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Items: 1 to 50 of 65

1.

Alpha-blockers as colorectal cancer chemopreventatives: findings from a case-control study, human cell cultures, and in vivo preclinical testing.

Suzuki N, Niikura R, Ihara S, Hikiba Y, Kinoshita H, Higashishima N, Hayakawa Y, Yamada A, Hirata Y, Nakata R, Okamoto M, Sano M, Kushiyama A, Ichinose M, Woods SL, Worthley D, Iwamoto Y, Koike K.

Cancer Prev Res (Phila). 2019 Jan 30. pii: canprevres.0288.2018. doi: 10.1158/1940-6207.CAPR-18-0288. [Epub ahead of print]

PMID:
30700439
2.

Treatment of two mitochondrial disease patients with a combination of febuxostat and inosine that enhances cellular ATP.

Kamatani N, Kushiyama A, Toyo-Oka L, Toyo-Oka T.

J Hum Genet. 2019 Jan 10. doi: 10.1038/s10038-018-0558-0. [Epub ahead of print]

PMID:
30631120
3.

The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model.

Inoue MK, Yamamotoya T, Nakatsu Y, Ueda K, Inoue Y, Matsunaga Y, Sakoda H, Fujishiro M, Ono H, Morii K, Sasaki K, Masaki T, Suzuki Y, Asano T, Kushiyama A.

Int J Mol Sci. 2018 Dec 10;19(12). pii: E3967. doi: 10.3390/ijms19123967.

4.

Development of Pin1 inhibitors and their potential as therapeutic agents.

Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK, Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T.

Curr Med Chem. 2018 Nov 5. doi: 10.2174/0929867325666181105120911. [Epub ahead of print]

PMID:
30394205
5.

Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications.

Okubo H, Kushiyama A, Nakatsu Y, Yamamotoya T, Matsunaga Y, Fujishiro M, Sakoda H, Ohno H, Yoneda M, Asano T.

Int J Mol Sci. 2018 Oct 8;19(10). pii: E3064. doi: 10.3390/ijms19103064. Review.

6.

Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages.

Yamazaki H, Kushiyama A, Sakoda H, Fujishiro M, Yamamotoya T, Nakatsu Y, Kikuchi T, Kaneko S, Tanaka H, Asano T.

Mediators Inflamm. 2018 Jun 25;2018:3062319. doi: 10.1155/2018/3062319. eCollection 2018.

7.

Gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus.

Fujishiro M, Kushiyama A, Yamazaki H, Kaneko S, Koketsu Y, Yamamotoya T, Kikuchi T, Sakoda H, Suzuki R, Kadowaki T.

World J Gastroenterol. 2017 Sep 28;23(36):6694-6704. doi: 10.3748/wjg.v23.i36.6694.

8.

Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.

Yamamotoya T, Nakatsu Y, Kushiyama A, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kiyonari H, Ishihara H, Asano T.

Sci Rep. 2017 Oct 12;7(1):13026. doi: 10.1038/s41598-017-13432-x.

9.

Gut Microbiota as a Therapeutic Target for Metabolic Disorders.

Okubo H, Nakatsu Y, Kushiyama A, Yamamotoya T, Matsunaga Y, Inoue MK, Fujishiro M, Sakoda H, Ohno H, Yoneda M, Ono H, Asano T.

Curr Med Chem. 2018;25(9):984-1001. doi: 10.2174/0929867324666171009121702. Review.

PMID:
28990516
10.

The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice.

Nakatsu Y, Kokubo H, Bumdelger B, Yoshizumi M, Yamamotoya T, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Fujishiro M, Kushiyama A, Ono H, Sakoda H, Asano T.

Int J Mol Sci. 2017 Aug 4;18(8). pii: E1704. doi: 10.3390/ijms18081704.

11.

The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.

Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H, Ishihara H, Asano T.

J Biol Chem. 2017 Jul 14;292(28):11886-11895. doi: 10.1074/jbc.M117.780726. Epub 2017 May 31.

12.

Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes.

Pang Z, Kushiyama A, Sun J, Kikuchi T, Yamazaki H, Iwamoto Y, Koriyama H, Yoshida S, Shimamura M, Higuchi M, Kawano T, Takami Y, Rakugi H, Morishita R, Nakagami H.

