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TAK-272 (imarikiren), a novel renin inhibitor, improves cardiac remodeling and mortality in a murine heart failure model.

Hara T, Nishimura S, Yamamoto T, Kajimoto Y, Kusumoto K, Kanagawa R, Ikeda S, Nishimoto T.

PLoS One. 2018 Aug 9;13(8):e0202176. doi: 10.1371/journal.pone.0202176. eCollection 2018.


The Effectiveness of Saireito, a Traditional Japanese Herbal Medicine, in Reducing Postoperative Edema after Acquired Ptosis Surgery: A Prospective Controlled Trial.

Morimoto N, Kakudo N, Mitsui T, Kuro A, Ueda Y, Hihara M, Tanaka Y, Ozaki Y, Suzuki K, Kusumoto K.

Evid Based Complement Alternat Med. 2018 Jun 27;2018:4742305. doi: 10.1155/2018/4742305. eCollection 2018.


FGF-2 combined with bilayer artificial dermis composed of collagen matrix prompts generation of fat pad in subcutis of mice.

Kakudo N, Morimoto N, Ogawa T, Taketani S, Kusumoto K.

Med Mol Morphol. 2018 Jul 18. doi: 10.1007/s00795-018-0203-1. [Epub ahead of print]


Sex-specific regulation of collagen I and III expression by 17β-Estradiol in cardiac fibroblasts: role of estrogen receptors.

Dworatzek E, Mahmoodzadeh S, Schriever C, Kusumoto K, Kramer L, Santos G, Fliegner D, Leung YK, Ho SM, Zimmermann WH, Lutz S, Regitz-Zagrosek V.

Cardiovasc Res. 2018 Jul 17. doi: 10.1093/cvr/cvy185. [Epub ahead of print]


Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.

Tokuhara H, Imaeda Y, Fukase Y, Iwanaga K, Taya N, Watanabe K, Kanagawa R, Matsuda K, Kajimoto Y, Kusumoto K, Kondo M, Snell G, Behnke CA, Kuroita T.

Bioorg Med Chem. 2018 Jul 23;26(12):3261-3286. doi: 10.1016/j.bmc.2018.04.051. Epub 2018 Apr 27.


Platelet-rich plasma enhances the proliferation of human adipose stem cells through multiple signaling pathways.

Lai F, Kakudo N, Morimoto N, Taketani S, Hara T, Ogawa T, Kusumoto K.

Stem Cell Res Ther. 2018 Apr 16;9(1):107. doi: 10.1186/s13287-018-0851-z.


Efficacy and safety of sofosbuvir and ledipasvir in Japanese patients aged 75 years or over with hepatitis C genotype 1.

Ozono Y, Nagata K, Hasuike S, Iwakiri H, Nakamura K, Tsuchimochi M, Yamada Y, Takaishi Y, Sueta M, Miike T, Tahara Y, Yamamoto S, Shide K, Hidaka T, Kubuki Y, Kusumoto K, Ochiai T, Kato J, Komada N, Hirono S, Kuroki K, Shigehira M, Shimoda K.

World J Hepatol. 2017 Dec 28;9(36):1340-1345. doi: 10.4254/wjh.v9.i36.1340.


A New Modified Method of Correcting Cryptotia with a Subcutaneous Pedicled Flap.

Hikiami R, Kakudo N, Morimoto N, Hihara M, Kusumoto K.

Plast Reconstr Surg Glob Open. 2017 Oct 24;5(10):e1548. doi: 10.1097/GOX.0000000000001548. eCollection 2017 Oct.


Combined Tongue Flap and Deepithelialized Advancement Flap for Thick Lower Lip Reconstruction.

Kakudo N, Kuro A, Morimoto N, Hihara M, Kusumoto K.

Plast Reconstr Surg Glob Open. 2017 Oct 24;5(10):e1513. doi: 10.1097/GOX.0000000000001513. eCollection 2017 Oct.


Acute intraventricular conduction disorder due to combination therapy with dabrafenib and trametinib for metastatic melanoma: Case report.

Yamamura K, Matsushita S, Aoki M, Kusumoto K.

J Dermatol. 2018 May;45(5):e120-e121. doi: 10.1111/1346-8138.14148. Epub 2017 Nov 27. No abstract available.


A case report of the first application of culture epithelial autograft (JACE®) for giant congenital melanocytic nevus after its approval in Japan.

Morimoto N, Kakudo N, Kako A, Nishimura K, Mitsui T, Miyake R, Kuro A, Hihara M, Kusumoto K.

J Artif Organs. 2018 Jun;21(2):261-264. doi: 10.1007/s10047-017-1007-0. Epub 2017 Nov 17.


Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure.

Sakamoto M, Morimoto N, Jinno C, Mahara A, Ogino S, Suzuki S, Kusumoto K, Yamaoka T.

PLoS One. 2017 Nov 1;12(11):e0186958. doi: 10.1371/journal.pone.0186958. eCollection 2017.


Enzymatic characterization of a novel Xaa-Pro aminopeptidase XpmA from Aspergillus oryzae expressed in Escherichia coli.

Matsushita-Morita M, Tada S, Suzuki S, Hattori R, Kusumoto KI.

J Biosci Bioeng. 2017 Nov;124(5):534-541. doi: 10.1016/j.jbiosc.2017.06.007. Epub 2017 Jul 8.


PEGylation of the GALA Peptide Enhances the Lung-Targeting Activity of Nanocarriers That Contain Encapsulated siRNA.

Santiwarangkool S, Akita H, Nakatani T, Kusumoto K, Kimura H, Suzuki M, Nishimura M, Sato Y, Harashima H.

J Pharm Sci. 2017 Sep;106(9):2420-2427. doi: 10.1016/j.xphs.2017.04.075. Epub 2017 May 5.


Adipose-derived stem cell (ASC)-enriched fat grafting: experiments using White rabbits and an automated cell processing apparatus.

Kakudo N, Morimoto N, Ogawa T, Hihara M, Lai F, Kusumoto K.

Med Mol Morphol. 2017 Sep;50(3):170-177. doi: 10.1007/s00795-017-0158-7. Epub 2017 Apr 24.


Coccygeal Pad With an Anterior Flexed Coccyx: A Case Report.

Hikiami R, Kakudo N, Iguchi Y, Katsube M, Morimoto N, Hihara M, Mitsui T, Yamauchi T, Kusumoto K.

Eplasty. 2016 Aug 31;16:e25. eCollection 2016.


Maternal immunoglobulin G avidity as a diagnostic tool to identify pregnant women at risk of congenital cytomegalovirus infection.

Kaneko M, Ohhashi M, Minematsu T, Muraoka J, Kusumoto K, Sameshima H.

J Infect Chemother. 2017 Mar;23(3):173-176. doi: 10.1016/j.jiac.2016.12.001. Epub 2016 Dec 26.


The superiority of the autografts inactivated by high hydrostatic pressure to decellularized allografts in a porcine model.

Morimoto N, Mahara A, Jinno C, Ogawa M, Kakudo N, Suzuki S, Fujisato T, Kusumoto K, Yamaoka T.

J Biomed Mater Res B Appl Biomater. 2017 Nov;105(8):2653-2661. doi: 10.1002/jbm.b.33807. Epub 2016 Oct 27.


Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.

Imaeda Y, Tokuhara H, Fukase Y, Kanagawa R, Kajimoto Y, Kusumoto K, Kondo M, Snell G, Behnke CA, Kuroita T.

ACS Med Chem Lett. 2016 Sep 12;7(10):933-938. eCollection 2016 Oct 13.


A Modified LeClerc Procedure with Oblique Osteotomy and V-shaped Notch for Habitual Dislocation of the Temporomandibular Joint.

Kushida S, Kakudo N, Kusumoto K.

J Maxillofac Oral Surg. 2016 Sep;15(3):408-409. Epub 2015 Oct 28.


The Alteration of the Epidermal Basement Membrane Complex of Human Nevus Tissue and Keratinocyte Attachment after High Hydrostatic Pressurization.

Morimoto N, Jinno C, Mahara A, Sakamoto M, Kakudo N, Inoie M, Fujisato T, Suzuki S, Kusumoto K, Yamaoka T.

Biomed Res Int. 2016;2016:1320909. Epub 2016 Sep 26.


Easy-to-Use Preservation and Application of Platelet-Rich Plasma in Combination Wound Therapy With a Gelatin Sheet and Freeze-Dried Platelet-Rich Plasma: A Case Report.

Morimoto N, Kakudo N, Ogura T, Hara T, Matsui M, Yamamoto M, Tabata Y, Kusumoto K.

Eplasty. 2016 Aug 5;16:e22. eCollection 2016.


Platelet-rich plasma stimulates human dermal fibroblast proliferation via a Ras-dependent extracellular signal-regulated kinase 1/2 pathway.

Hara T, Kakudo N, Morimoto N, Ogawa T, Lai F, Kusumoto K.

J Artif Organs. 2016 Dec;19(4):372-377. Epub 2016 Jul 7.


AT1 receptor blocker azilsartan medoxomil normalizes plasma miR-146a and miR-342-3p in a murine heart failure model.

