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Tamoxifen suppresses pancreatic β-cell proliferation in mice.

Ahn SH, Granger A, Rankin MM, Lam CJ, Cox AR, Kushner JA.

PLoS One. 2019 Sep 6;14(9):e0214829. doi: 10.1371/journal.pone.0214829. eCollection 2019.


Dose-dependent glycometabolic effects of sotagliflozin on type 1 diabetes over 12 weeks: The inTandem4 trial.

Baker C, Wason S, Banks P, Sawhney S, Chang A, Danne T, Gesty-Palmer D, Kushner JA, McGuire DK, Mikell F, O'Neill M, Peters AL, Strumph P.

Diabetes Obes Metab. 2019 Nov;21(11):2440-2449. doi: 10.1111/dom.13825. Epub 2019 Aug 1.


Outcomes, care utilization, and expenditures in adolescent pregnancy complicated by diabetes.

Kohn JR, Rajan SS, Kushner JA, Fox KA.

Pediatr Diabetes. 2019 Sep;20(6):769-777. doi: 10.1111/pedi.12871. Epub 2019 Jul 1.


Adjunct Therapy in Type 1 Diabetes: A Survey to Uncover Unmet Needs and Patient Preferences Beyond HbA1c Measures.

Pettus JH, Kushner JA, Valentine V, Wood R, Pang C, Paranjape S, Berria R, Deluzio A, Edelman SE.

Diabetes Technol Ther. 2019 Jun;21(6):336-343. doi: 10.1089/dia.2019.0027. Epub 2019 May 16.


Improving the scientific rigour of nutritional recommendations for adults with type 2 diabetes: A comprehensive review of the American Diabetes Association guideline-recommended eating patterns.

Hallberg SJ, Dockter NE, Kushner JA, Athinarayanan SJ.

Diabetes Obes Metab. 2019 Aug;21(8):1769-1779. doi: 10.1111/dom.13736. Epub 2019 May 9. Review.


Glucagon Receptor Antagonist-Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age.

Lam CJ, Rankin MM, King KB, Wang MC, Shook BC, Kushner JA.

Diabetes. 2019 May;68(5):963-974. doi: 10.2337/db18-1293. Epub 2019 Mar 4.


Improved Time in Range and Glycemic Variability With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: A Pooled Analysis of 24-Week Continuous Glucose Monitoring Data From the inTandem Program.

Danne T, Cariou B, Buse JB, Garg SK, Rosenstock J, Banks P, Kushner JA, McGuire DK, Peters AL, Sawhney S, Strumph P.

Diabetes Care. 2019 May;42(5):919-930. doi: 10.2337/dc18-2149. Epub 2019 Mar 4.


The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice.

Pandey R, Bakay M, Hain HS, Strenkowski B, Yermakova A, Kushner JA, Orange JS, Hakonarson H.

Front Immunol. 2019 Feb 1;10:68. doi: 10.3389/fimmu.2019.00068. eCollection 2019.


International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium-Glucose Cotransporter (SGLT) Inhibitors.

Danne T, Garg S, Peters AL, Buse JB, Mathieu C, Pettus JH, Alexander CM, Battelino T, Ampudia-Blasco FJ, Bode BW, Cariou B, Close KL, Dandona P, Dutta S, Ferrannini E, Fourlanos S, Grunberger G, Heller SR, Henry RR, Kurian MJ, Kushner JA, Oron T, Parkin CG, Pieber TR, Rodbard HW, Schatz D, Skyler JS, Tamborlane WV, Yokote K, Phillip M.

Diabetes Care. 2019 Jun;42(6):1147-1154. doi: 10.2337/dc18-2316. Epub 2019 Feb 6. Review.


Low-Level Insulin Content Within Abundant Non-β Islet Endocrine Cells in Long-standing Type 1 Diabetes.

Lam CJ, Chatterjee A, Shen E, Cox AR, Kushner JA.

Diabetes. 2019 Mar;68(3):598-608. doi: 10.2337/db18-0305. Epub 2018 Dec 14.


