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Items: 1 to 50 of 385

1.

Letter to the Editor Re: Scott S.N., et al. Nutrients 2019, 11(5), 1022.

Kushner JA.

Nutrients. 2019 Nov 7;11(11). pii: E2700. doi: 10.3390/nu11112700.

2.

Tamoxifen suppresses pancreatic β-cell proliferation in mice.

Ahn SH, Granger A, Rankin MM, Lam CJ, Cox AR, Kushner JA.

PLoS One. 2019 Sep 6;14(9):e0214829. doi: 10.1371/journal.pone.0214829. eCollection 2019.

3.

Addressing Social Determinants of Health through Medicaid: Lessons from Oregon.

Kushner J, McConnell KJ.

J Health Polit Policy Law. 2019 Dec 1;44(6):919-935. doi: 10.1215/03616878-7785823.

PMID:
31408877
4.

Caring for the transgender adolescent and young adult: Current concepts of an evolving process in the 21st century.

Agana MG, Greydanus DE, Indyk JA, Calles JL Jr, Kushner J, Leibowitz S, Chelvakumar G, Cabral MD.

Dis Mon. 2019 Sep;65(9):303-356. doi: 10.1016/j.disamonth.2019.07.004. Epub 2019 Aug 9.

PMID:
31405516
5.

Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.

Ma J, Zhao S, Qiao X, Knight T, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Wang G, Zhao L, Lin H, Wang Y, Taub JW, Ge Y.

Clin Cancer Res. 2019 Nov 15;25(22):6815-6826. doi: 10.1158/1078-0432.CCR-19-0832. Epub 2019 Jul 18.

PMID:
31320594
6.

Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.

Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz JD, Li J, Hou Z, Dann CE 3rd, Gangjee A, Matherly LH.

Mol Cancer Ther. 2019 Oct;18(10):1787-1799. doi: 10.1158/1535-7163.MCT-19-0037. Epub 2019 Jul 9.

PMID:
31289137
7.

Dose-dependent glycometabolic effects of sotagliflozin on type 1 diabetes over 12 weeks: The inTandem4 trial.

Baker C, Wason S, Banks P, Sawhney S, Chang A, Danne T, Gesty-Palmer D, Kushner JA, McGuire DK, Mikell F, O'Neill M, Peters AL, Strumph P.

Diabetes Obes Metab. 2019 Nov;21(11):2440-2449. doi: 10.1111/dom.13825. Epub 2019 Aug 1.

8.

Outcomes, care utilization, and expenditures in adolescent pregnancy complicated by diabetes.

Kohn JR, Rajan SS, Kushner JA, Fox KA.

Pediatr Diabetes. 2019 Sep;20(6):769-777. doi: 10.1111/pedi.12871. Epub 2019 Jul 1.

PMID:
31125158
9.

Adjunct Therapy in Type 1 Diabetes: A Survey to Uncover Unmet Needs and Patient Preferences Beyond HbA1c Measures.

Pettus JH, Kushner JA, Valentine V, Wood R, Pang C, Paranjape S, Berria R, Deluzio A, Edelman SE.

Diabetes Technol Ther. 2019 Jun;21(6):336-343. doi: 10.1089/dia.2019.0027. Epub 2019 May 16.

10.

Improving the scientific rigour of nutritional recommendations for adults with type 2 diabetes: A comprehensive review of the American Diabetes Association guideline-recommended eating patterns.

Hallberg SJ, Dockter NE, Kushner JA, Athinarayanan SJ.

Diabetes Obes Metab. 2019 Aug;21(8):1769-1779. doi: 10.1111/dom.13736. Epub 2019 May 9. Review.

11.

Glucagon Receptor Antagonist-Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age.

Lam CJ, Rankin MM, King KB, Wang MC, Shook BC, Kushner JA.

Diabetes. 2019 May;68(5):963-974. doi: 10.2337/db18-1293. Epub 2019 Mar 4.

12.

Improved Time in Range and Glycemic Variability With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: A Pooled Analysis of 24-Week Continuous Glucose Monitoring Data From the inTandem Program.

Danne T, Cariou B, Buse JB, Garg SK, Rosenstock J, Banks P, Kushner JA, McGuire DK, Peters AL, Sawhney S, Strumph P.

Diabetes Care. 2019 May;42(5):919-930. doi: 10.2337/dc18-2149. Epub 2019 Mar 4.

PMID:
30833371
13.

Antileukemic activity and mechanism of action of the novel PI3K and histone deacetylase dual inhibitor CUDC-907 in acute myeloid leukemia.

