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Items: 1 to 50 of 284

1.

Optimized protocol for the hepatic differentiation of iPSCs in a fluidic microenvironment.

Danoy M, Bernier ML, Kimura K, Poulain S, Kato S, Mori D, Kido T, Plessy C, Kusuhara H, Miyajima A, Sakai Y, Leclerc E.

Biotechnol Bioeng. 2019 Mar 18. doi: 10.1002/bit.26970. [Epub ahead of print]

PMID:
30883676
2.

Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers.

Funakoshi R, Tomoda Y, Kudo T, Furihata K, Kusuhara H, Ito K.

Br J Clin Pharmacol. 2019 Mar 7. doi: 10.1111/bcp.13914. [Epub ahead of print]

PMID:
30845361
3.

Correction to: Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers.

Takehara I, Yoshikado T, Ishigame K, Mori D, Furihata KI, Watanabe N, Ando O, Maeda K, Kusuhara H, Sugiyama Y.

Pharm Res. 2019 Feb 21;36(4):55. doi: 10.1007/s11095-019-2585-8.

PMID:
30790061
4.

Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components.

Mizuno T, Kinoshita S, Ito T, Maedera S, Kusuhara H.

Sci Rep. 2019 Feb 12;9(1):1824. doi: 10.1038/s41598-019-38528-4.

5.

Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories.

Nomura H, Mizuta H, Norimoto H, Masuda F, Miura Y, Kubo A, Kojima H, Ashizuka A, Matsukawa N, Baraki Z, Hitora-Imamura N, Nakayama D, Ishikawa T, Okada M, Orita K, Saito R, Yamauchi N, Sano Y, Kusuhara H, Minami M, Takahashi H, Ikegaya Y.

Biol Psychiatry. 2018 Dec 19. pii: S0006-3223(18)32021-3. doi: 10.1016/j.biopsych.2018.11.009. [Epub ahead of print]

PMID:
30635130
6.

A clinical multi-center registry study on digital nerve repair using a biodegradable nerve conduit of PGA with external and internal collagen scaffolding.

Kusuhara H, Hirase Y, Isogai N, Sueyoshi Y.

Microsurgery. 2018 Dec 18. doi: 10.1002/micr.30417. [Epub ahead of print]

PMID:
30562848
7.

Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney.

Kito T, Ito S, Mizuno T, Maeda K, Kusuhara H.

Drug Metab Pharmacokinet. 2019 Feb;34(1):87-94. doi: 10.1016/j.dmpk.2018.08.005. Epub 2018 Sep 20.

PMID:
30528339
8.

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.

Mori D, Kashihara Y, Yoshikado T, Kimura M, Hirota T, Matsuki S, Maeda K, Irie S, Ieiri I, Sugiyama Y, Kusuhara H.

Drug Metab Pharmacokinet. 2019 Feb;34(1):78-86. doi: 10.1016/j.dmpk.2018.09.003. Epub 2018 Sep 20.

PMID:
30528195
9.

GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages.

Maedera S, Mizuno T, Ishiguro H, Ito T, Soga T, Kusuhara H.

FEBS Lett. 2019 Jan;593(2):195-208. doi: 10.1002/1873-3468.13298. Epub 2018 Dec 4.

PMID:
30431159
10.

A basic fibroblast growth factor slow-release system combined to a biodegradable nerve conduit improves endothelial cell and Schwann cell proliferation: A preliminary study in a rat model.

Fukuda T, Kusuhara H, Nakagoshi T, Isogai N, Sueyoshi Y.

Microsurgery. 2018 Nov;38(8):899-906. doi: 10.1002/micr.30387. Epub 2018 Oct 31.

PMID:
30380172
11.

Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Kurosawa T, Tega Y, Higuchi K, Yamaguchi T, Nakakura T, Mochizuki T, Kusuhara H, Kawabata K, Deguchi Y.

Mol Pharm. 2018 Nov 12. doi: 10.1021/acs.molpharmaceut.8b00697. [Epub ahead of print]

PMID:
30376629
12.

Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium.

Chu X, Liao M, Shen H, Yoshida K, Zur AA, Arya V, Galetin A, Giacomini KM, Hanna I, Kusuhara H, Lai Y, Rodrigues D, Sugiyama Y, Zamek-Gliszczynski MJ, Zhang L; International Transporter Consortium.

Clin Pharmacol Ther. 2018 Nov;104(5):836-864. doi: 10.1002/cpt.1216.

PMID:
30347454
13.

PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3.

Yoshikado T, Toshimoto K, Maeda K, Kusuhara H, Kimoto E, Rodrigues AD, Chiba K, Sugiyama Y.

