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Items: 28

1.

Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1.

Nasser MW, Datta J, Nuovo G, Kutay H, Motiwala T, Majumder S, Wang B, Suster S, Jacob ST, Ghoshal K.

J Biol Chem. 2018 Aug 17;293(33):12945. doi: 10.1074/jbc.W118.004967. No abstract available.

2.

Correction for Ghoshal et al., "5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal".

Ghoshal K, Datta J, Majumder S, Bai S, Kutay H, Motiwala T, Jacob ST.

Mol Cell Biol. 2018 Apr 30;38(10). pii: e00539-17. doi: 10.1128/MCB.00539-17. Print 2018 May 15. No abstract available.

3.

PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.

Motiwala T, Majumder S, Ghoshal K, Kutay H, Datta J, Roy S, Lucas DM, Jacob ST.

J Biol Chem. 2018 Mar 9;293(10):3589. doi: 10.1074/jbc.W118.002431. No abstract available.

4.

ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5.

Sun HL, Cui R, Zhou J, Teng KY, Hsiao YH, Nakanishi K, Fassan M, Luo Z, Shi G, Tili E, Kutay H, Lovat F, Vicentini C, Huang HL, Wang SW, Kim T, Zanesi N, Jeon YJ, Lee TJ, Guh JH, Hung MC, Ghoshal K, Teng CM, Peng Y, Croce CM.

Cancer Cell. 2016 Nov 14;30(5):723-736. doi: 10.1016/j.ccell.2016.10.001.

5.

RNA interference-induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice.

Valdmanis PN, Gu S, Chu K, Jin L, Zhang F, Munding EM, Zhang Y, Huang Y, Kutay H, Ghoshal K, Lisowski L, Kay MA.

Nat Med. 2016 May;22(5):557-62. doi: 10.1038/nm.4079. Epub 2016 Apr 11.

6.

MicroRNA-122 regulates polyploidization in the murine liver.

Hsu SH, Delgado ER, Otero PA, Teng KY, Kutay H, Meehan KM, Moroney JB, Monga JK, Hand NJ, Friedman JR, Ghoshal K, Duncan AW.

Hepatology. 2016 Aug;64(2):599-615. doi: 10.1002/hep.28573. Epub 2016 May 12.

7.

PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model.

Motiwala T, Kutay H, Zanesi N, Frissora FW, Mo X, Muthusamy N, Jacob ST.

Leukemia. 2015 Jun;29(6):1350-9. doi: 10.1038/leu.2014.341. Epub 2014 Dec 8.

8.

Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure.

Hsu SH, Wang B, Kutay H, Bid H, Shreve J, Zhang X, Costinean S, Bratasz A, Houghton P, Ghoshal K.

Am J Pathol. 2013 Dec;183(6):1719-1730. doi: 10.1016/j.ajpath.2013.08.004. Epub 2013 Oct 8.

9.

Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2.

Wang B, Hsu SH, Wang X, Kutay H, Bid HK, Yu J, Ganju RK, Jacob ST, Yuneva M, Ghoshal K.

Hepatology. 2014 Feb;59(2):555-66. doi: 10.1002/hep.26712. Epub 2013 Dec 20.

10.

Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet.

Kutay H, Klepper C, Wang B, Hsu SH, Datta J, Yu L, Zhang X, Majumder S, Motiwala T, Khan N, Belury M, McClain C, Jacob S, Ghoshal K.

PLoS One. 2012;7(8):e41949. doi: 10.1371/journal.pone.0041949. Epub 2012 Aug 8.

11.

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.

Hsu SH, Wang B, Kota J, Yu J, Costinean S, Kutay H, Yu L, Bai S, La Perle K, Chivukula RR, Mao H, Wei M, Clark KR, Mendell JR, Caligiuri MA, Jacob ST, Mendell JT, Ghoshal K.

J Clin Invest. 2012 Aug;122(8):2871-83. doi: 10.1172/JCI63539. Epub 2012 Jul 23.

12.

AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia.

Motiwala T, Zanesi N, Datta J, Roy S, Kutay H, Checovich AM, Kaou M, Zhong Y, Johnson AJ, Lucas DM, Heerema NA, Hagan J, Mo X, Jarjoura D, Byrd JC, Croce CM, Jacob ST.

