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Items: 1 to 50 of 292

1.

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.

Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, Arai F, Hagihara S, Yamaguchi J, Tama F, Kunisaki Y, Yagita K, Ikeda M, Kinoshita T, Kay SA, Itami K, Hirota T.

Sci Adv. 2019 Jan 23;5(1):eaau9060. doi: 10.1126/sciadv.aau9060. eCollection 2019 Jan.

2.

Development of a Nitric Oxide-Responsive Labeling Reagent for Proteome Analysis of Live Cells.

Nishikawa Y, Miki T, Awa M, Kuwata K, Tamura T, Hamachi I.

ACS Chem Biol. 2019 Mar 15;14(3):397-404. doi: 10.1021/acschembio.8b01021. Epub 2019 Feb 14.

PMID:
30715847
3.

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.

Shindo N, Fuchida H, Sato M, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunaga K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A.

Nat Chem Biol. 2019 Mar;15(3):250-258. doi: 10.1038/s41589-018-0204-3. Epub 2019 Jan 14.

PMID:
30643284
4.

A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia.

Kakuda K, Niwa A, Honda R, Yamaguchi KI, Tomita H, Nojebuzzaman M, Hara A, Goto Y, Osawa M, Kuwata K.

J Biochem. 2019 Apr 1;165(4):369-378. doi: 10.1093/jb/mvy116.

PMID:
30561706
5.

A Covalent Inhibitor for Glutathione S-Transferase Pi (GSTP1-1 ) in Human Cells.

Shishido Y, Tomoike F, Kuwata K, Fujikawa H, Sekido Y, Murakami-Tonami Y, Kameda T, Abe N, Kimura Y, Shuto S, Abe H.

Chembiochem. 2018 Dec 7. doi: 10.1002/cbic.201800671. [Epub ahead of print]

PMID:
30548113
6.

A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica.

Uraguchi D, Kuwata K, Hijikata Y, Yamaguchi R, Imaizumi H, Am S, Rakers C, Mori N, Akiyama K, Irle S, McCourt P, Kinoshita T, Ooi T, Tsuchiya Y.

Science. 2018 Dec 14;362(6420):1301-1305. doi: 10.1126/science.aau5445.

PMID:
30545887
7.

Chemical Profiling of the Endoplasmic Reticulum Proteome Using Designer Labeling Reagents.

Fujisawa A, Tamura T, Yasueda Y, Kuwata K, Hamachi I.

J Am Chem Soc. 2018 Nov 28. doi: 10.1021/jacs.8b08606. [Epub ahead of print]

PMID:
30433779
8.

Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability.

Lu Y, Maruyama J, Kuwata K, Fukuda H, Iwasa H, Arimoto-Matsuzaki K, Sugimura H, Hata Y.

Biochem Biophys Rep. 2018 Oct 30;16:130-137. doi: 10.1016/j.bbrep.2018.10.014. eCollection 2018 Dec.

9.

A valine-to-lysine substitution at position 210 induces structural conversion of prion protein into a β-sheet rich oligomer.

Kakuda K, Yamaguchi KI, Kuwata K, Honda R.

Biochem Biophys Res Commun. 2018 Nov 17;506(1):81-86. doi: 10.1016/j.bbrc.2018.10.075. Epub 2018 Oct 16.

PMID:
30336980
10.

Tissue-specific and intracellular localization of indican synthase from Polygonum tinctorium.

Inoue S, Morita R, Kuwata K, Kunieda T, Ueda H, Hara-Nishimura I, Minami Y.

Plant Physiol Biochem. 2018 Nov;132:138-144. doi: 10.1016/j.plaphy.2018.08.034. Epub 2018 Aug 28.

PMID:
30189417
11.

Poly-L-histidine inhibits prion propagation in a prion-infected cell line.

Honda R, Yamaguchi KI, Elhelaly AE, Fuji M, Kuwata K.

Prion. 2018;12(3-4):226-233. doi: 10.1080/19336896.2018.1505395. Epub 2018 Aug 17.