Kaneko M, Satomi T, Fujiwara S, Uchiyama H, Kusumoto K, Nishimoto T.

Biomarkers. 2017 May - Jun;22(3-4):253-260. doi: 10.1080/1354750X.2016.1204001. Epub 2016 Jul 11.


Negativity Bias in Media Multitasking: The Effects of Negative Social Media Messages on Attention to Television News Broadcasts.

Kätsyri J, Kinnunen T, Kusumoto K, Oittinen P, Ravaja N.

PLoS One. 2016 May 4;11(5):e0153712. doi: 10.1371/journal.pone.0153712. eCollection 2016.


A novel non-thermostable deuterolysin from Aspergillus oryzae.

Maeda H, Katase T, Sakai D, Takeuchi M, Kusumoto K, Amano H, Ishida H, Abe K, Yamagata Y.

Biosci Biotechnol Biochem. 2016 Sep;80(9):1813-9. doi: 10.1080/09168451.2016.1166933. Epub 2016 Apr 6.


Verification of the Inactivation of Melanocytic Nevus in vitro Using a Newly Developed Portable High Hydrostatic Pressure Device.

Morimoto N, Jinno C, Mahara A, Kakudo N, Fujisato T, Kusumoto K, Suzuki S, Yamaoka T.

Cells Tissues Organs. 2016;201(3):170-9. doi: 10.1159/000444048. Epub 2016 Mar 23.


An evaluation of the engraftment and the blood flow of porcine skin autografts inactivated by high hydrostatic pressure.

Morimoto N, Mahara A, Jinno C, Ogawa M, Kakudo N, Suzuki S, Kusumoto K, Fujisato T, Yamaoka T.

J Biomed Mater Res B Appl Biomater. 2017 Jul;105(5):1091-1101. doi: 10.1002/jbm.b.33631. Epub 2016 Mar 21.


Three extracellular dipeptidyl peptidases found in Aspergillus oryzae show varying substrate specificities.

Maeda H, Sakai D, Kobayashi T, Morita H, Okamoto A, Takeuchi M, Kusumoto K, Amano H, Ishida H, Yamagata Y.

Appl Microbiol Biotechnol. 2016 Jun;100(11):4947-58. doi: 10.1007/s00253-016-7339-5. Epub 2016 Feb 5.


A dramatic enhancing effect of InBr3 towards the oxidative Sonogashira cross-coupling reaction of 2-ethynylanilines.

Ikeda A, Omote M, Kusumoto K, Komori M, Tarui A, Sato K, Ando A.

Org Biomol Chem. 2016 Feb 14;14(6):2127-33. doi: 10.1039/c5ob02558c.


Angiogenic effect of platelet-rich plasma combined with gelatin hydrogel granules injected into murine subcutis.

Kakudo N, Morimoto N, Ogawa T, Hihara M, Notodihardjo PV, Matsui M, Tabata Y, Kusumoto K.

J Tissue Eng Regen Med. 2017 Jul;11(7):1941-1948. doi: 10.1002/term.2091. Epub 2015 Oct 21.


Sex differences in neurophysiological responses are modulated by attentional aspects of impulse control.

Omura K, Kusumoto K.

Brain Cogn. 2015 Nov;100:49-59. doi: 10.1016/j.bandc.2015.09.006.


Hypoxia Enhances Proliferation of Human Adipose-Derived Stem Cells via HIF-1ɑ Activation.

Kakudo N, Morimoto N, Ogawa T, Taketani S, Kusumoto K.

PLoS One. 2015 Oct 14;10(10):e0139890. doi: 10.1371/journal.pone.0139890. eCollection 2015.


[Two cases of acute hepatitis E infected with descendant strains of hepatitis E virus genotype 3 strain isolated from swine herd in Miyazaki Prefecture 12 years ago - one case had acute facial paralysis].

Nakamura M, Kusumoto K, Ochiai T, Kawagoe T, Tai H, Matsuoka H, Nakano T, Nagata K, Shimoda K, Okamoto H.

Nihon Shokakibyo Gakkai Zasshi. 2015 Aug;112(8):1533-41. doi: 10.11405/nisshoshi.112.1533. Japanese.


Preparation of Inactivated Human Skin Using High Hydrostatic Pressurization for Full-Thickness Skin Reconstruction.

Liem PH, Morimoto N, Mahara A, Jinno C, Shima K, Ogino S, Sakamoto M, Kakudo N, Inoie M, Kusumoto K, Fujisato T, Suzuki S, Yamaoka T.

PLoS One. 2015 Jul 30;10(7):e0133979. doi: 10.1371/journal.pone.0133979. eCollection 2015.