Li X, Su Y, Madlambayan G, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Ma J, Knight T, Wang G, Wang Y, Yang J, Taub JW, Lin H, Ge Y.

Haematologica. 2019 Nov;104(11):2225-2240. doi: 10.3324/haematol.2018.201343. Epub 2019 Feb 28.

14.

The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice.

Pandey R, Bakay M, Hain HS, Strenkowski B, Yermakova A, Kushner JA, Orange JS, Hakonarson H.

Front Immunol. 2019 Feb 1;10:68. doi: 10.3389/fimmu.2019.00068. eCollection 2019.

15.

International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium-Glucose Cotransporter (SGLT) Inhibitors.

Danne T, Garg S, Peters AL, Buse JB, Mathieu C, Pettus JH, Alexander CM, Battelino T, Ampudia-Blasco FJ, Bode BW, Cariou B, Close KL, Dandona P, Dutta S, Ferrannini E, Fourlanos S, Grunberger G, Heller SR, Henry RR, Kurian MJ, Kushner JA, Oron T, Parkin CG, Pieber TR, Rodbard HW, Schatz D, Skyler JS, Tamborlane WV, Yokote K, Phillip M.

Diabetes Care. 2019 Jun;42(6):1147-1154. doi: 10.2337/dc18-2316. Epub 2019 Feb 6. Review.

PMID:
30728224
16.

Low-Level Insulin Content Within Abundant Non-β Islet Endocrine Cells in Long-standing Type 1 Diabetes.

Lam CJ, Chatterjee A, Shen E, Cox AR, Kushner JA.

Diabetes. 2019 Mar;68(3):598-608. doi: 10.2337/db18-0305. Epub 2018 Dec 14.

17.

Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.

Yang L, Katchman A, Kushner J, Kushnir A, Zakharov SI, Chen BX, Shuja Z, Subramanyam P, Liu G, Papa A, Roybal D, Pitt GS, Colecraft HM, Marx SO.

J Clin Invest. 2019 Feb 1;129(2):647-658. doi: 10.1172/JCI123878. Epub 2019 Jan 7.

18.

Identifying and addressing gaps in reproductive health education for adolescent girls with type 1 diabetes.

Kohn JR, Hilliard ME, Lyons SK, Fox KA, Kushner JA.

PLoS One. 2018 Nov 6;13(11):e0206102. doi: 10.1371/journal.pone.0206102. eCollection 2018.

19.

CLEC16A regulates splenocyte and NK cell function in part through MEK signaling.

Pandey R, Bakay M, Hain HS, Strenkowski B, Elsaqa BZB, Roizen JD, Kushner JA, Orange JS, Hakonarson H.

PLoS One. 2018 Sep 18;13(9):e0203952. doi: 10.1371/journal.pone.0203952. eCollection 2018.

20.

HbA1c and Hypoglycemia Reductions at 24 and 52 Weeks With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: The European inTandem2 Study.

Danne T, Cariou B, Banks P, Brandle M, Brath H, Franek E, Kushner JA, Lapuerta P, McGuire DK, Peters AL, Sawhney S, Strumph P.

Diabetes Care. 2018 Sep;41(9):1981-1990. doi: 10.2337/dc18-0342. Epub 2018 Jun 24.

PMID:
29937431
21.

Sotagliflozin in Combination With Optimized Insulin Therapy in Adults With Type 1 Diabetes: The North American inTandem1 Study.

Buse JB, Garg SK, Rosenstock J, Bailey TS, Banks P, Bode BW, Danne T, Kushner JA, Lane WS, Lapuerta P, McGuire DK, Peters AL, Reed J, Sawhney S, Strumph P.

Diabetes Care. 2018 Sep;41(9):1970-1980. doi: 10.2337/dc18-0343. Epub 2018 Jun 24.

22.

Quantifying and reducing powder shear sensitivity when manufacturing capsules with lubricants.

Blackwood D, Ketterhagen W, Kresevic J, Kushner J 4th, Moriarty J, Mullarney MP.

Drug Dev Ind Pharm. 2018 Aug;44(8):1350-1356. doi: 10.1080/03639045.2018.1451877. Epub 2018 May 3.

PMID:
29712481
23.

Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.

Ravindra M, Wilson MR, Tong N, O'Connor C, Karim M, Polin L, Wallace-Povirk A, White K, Kushner J, Hou Z, Matherly LH, Gangjee A.

J Med Chem. 2018 May 10;61(9):4228-4248. doi: 10.1021/acs.jmedchem.8b00408. Epub 2018 Apr 27.

24.

Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis.

Ravindra M, Wallace-Povirk A, Karim MA, Wilson MR, O'Connor C, White K, Kushner J, Polin L, George C, Hou Z, Matherly LH, Gangjee A.