FASEB J. 2017 Sep;31(9):4053-4063. doi: 10.1096/fj.201700110R. Epub 2017 May 25.

PMID:
28546444
13.

Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice.

Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H.

Int J Mol Sci. 2017 Feb 4;18(2). pii: E326. doi: 10.3390/ijms18020326.

14.

Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis.

Kushiyama A, Nakatsu Y, Matsunaga Y, Yamamotoya T, Mori K, Ueda K, Inoue Y, Sakoda H, Fujishiro M, Ono H, Asano T.

Mediators Inflamm. 2016;2016:8603164. doi: 10.1155/2016/8603164. Epub 2016 Dec 14. Review.

15.

Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance.

Sano T, Nagayasu S, Suzuki S, Iwashita M, Yamashita A, Shinjo T, Sanui T, Kushiyama A, Kanematsu T, Asano T, Nishimura F.

Nutr Metab Cardiovasc Dis. 2017 Mar;27(3):249-259. doi: 10.1016/j.numecd.2016.11.008. Epub 2016 Nov 23.

PMID:
28062181
16.

Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations.

Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mori K, Sakoda H, Fujishiro M, Ono H, Kushiyama A, Asano T.

Int J Mol Sci. 2016 Sep 7;17(9). pii: E1495. doi: 10.3390/ijms17091495. Review.

17.

Prediction of the effect on antihyperglycaemic action of sitagliptin by plasma active form glucagon-like peptide-1.

Kushiyama A, Kikuchi T, Tanaka K, Tahara T, Takao T, Onishi Y, Yoshida Y, Kawazu S, Iwamoto Y.

World J Diabetes. 2016 Jun 10;7(11):230-8. doi: 10.4239/wjd.v7.i11.230. Epub 2016 Jun 11.

18.

[Severe Perioperative Coronary Artery Spasm in Thoracic Aortic Surgery; Report of Two Cases].

Osada H, Kanemitsu N, Kushiyama A, Kato M, Meshii K, Ohnaka M, Nakajima H.

Kyobu Geka. 2016 May;69(5):392-5. Japanese.

PMID:
27220931
19.

C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus.

Sonoda R, Tanaka K, Kikuchi T, Onishi Y, Takao T, Tahara T, Yoshida Y, Suzawa N, Kawazu S, Iwamoto Y, Kushiyama A.

PLoS One. 2016 Feb 5;11(2):e0147303. doi: 10.1371/journal.pone.0147303. eCollection 2016.

20.

Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.

Okubo H, Kushiyama A, Sakoda H, Nakatsu Y, Iizuka M, Taki N, Fujishiro M, Fukushima T, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Asahara T, Yoshida Y, Chonan O, Encinas J, Asano T.

Sci Rep. 2016 Jan 28;6:20157. doi: 10.1038/srep20157.

21.

Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus.

Qiang S, Nakatsu Y, Seno Y, Fujishiro M, Sakoda H, Kushiyama A, Mori K, Matsunaga Y, Yamamotoya T, Kamata H, Asano T.

Diabetol Metab Syndr. 2015 Nov 19;7:104. doi: 10.1186/s13098-015-0102-8. eCollection 2015.

22.

Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit.

Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T.

J Biol Chem. 2015 Oct 2;290(40):24255-66. doi: 10.1074/jbc.M115.658559. Epub 2015 Aug 14.

23.

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.

Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, Asano T.

Mediators Inflamm. 2015;2015:125380. doi: 10.1155/2015/125380. Epub 2015 Jun 10.

24.

High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice.

Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Nishimura F, Asano T.

Diabetol Metab Syndr. 2015 Jun 2;7:50. doi: 10.1186/s13098-015-0047-y. eCollection 2015.

25.

Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling.

Sano T, Iwashita M, Nagayasu S, Yamashita A, Shinjo T, Hashikata A, Asano T, Kushiyama A, Ishimaru N, Takahama Y, Nishimura F.

Obesity (Silver Spring). 2015 Jul;23(7):1460-71. doi: 10.1002/oby.21127. Epub 2015 Jun 12.