Identifying and addressing gaps in reproductive health education for adolescent girls with type 1 diabetes.

Kohn JR, Hilliard ME, Lyons SK, Fox KA, Kushner JA.

PLoS One. 2018 Nov 6;13(11):e0206102. doi: 10.1371/journal.pone.0206102. eCollection 2018.


CLEC16A regulates splenocyte and NK cell function in part through MEK signaling.

Pandey R, Bakay M, Hain HS, Strenkowski B, Elsaqa BZB, Roizen JD, Kushner JA, Orange JS, Hakonarson H.

PLoS One. 2018 Sep 18;13(9):e0203952. doi: 10.1371/journal.pone.0203952. eCollection 2018.


HbA1c and Hypoglycemia Reductions at 24 and 52 Weeks With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: The European inTandem2 Study.

Danne T, Cariou B, Banks P, Brandle M, Brath H, Franek E, Kushner JA, Lapuerta P, McGuire DK, Peters AL, Sawhney S, Strumph P.

Diabetes Care. 2018 Sep;41(9):1981-1990. doi: 10.2337/dc18-0342. Epub 2018 Jun 24.


Sotagliflozin in Combination With Optimized Insulin Therapy in Adults With Type 1 Diabetes: The North American inTandem1 Study.

Buse JB, Garg SK, Rosenstock J, Bailey TS, Banks P, Bode BW, Danne T, Kushner JA, Lane WS, Lapuerta P, McGuire DK, Peters AL, Reed J, Sawhney S, Strumph P.

Diabetes Care. 2018 Sep;41(9):1970-1980. doi: 10.2337/dc18-0343. Epub 2018 Jun 24.


Highly Proliferative α-Cell-Related Islet Endocrine Cells in Human Pancreata.

Lam CJ, Cox AR, Jacobson DR, Rankin MM, Kushner JA.

Diabetes. 2018 Apr;67(4):674-686. doi: 10.2337/db17-1114. Epub 2018 Jan 11.


Area IV Knockout Reveals How Pdx1 Is Regulated in Postnatal β-Cell Development.

Cox AR, Kushner JA.

Diabetes. 2017 Nov;66(11):2738-2740. doi: 10.2337/dbi17-0036. No abstract available.


Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes.

Garg SK, Henry RR, Banks P, Buse JB, Davies MJ, Fulcher GR, Pozzilli P, Gesty-Palmer D, Lapuerta P, Simó R, Danne T, McGuire DK, Kushner JA, Peters A, Strumph P.

N Engl J Med. 2017 Dec 14;377(24):2337-2348. doi: 10.1056/NEJMoa1708337. Epub 2017 Sep 13.


Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

O'Kell AL, Wasserfall C, Catchpole B, Davison LJ, Hess RS, Kushner JA, Atkinson MA.

Diabetes. 2017 Jun;66(6):1443-1452. doi: 10.2337/db16-1551.


Incretin Therapies Do Not Expand β-Cell Mass or Alter Pancreatic Histology in Young Male Mice.

Cox AR, Lam CJ, Rankin MM, Rios JS, Chavez J, Bonnyman CW, King KB, Wells RA, Anthony D, Tu JX, Kim JJ, Li C, Kushner JA.

Endocrinology. 2017 Jun 1;158(6):1701-1714. doi: 10.1210/en.2017-00027.


β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis.

Lam CJ, Jacobson DR, Rankin MM, Cox AR, Kushner JA.

J Clin Endocrinol Metab. 2017 Aug 1;102(8):2647-2659. doi: 10.1210/jc.2016-3806.


Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.

Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA.

Diabetologia. 2017 Jan;60(1):35-38. Epub 2016 Oct 26.


Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy.

Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA.

PLoS One. 2016 Jul 13;11(7):e0159276. doi: 10.1371/journal.pone.0159276. eCollection 2016.


Strengthening the Pipeline for Clinician-Scientists: The Pediatrician-Scientist Training and Development Program at Texas Children's Hospital.

Burns AM, Kushner JA, Ward MA, Turner TL, Kline MW, Orange JS.