J Med Chem. 2018 Mar 8;61(5):2027-2040. doi: 10.1021/acs.jmedchem.7b01708. Epub 2018 Feb 21.

25.

Cutaneous polyarteritis nodosa resulting from a paclitaxel-eluting balloon angioplasty.

Montgomery A, Kushner J, Altman D.

JAAD Case Rep. 2017 Dec 19;4(1):50-52. doi: 10.1016/j.jdcr.2017.09.024. eCollection 2018 Jan. No abstract available.

26.

Highly Proliferative α-Cell-Related Islet Endocrine Cells in Human Pancreata.

Lam CJ, Cox AR, Jacobson DR, Rankin MM, Kushner JA.

Diabetes. 2018 Apr;67(4):674-686. doi: 10.2337/db17-1114. Epub 2018 Jan 11.

27.

Area IV Knockout Reveals How Pdx1 Is Regulated in Postnatal β-Cell Development.

Cox AR, Kushner JA.

Diabetes. 2017 Nov;66(11):2738-2740. doi: 10.2337/dbi17-0036. No abstract available.

28.

Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes.

Garg SK, Henry RR, Banks P, Buse JB, Davies MJ, Fulcher GR, Pozzilli P, Gesty-Palmer D, Lapuerta P, Simó R, Danne T, McGuire DK, Kushner JA, Peters A, Strumph P.

N Engl J Med. 2017 Dec 14;377(24):2337-2348. doi: 10.1056/NEJMoa1708337. Epub 2017 Sep 13.

29.

Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart.

Katchman A, Yang L, Zakharov SI, Kushner J, Abrams J, Chen BX, Liu G, Pitt GS, Colecraft HM, Marx SO.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9194-9199. doi: 10.1073/pnas.1706054114. Epub 2017 Aug 7.

30.

Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

O'Kell AL, Wasserfall C, Catchpole B, Davison LJ, Hess RS, Kushner JA, Atkinson MA.

Diabetes. 2017 Jun;66(6):1443-1452. doi: 10.2337/db16-1551.

31.

Erratum to: At the Heart of the Pregnancy: What Prenatal and Cardiovascular Genetic Counselors Need to Know about Maternal Heart Disease.

Morales A, Allain DC, Arscott P, James E, MacCarrick G, Murray B, Tichnell C, Shikany AR, Spencer S, Fitzgerald-Butt SM, Kushner JD, Munn C, Smith E, Spoonamore KG, Tandri HS, Aaron Kay W.

J Genet Couns. 2017 Aug;26(4):689. doi: 10.1007/s10897-017-0101-z. No abstract available.

32.

Incretin Therapies Do Not Expand β-Cell Mass or Alter Pancreatic Histology in Young Male Mice.

Cox AR, Lam CJ, Rankin MM, Rios JS, Chavez J, Bonnyman CW, King KB, Wells RA, Anthony D, Tu JX, Kim JJ, Li C, Kushner JA.

Endocrinology. 2017 Jun 1;158(6):1701-1714. doi: 10.1210/en.2017-00027.

33.

β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis.

Lam CJ, Jacobson DR, Rankin MM, Cox AR, Kushner JA.

J Clin Endocrinol Metab. 2017 Aug 1;102(8):2647-2659. doi: 10.1210/jc.2016-3806.

34.

At the Heart of the Pregnancy: What Prenatal and Cardiovascular Genetic Counselors Need to Know about Maternal Heart Disease.

Morales A, Allain DC, Arscott P, James E, MacCarrick G, Murray B, Tichnell C, Shikany AR, Spencer S, Fitzgerald-Butt SM, Kushner JD, Munn C, Smith E, Spoonamore KG, Tandri HS, Kay WA.

J Genet Couns. 2017 Aug;26(4):669-688. doi: 10.1007/s10897-017-0081-z. Epub 2017 Mar 10. Review. Erratum in: J Genet Couns. 2017 May 4;:.

35.

Mitral valve coaptation and its relationship to late diastolic flow: A color Doppler and vector flow map echocardiographic study in normal subjects.

Sherrid MV, Kushner J, Yang G, Ro R.

Echocardiography. 2017 Apr;34(4):537-548. doi: 10.1111/echo.13480. Epub 2017 Mar 1.

PMID:
28247433
36.

Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates.

Hou Z, Gattoc L, O'Connor C, Yang S, Wallace-Povirk A, George C, Orr S, Polin L, White K, Kushner J, Morris RT, Gangjee A, Matherly LH.