Utilization of Platelet-Rich Plasma for a Fistula With Subcutaneous Cavity Following Septic Bursitis: A Case Report.

Kushida S, Kakudo N, Morimoto N, Mori Y, Kusumoto K.

Eplasty. 2015 Jul 21;15:e31. eCollection 2015.


One-pot synthesis of 1,3-enynes with a CF3 group on the terminal sp(2) carbon by an oxidative Sonogashira cross-coupling reaction.

Ikeda A, Omote M, Kusumoto K, Tarui A, Sato K, Ando A.

Org Biomol Chem. 2015 Sep 7;13(33):8886-92. doi: 10.1039/c5ob01290b.


Inactivation of Human Nevus Tissue Using High Hydrostatic Pressure for Autologous Skin Reconstruction: A Novel Treatment for Giant Congenital Melanocytic Nevi.

Jinno C, Morimoto N, Mahara A, Liem PH, Sakamoto M, Ogino S, Kakudo N, Inoie M, Fujisato T, Kusumoto K, Suzuki S, Yamaoka T.

Tissue Eng Part C Methods. 2015 Nov;21(11):1178-87. doi: 10.1089/ten.TEC.2015.0054. Epub 2015 Aug 21.


Elastofibroma dorsi: a case report with an immunohistochemical and ultrastructural studies.

Kakudo N, Morimoto N, Ogawa T, Hihara M, Koseki R, Kusumoto K.

Med Mol Morphol. 2016 Mar;49(1):42-7. doi: 10.1007/s00795-015-0112-5. Epub 2015 Jun 4.


Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet-rich plasma in patients with chronic skin ulcers: study protocol.

Morimoto N, Kakudo N, Matsui M, Ogura T, Hara T, Suzuki K, Yamamoto M, Tabata Y, Kusumoto K.

BMJ Open. 2015 May 11;5(5):e007733. doi: 10.1136/bmjopen-2015-007733.


Culture-independent bacterial community analysis of the salty-fermented fish paste products of Thailand and Laos.

Marui J, Boulom S, Panthavee W, Momma M, Kusumoto K, Nakahara K, Saito M.

Biosci Microbiota Food Health. 2015;34(2):45-52. doi: 10.12938/bmfh.2014-018. Epub 2015 Jan 21.


The rapid inactivation of porcine skin by applying high hydrostatic pressure without damaging the extracellular matrix.

Morimoto N, Mahara A, Shima K, Ogawa M, Jinno C, Kakudo N, Kusumoto K, Fujisato T, Suzuki S, Yamaoka T.

Biomed Res Int. 2015;2015:587247. doi: 10.1155/2015/587247. Epub 2015 Mar 24.


Effect of aging on the osteoinductive activity of recombinant human bone morphogenetic protein-2 in rats.

Hara T, Kakudo N, Morimoto N, Horio O, Ogura T, Kusumoto K.

J Surg Res. 2015 May 1;195(1):377-83. doi: 10.1016/j.jss.2015.01.050. Epub 2015 Jan 30.


Combined use of fenestrated-type artificial dermis and topical negative pressure wound therapy for the venous leg ulcer of a rheumatoid arthritis patient.

Morimoto N, Kuro A, Yamauchi T, Horiuchi A, Kakudo N, Sakamoto M, Suzuki K, Kusumoto K.

Int Wound J. 2016 Feb;13(1):137-40. doi: 10.1111/iwj.12422. Epub 2015 Feb 3.


A Japanese family with popliteal pterygium syndrome.

Katsube M, Yoshiura K, Kusumoto K.

Case Reports Plast Surg Hand Surg. 2015 Apr 24;2(3-4):50-2. doi: 10.3109/23320885.2015.1038347. eCollection 2015.


Combined use of fenestrated-type artificial dermis and topical negative-pressure wound therapy to treat the complex wound in the lower leg.

Kuro A, Morimoto N, Ueda M, Horiuchi A, Yamauchi T, Sakamoto M, Suzuki K, Kusumoto K.

J Plast Reconstr Aesthet Surg. 2015 Feb;68(2):286-8. doi: 10.1016/j.bjps.2014.09.048. Epub 2014 Oct 13. No abstract available.


Gelatin hydrogel impregnated with platelet-rich plasma releasate promotes angiogenesis and wound healing in murine model.

Notodihardjo PV, Morimoto N, Kakudo N, Matsui M, Sakamoto M, Liem PH, Suzuki K, Tabata Y, Kusumoto K.

J Artif Organs. 2015 Mar;18(1):64-71. doi: 10.1007/s10047-014-0795-8. Epub 2014 Oct 18.


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