J Pediatr. 2016 May;172:5-6.e5. doi: 10.1016/j.jpeds.2016.02.002. No abstract available.


Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage.

Cox AR, Lam CJ, Rankin MM, King KA, Chen P, Martinez R, Li C, Kushner JA.

Diabetologia. 2016 Jun;59(6):1231-41. doi: 10.1007/s00125-016-3922-7. Epub 2016 Mar 22.


Type I interferons mediate pancreatic toxicities of PERK inhibition.

Yu Q, Zhao B, Gui J, Katlinski KV, Brice A, Gao Y, Li C, Kushner JA, Koumenis C, Diehl JA, Fuchs SY.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15420-5. doi: 10.1073/pnas.1516362112. Epub 2015 Dec 1.


Dissatisfaction with maintenance of certification in academic pediatrics.

Ackerman KG, Lee B, Kushner JA.

Pediatr Res. 2016 Feb;79(2):240-2. doi: 10.1038/pr.2015.189. Epub 2015 Sep 30. No abstract available.


Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention.

Michels A, Zhang L, Khadra A, Kushner JA, Redondo MJ, Pietropaolo M.

Pediatr Diabetes. 2015 Nov;16(7):465-84. doi: 10.1111/pedi.12299. Epub 2015 Jul 23. Review.


Extreme Beta-Cell Deficiency in Pancreata of Dogs with Canine Diabetes.

Shields EJ, Lam CJ, Cox AR, Rankin MM, Van Winkle TJ, Hess RS, Kushner JA.

PLoS One. 2015 Jun 9;10(6):e0129809. doi: 10.1371/journal.pone.0129809. eCollection 2015.


Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice.

Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios JS, Kushner JA.

Diabetologia. 2015 Jul;58(7):1523-31. doi: 10.1007/s00125-015-3590-z. Epub 2015 Apr 28.


Stem cells to insulin secreting cells: two steps forward and now a time to pause?

Kushner JA, MacDonald PE, Atkinson MA.

Cell Stem Cell. 2014 Nov 6;15(5):535-6. doi: 10.1016/j.stem.2014.10.012. Epub 2014 Nov 6.


Polyethylene glycol improves elution properties of polymethyl methacrylate bone cements.

Handal JA, Tiedeken NC, Gershkovich GE, Kushner JA, Dratch B, Samuel SP.

J Surg Res. 2015 Mar;194(1):161-6. doi: 10.1016/j.jss.2014.10.051. Epub 2014 Nov 6.


An unusual location of a pilar sheath acanthoma.

Kushner JA, Thomas RS, Young RJ.

Int J Trichology. 2014 Oct;6(4):185-6. doi: 10.4103/0974-7753.142886.


Editorial: in praise of scientific review officers.

Elahi D, Mirmira RG, Kushner JA.

Mol Endocrinol. 2014 Jul;28(7):987-8. doi: 10.1210/me.2014-1179. No abstract available.


The diabetes susceptibility gene Clec16a regulates mitophagy.

Soleimanpour SA, Gupta A, Bakay M, Ferrari AM, Groff DN, Fadista J, Spruce LA, Kushner JA, Groop L, Seeholzer SH, Kaufman BA, Hakonarson H, Stoffers DA.

Cell. 2014 Jun 19;157(7):1577-90. doi: 10.1016/j.cell.2014.05.016.


GATA factors promote ER integrity and β-cell survival and contribute to type 1 diabetes risk.

Sartori DJ, Wilbur CJ, Long SY, Rankin MM, Li C, Bradfield JP, Hakonarson H, Grant SF, Pu WT, Kushner JA.

Mol Endocrinol. 2014 Jan;28(1):28-39. doi: 10.1210/me.2013-1265. Epub 2013 Jan 1.


Permanent neonatal diabetes mellitus in monozygotic twins achieving low-dose sulfonylurea therapy.

Hicks KA, Kushner JA, Heptulla R, Ham JN.

J Pediatr Endocrinol Metab. 2014 Jan;27(1-2):135-8. doi: 10.1515/jpem-2013-0171.