Mol Cancer Ther. 2017 May;16(5):819-830. doi: 10.1158/1535-7163.MCT-16-0444. Epub 2017 Jan 30.

37.

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.

Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA.

Diabetologia. 2017 Jan;60(1):35-38. Epub 2016 Oct 26.

38.

Nonhealing Lower Leg Ulcers.

Reichel S, Kushner J, LaFond AA.

JAMA Dermatol. 2017 Jan 1;153(1):81-82. doi: 10.1001/jamadermatol.2016.3400. No abstract available.

PMID:
27680781
39.

Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.

Golani LK, Wallace-Povirk A, Deis SM, Wong J, Ke J, Gu X, Raghavan S, Wilson MR, Li X, Polin L, de Waal PW, White K, Kushner J, O'Connor C, Hou Z, Xu HE, Melcher K, Dann CE 3rd, Matherly LH, Gangjee A.

J Med Chem. 2016 Sep 8;59(17):7856-76. doi: 10.1021/acs.jmedchem.6b00594. Epub 2016 Aug 26.

40.

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy.

Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA.

PLoS One. 2016 Jul 13;11(7):e0159276. doi: 10.1371/journal.pone.0159276. eCollection 2016.

41.

Strengthening the Pipeline for Clinician-Scientists: The Pediatrician-Scientist Training and Development Program at Texas Children's Hospital.

Burns AM, Kushner JA, Ward MA, Turner TL, Kline MW, Orange JS.

J Pediatr. 2016 May;172:5-6.e5. doi: 10.1016/j.jpeds.2016.02.002. No abstract available.

PMID:
27112081
42.

Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage.

Cox AR, Lam CJ, Rankin MM, King KA, Chen P, Martinez R, Li C, Kushner JA.

Diabetologia. 2016 Jun;59(6):1231-41. doi: 10.1007/s00125-016-3922-7. Epub 2016 Mar 22.

43.

Extended-Release Once-Daily Formulation of Tofacitinib: Evaluation of Pharmacokinetics Compared With Immediate-Release Tofacitinib and Impact of Food.

Lamba M, Wang R, Fletcher T, Alvey C, Kushner J 4th, Stock TC.

J Clin Pharmacol. 2016 Nov;56(11):1362-1371. doi: 10.1002/jcph.734.

44.

Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates.

Wilson MR, Hou Z, Yang S, Polin L, Kushner J, White K, Huang J, Ratnam M, Gangjee A, Matherly LH.

Mol Pharmacol. 2016 Apr;89(4):425-34. doi: 10.1124/mol.115.102798. Epub 2016 Feb 2.

45.

Research and Evaluations of the Health Aspects of Disasters, Part VI: Interventional Research and the Disaster Logic Model.

Birnbaum ML, Daily EK, O'Rourke AP, Kushner J.

Prehosp Disaster Med. 2016 Apr;31(2):181-94. doi: 10.1017/S1049023X16000017. Epub 2016 Feb 2.

PMID:
26830875
46.

DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes.

Bansal N, Hampe CS, Rodriguez L, O'Brian Smith E, Kushner J, Balasubramanyam A, Redondo MJ.

Diabet Med. 2017 May;34(5):641-646. doi: 10.1111/dme.13077. Epub 2016 Feb 12.

47.

Nutritional Support on the Medical Wards--Thought for Food.

Kushner JP, Lacy JA, Gay SR.

JAMA Intern Med. 2016 Jan;176(1):53-4. doi: 10.1001/jamainternmed.2015.7062. No abstract available.

PMID:
26720103
48.

Type I interferons mediate pancreatic toxicities of PERK inhibition.

Yu Q, Zhao B, Gui J, Katlinski KV, Brice A, Gao Y, Li C, Kushner JA, Koumenis C, Diehl JA, Fuchs SY.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15420-5. doi: 10.1073/pnas.1516362112. Epub 2015 Dec 1.

49.

Doppler Systolic Signal Void in Hypertrophic Cardiomyopathy: Apical Aneurysm and Severe Obstruction without Elevated Intraventricular Velocities.

Po JR, Kim B, Aslam F, Arabadjian M, Winson G, Cantales D, Kushner J, Kornberg R, Sherrid MV.

J Am Soc Echocardiogr. 2015 Dec;28(12):1462-73. doi: 10.1016/j.echo.2015.08.015. Epub 2015 Sep 28.

PMID:
26422555
50.

Dissatisfaction with maintenance of certification in academic pediatrics.

Ackerman KG, Lee B, Kushner JA.

Pediatr Res. 2016 Feb;79(2):240-2. doi: 10.1038/pr.2015.189. Epub 2015 Sep 30. No abstract available.

PMID:
26421351

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