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Items: 32

1.

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance.

Kale J, Kutuk O, Brito GC, Andrews TS, Leber B, Letai A, Andrews DW.

EMBO Rep. 2018 Jul 9. pii: e45235. doi: 10.15252/embr.201745235. [Epub ahead of print]

2.

Migraine and associated comorbidities are three times more frequent in children with ADHD and their mothers.

Kutuk MO, Tufan AE, Guler G, Yalin OO, Altintas E, Bag HG, Uluduz D, Toros F, Aytan N, Kutuk O, Ozge A.

Brain Dev. 2018 Jun 16. pii: S0387-7604(18)30253-5. doi: 10.1016/j.braindev.2018.06.001. [Epub ahead of print]

PMID:
29921473
3.

Cytotoxic and apoptotic effects of novel pyrrolo[2,3-d]pyrimidine derivatives containing urea moieties on cancer cell lines.

Kilic-Kurt Z, Bakar-Ates F, Karakas B, Kutuk O.

Anticancer Agents Med Chem. 2018 Jun 4. doi: 10.2174/1871520618666180605082026. [Epub ahead of print]

PMID:
29866023
4.

Selective targeting of antiapoptotic BCL-2 proteins in cancer.

Timucin AC, Basaga H, Kutuk O.

Med Res Rev. 2018 May 30. doi: 10.1002/med.21516. [Epub ahead of print] Review.

PMID:
29846950
5.

Distinct apoptotic blocks mediate resistance to panHER inhibitors in HER2+ breast cancer cells.

Karakas B, Ozmay Y, Basaga H, Gul O, Kutuk O.

Biochim Biophys Acta. 2018 Aug;1865(8):1073-1087. doi: 10.1016/j.bbamcr.2018.05.002. Epub 2018 May 4.

PMID:
29733883
6.

Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer.

Saatci Ö, Borgoni S, Akbulut Ö, Durmuş S, Raza U, Eyüpoğlu E, Alkan C, Akyol A, Kütük Ö, Wiemann S, Şahin Ö.

Oncogene. 2018 Apr;37(17):2251-2269. doi: 10.1038/s41388-017-0108-9. Epub 2018 Feb 2.

PMID:
29391599
7.

Developmental delays and psychiatric diagnoses are elevated in offspring staying in prisons with their mothers.

Kutuk MO, Altintas E, Tufan AE, Guler G, Aslan B, Aytan N, Kutuk O.

Sci Rep. 2018 Jan 30;8(1):1856. doi: 10.1038/s41598-018-20263-x.

8.

Hiccup Due to Aripiprazole Plus Methylphenidate Treatment in an Adolescent with Attention Deficit and Hyperactivity Disorder and Conduct Disorder: A Case Report.

Kutuk MO, Guler G, Tufan AE, Kutuk O.

Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):410-412. doi: 10.9758/cpn.2017.15.4.410.

9.

Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells.

Kutuk O, Aytan N, Karakas B, Kurt AG, Acikbas U, Temel SG, Basaga H.

PLoS One. 2017 Aug 10;12(8):e0182809. doi: 10.1371/journal.pone.0182809. eCollection 2017.

10.

Manic symptoms as a symptom of antidepressant discontinuation syndrome in a child.

Özcan Ö, Özdemir S, Kütük ÖM.

J Child Adolesc Psychopharmacol. 2013 Sep;23(7):507-8. doi: 10.1089/cap.2013.0013. Epub 2013 Sep 11. No abstract available.

PMID:
24024536
11.

Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling.

Bodur C, Kutuk O, Karsli-Uzunbas G, Isimjan TT, Harrison P, Basaga H.

PLoS One. 2013;8(2):e56369. doi: 10.1371/journal.pone.0056369. Epub 2013 Feb 18.

12.

Antibody array-based immunosensor for detecting cardiovascular disease risk markers.

Timucin C, Gul O, Kutuk O, Basaga H.

J Immunoassay Immunochem. 2012;33(3):275-90. doi: 10.1080/15321819.2011.638407.

PMID:
22738651
13.

IKK-β mediates chemoresistance by sequestering FOXO3; a critical factor for cell survival and death.

Tezil T, Bodur C, Kutuk O, Basaga H.

Cell Signal. 2012 Jun;24(6):1361-8. doi: 10.1016/j.cellsig.2012.01.012. Epub 2012 Jan 31.