CPT Pharmacometrics Syst Pharmacol. 2018 Nov;7(11):739-747. doi: 10.1002/psp4.12348. Epub 2018 Sep 30.

14.

Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier.

Sano Y, Mizuno T, Mochizuki T, Uchida Y, Umetsu M, Terasaki T, Kusuhara H.

Drug Metab Dispos. 2018 Nov;46(11):1767-1775. doi: 10.1124/dmd.118.081877. Epub 2018 Aug 28.

PMID:
30154106
16.

Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers.

Takehara I, Yoshikado T, Ishigame K, Mori D, Furihata KI, Watanabe N, Ando O, Maeda K, Sugiyama Y, Kusuhara H.

Pharm Res. 2018 May 10;35(7):138. doi: 10.1007/s11095-018-2416-3. Erratum in: Pharm Res. 2019 Feb 21;36(4):55.

PMID:
29748935
17.

Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes.

Izumi S, Nozaki Y, Kusuhara H, Hotta K, Mochizuki T, Komori T, Maeda K, Sugiyama Y.

Mol Pharm. 2018 Jun 4;15(6):2277-2288. doi: 10.1021/acs.molpharmaceut.8b00138. Epub 2018 May 16.

PMID:
29746136
18.

A Clinical Quantitative Evaluation of Hepatobiliary Transport of [11C]Dehydropravastatin in Humans Using Positron Emission Tomography.

Kaneko K, Tanaka M, Ishii A, Katayama Y, Nakaoka T, Irie S, Kawahata H, Yamanaga T, Wada Y, Miyake T, Toshimoto K, Maeda K, Cui Y, Enomoto M, Kawamura E, Kawada N, Kawabe J, Shiomi S, Kusuhara H, Sugiyama Y, Watanabe Y.

Drug Metab Dispos. 2018 May;46(5):719-728. doi: 10.1124/dmd.118.080408. Epub 2018 Mar 19.

PMID:
29555827
19.

Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo.

Kuwahara H, Song J, Shimoura T, Yoshida-Tanaka K, Mizuno T, Mochizuki T, Zeniya S, Li F, Nishina K, Nagata T, Ito S, Kusuhara H, Yokota T.

Sci Rep. 2018 Mar 12;8(1):4377. doi: 10.1038/s41598-018-22577-2.

20.

Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis.

Imagawa K, Hayashi H, Sabu Y, Tanikawa K, Fujishiro J, Kajikawa D, Wada H, Kudo T, Kage M, Kusuhara H, Sumazaki R.

J Hum Genet. 2018 May;63(5):569-577. doi: 10.1038/s10038-018-0431-1. Epub 2018 Mar 5. Review.

PMID:
29507376
21.

Viral shedding and clinical status of feline-norovirus-infected cats after reinfection with the same strain.

Takano T, Hiramatsu K, Matsuyama M, Mutoh K, Matsumoto Y, Fukushima T, Doki T, Kusuhara H, Hohdatsu T.

Arch Virol. 2018 Jun;163(6):1503-1510. doi: 10.1007/s00705-018-3770-5. Epub 2018 Feb 14.

PMID:
29445988
22.

Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model.

Nakada T, Kudo T, Kume T, Kusuhara H, Ito K.

Drug Metab Pharmacokinet. 2018 Feb;33(1):103-110. doi: 10.1016/j.dmpk.2017.11.314. Epub 2017 Dec 5.

PMID:
29361388
23.

Organic Anion Transporting Polypeptide 1a4 is Responsible for the Hepatic Uptake of Cardiac Glycosides in Mice.

Takano J, Maeda K, Kusuhara H, Sugiyama Y.

Drug Metab Dispos. 2018 May;46(5):652-657. doi: 10.1124/dmd.117.079483. Epub 2018 Jan 18.

PMID:
29348124
24.

Preliminary Study of PGA Fabric for Seromas at Latissimus Dorsi Flap Donor Sites.

Itani Y, Hagiwara A, Hashimoto T, Isogai N, Kusuhara H.

Plast Reconstr Surg Glob Open. 2017 Oct 5;5(10):e1499. doi: 10.1097/GOX.0000000000001499. eCollection 2017 Oct.

25.

Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.

Kusuhara H, Takashima T, Fujii H, Takashima T, Tanaka M, Ishii A, Tazawa S, Takahashi K, Takahashi K, Tokai H, Yano T, Kataoka M, Inano A, Yoshida S, Hosoya T, Sugiyama Y, Yamashita S, Hojo T, Watanabe Y.