PMID:
30074430
12.

Identification of Alprenolol Hydrochloride as an Anti-prion Compound Using Surface Plasmon Resonance Imaging.

Miyazaki Y, Ishikawa T, Kamatari YO, Nakagaki T, Takatsuki H, Ishibashi D, Kuwata K, Nishida N, Atarashi R.

Mol Neurobiol. 2019 Jan;56(1):367-377. doi: 10.1007/s12035-018-1088-7. Epub 2018 Apr 27.

PMID:
29704200
13.

Daidzein reductase of Eggerthella sp. YY7918, its octameric subunit structure containing FMN/FAD/4Fe-4S, and its enantioselective production of R-dihydroisoflavones.

Kawada Y, Goshima T, Sawamura R, Yokoyama SI, Yanase E, Niwa T, Ebihara A, Inagaki M, Yamaguchi K, Kuwata K, Kato Y, Sakurada O, Suzuki T.

J Biosci Bioeng. 2018 Sep;126(3):301-309. doi: 10.1016/j.jbiosc.2018.03.018. Epub 2018 Apr 23.

PMID:
29699942
14.

Discovery of Shoot Branching Regulator Targeting Strigolactone Receptor DWARF14.

Yoshimura M, Sato A, Kuwata K, Inukai Y, Kinoshita T, Itami K, Tsuchiya Y, Hagihara S.

ACS Cent Sci. 2018 Feb 28;4(2):230-234. doi: 10.1021/acscentsci.7b00554. Epub 2018 Feb 7.

15.

The Phosphate Fast-Responsive Genes PECP1 and PPsPase1 Affect Phosphocholine and Phosphoethanolamine Content.

Hanchi M, Thibaud MC, Légeret B, Kuwata K, Pochon N, Beisson F, Cao A, Cuyas L, David P, Doerner P, Ferjani A, Lai F, Li-Beisson Y, Mutterer J, Philibert M, Raghothama KG, Rivasseau C, Secco D, Whelan J, Nussaume L, Javot H.

Plant Physiol. 2018 Apr;176(4):2943-2962. doi: 10.1104/pp.17.01246. Epub 2018 Feb 23.

16.

Time-Course Transcriptomics Analysis Reveals Key Responses of Submerged Deepwater Rice to Flooding.

Minami A, Yano K, Gamuyao R, Nagai K, Kuroha T, Ayano M, Nakamori M, Koike M, Kondo Y, Niimi Y, Kuwata K, Suzuki T, Higashiyama T, Takebayashi Y, Kojima M, Sakakibara H, Toyoda A, Fujiyama A, Kurata N, Ashikari M, Reuscher S.

Plant Physiol. 2018 Apr;176(4):3081-3102. doi: 10.1104/pp.17.00858. Epub 2018 Feb 23.

PMID:
29475897
17.

Molecular basis for diversification of yeast prion strain conformation.

Ohhashi Y, Yamaguchi Y, Kurahashi H, Kamatari YO, Sugiyama S, Uluca B, Piechatzek T, Komi Y, Shida T, Müller H, Hanashima S, Heise H, Kuwata K, Tanaka M.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2389-2394. doi: 10.1073/pnas.1715483115. Epub 2018 Feb 21.

18.

Quantum Chemical and Statistical Rate Theory Studies of the Vinyl Hydroperoxides Formed in trans-2-Butene and 2,3-Dimethyl-2-butene Ozonolysis.

Kuwata KT, Luu L, Weberg AB, Huang K, Parsons AJ, Peebles LA, Rackstraw NB, Kim MJ.

J Phys Chem A. 2018 Mar 8;122(9):2485-2502. doi: 10.1021/acs.jpca.8b00287. Epub 2018 Feb 21.

PMID:
29431443
19.

Acceleration of nucleation of prion protein during continuous ultrasonication.

Yamaguchi KI, Honda RP, Elhelaly AE, Kuwata K.

J Biochem. 2018 Jun 1;163(6):503-513. doi: 10.1093/jb/mvy015.

PMID:
29409004
20.