26.

Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines.

Kanaoka R, Kushiyama A, Seno Y, Nakatsu Y, Matsunaga Y, Fukushima T, Tsuchiya Y, Sakoda H, Fujishiro M, Yamamotoya T, Kamata H, Matsubara A, Asano T.

PLoS One. 2015 Jun 3;10(6):e0127467. doi: 10.1371/journal.pone.0127467. eCollection 2015.

27.

DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.

Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Asano T.

Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E214-23. doi: 10.1152/ajpendo.00553.2014. Epub 2015 May 26.

28.

The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.

Nakatsu Y, Seno Y, Kushiyama A, Sakoda H, Fujishiro M, Katasako A, Mori K, Matsunaga Y, Fukushima T, Kanaoka R, Yamamotoya T, Kamata H, Asano T.

Am J Physiol Gastrointest Liver Physiol. 2015 Jul 1;309(1):G42-51. doi: 10.1152/ajpgi.00443.2014. Epub 2015 May 21.

29.

Role of elevated serum uric acid levels at the onset of overt nephropathy in the risk for renal function decline in patients with type 2 diabetes.

Tanaka K, Hara S, Hattori M, Sakai K, Onishi Y, Yoshida Y, Kawazu S, Kushiyama A.

J Diabetes Investig. 2015 Jan;6(1):98-104. doi: 10.1111/jdi.12243. Epub 2014 Jun 2.

30.

Linking uric acid metabolism to diabetic complications.

Kushiyama A, Tanaka K, Hara S, Kawazu S.

World J Diabetes. 2014 Dec 15;5(6):787-95. doi: 10.4239/wjd.v5.i6.787. Review.

31.

Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.

Okubo H, Nakatsu Y, Sakoda H, Kushiyama A, Fujishiro M, Fukushima T, Matsunaga Y, Ohno H, Yoneda M, Kamata H, Shinjo T, Iwashita M, Nishimura F, Asano T.

Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G151-8. doi: 10.1152/ajpgi.00198.2014. Epub 2014 Nov 26.

32.

Twenty-year trend of increasing obesity in young patients with poorly controlled type 2 diabetes at first diagnosis in urban Japan.

Kushiyama A, Yoshida Y, Kikuchi T, Suzawa N, Yamamoto M, Tanaka K, Okayasu M, Tahara T, Takao T, Onishi Y, Kawazu S.

J Diabetes Investig. 2013 Nov 27;4(6):540-5. doi: 10.1111/jdi.12090. Epub 2013 May 15.

33.

The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease.

Hashikata A, Yamashita A, Suzuki S, Nagayasu S, Shinjo T, Taniguchi A, Fukushima M, Nakai Y, Nin K, Watanabe N, Asano T, Abiko Y, Kushiyama A, Nagasaka S, Nishimura F.

Nephrol Dial Transplant. 2014 Mar;29(3):611-8. doi: 10.1093/ndt/gft449. Epub 2013 Nov 13.

PMID:
24235082
34.

Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.

Okubo H, Sakoda H, Kushiyama A, Fujishiro M, Nakatsu Y, Fukushima T, Matsunaga Y, Kamata H, Asahara T, Yoshida Y, Chonan O, Iwashita M, Nishimura F, Asano T.

Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G911-8. doi: 10.1152/ajpgi.00225.2013. Epub 2013 Oct 10.

35.

Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.

Zhang J, Nakatsu Y, Shinjo T, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Iwashita M, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T.

J Biol Chem. 2013 Jul 12;288(28):20692-701. doi: 10.1074/jbc.M113.485730. Epub 2013 May 29.

36.

Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development.

Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1986-93. doi: 10.1161/ATVBAHA.113.301546. Epub 2013 May 23.

PMID:
23702657
37.

Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice.

Iwashita M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima T, Kumamoto S, Shinjo T, Kamata H, Nishimura F, Asano T.

Adipocyte. 2013 Jan 1;2(1):28-32.

38.

Integrator complex plays an essential role in adipose differentiation.