Drug Metab Pharmacokinet. 2017 Dec;32(6):293-300. doi: 10.1016/j.dmpk.2017.09.003. Epub 2017 Sep 21.

PMID:
29137842
26.

Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages.

Hayashi H, Naoi S, Togawa T, Hirose Y, Kondou H, Hasegawa Y, Abukawa D, Sasaki M, Muroya K, Watanabe S, Nakano S, Minowa K, Inui A, Fukuda A, Kasahara M, Nagasaka H, Bessho K, Suzuki M, Kusuhara H.

EBioMedicine. 2018 Jan;27:187-199. doi: 10.1016/j.ebiom.2017.10.007. Epub 2017 Oct 7.

27.

Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.

Shimanaka Y, Kono N, Taketomi Y, Arita M, Okayama Y, Tanaka Y, Nishito Y, Mochizuki T, Kusuhara H, Adibekian A, Cravatt BF, Murakami M, Arai H.

Nat Med. 2017 Nov;23(11):1287-1297. doi: 10.1038/nm.4417. Epub 2017 Oct 9.

PMID:
29035365
28.

A Novel Method to Induce Cartilage Regeneration with Cubic Microcartilage.

Nishiwaki H, Fujita M, Yamauchi M, Isogai N, Tabata Y, Kusuhara H.

Cells Tissues Organs. 2017;204(5-6):251-260. doi: 10.1159/000479790. Epub 2017 Oct 4.

PMID:
28972948
29.

Reconstruction of Severely Crushed Fingertip Amputations with Basic Fibroblast Growth Factor Slow Release System.

Kusuhara H, Ichinohashi K, Sueyoshi Y, Tabata Y, Isogai N.

Plast Reconstr Surg Glob Open. 2017 Jun 28;5(6):e1384. doi: 10.1097/GOX.0000000000001384. eCollection 2017 Jun.

30.

Corrigendum to "Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data" [Drug Metab Pharmacokinet 32 (2017) 135-144].

Kanamitsu K, Nozaki Y, Nagaya Y, Sugiyama Y, Kusuhara H.

Drug Metab Pharmacokinet. 2017 Aug;32(4):228. doi: 10.1016/j.dmpk.2017.05.003. Epub 2017 May 22. No abstract available.

PMID:
28587746
31.

Endogenous Probes for Drug Transporters: Balancing Vision With Reality.

Rodrigues AD, Taskar KS, Kusuhara H, Sugiyama Y.

Clin Pharmacol Ther. 2018 Mar;103(3):434-448. doi: 10.1002/cpt.749. Epub 2017 Jul 14. Review.

PMID:
28560712
32.

Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers.

Takehara I, Terashima H, Nakayama T, Yoshikado T, Yoshida M, Furihata K, Watanabe N, Maeda K, Ando O, Sugiyama Y, Kusuhara H.

Pharm Res. 2017 Aug;34(8):1601-1614. doi: 10.1007/s11095-017-2184-5. Epub 2017 May 26.

PMID:
28550384
33.

Possible Role of Organic Cation Transporters in the Distribution of [11C]Sulpiride, a Dopamine D2 Receptor Antagonist.

Takano H, Ito S, Zhang X, Ito H, Zhang MR, Suzuki H, Maeda K, Kusuhara H, Suhara T, Sugiyama Y.

J Pharm Sci. 2017 Sep;106(9):2558-2565. doi: 10.1016/j.xphs.2017.05.006. Epub 2017 May 10.

PMID:
28499878
34.
35.

A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions.

Yoshikado T, Maeda K, Furihata S, Terashima H, Nakayama T, Ishigame K, Tsunemoto K, Kusuhara H, Furihata KI, Sugiyama Y.

Pharm Res. 2017 Aug;34(8):1570-1583. doi: 10.1007/s11095-017-2168-5. Epub 2017 May 8.

PMID:
28484975
36.

Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide.

Miyake T, Mizuno T, Mochizuki T, Kimura M, Matsuki S, Irie S, Ieiri I, Maeda K, Kusuhara H.

J Pharm Sci. 2017 Sep;106(9):2542-2550. doi: 10.1016/j.xphs.2017.04.067. Epub 2017 May 4.

PMID:
28479364
37.

Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist.

Kusuhara H, Obach RS, Rostami-Hodjegan A, Pang KS, Hammarlund-Udenaes M, Derendorf H, Artursson P, Huang SM, Suzuki H, Terasaki T.

J Pharm Sci. 2017 Sep;106(9):2188-2194. doi: 10.1016/j.xphs.2017.04.072. Epub 2017 May 4. No abstract available.