Evidence for a central role of PrP helix 2 in the nucleation of amyloid fibrils.

Honda R, Kuwata K.

FASEB J. 2018 Jul;32(7):3641-3652. doi: 10.1096/fj.201701183RR. Epub 2018 Feb 1.

PMID:
29401635
21.

Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.

Endo S, Xia S, Suyama M, Morikawa Y, Oguri H, Hu D, Ao Y, Takahara S, Horino Y, Hayakawa Y, Watanabe Y, Gouda H, Hara A, Kuwata K, Toyooka N, Matsunaga T, Ikari A.

J Med Chem. 2018 Feb 8;61(3):1380. doi: 10.1021/acs.jmedchem.7b01911. Epub 2018 Jan 11. No abstract available.

PMID:
29323483
22.

Drug-Excipient Interactions: Effect on Molecular Mobility and Physical Stability of Ketoconazole-Organic Acid Coamorphous Systems.

Fung MH, DeVault M, Kuwata KT, Suryanarayanan R.

Mol Pharm. 2018 Mar 5;15(3):1052-1061. doi: 10.1021/acs.molpharmaceut.7b00932. Epub 2018 Feb 16.

PMID:
29309158
23.

Formation and properties of amyloid fibrils of prion protein.

Yamaguchi KI, Kuwata K.

Biophys Rev. 2018 Apr;10(2):517-525. doi: 10.1007/s12551-017-0377-0. Epub 2017 Dec 4. Review.

24.

Protein-Ligand Dissociation Simulated by Parallel Cascade Selection Molecular Dynamics.

Tran DP, Takemura K, Kuwata K, Kitao A.

J Chem Theory Comput. 2018 Jan 9;14(1):404-417. doi: 10.1021/acs.jctc.7b00504. Epub 2017 Dec 8.

25.

Characterization of UDP-glucosyltransferase from Indigofera tinctoria.

Inoue S, Moriya T, Morita R, Kuwata K, Thul ST, Sarangi BK, Minami Y.

Plant Physiol Biochem. 2017 Dec;121:226-233. doi: 10.1016/j.plaphy.2017.11.002. Epub 2017 Nov 6.

PMID:
29156217
26.

Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.

Endo S, Xia S, Suyama M, Morikawa Y, Oguri H, Hu D, Ao Y, Takahara S, Horino Y, Hayakawa Y, Watanabe Y, Gouda H, Hara A, Kuwata K, Toyooka N, Matsunaga T, Ikari A.

J Med Chem. 2017 Oct 26;60(20):8441-8455. doi: 10.1021/acs.jmedchem.7b00830. Epub 2017 Oct 13. Erratum in: J Med Chem. 2018 Feb 8;61(3):1380.

PMID:
28976752
27.

The calcium-binding protein ALG-2 regulates protein secretion and trafficking via interactions with MISSL and MAP1B proteins.

Takahara T, Inoue K, Arai Y, Kuwata K, Shibata H, Maki M.

J Biol Chem. 2017 Oct 13;292(41):17057-17072. doi: 10.1074/jbc.M117.800201. Epub 2017 Sep 1.

28.

A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP1-1).

Shishido Y, Tomoike F, Kimura Y, Kuwata K, Yano T, Fukui K, Fujikawa H, Sekido Y, Murakami-Tonami Y, Kameda T, Shuto S, Abe H.

Chem Commun (Camb). 2017 Oct 10;53(81):11138-11141. doi: 10.1039/c7cc05829b.

PMID:
28848941
29.

PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA.

Sugiyama T, Hasegawa G, Niikura C, Kuwata K, Imamura Y, Demizu Y, Kurihara M, Kittaka A.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3337-3341. doi: 10.1016/j.bmcl.2017.06.015. Epub 2017 Jun 3.

PMID:
28610975
30.

β-catenin Mutations Are Not Involved in Early-stage Hepatocarcinogenesis Induced by Protoporphyrinogen Oxidase Inhibitors in Mice.

