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Items: 1 to 50 of 297

1.

Dose-Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs.

Mori D, Kimoto E, Rago B, Kondo Y, King-Ahmad A, Ramanathan R, Wood LS, Johnson JG, Le VH, Vourvahis M, Rodrigues AD, Muto C, Furihata K, Sugiyama Y, Kusuhara H.

Clin Pharmacol Ther. 2019 Oct 18. doi: 10.1002/cpt.1695. [Epub ahead of print]

PMID:
31628668
2.

[Quantitative assessment of the risk of OATP1B1/1B3-mediated drug-drug interactions].

Mori D, Maeda K, Kusuhara H.

Nihon Yakurigaku Zasshi. 2019;154(4):210-216. doi: 10.1254/fpj.154.210. Japanese.

PMID:
31597901
3.

Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients.

Lee N, Maeda K, Fukizawa S, Ieiri I, Tomaru A, Akao H, Takeda K, Iwadare M, Niwa O, Masauji T, Yamane N, Kajinami K, Kusuhara H, Sugiyama Y.

Drug Metab Pharmacokinet. 2019 Aug 29. pii: S1347-4367(19)30068-0. doi: 10.1016/j.dmpk.2019.08.004. [Epub ahead of print]

PMID:
31594719
4.

Quantitative investigation of hepatobiliary transport of [11C]telmisartan in humans by PET imaging.

Maeda K, Ohnishi A, Sasaki M, Ikari Y, Aita K, Watanabe Y, Kusuhara H, Sugiyama Y, Senda M.

Drug Metab Pharmacokinet. 2019 Oct;34(5):293-299. doi: 10.1016/j.dmpk.2019.02.004. Epub 2019 Mar 9.

PMID:
31564410
5.

Elucidation of N 1-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters.

Miyake T, Mizuno T, Takehara I, Mochizuki T, Kimura M, Matsuki S, Irie S, Watanabe N, Kato Y, Ieiri I, Maeda K, Ando O, Kusuhara H.

Drug Metab Dispos. 2019 Nov;47(11):1270-1280. doi: 10.1124/dmd.119.087262. Epub 2019 Sep 11.

PMID:
31511257
6.

Proposal of a Parameter for OATP1B1 Inhibition Screening at the Early Drug Discovery Stage.

Murata H, Ito S, Kusuhara H, Nomura Y, Taniguchi T.

J Pharm Sci. 2019 Aug 22. pii: S0022-3549(19)30509-X. doi: 10.1016/j.xphs.2019.08.012. [Epub ahead of print]

PMID:
31446145
7.

Expanded Physiologically-Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction.

Asaumi R, Menzel K, Lee W, Nunoya KI, Imawaka H, Kusuhara H, Sugiyama Y.

CPT Pharmacometrics Syst Pharmacol. 2019 Aug 16. doi: 10.1002/psp4.12457. [Epub ahead of print]

8.

Evaluation of transporter-mediated hepatobiliary transport of newly developed 18F-labeled pitavastatin derivative, PTV-F1, in rats by PET imaging.

Kimura H, Yagi Y, Mikamo M, Maeda K, Kagawa S, Arimitsu K, Higashi T, Nishii R, Ono M, Nakamoto Y, Togashi K, Kusuhara H, Saji H.

Drug Metab Pharmacokinet. 2019 Oct;34(5):317-324. doi: 10.1016/j.dmpk.2019.05.006. Epub 2019 Jun 4.

PMID:
31331824
9.

[Development of in vivo drug sensing system with needle-type diamond microelectrode].

Ogata G, Asai K, Sano Y, Sawamura S, Takai M, Kusuhara H, Einaga Y, Hibino H.

Nihon Yakurigaku Zasshi. 2019;153(6):273-277. doi: 10.1254/fpj.153.273. Japanese.

PMID:
31178532
10.

Estimation of changes in serum creatinine and creatinine clearance caused by renal transporter inhibition in healthy subjects.

Nakada T, Kudo T, Kume T, Kusuhara H, Ito K.

Drug Metab Pharmacokinet. 2019 Aug;34(4):233-238. doi: 10.1016/j.dmpk.2019.02.006. Epub 2019 Mar 2.

PMID:
31176593
11.

Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion.

Takehara I, Watanabe N, Mori D, Ando O, Kusuhara H.

J Pharm Sci. 2019 Aug;108(8):2756-2764. doi: 10.1016/j.xphs.2019.03.021. Epub 2019 Mar 21.

PMID:
30905707
12.

Influence of Periosteum Location on the Bone and Cartilage in Tissue-Engineered Phalanx.

Iuchi T, Kusuhara H, Ueda Y, Morotomi T, Isogai N.

J Hand Surg Am. 2019 Mar 19. pii: S0363-5023(18)30069-8. doi: 10.1016/j.jhsa.2019.02.002. [Epub ahead of print]

PMID:
30902355
13.

Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment.

Danoy M, Bernier ML, Kimura K, Poulain S, Kato S, Mori D, Kido T, Plessy C, Kusuhara H, Miyajima A, Sakai Y, Leclerc E.

Biotechnol Bioeng. 2019 Jul;116(7):1762-1776. doi: 10.1002/bit.26970. Epub 2019 Mar 29.

PMID:
30883676
14.

Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers.

Funakoshi R, Tomoda Y, Kudo T, Furihata K, Kusuhara H, Ito K.

Br J Clin Pharmacol. 2019 Jul;85(7):1454-1463. doi: 10.1111/bcp.13914. Epub 2019 Apr 16.

PMID:
30845361
15.

Correction to: Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers.

Takehara I, Yoshikado T, Ishigame K, Mori D, Furihata KI, Watanabe N, Ando O, Maeda K, Kusuhara H, Sugiyama Y.

Pharm Res. 2019 Feb 21;36(4):55. doi: 10.1007/s11095-019-2585-8.

PMID:
30790061
16.

Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components.

Mizuno T, Kinoshita S, Ito T, Maedera S, Kusuhara H.

Sci Rep. 2019 Feb 12;9(1):1824. doi: 10.1038/s41598-019-38528-4.

17.

Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories.

Nomura H, Mizuta H, Norimoto H, Masuda F, Miura Y, Kubo A, Kojima H, Ashizuka A, Matsukawa N, Baraki Z, Hitora-Imamura N, Nakayama D, Ishikawa T, Okada M, Orita K, Saito R, Yamauchi N, Sano Y, Kusuhara H, Minami M, Takahashi H, Ikegaya Y.

Biol Psychiatry. 2019 Aug 1;86(3):230-239. doi: 10.1016/j.biopsych.2018.11.009. Epub 2019 Jan 8.

PMID:
30635130
18.

A clinical multi-center registry study on digital nerve repair using a biodegradable nerve conduit of PGA with external and internal collagen scaffolding.

Kusuhara H, Hirase Y, Isogai N, Sueyoshi Y.

Microsurgery. 2019 Jul;39(5):395-399. doi: 10.1002/micr.30417. Epub 2018 Dec 18.

PMID:
30562848
19.

Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney.

Kito T, Ito S, Mizuno T, Maeda K, Kusuhara H.

Drug Metab Pharmacokinet. 2019 Feb;34(1):87-94. doi: 10.1016/j.dmpk.2018.08.005. Epub 2018 Sep 20.

PMID:
30528339
20.

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.

Mori D, Kashihara Y, Yoshikado T, Kimura M, Hirota T, Matsuki S, Maeda K, Irie S, Ieiri I, Sugiyama Y, Kusuhara H.

Drug Metab Pharmacokinet. 2019 Feb;34(1):78-86. doi: 10.1016/j.dmpk.2018.09.003. Epub 2018 Sep 20.

PMID:
30528195
21.

GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages.

Maedera S, Mizuno T, Ishiguro H, Ito T, Soga T, Kusuhara H.

FEBS Lett. 2019 Jan;593(2):195-208. doi: 10.1002/1873-3468.13298. Epub 2018 Dec 4.

PMID:
30431159
22.

A basic fibroblast growth factor slow-release system combined to a biodegradable nerve conduit improves endothelial cell and Schwann cell proliferation: A preliminary study in a rat model.

Fukuda T, Kusuhara H, Nakagoshi T, Isogai N, Sueyoshi Y.

Microsurgery. 2018 Nov;38(8):899-906. doi: 10.1002/micr.30387. Epub 2018 Oct 31.

PMID:
30380172
23.

Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Kurosawa T, Tega Y, Higuchi K, Yamaguchi T, Nakakura T, Mochizuki T, Kusuhara H, Kawabata K, Deguchi Y.

Mol Pharm. 2018 Dec 3;15(12):5546-5555. doi: 10.1021/acs.molpharmaceut.8b00697. Epub 2018 Nov 12.

PMID:
30376629
24.

Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium.

Chu X, Liao M, Shen H, Yoshida K, Zur AA, Arya V, Galetin A, Giacomini KM, Hanna I, Kusuhara H, Lai Y, Rodrigues D, Sugiyama Y, Zamek-Gliszczynski MJ, Zhang L; International Transporter Consortium.

Clin Pharmacol Ther. 2018 Nov;104(5):836-864. doi: 10.1002/cpt.1216. Review.

PMID:
30347454
25.

PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3.

Yoshikado T, Toshimoto K, Maeda K, Kusuhara H, Kimoto E, Rodrigues AD, Chiba K, Sugiyama Y.

