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Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation.

Ferreras L, Moles A, Situmorang GR, El Masri R, Wilson IL, Cooke K, Thompson E, Kusche-Gullberg M, Vivès RR, Sheerin NS, Ali S.

Biochim Biophys Acta Gen Subj. 2019 May;1863(5):839-848. doi: 10.1016/j.bbagen.2019.02.009. Epub 2019 Feb 19.


The exostosin family of glycosyltransferases: mRNA expression profiles and heparan sulphate structure in human breast carcinoma cell lines.

Sembajwe LF, Katta K, Grønning M, Kusche-Gullberg M.

Biosci Rep. 2018 Aug 31;38(4). pii: BSR20180770. doi: 10.1042/BSR20180770. Print 2018 Aug 31.


Potential role for Ext1-dependent heparan sulfate in regulating P311 gene expression in A549 carcinoma cells.

Katta K, Sembajwe LF, Kusche-Gullberg M.

Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1472-1481. doi: 10.1016/j.bbagen.2018.03.024. Epub 2018 Mar 24.


Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy.

Talsma DT, Katta K, Ettema MAB, Kel B, Kusche-Gullberg M, Daha MR, Stegeman CA, van den Born J, Wang L.

Lab Invest. 2018 Apr;98(4):427-438. doi: 10.1038/s41374-017-0015-2. Epub 2018 Jan 12.


Heparan Sulfate: Biosynthesis, Structure, and Function.

Li JP, Kusche-Gullberg M.

Int Rev Cell Mol Biol. 2016;325:215-73. doi: 10.1016/bs.ircmb.2016.02.009. Epub 2016 Apr 13. Review.


Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.

Katta K, Imran T, Busse-Wicher M, Grønning M, Czajkowski S, Kusche-Gullberg M.

J Biol Chem. 2015 May 22;290(21):13168-77. doi: 10.1074/jbc.M114.631754. Epub 2015 Mar 31.


Fibroblast α11β1 integrin regulates tensional homeostasis in fibroblast/A549 carcinoma heterospheroids.

Lu N, Karlsen TV, Reed RK, Kusche-Gullberg M, Gullberg D.

PLoS One. 2014 Jul 30;9(7):e103173. doi: 10.1371/journal.pone.0103173. eCollection 2014.


Role of 6-O-sulfated heparan sulfate in chronic renal fibrosis.

Alhasan AA, Spielhofer J, Kusche-Gullberg M, Kirby JA, Ali S.

J Biol Chem. 2014 Jul 18;289(29):20295-306. doi: 10.1074/jbc.M114.554691. Epub 2014 May 30.


The exostosin family: proteins with many functions.

Busse-Wicher M, Wicher KB, Kusche-Gullberg M.

Matrix Biol. 2014 Apr;35:25-33. doi: 10.1016/j.matbio.2013.10.001. Epub 2013 Oct 12. Review.


Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids.

Österholm C, Lu N, Lidén Å, Karlsen TV, Gullberg D, Reed RK, Kusche-Gullberg M.

PLoS One. 2012;7(7):e41334. doi: 10.1371/journal.pone.0041334. Epub 2012 Jul 25.


Drosophila heparan sulfate, a novel design.

Kusche-Gullberg M, Nybakken K, Perrimon N, Lindahl U.

J Biol Chem. 2012 Jun 22;287(26):21950-6. doi: 10.1074/jbc.M112.350389. Epub 2012 May 3.


Heparan sulfate expression is affected by inflammatory stimuli in primary human endothelial cells.

Reine TM, Kusche-Gullberg M, Feta A, Jenssen T, Kolset SO.

Glycoconj J. 2012 Jan;29(1):67-76. doi: 10.1007/s10719-011-9365-y. Epub 2011 Dec 22. Erratum in: Glycoconj J. 2013 Oct;30(7):733.


Target selection of heparan sulfate hexuronic acid 2-O-sulfotransferase.

Smeds E, Feta A, Kusche-Gullberg M.

Glycobiology. 2010 Oct;20(10):1274-82. doi: 10.1093/glycob/cwq089. Epub 2010 Jun 16.


Mutation in the heparan sulfate biosynthesis enzyme EXT1 influences growth factor signaling and fibroblast interactions with the extracellular matrix.