Kuwata K, Inoue K, Ichimura R, Takahashi M, Kodama Y, Shibutani M, Yoshida M.

Toxicol Pathol. 2017 Jun;45(4):493-505. doi: 10.1177/0192623317708898. Epub 2017 Jun 5.

PMID:
28580885
31.

The effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS).

Suzuki Y, Enokido Y, Yamada K, Inaba M, Kuwata K, Hanada N, Morishita T, Mizuno S, Wakamatsu N.

Oncotarget. 2017 Jul 11;8(28):45470-45483. doi: 10.18632/oncotarget.17566.

32.

Drosophila Dalmatian combines sororin and shugoshin roles in establishment and protection of cohesion.

Yamada T, Tahara E, Kanke M, Kuwata K, Nishiyama T.

EMBO J. 2017 Jun 1;36(11):1513-1527. doi: 10.15252/embj.201695607. Epub 2017 May 8.

33.

Capsular polysaccharide inhibits adhesion of Bifidobacterium longum 105-A to enterocyte-like Caco-2 cells and phagocytosis by macrophages.

Tahoun A, Masutani H, El-Sharkawy H, Gillespie T, Honda RP, Kuwata K, Inagaki M, Yabe T, Nomura I, Suzuki T.

Gut Pathog. 2017 May 1;9:27. doi: 10.1186/s13099-017-0177-x. eCollection 2017.

34.

Cu-Catalyzed aromatic C-H imidation with N-fluorobenzenesulfonimide: mechanistic details and predictive models.

Haines BE, Kawakami T, Kuwata K, Murakami K, Itami K, Musaev DG.

Chem Sci. 2017 Feb 1;8(2):988-1001. doi: 10.1039/c6sc04145k. Epub 2016 Oct 19.

35.

The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro.

Honda RP, Kuwata K.

Sci Rep. 2017 Apr 3;7(1):562. doi: 10.1038/s41598-017-00710-x.

36.

The role of estrogen receptor subtypes for induction of delayed effects on the estrous cycle and female reproductive organs in rats.

Takahashi M, Ichimura R, Inoue K, Morikawa T, Kuwata K, Watanabe G, Yoshida M.

Reprod Biol. 2017 Mar;17(1):111-119. doi: 10.1016/j.repbio.2017.01.007. Epub 2017 Feb 17.

PMID:
28215489
37.

Instability of C154Y variant of aldo-keto reductase 1C3.

Endo S, Takada S, Honda RP, Müller K, Weishaupt JH, Andersen PM, Ludolph AC, Kamatari YO, Matsunaga T, Kuwata K, El-Kabbani O, Ikari A.

Chem Biol Interact. 2017 Oct 1;276:194-202. doi: 10.1016/j.cbi.2016.12.018. Epub 2016 Dec 23.

PMID:
28025170
38.

Evaluation of compound selectivity of aldo-keto reductases using differential scanning fluorimetry.

Kabir A, Endo S, Toyooka N, Fukuoka M, Kuwata K, Kamatari YO.

J Biochem. 2017 Feb 1;161(2):215-222. doi: 10.1093/jb/mvw063.

PMID:
28003428
39.

The calcium-binding protein ALG-2 promotes endoplasmic reticulum exit site localization and polymerization of Trk-fused gene (TFG) protein.

Kanadome T, Shibata H, Kuwata K, Takahara T, Maki M.

FEBS J. 2017 Jan;284(1):56-76. doi: 10.1111/febs.13949. Epub 2016 Nov 29.

40.

Visualization of specific repetitive genomic sequences with fluorescent TALEs in Arabidopsis thaliana.

Fujimoto S, Sugano SS, Kuwata K, Osakabe K, Matsunaga S.

J Exp Bot. 2016 Nov;67(21):6101-6110. Epub 2016 Oct 6.

41.

Effects of ligand binding on the stability of aldo-keto reductases: Implications for stabilizer or destabilizer chaperones.

Kabir A, Honda RP, Kamatari YO, Endo S, Fukuoka M, Kuwata K.