CPT Pharmacometrics Syst Pharmacol. 2018 Nov;7(11):739-747. doi: 10.1002/psp4.12348. Epub 2018 Sep 30.

26.

Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier.

Sano Y, Mizuno T, Mochizuki T, Uchida Y, Umetsu M, Terasaki T, Kusuhara H.

Drug Metab Dispos. 2018 Nov;46(11):1767-1775. doi: 10.1124/dmd.118.081877. Epub 2018 Aug 28.

PMID:
30154106
28.

Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers.

Takehara I, Yoshikado T, Ishigame K, Mori D, Furihata KI, Watanabe N, Ando O, Maeda K, Sugiyama Y, Kusuhara H.

Pharm Res. 2018 May 10;35(7):138. doi: 10.1007/s11095-018-2416-3. Erratum in: Pharm Res. 2019 Feb 21;36(4):55.

PMID:
29748935
29.

Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes.

Izumi S, Nozaki Y, Kusuhara H, Hotta K, Mochizuki T, Komori T, Maeda K, Sugiyama Y.

Mol Pharm. 2018 Jun 4;15(6):2277-2288. doi: 10.1021/acs.molpharmaceut.8b00138. Epub 2018 May 16.

PMID:
29746136
30.

A Clinical Quantitative Evaluation of Hepatobiliary Transport of [11C]Dehydropravastatin in Humans Using Positron Emission Tomography.

Kaneko K, Tanaka M, Ishii A, Katayama Y, Nakaoka T, Irie S, Kawahata H, Yamanaga T, Wada Y, Miyake T, Toshimoto K, Maeda K, Cui Y, Enomoto M, Kawamura E, Kawada N, Kawabe J, Shiomi S, Kusuhara H, Sugiyama Y, Watanabe Y.

Drug Metab Dispos. 2018 May;46(5):719-728. doi: 10.1124/dmd.118.080408. Epub 2018 Mar 19.

PMID:
29555827
31.

Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo.

Kuwahara H, Song J, Shimoura T, Yoshida-Tanaka K, Mizuno T, Mochizuki T, Zeniya S, Li F, Nishina K, Nagata T, Ito S, Kusuhara H, Yokota T.

Sci Rep. 2018 Mar 12;8(1):4377. doi: 10.1038/s41598-018-22577-2.

32.

Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis.

Imagawa K, Hayashi H, Sabu Y, Tanikawa K, Fujishiro J, Kajikawa D, Wada H, Kudo T, Kage M, Kusuhara H, Sumazaki R.

J Hum Genet. 2018 May;63(5):569-577. doi: 10.1038/s10038-018-0431-1. Epub 2018 Mar 5. Review.

PMID:
29507376
33.

Viral shedding and clinical status of feline-norovirus-infected cats after reinfection with the same strain.

Takano T, Hiramatsu K, Matsuyama M, Mutoh K, Matsumoto Y, Fukushima T, Doki T, Kusuhara H, Hohdatsu T.

Arch Virol. 2018 Jun;163(6):1503-1510. doi: 10.1007/s00705-018-3770-5. Epub 2018 Feb 14.

PMID:
29445988
34.

Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model.

Nakada T, Kudo T, Kume T, Kusuhara H, Ito K.

Drug Metab Pharmacokinet. 2018 Feb;33(1):103-110. doi: 10.1016/j.dmpk.2017.11.314. Epub 2017 Dec 5.

PMID:
29361388
35.

Organic Anion Transporting Polypeptide 1a4 is Responsible for the Hepatic Uptake of Cardiac Glycosides in Mice.

Takano J, Maeda K, Kusuhara H, Sugiyama Y.

Drug Metab Dispos. 2018 May;46(5):652-657. doi: 10.1124/dmd.117.079483. Epub 2018 Jan 18.

PMID:
29348124
36.

Preliminary Study of PGA Fabric for Seromas at Latissimus Dorsi Flap Donor Sites.

Itani Y, Hagiwara A, Hashimoto T, Isogai N, Kusuhara H.

Plast Reconstr Surg Glob Open. 2017 Oct 5;5(10):e1499. doi: 10.1097/GOX.0000000000001499. eCollection 2017 Oct.

37.

Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.

Kusuhara H, Takashima T, Fujii H, Takashima T, Tanaka M, Ishii A, Tazawa S, Takahashi K, Takahashi K, Tokai H, Yano T, Kataoka M, Inano A, Yoshida S, Hosoya T, Sugiyama Y, Yamashita S, Hojo T, Watanabe Y.

Drug Metab Pharmacokinet. 2017 Dec;32(6):293-300. doi: 10.1016/j.dmpk.2017.09.003. Epub 2017 Sep 21.

PMID:
29137842
38.

Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages.