Osterholm C, Barczyk MM, Busse M, Grønning M, Reed RK, Kusche-Gullberg M.

J Biol Chem. 2009 Dec 11;284(50):34935-43. doi: 10.1074/jbc.M109.005264. Epub 2009 Oct 22.


Molecular analysis of heparan sulfate biosynthetic enzyme machinery and characterization of heparan sulfate structure in Nematostella vectensis.

Feta A, Do AT, Rentzsch F, Technau U, Kusche-Gullberg M.

Biochem J. 2009 May 1;419(3):585-93. doi: 10.1042/BJ20082081.


Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation.

Presto J, Thuveson M, Carlsson P, Busse M, Wilén M, Eriksson I, Kusche-Gullberg M, Kjellén L.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4751-6. doi: 10.1073/pnas.0705807105. Epub 2008 Mar 12.


Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration.

Langsdorf A, Do AT, Kusche-Gullberg M, Emerson CP Jr, Ai X.

Dev Biol. 2007 Nov 15;311(2):464-77. Epub 2007 Sep 7.


Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways.

Whiteford JR, Behrends V, Kirby H, Kusche-Gullberg M, Muramatsu T, Couchman JR.

Exp Cell Res. 2007 Nov 1;313(18):3902-13. Epub 2007 Aug 10.


Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.

Busse M, Feta A, Presto J, Wilén M, Grønning M, Kjellén L, Kusche-Gullberg M.

J Biol Chem. 2007 Nov 9;282(45):32802-10. Epub 2007 Aug 29.


SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.

Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP Jr.

Development. 2007 Sep;134(18):3327-38.


Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation.

Ledin J, Ringvall M, Thuveson M, Eriksson I, Wilén M, Kusche-Gullberg M, Forsberg E, Kjellén L.

J Biol Chem. 2006 Nov 24;281(47):35727-34. Epub 2006 Sep 19.


Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2.

Ai X, Do AT, Kusche-Gullberg M, Lindahl U, Lu K, Emerson CP Jr.

J Biol Chem. 2006 Feb 24;281(8):4969-76. Epub 2005 Dec 23.


Overexpression of heparan sulfate 6-O-sulfotransferases in human embryonic kidney 293 cells results in increased N-acetylglucosaminyl 6-O-sulfation.

Do AT, Smeds E, Spillmann D, Kusche-Gullberg M.

J Biol Chem. 2006 Mar 3;281(9):5348-56. Epub 2005 Dec 2.


Generation of "neoheparin" from E. coli K5 capsular polysaccharide.

Lindahl U, Li JP, Kusche-Gullberg M, Salmivirta M, Alaranta S, Veromaa T, Emeis J, Roberts I, Taylor C, Oreste P, Zoppetti G, Naggi A, Torri G, Casu B.

J Med Chem. 2005 Jan 27;48(2):349-52.


Biosynthesis of hyaluronan: direction of chain elongation.

Bodevin-Authelet S, Kusche-Gullberg M, Pummill PE, DeAngelis PL, Lindahl U.

J Biol Chem. 2005 Mar 11;280(10):8813-8. Epub 2004 Dec 28.


Purification of a 75 kDa protein from the organelle matrix of human neutrophils and identification as N-acetylglucosamine-6-sulphatase.

Xu S, Zhao L, Larsson A, Smeds E, Kusche-Gullberg M, Venge P.

Biochem J. 2005 May 1;387(Pt 3):841-7.


Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.

Holmborn K, Ledin J, Smeds E, Eriksson I, Kusche-Gullberg M, Kjellén L.

J Biol Chem. 2004 Oct 8;279(41):42355-8. Epub 2004 Aug 19.


Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains.

Yamada S, Busse M, Ueno M, Kelly OG, Skarnes WC, Sugahara K, Kusche-Gullberg M.

J Biol Chem. 2004 Jul 30;279(31):32134-41. Epub 2004 May 25.


Sulfotransferases in glycosaminoglycan biosynthesis.

Kusche-Gullberg M, Kjellén L.

Curr Opin Struct Biol. 2003 Oct;13(5):605-11. Review.


In vitro polymerization of heparan sulfate backbone by the EXT proteins.

Busse M, Kusche-Gullberg M.

J Biol Chem. 2003 Oct 17;278(42):41333-7. Epub 2003 Aug 7.


QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling.

Ai X, Do AT, Lozynska O, Kusche-Gullberg M, Lindahl U, Emerson CP Jr.

J Cell Biol. 2003 Jul 21;162(2):341-51. Epub 2003 Jul 14.


Overexpression of UDP-glucose dehydrogenase in Escherichia coli results in decreased biosynthesis of K5 polysaccharide.

Roman E, Roberts I, Lidholt K, Kusche-Gullberg M.

Biochem J. 2003 Sep 15;374(Pt 3):767-72.


Oligosaccharide library-based assessment of heparan sulfate 6-O-sulfotransferase substrate specificity.

Jemth P, Smeds E, Do AT, Habuchi H, Kimata K, Lindahl U, Kusche-Gullberg M.

J Biol Chem. 2003 Jul 4;278(27):24371-6. Epub 2003 Apr 16.


Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases.

Smeds E, Habuchi H, Do AT, Hjertson E, Grundberg H, Kimata K, Lindahl U, Kusche-Gullberg M.

Biochem J. 2003 Jun 1;372(Pt 2):371-80.


Biosynthetic oligosaccharide libraries for identification of protein-binding heparan sulfate motifs. Exploring the structural diversity by screening for fibroblast growth factor (FGF)1 and FGF2 binding.

Jemth P, Kreuger J, Kusche-Gullberg M, Sturiale L, Giménez-Gallego G, Lindahl U.

J Biol Chem. 2002 Aug 23;277(34):30567-73. Epub 2002 Jun 10.


Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation.

Kim BT, Kitagawa H, Tamura Ji J, Kusche-Gullberg M, Lindahl U, Sugahara K.

J Biol Chem. 2002 Apr 19;277(16):13659-65. Epub 2002 Feb 6.


Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.

Kim BT, Kitagawa H, Tamura J, Saito T, Kusche-Gullberg M, Lindahl U, Sugahara K.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7176-81. Epub 2001 Jun 5.


Substrate specificity of the heparan sulfate hexuronic acid 2-O-sulfotransferase.

Rong J, Habuchi H, Kimata K, Lindahl U, Kusche-Gullberg M.

Biochemistry. 2001 May 8;40(18):5548-55.


The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.

Senay C, Lind T, Muguruma K, Tone Y, Kitagawa H, Sugahara K, Lidholt K, Lindahl U, Kusche-Gullberg M.

EMBO Rep. 2000 Sep;1(3):282-6.


Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases.

Kramerova IA, Kawaguchi N, Fessler LI, Nelson RE, Chen Y, Kramerov AA, Kusche-Gullberg M, Kramer JM, Ackley BD, Sieron AL, Prockop DJ, Fessler JH.

Development. 2000 Dec;127(24):5475-85.


Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme.

Forsberg E, Pejler G, Ringvall M, Lunderius C, Tomasini-Johansson B, Kusche-Gullberg M, Eriksson I, Ledin J, Hellman L, Kjellén L.

Nature. 1999 Aug 19;400(6746):773-6.


cDNA cloning and expression of UDP-glucose dehydrogenase from bovine kidney.

Lind T, Falk E, Hjertson E, Kusche-Gullberg M, Lidholt K.

Glycobiology. 1999 Jun;9(6):595-600.


Regulated diversity of heparan sulfate.

Lindahl U, Kusche-Gullberg M, Kjellén L.

J Biol Chem. 1998 Sep 25;273(39):24979-82. Review. No abstract available.


Identification and expression in mouse of two heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase genes.

Kusche-Gullberg M, Eriksson I, Pikas DS, Kjellén L.

J Biol Chem. 1998 May 8;273(19):11902-7.


Mouse mastocytoma cells synthesize undersulfated heparin and chondroitin sulfate in the presence of brefeldin A.

Uhlin-Hansen L, Kusche-Gullberg M, Berg E, Eriksson I, Kjellén L.

J Biol Chem. 1997 Feb 7;272(6):3200-6.


Stem cell factor-dependent human cord blood derived mast cells express alpha- and beta-tryptase, heparin and chondroitin sulphate.

Nilsson G, Blom T, Harvima I, Kusche-Gullberg M, Nilsson K, Hellman L.

Immunology. 1996 Jun;88(2):308-14.

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