The capacity of red blood cells to reduce nitrite determines nitric oxide generation under hypoxic conditions.

Fens MH, Larkin SK, Oronsky B, Scicinski J, Morris CR, Kuypers FA.

PLoS One. 2014 Jul 9;9(7):e101626. doi: 10.1371/journal.pone.0101626. eCollection 2014.


Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia.

Wun T, Styles L, DeCastro L, Telen MJ, Kuypers F, Cheung A, Kramer W, Flanner H, Rhee S, Magnani JL, Thackray H.

PLoS One. 2014 Jul 2;9(7):e101301. doi: 10.1371/journal.pone.0101301. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e111690.


Hemoglobin s polymerization and red cell membrane changes.

Kuypers FA.

Hematol Oncol Clin North Am. 2014 Apr;28(2):155-79. doi: 10.1016/j.hoc.2013.12.002. Epub 2014 Jan 22. Review.


Elevated tricuspid regurgitant jet velocity in subgroups of thalassemia patients: insight into pathophysiology and the effect of splenectomy.

Singer ST, Kuypers F, Fineman J, Gildengorin G, Larkin S, Sweeters N, Rosenfeld H, Kurio G, Higa A, Jeng M, Huang J, Vichinsky EP.

Ann Hematol. 2014 Jul;93(7):1139-48. doi: 10.1007/s00277-014-2037-9. Epub 2014 Feb 28.


Thiol/redox metabolomic profiling implicates GSH dysregulation in early experimental graft versus host disease (GVHD).

Suh JH, Kanathezhath B, Shenvi S, Guo H, Zhou A, Tiwana A, Kuypers F, Ames BN, Walters MC.

PLoS One. 2014 Feb 18;9(2):e88868. doi: 10.1371/journal.pone.0088868. eCollection 2014.


RBC deformability and amino acid concentrations after hypo-osmotic challenge may reflect chronic cell hydration status in healthy young men.

Stookey JD, Klein A, Hamer J, Chi C, Higa A, Ng V, Arieff A, Kuypers FA, Larkin S, Perrier E, Lang F.

Physiol Rep. 2013 Oct;1(5):e00117. doi: 10.1002/phy2.117. Epub 2013 Oct 23.


A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes.

Morris CR, Kuypers FA, Lavrisha L, Ansari M, Sweeters N, Stewart M, Gildengorin G, Neumayr L, Vichinsky EP.

Haematologica. 2013 Sep;98(9):1375-82. doi: 10.3324/haematol.2013.086637. Epub 2013 May 3.


Sildenafil therapy in thalassemia patients with Doppler-defined risk of pulmonary hypertension.

Morris CR, Kim HY, Wood J, Porter JB, Klings ES, Trachtenberg FL, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Singer ST, Taher A, Neufeld EJ, Thompson AA, Sachdev V, Larkin S, Suh JH, Kuypers FA, Vichinsky EP; Thalassemia Clinical Research Network.

Haematologica. 2013 Sep;98(9):1359-67. doi: 10.3324/haematol.2012.082065. Epub 2013 Apr 12.


Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential.

Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay MA, Kuypers FA, Serikov VB.

Stem Cells Transl Med. 2012 May;1(5):359-72. doi: 10.5966/sctm.2011-0021. Epub 2012 May 8.


Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium.

Smith S, Witkowski A, Moghul A, Yoshinaga Y, Nefedov M, de Jong P, Feng D, Fong L, Tu Y, Hu Y, Young SG, Pham T, Cheung C, Katzman SM, Brand MD, Quinlan CL, Fens M, Kuypers F, Misquitta S, Griffey SM, Tran S, Gharib A, Knudsen J, Hannibal-Bach HK, Wang G, Larkin S, Thweatt J, Pasta S.

PLoS One. 2012;7(10):e47196. doi: 10.1371/journal.pone.0047196. Epub 2012 Oct 15.


Phosphatidylcholine formation by LPCAT1 is regulated by Ca(2+) and the redox status of the cell.

Soupene E, Kuypers FA.

BMC Biochem. 2012 Jun 7;13:8. doi: 10.1186/1471-2091-13-8.


Eukaryotic protein recruitment into the Chlamydia inclusion: implications for survival and growth.

Soupene E, Rothschild J, Kuypers FA, Dean D.

PLoS One. 2012;7(5):e36843. doi: 10.1371/journal.pone.0036843. Epub 2012 May 9.


Deformation measurement of individual cells in large populations using a single-cell microchamber array chip.

Doh I, Lee WC, Cho YH, Pisano AP, Kuypers FA.

Appl Phys Lett. 2012 Apr 23;100(17):173702-1737023.


Research in athletes with sickle cell trait: just do it.

Kuypers FA, Marsh AM.

J Appl Physiol (1985). 2012 May;112(9):1433. doi: 10.1152/japplphysiol.00221.2012. Epub 2012 Feb 23. No abstract available.


A transgenic mouse model expressing exclusively human hemoglobin E: indications of a mild oxidative stress.

Chen Q, Fabry ME, Rybicki AC, Suzuka SM, Balazs TC, Etzion Z, de Jong K, Akoto EK, Canterino JE, Kaul DK, Kuypers FA, Lefer D, Bouhassira EE, Hirsch RE.

Blood Cells Mol Dis. 2012 Feb 15;48(2):91-101. doi: 10.1016/j.bcmd.2011.12.002. Epub 2012 Jan 18.


Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S.

Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL.

Am J Physiol Cell Physiol. 2011 Dec;301(6):C1325-43. doi: 10.1152/ajpcell.00054.2011. Epub 2011 Aug 17.


Tapered oral dexamethasone for the acute chest syndrome of sickle cell disease.

Quinn CT, Stuart MJ, Kesler K, Ataga KI, Wang WC, Styles L, Smith-Whitley K, Wun T, Raj A, Hsu LL, Krishnan S, Kuypers FA, Setty Y, Rhee S, Key NS, Buchanan GR; Investigators of the Comprehensive Sickle Cell Centers.

Br J Haematol. 2011 Oct;155(2):263-7. doi: 10.1111/j.1365-2141.2011.08827.x. Epub 2011 Aug 16.


A pilot study of subcutaneous decitabine in β-thalassemia intermedia.

Olivieri NF, Saunthararajah Y, Thayalasuthan V, Kwiatkowski J, Ware RE, Kuypers FA, Kim HY, Trachtenberg FL, Vichinsky EP; Thalassemia Clinical Research Network.

Blood. 2011 Sep 8;118(10):2708-11. doi: 10.1182/blood-2011-03-341909. Epub 2011 Jun 23.


A pilot study of the short-term use of simvastatin in sickle cell disease: effects on markers of vascular dysfunction.

Hoppe C, Kuypers F, Larkin S, Hagar W, Vichinsky E, Styles L.

Br J Haematol. 2011 Jun;153(5):655-63. doi: 10.1111/j.1365-2141.2010.08480.x. Epub 2011 Apr 8.


Improved engraftment with minimal graft-versus-host disease after major histocompatibility complex-mismatched cord blood transplantation with photochemically treated donor lymphocytes.

Kanathezhath B, Mizokami M, Stanislaus S, Hounshell C, Neumayr L, Guo H, Hearst JE, Walters MC, Kuypers FA.

Exp Biol Med (Maywood). 2011 Apr 1;236(4):492-504. doi: 10.1258/ebm.2011.010216. Epub 2011 Mar 31.


Large-scale arrays of picolitre chambers for single-cell analysis of large cell populations.

Lee WC, Rigante S, Pisano AP, Kuypers FA.

Lab Chip. 2010 Nov 7;10(21):2952-8. doi: 10.1039/c0lc00139b. Epub 2010 Sep 13.


Secretory phospholipase A2: a marker of infection in febrile children presenting to a pediatric ED.

Mansour KM, Kuypers FA, Wang TN, Miller AM, Larkin SK, Morris CR.

Am J Emerg Med. 2011 Nov;29(9):1163-8. doi: 10.1016/j.ajem.2010.06.024. Epub 2010 Aug 13.


Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton.

Moyer JD, Nowak RB, Kim NE, Larkin SK, Peters LL, Hartwig J, Kuypers FA, Fowler VM.

Blood. 2010 Oct 7;116(14):2590-9. doi: 10.1182/blood-2010-02-268458. Epub 2010 Jun 28.


Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains.

Soupene E, Dinh NP, Siliakus M, Kuypers FA.

BMC Biochem. 2010 Apr 29;11:18. doi: 10.1186/1471-2091-11-18.


The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism.

Johnson RM, Ho YS, Yu DY, Kuypers FA, Ravindranath Y, Goyette GW.

Free Radic Biol Med. 2010 Feb 15;48(4):519-25. doi: 10.1016/j.freeradbiomed.2009.11.021. Epub 2009 Dec 4.


Hemoglobin Hakkari: an autosomal dominant form of beta thalassemia with inclusion bodies arising from de novo mutation in exon 2 of beta globin gene.

Kanathezhath B, Hazard FK, Guo H, Kidd J, Azimi M, Kuypers FA, Vichinsky EP, Lal A.

Pediatr Blood Cancer. 2010 Feb;54(2):332-5. doi: 10.1002/pbc.22167.


Human term placenta as a source of hematopoietic cells.

Serikov V, Hounshell C, Larkin S, Green W, Ikeda H, Walters MC, Kuypers FA.

Exp Biol Med (Maywood). 2009 Jul;234(7):813-23. doi: 10.3181/0809-BC-262. Epub 2009 May 8.


Imaging of the diffusion of single band 3 molecules on normal and mutant erythrocytes.

Kodippili GC, Spector J, Sullivan C, Kuypers FA, Labotka R, Gallagher PG, Ritchie K, Low PS.

Blood. 2009 Jun 11;113(24):6237-45. doi: 10.1182/blood-2009-02-205450. Epub 2009 Apr 15.


Red cell membrane lipids in hemoglobinopathies.

Kuypers FA.

Curr Mol Med. 2008 Nov;8(7):633-8. Review.


Hydroxycarbamide-induced changes in E/beta thalassemia red blood cells.

Singer ST, Vichinsky EP, Larkin S, Olivieri N, Sweeters N, Kuypers FA; E/beta Thalassemia Study Group.

Am J Hematol. 2008 Nov;83(11):842-5. doi: 10.1002/ajh.21266.


Mammalian long-chain acyl-CoA synthetases.

Soupene E, Kuypers FA.

Exp Biol Med (Maywood). 2008 May;233(5):507-21. doi: 10.3181/0710-MR-287. Epub 2008 Mar 28. Review.

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