Hayashi H, Naoi S, Togawa T, Hirose Y, Kondou H, Hasegawa Y, Abukawa D, Sasaki M, Muroya K, Watanabe S, Nakano S, Minowa K, Inui A, Fukuda A, Kasahara M, Nagasaka H, Bessho K, Suzuki M, Kusuhara H.

EBioMedicine. 2018 Jan;27:187-199. doi: 10.1016/j.ebiom.2017.10.007. Epub 2017 Oct 7.

39.

Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.

Shimanaka Y, Kono N, Taketomi Y, Arita M, Okayama Y, Tanaka Y, Nishito Y, Mochizuki T, Kusuhara H, Adibekian A, Cravatt BF, Murakami M, Arai H.

Nat Med. 2017 Nov;23(11):1287-1297. doi: 10.1038/nm.4417. Epub 2017 Oct 9.

PMID:
29035365
40.

A Novel Method to Induce Cartilage Regeneration with Cubic Microcartilage.

Nishiwaki H, Fujita M, Yamauchi M, Isogai N, Tabata Y, Kusuhara H.

Cells Tissues Organs. 2017;204(5-6):251-260. doi: 10.1159/000479790. Epub 2017 Oct 4.

PMID:
28972948
41.

A microsensing system for the in vivo real-time detection of local drug kinetics.

Ogata G, Ishii Y, Asai K, Sano Y, Nin F, Yoshida T, Higuchi T, Sawamura S, Ota T, Hori K, Maeda K, Komune S, Doi K, Takai M, Findlay I, Kusuhara H, Einaga Y, Hibino H.

Nat Biomed Eng. 2017 Aug;1(8):654-666. doi: 10.1038/s41551-017-0118-5. Epub 2017 Aug 9.

PMID:
31015607
42.

Reconstruction of Severely Crushed Fingertip Amputations with Basic Fibroblast Growth Factor Slow Release System.

Kusuhara H, Ichinohashi K, Sueyoshi Y, Tabata Y, Isogai N.

Plast Reconstr Surg Glob Open. 2017 Jun 28;5(6):e1384. doi: 10.1097/GOX.0000000000001384. eCollection 2017 Jun.

43.

Corrigendum to "Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data" [Drug Metab Pharmacokinet 32 (2017) 135-144].

Kanamitsu K, Nozaki Y, Nagaya Y, Sugiyama Y, Kusuhara H.

Drug Metab Pharmacokinet. 2017 Aug;32(4):228. doi: 10.1016/j.dmpk.2017.05.003. Epub 2017 May 22. No abstract available.

PMID:
28587746
44.

Endogenous Probes for Drug Transporters: Balancing Vision With Reality.

Rodrigues AD, Taskar KS, Kusuhara H, Sugiyama Y.

Clin Pharmacol Ther. 2018 Mar;103(3):434-448. doi: 10.1002/cpt.749. Epub 2017 Jul 14. Review.

PMID:
28560712
45.

Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers.

Takehara I, Terashima H, Nakayama T, Yoshikado T, Yoshida M, Furihata K, Watanabe N, Maeda K, Ando O, Sugiyama Y, Kusuhara H.

Pharm Res. 2017 Aug;34(8):1601-1614. doi: 10.1007/s11095-017-2184-5. Epub 2017 May 26.

PMID:
28550384
46.

Possible Role of Organic Cation Transporters in the Distribution of [11C]Sulpiride, a Dopamine D2 Receptor Antagonist.

Takano H, Ito S, Zhang X, Ito H, Zhang MR, Suzuki H, Maeda K, Kusuhara H, Suhara T, Sugiyama Y.

J Pharm Sci. 2017 Sep;106(9):2558-2565. doi: 10.1016/j.xphs.2017.05.006. Epub 2017 May 10.

PMID:
28499878
47.
48.

A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions.

Yoshikado T, Maeda K, Furihata S, Terashima H, Nakayama T, Ishigame K, Tsunemoto K, Kusuhara H, Furihata KI, Sugiyama Y.

Pharm Res. 2017 Aug;34(8):1570-1583. doi: 10.1007/s11095-017-2168-5. Epub 2017 May 8.

PMID:
28484975
49.

Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide.

Miyake T, Mizuno T, Mochizuki T, Kimura M, Matsuki S, Irie S, Ieiri I, Maeda K, Kusuhara H.

J Pharm Sci. 2017 Sep;106(9):2542-2550. doi: 10.1016/j.xphs.2017.04.067. Epub 2017 May 4.

PMID:
28479364
50.

Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist.

Kusuhara H, Obach RS, Rostami-Hodjegan A, Pang KS, Hammarlund-Udenaes M, Derendorf H, Artursson P, Huang SM, Suzuki H, Terasaki T.

J Pharm Sci. 2017 Sep;106(9):2188-2194. doi: 10.1016/j.xphs.2017.04.072. Epub 2017 May 4. No abstract available.

PMID:
28479350

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