PMID:
22313691
14.

Inactivation of Bcl-2 through IκB kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE).

Bodur C, Kutuk O, Tezil T, Basaga H.

J Cell Physiol. 2012 Nov;227(11):3556-65. doi: 10.1002/jcp.24057.

PMID:
22262057
15.

Effects of pulsed electric field on secondary metabolism of Vitis vinifera L. cv. Gamay Fréaux suspension culture and exudates.

Cai Z, Riedel H, Thaw Saw NM, Kütük O, Mewis I, Jäger H, Knorr D, Smetanska I.

Appl Biochem Biotechnol. 2011 Jun;164(4):443-53. doi: 10.1007/s12010-010-9146-2. Epub 2010 Dec 29.

PMID:
21190090
16.

Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL.

Kutuk O, Temel SG, Tolunay S, Basaga H.

Eur J Cancer. 2010 Sep;46(13):2494-505. doi: 10.1016/j.ejca.2010.06.011. Epub 2010 Jul 7.

PMID:
20619636
17.

Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells.

Kutuk O, Letai A.

Cell Death Differ. 2010 Oct;17(10):1624-35. doi: 10.1038/cdd.2010.41. Epub 2010 Apr 30.

18.

Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation.

Kutuk O, Arisan ED, Tezil T, Shoshan MC, Basaga H.

Carcinogenesis. 2009 Sep;30(9):1517-27. doi: 10.1093/carcin/bgp165. Epub 2009 Jul 3.

PMID:
19578044
19.

Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation.

Hernlund E, Kutuk O, Basaga H, Linder S, Panaretakis T, Shoshan M.

Free Radic Biol Med. 2009 Jun 15;46(12):1607-13. doi: 10.1016/j.freeradbiomed.2009.03.015. Epub 2009 Mar 26.

PMID:
19328230
20.

Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells.

Arisan ED, Kutuk O, Tezil T, Bodur C, Telci D, Basaga H.

Breast Cancer Res Treat. 2010 Jan;119(2):271-81. doi: 10.1007/s10549-009-0343-z. Epub 2009 Feb 24.

PMID:
19238538
21.

Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737.

Kutuk O, Letai A.

Cancer Res. 2008 Oct 1;68(19):7985-94. doi: 10.1158/0008-5472.CAN-08-1418.

22.

Regulation of Bcl-2 family proteins by posttranslational modifications.

Kutuk O, Letai A.

Curr Mol Med. 2008 Mar;8(2):102-18. Review.

PMID:
18336291
23.

Apoptotic blocks and chemotherapy resistance: strategies to identify Bcl-2 protein signatures.

Gul O, Basaga H, Kutuk O.

Brief Funct Genomic Proteomic. 2008 Jan;7(1):27-34. doi: 10.1093/bfgp/eln002. Epub 2008 Feb 18. Review.

PMID:
18283052
24.
25.

Protein kinases as drug targets in cancer.

Arslan MA, Kutuk O, Basaga H.

Curr Cancer Drug Targets. 2006 Nov;6(7):623-34. Review.

PMID:
17100568
26.

Bcl-2 protein family: implications in vascular apoptosis and atherosclerosis.

Kutuk O, Basaga H.

Apoptosis. 2006 Oct;11(10):1661-75. Review.

PMID:
16951924
27.

Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1 signaling.

Kutuk O, Poli G, Basaga H.

Toxicol Sci. 2006 Mar;90(1):120-32. Epub 2005 Dec 1.

PMID:
16322078
28.

Pramanicin induces apoptosis in Jurkat leukemia cells: a role for JNK, p38 and caspase activation.

Kutuk O, Pedrech A, Harrison P, Basaga H.

Apoptosis. 2005 May;10(3):597-609.

PMID:
15909121
29.

Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts.

Kutuk O, Adli M, Poli G, Basaga H.

Biofactors. 2004;20(1):1-10.

PMID:
15096656
30.
31.

Aspirin prevents apoptosis and NF-kappaB activation induced by H2O2 in hela cells.

Kutuk O, Basaga H.

Free Radic Res. 2003 Dec;37(12):1267-76.

PMID:
14753751
32.

Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis.

Kutuk O, Basaga H.

Trends Mol Med. 2003 Dec;9(12):549-57. Review.

PMID:
14659470

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