Protein Sci. 2016 Dec;25(12):2132-2141. doi: 10.1002/pro.3036. Epub 2016 Sep 19.

42.

PRION 2016 Tokyo Declaration.

Mizusawa H, Kuwata K.

Prion. 2016 Jul 3;10(4):265-6. doi: 10.1080/19336896.2016.1220242. No abstract available.

43.

Combination of Synthetic Chemistry and Live-Cell Imaging Identified a Rapid Cell Division Inhibitor in Tobacco and Arabidopsis thaliana.

Nambo M, Kurihara D, Yamada T, Nishiwaki-Ohkawa T, Kadofusa N, Kimata Y, Kuwata K, Umeda M, Ueda M.

Plant Cell Physiol. 2016 Nov;57(11):2255-2268. Epub 2016 Aug 12.

PMID:
27519314
44.

Neonatal exposure to SERMs disrupts neuroendocrine development and postnatal reproductive function through alteration of hypothalamic kisspeptin neurons in female rats.

Ichimura R, Takahashi M, Morikawa T, Inoue K, Kuwata K, Usuda K, Yokosuka M, Watanabe G, Yoshida M.

Neurotoxicology. 2016 Sep;56:64-75. doi: 10.1016/j.neuro.2016.07.003. Epub 2016 Jul 6.

PMID:
27395752
45.

Peptide Nucleic Acid with a Lysine Side Chain at the β-Position: Synthesis and Application for DNA Cleavage.

Sugiyama T, Kuwata K, Imamura Y, Demizu Y, Kurihara M, Takano M, Kittaka A.

Chem Pharm Bull (Tokyo). 2016;64(7):817-23. doi: 10.1248/cpb.c16-00191.

46.

Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2.

Ali F, Yamaguchi K, Fukuoka M, Elhelaly AE, Kuwata K.

Cancer Sci. 2016 Sep;107(9):1321-8. doi: 10.1111/cas.12995. Epub 2016 Aug 16.

47.

A Set of Organelle-Localizable Reactive Molecules for Mitochondrial Chemical Proteomics in Living Cells and Brain Tissues.

Yasueda Y, Tamura T, Fujisawa A, Kuwata K, Tsukiji S, Kiyonaka S, Hamachi I.

J Am Chem Soc. 2016 Jun 22;138(24):7592-602. doi: 10.1021/jacs.6b02254. Epub 2016 Jun 10.

PMID:
27228550
48.

A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions.

Sriwilaijaroen N, Magesh S, Imamura A, Ando H, Ishida H, Sakai M, Ishitsubo E, Hori T, Moriya S, Ishikawa T, Kuwata K, Odagiri T, Tashiro M, Hiramatsu H, Tsukamoto K, Miyagi T, Tokiwa H, Kiso M, Suzuki Y.

J Med Chem. 2016 May 26;59(10):4563-77. doi: 10.1021/acs.jmedchem.5b01863. Epub 2016 May 4.

PMID:
27095056
49.

The AMOR Arabinogalactan Sugar Chain Induces Pollen-Tube Competency to Respond to Ovular Guidance.

Mizukami AG, Inatsugi R, Jiao J, Kotake T, Kuwata K, Ootani K, Okuda S, Sankaranarayanan S, Sato Y, Maruyama D, Iwai H, Garénaux E, Sato C, Kitajima K, Tsumuraya Y, Mori H, Yamaguchi J, Itami K, Sasaki N, Higashiyama T.

Curr Biol. 2016 Apr 25;26(8):1091-7. doi: 10.1016/j.cub.2016.02.040. Epub 2016 Apr 7.

50.

Syndecan-4 Is a Receptor for Clathrin-Mediated Endocytosis of Arginine-Rich Cell-Penetrating Peptides.

Kawaguchi Y, Takeuchi T, Kuwata K, Chiba J, Hatanaka Y, Nakase I, Futaki S.

Bioconjug Chem. 2016 Apr 20;27(4):1119-30. doi: 10.1021/acs.bioconjchem.6b00082. Epub 2016 Apr 5.

PMID:
27019270

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