Blood. 2011 Dec 1;118(23):6132-40. doi: 10.1182/blood-2011-01-323147. Epub 2011 Oct 14.

13.

Lyn kinase and ZAP70 are substrates of PTPROt in B-cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor pazopanib.

Motiwala T, Datta J, Kutay H, Roy S, Jacob ST.

J Cell Biochem. 2010 Jul 1;110(4):846-56. doi: 10.1002/jcb.22593.

14.

HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors.

Ghoshal K, Motiwala T, Claus R, Yan P, Kutay H, Datta J, Majumder S, Bai S, Majumder A, Huang T, Plass C, Jacob ST.

PLoS One. 2010 Apr 29;5(4):e10338. doi: 10.1371/journal.pone.0010338.

15.

TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3.

Wang B, Hsu SH, Majumder S, Kutay H, Huang W, Jacob ST, Ghoshal K.

Oncogene. 2010 Mar 25;29(12):1787-97. doi: 10.1038/onc.2009.468. Epub 2009 Dec 21.

16.

MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib.

Bai S, Nasser MW, Wang B, Hsu SH, Datta J, Kutay H, Yadav A, Nuovo G, Kumar P, Ghoshal K.

J Biol Chem. 2009 Nov 13;284(46):32015-27. doi: 10.1074/jbc.M109.016774. Epub 2009 Sep 2.

17.

Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice.

Wang B, Majumder S, Nuovo G, Kutay H, Volinia S, Patel T, Schmittgen TD, Croce C, Ghoshal K, Jacob ST.

Hepatology. 2009 Oct;50(4):1152-61. doi: 10.1002/hep.23100.

18.

Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.

Ramaswamy B, Majumder S, Roy S, Ghoshal K, Kutay H, Datta J, Younes M, Shapiro CL, Motiwala T, Jacob ST.

Mol Endocrinol. 2009 Feb;23(2):176-87. doi: 10.1210/me.2008-0211. Epub 2008 Dec 18.

19.

PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.

Motiwala T, Majumder S, Ghoshal K, Kutay H, Datta J, Roy S, Lucas DM, Jacob ST.

J Biol Chem. 2009 Jan 2;284(1):455-64. doi: 10.1074/jbc.M802840200. Epub 2008 Nov 7. Retraction in: J Biol Chem. 2018 Mar 9;293(10 ):3589.

20.

Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1.

Nasser MW, Datta J, Nuovo G, Kutay H, Motiwala T, Majumder S, Wang B, Suster S, Jacob ST, Ghoshal K.

J Biol Chem. 2008 Nov 28;283(48):33394-405. doi: 10.1074/jbc.M804788200. Epub 2008 Sep 25. Retraction in: J Biol Chem. 2018 Aug 17;293(33):12945.

21.

Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.

Datta J, Kutay H, Nasser MW, Nuovo GJ, Wang B, Majumder S, Liu CG, Volinia S, Croce CM, Schmittgen TD, Ghoshal K, Jacob ST.

Cancer Res. 2008 Jul 1;68(13):5049-58. doi: 10.1158/0008-5472.CAN-07-6655.

22.

Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia.

Motiwala T, Majumder S, Kutay H, Smith DS, Neuberg DS, Lucas DM, Byrd JC, Grever M, Jacob ST.

Clin Cancer Res. 2007 Jun 1;13(11):3174-81.

23.
24.

Downregulation of miR-122 in the rodent and human hepatocellular carcinomas.

Kutay H, Bai S, Datta J, Motiwala T, Pogribny I, Frankel W, Jacob ST, Ghoshal K.

J Cell Biochem. 2006 Oct 15;99(3):671-8.

25.
26.

Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells.

Datta J, Majumder S, Bai S, Ghoshal K, Kutay H, Smith DS, Crabb JW, Jacob ST.

Cancer Res. 2005 Dec 1;65(23):10891-900.

28.

Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer.

Motiwala T, Kutay H, Ghoshal K, Bai S, Seimiya H, Tsuruo T, Suster S, Morrison C, Jacob ST.

Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13844-9. Epub 2004 Sep 8.

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