PMID:
28479350
38.

Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins.

Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Kusuhara H, Maeda K, Sugiyama Y.

Drug Metab Dispos. 2017 Jul;45(7):779-789. doi: 10.1124/dmd.116.074823. Epub 2017 May 3.

PMID:
28468836
39.

Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban.

Tsuruya Y, Nakanishi T, Komori H, Wang X, Ishiguro N, Kito T, Ikukawa K, Kishimoto W, Ito S, Schaefer O, Ebner T, Yamamura N, Kusuhara H, Tamai I.

J Pharm Sci. 2017 Sep;106(9):2524-2534. doi: 10.1016/j.xphs.2017.04.044. Epub 2017 Apr 26.

PMID:
28456731
40.

Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.

Kanamitsu K, Kusuhara H, Schuetz JD, Takeuchi K, Sugiyama Y.

J Pharm Sci. 2017 Sep;106(9):2566-2575. doi: 10.1016/j.xphs.2017.04.040. Epub 2017 Apr 27.

41.

Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells.

Kurosawa T, Higuchi K, Okura T, Kobayashi K, Kusuhara H, Deguchi Y.

J Pharm Sci. 2017 Sep;106(9):2576-2582. doi: 10.1016/j.xphs.2017.04.032. Epub 2017 Apr 26.

PMID:
28454746
42.

Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP.

Kashihara Y, Ieiri I, Yoshikado T, Maeda K, Fukae M, Kimura M, Hirota T, Matsuki S, Irie S, Izumi N, Kusuhara H, Sugiyama Y.

J Pharm Sci. 2017 Sep;106(9):2688-2694. doi: 10.1016/j.xphs.2017.03.010. Epub 2017 Mar 18.

PMID:
28322941
43.

Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches.

Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y.

J Pharm Sci. 2017 Sep;106(9):2678-2687. doi: 10.1016/j.xphs.2017.02.012. Epub 2017 Feb 24.

PMID:
28238896
44.

Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data.

Kanamitsu K, Nozaki Y, Nagaya Y, Sugiyama Y, Kusuhara H.

Drug Metab Pharmacokinet. 2017 Apr;32(2):135-144. doi: 10.1016/j.dmpk.2016.11.007. Epub 2016 Nov 18. Erratum in: Drug Metab Pharmacokinet. 2017 Aug;32(4):228.

PMID:
28190755
45.

Difference in Mechanism-Based Inhibition of Cytochrome P450 3A4 and 3A5 by a Series of Fluoroquinolone Antibacterial Agents.

Watanabe A, Takakusa H, Kimura T, Inoue SI, Kusuhara H, Ando O.

Drug Metab Dispos. 2017 Mar;45(3):336-341. doi: 10.1124/dmd.116.073783. Epub 2016 Dec 14.

PMID:
27974381
46.

Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity.

Shimura S, Watashi K, Fukano K, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Takeuchi JS, Miyake T, Sugiyama M, Ogasawara Y, Park SY, Tanaka Y, Kusuhara H, Mizokami M, Sureau C, Wakita T.

J Hepatol. 2017 Apr;66(4):685-692. doi: 10.1016/j.jhep.2016.11.009. Epub 2016 Nov 25.

PMID:
27890789
47.

Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-0802.

Ito M, Kusuhara H, Ose A, Kondo T, Tanabe K, Nakayama H, Horita S, Fujita T, Sugiyama Y.

AAPS J. 2017 Jan;19(1):286-297. doi: 10.1208/s12248-016-9992-0. Epub 2016 Oct 31.

PMID:
27800573
48.

Investigation of Endogenous Compounds Applicable to Drug-Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans.

Tsuruya Y, Kato K, Sano Y, Imamura Y, Maeda K, Kumagai Y, Sugiyama Y, Kusuhara H.

Drug Metab Dispos. 2016 Dec;44(12):1925-1933. Epub 2016 Sep 16.

PMID:
27638508
49.

Pim-1L Protects Cell Surface-Resident ABCA1 From Lysosomal Degradation in Hepatocytes and Thereby Regulates Plasma High-Density Lipoprotein Level.

Katsube A, Hayashi H, Kusuhara H.

Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2304-2314. Epub 2016 Oct 20.

PMID:
27765770
50.

Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments.

Kanamitsu K, Arakawa R, Sugiyama Y, Suhara T, Kusuhara H.

Drug Metab Pharmacokinet. 2016 Dec;31(6):395-404. doi: 10.1016/j.dmpk.2016.07.003. Epub 2016 Jul 30.

PMID:
27745731

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