Otani Y, Nakatsu Y, Sakoda H, Fukushima T, Fujishiro M, Kushiyama A, Okubo H, Tsuchiya Y, Ohno H, Takahashi S, Nishimura F, Kamata H, Katagiri H, Asano T.

Biochem Biophys Res Commun. 2013 May 3;434(2):197-202. doi: 10.1016/j.bbrc.2013.03.029. Epub 2013 Mar 21.

PMID:
23523797
39.

Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model.

Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuch T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T.

J Biol Chem. 2012 Dec 28;287(53):44526-35. doi: 10.1074/jbc.M112.397133. Epub 2012 Oct 29.

40.

Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages.

Kumamoto S, Kushiyama A, Nakatsu Y, Sakoda H, Fujishiro M, Iwashita M, Ohno H, Zhang J, Guo Y, Aburatani H, Kamata H, Nishimura F, Asano T.

Obes Res Clin Pract. 2012 Oct-Dec;6(4):e263-346. doi: 10.1016/j.orcp.2012.05.005.

PMID:
24331589
41.

LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8.

Kikuchi T, Zhang J, Sakoda H, Koketsu Y, Fujishiro M, Kushiyama A, Nakatsu Y, Kamata H, Inoki K, Takahashi S, Kurihara H, Hideki K, Oka Y, Asano T.

Obes Res Clin Pract. 2012 Jul-Sep;6(3):e175-262. doi: 10.1016/j.orcp.2011.10.002.

PMID:
24331524
42.

Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development.

Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):291-8. doi: 10.1161/ATVBAHA.111.234559. Epub 2011 Nov 17.

PMID:
22095983
43.

Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.

Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.

Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E286-96. doi: 10.1152/ajpendo.00324.2011. Epub 2011 Nov 1.

44.

Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis.

Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi S, Kurihara H, Uchida T, Asano T.

J Biol Chem. 2011 Jun 10;286(23):20812-22. doi: 10.1074/jbc.M110.206904. Epub 2011 Mar 17.

45.

Risk of macrovascular disease stratified by stage of chronic kidney disease in type 2 diabetic patients: critical level of the estimated glomerular filtration rate and the significance of hyperuricemia.

Tanaka K, Hara S, Kushiyama A, Ubara Y, Yoshida Y, Mizuiri S, Aikawa A, Kawatzu S.

Clin Exp Nephrol. 2011 Jun;15(3):391-397. doi: 10.1007/s10157-011-0420-6. Epub 2011 Feb 18.

PMID:
21331740
46.

4F2hc stabilizes GLUT1 protein and increases glucose transport activity.

Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T.

Am J Physiol Cell Physiol. 2011 May;300(5):C1047-54. doi: 10.1152/ajpcell.00416.2010. Epub 2011 Jan 26.

47.

Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications.

Nakarai H, Yamashita A, Nagayasu S, Iwashita M, Kumamoto S, Ohyama H, Hata M, Soga Y, Kushiyama A, Asano T, Abiko Y, Nishimura F.

Innate Immun. 2012 Feb;18(1):164-70. doi: 10.1177/1753425910393370. Epub 2011 Jan 14.

PMID:
21239459
48.

Atrio-His (James) accessory pathway and infiltration of γδ T cells in the heart with MELAS.

Matsuzaki G, Kushiyama A, Uto K, Shoda M, Seko Y.

BMJ Case Rep. 2011 Feb 2;2011. pii: bcr0920103359. doi: 10.1136/bcr.09.2010.3359. No abstract available.

49.

Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.

Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Tsuchiya Y, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi S, Kurihara H, Uchida T, Asano T.

J Biol Chem. 2010 Oct 22;285(43):33018-27. doi: 10.1074/jbc.M110.137836. Epub 2010 Jul 30.

50.

Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase.

Yoneda M, Guo Y, Ono H, Nakatsu Y, Zhang J, Cui X, Iwashita M, Kumamoto S, Tsuchiya Y, Sakoda H, Fujishiro M, Kushiyama A, Koketsu Y, Kikuchi T, Kamata H, Nishimura F, Asano T.

Obes Res Clin Pract. 2010 Jul-Sep;4(3):e163-246. doi: 10.1016/j.orcp.2010.02.002.

PMID:
24345663

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