The role of aging upon β cell turnover.

Kushner JA.

J Clin Invest. 2013 Mar;123(3):990-5. doi: 10.1172/JCI64095. Epub 2013 Mar 1. Review.


β-Cells are not generated in pancreatic duct ligation-induced injury in adult mice.

Rankin MM, Wilbur CJ, Rak K, Shields EJ, Granger A, Kushner JA.

Diabetes. 2013 May;62(5):1634-45. doi: 10.2337/db12-0848. Epub 2013 Jan 24.


PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis.

Gao Y, Sartori DJ, Li C, Yu QC, Kushner JA, Simon MC, Diehl JA.

Mol Cell Biol. 2012 Dec;32(24):5129-39. doi: 10.1128/MCB.01009-12. Epub 2012 Oct 15.


miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, Maas NL, Frederick B, Kushner JA, Chodosh LA, Koumenis C, Fuchs SY, Diehl JA.

Mol Cell. 2012 Nov 9;48(3):353-64. doi: 10.1016/j.molcel.2012.08.025. Epub 2012 Sep 27.


Development. Esophageal stem cells, where art thou?

Kushner JA.

Science. 2012 Aug 31;337(6098):1051-2. doi: 10.1126/science.1227506. No abstract available.


Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets.

Rieck S, Zhang J, Li Z, Liu C, Naji A, Takane KK, Fiaschi-Taesch NM, Stewart AF, Kushner JA, Kaestner KH.

Mol Endocrinol. 2012 Sep;26(9):1590-602. doi: 10.1210/me.2012-1019. Epub 2012 Jul 13.


Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: control of islet vasculature and vascular endothelial growth factor by glucose.

Akirav EM, Baquero MT, Opare-Addo LW, Akirav M, Galvan E, Kushner JA, Rimm DL, Herold KC.

Diabetes. 2011 Mar;60(3):876-83. doi: 10.2337/db10-0793. Epub 2011 Feb 9.


Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue.

Tuttle AH, Rankin MM, Teta M, Sartori DJ, Stein GM, Kim GJ, Virgilio C, Granger A, Zhou D, Long SH, Schiffman AB, Kushner JA.

J Vis Exp. 2010 Dec 7;(46). pii: 2166. doi: 10.3791/2166.


Aging induces a distinct gene expression program in mouse islets.

Rankin MM, Kushner JA.

Islets. 2010 Nov-Dec;2(6):345-52. doi: 10.4161/isl.2.6.13376. Epub 2010 Nov 1.


Calcineurin signaling regulates human islet {beta}-cell survival.

Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Groff DN, Rankin MM, Liu C, De León DD, Naji A, Kushner JA, Stoffers DA.

J Biol Chem. 2010 Dec 17;285(51):40050-9. doi: 10.1074/jbc.M110.154955. Epub 2010 Oct 13.


Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating.

Perl S, Kushner JA, Buchholz BA, Meeker AK, Stein GM, Hsieh M, Kirby M, Pechhold S, Liu EH, Harlan DM, Tisdale JF.

J Clin Endocrinol Metab. 2010 Oct;95(10):E234-9. doi: 10.1210/jc.2010-0932. Epub 2010 Jul 21.


Ductal origin hypothesis of pancreatic regeneration under attack.

Kushner JA, Weir GC, Bonner-Weir S.

Cell Metab. 2010 Jan;11(1):2-3. doi: 10.1016/j.cmet.2009.12.005. No abstract available. Erratum in: Cell Metab. 2010 Feb 3;11(2):172.


Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis.

Liang L, Guo WH, Esquiliano DR, Asai M, Rodriguez S, Giraud J, Kushner JA, White MF, Lopez MF.

Endocrinology. 2010 Feb;151(2):741-7. doi: 10.1210/en.2009-0705. Epub 2009 Dec 23.


Cellular origins of beta-cell regeneration: a legacy view of historical controversies.

Granger A, Kushner JA.

J Intern Med. 2009 Oct;266(4):325-38. doi: 10.1111/j.1365-2796.2009.02156.x. Review.

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