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Aryne-Induced SNAr/Dearylation Strategy for the Synthesis of Fluorinated Dibenzophospholes from Triarylphosphines via a P(V) Intermediate.

Fujimoto H, Kusano M, Kodama T, Tobisu M.

Org Lett. 2020 Mar 20;22(6):2293-2297. doi: 10.1021/acs.orglett.0c00489. Epub 2020 Mar 2.


Metabolite and Phytohormone Profiling Illustrates Metabolic Reprogramming as an Escape Strategy of Deepwater Rice during Partially Submerged Stress.

Fukushima A, Kuroha T, Nagai K, Hattori Y, Kobayashi M, Nishizawa T, Kojima M, Utsumi Y, Oikawa A, Seki M, Sakakibara H, Saito K, Ashikari M, Kusano M.

Metabolites. 2020 Feb 14;10(2). pii: E68. doi: 10.3390/metabo10020068.


Metabolite/phytohormone-gene regulatory networks in soybean organs under dehydration conditions revealed by integration analysis.

Maruyama K, Urano K, Kusano M, Sakurai T, Takasaki H, Kishimoto M, Yoshiwara K, Kobayashi M, Kojima M, Sakakibara H, Saito K, Shinozaki K.

Plant J. 2020 Feb 18. doi: 10.1111/tpj.14719. [Epub ahead of print]


Cytosolic GLUTAMINE SYNTHETASE1;1 Modulates Metabolism and Chloroplast Development in Roots.

Kusano M, Fukushima A, Tabuchi-Kobayashi M, Funayama K, Kojima S, Maruyama K, Yamamoto YY, Nishizawa T, Kobayashi M, Wakazaki M, Sato M, Toyooka K, Osanai-Kondo K, Utsumi Y, Seki M, Fukai C, Saito K, Yamaya T.

Plant Physiol. 2020 Apr;182(4):1894-1909. doi: 10.1104/pp.19.01118. Epub 2020 Feb 5.


Randomised trial of acid inhibition by vonoprazan 10/20 mg once daily vs rabeprazole 10/20 mg twice daily in healthy Japanese volunteers (SAMURAI pH study).

Takeuchi T, Furuta T, Fujiwara Y, Sugimoto M, Kasugai K, Kusano M, Okada H, Suzuki T, Higuchi T, Kagami T, Uotani T, Yamade M, Sawada A, Tanaka F, Harada S, Ota K, Kojima Y, Murata M, Tamura Y, Funaki Y, Kawamura O, Okamoto Y, Fujimoto K, Higuchi K.

Aliment Pharmacol Ther. 2020 Mar;51(5):534-543. doi: 10.1111/apt.15641. Epub 2020 Jan 28.


PrP (122-139) is a covert mitochondrial targeting signal of prion protein and it specifically triggers the perinuclear clustering of mitochondria in neuronal culture cells.

Shimizu T, Kozuka Y, Kusano M, Nagane M, Yamashita T, Hachiya N.

Biochem Biophys Res Commun. 2020 Apr 2;524(2):301-307. doi: 10.1016/j.bbrc.2020.01.099. Epub 2020 Jan 24.


Association analysis of phenotypic and metabolomic changes in Arabidopsis accessions and their F1 hybrids affected by different photoperiod and sucrose supply.

Le QTN, Sugi N, Furukawa J, Kobayashi M, Saito K, Kusano M, Shiba H.

Plant Biotechnol (Tokyo). 2019 Sep 25;36(3):155-165. doi: 10.5511/plantbiotechnology.19.0604a.


Comparative co-expression network analysis extracts the SlHSP70 gene affecting to shoot elongation of tomato.

Vu NT, Kamiya K, Fukushima A, Hao S, Ning W, Ariizumi T, Ezura H, Kusano M.

Plant Biotechnol (Tokyo). 2019 Sep 25;36(3):143-153. doi: 10.5511/plantbiotechnology.19.0603a.


Transcriptome Analysis of the Hierarchical Response of Histone Deacetylase Proteins That Respond in an Antagonistic Manner to Salinity Stress.

Ueda M, Matsui A, Watanabe S, Kobayashi M, Saito K, Tanaka M, Ishida J, Kusano M, Seo M, Seki M.

Front Plant Sci. 2019 Oct 18;10:1323. doi: 10.3389/fpls.2019.01323. eCollection 2019.


Complication associated with intravitreal injection of tissue plasminogen activator for treatment of submacular hemorrhage due to rupture of retinal arterial macroaneurysm.

Tsuiki E, Kusano M, Kitaoka T.

Am J Ophthalmol Case Rep. 2019 Sep 19;16:100556. doi: 10.1016/j.ajoc.2019.100556. eCollection 2019 Dec.


Divergent metabolic adjustments in nodules are indispensable for efficient N2 fixation of soybean under phosphate stress.

Sulieman S, Kusano M, Ha CV, Watanabe Y, Abdalla MA, Abdelrahman M, Kobayashi M, Saito K, Mühling KH, Tran LP.

Plant Sci. 2019 Dec;289:110249. doi: 10.1016/j.plantsci.2019.110249. Epub 2019 Sep 3.


Response to the letter by Dr. Costa-Moreira, Dr. Peixoto, Dr. Ramalho, and Dr. Macedo regarding our manuscript: "Relationship between esophageal motility abnormalities and skin or lung involvements in patients with systemic sclerosis".

Kuribayashi S, Motegi SI, Hara K, Sekiguchi A, Hosaka H, Kusano M, Uraoka T.

J Gastroenterol. 2020 Feb;55(2):246-247. doi: 10.1007/s00535-019-01630-5. Epub 2019 Sep 23. No abstract available.


Clinical impact of different cut-off values in high-resolution manometry systems on diagnosing esophageal motility disorders.

Kuribayashi S, Iwakiri K, Shinozaki T, Hosaka H, Kawada A, Kawami N, Hoshino S, Takenouchi N, Shimoyama Y, Kawamura O, Kusano M, Uraoka T.

J Gastroenterol. 2019 Dec;54(12):1078-1082. doi: 10.1007/s00535-019-01608-3. Epub 2019 Aug 6.


Erratum to "Tibial insertion of the anterior cruciate ligament and anterior horn of the lateral meniscus share the lateral slope of the medial intercondylar ridge: A computed tomography study in a young, healthy population" [Knee 26 (2019) 612-618].

Yonetani Y, Kusano M, Tsujii A, Kinugasa K, Hamada M, Shino K.

Knee. 2019 Aug;26(4):951. doi: 10.1016/j.knee.2019.06.006. Epub 2019 Jun 27. No abstract available.


Cyclization of Bisphosphines to Phosphacycles via the Cleavage of Two Carbon-Phosphorus Bonds by Nickel Catalysis.

Fujimoto H, Kusano M, Kodama T, Tobisu M.

Org Lett. 2019 Jun 7;21(11):4177-4181. doi: 10.1021/acs.orglett.9b01355. Epub 2019 May 22.


Development of "Quick-DB forensic": A total workflow from QuEChERS-dSPE method to GC-MS/MS quantification of forensically relevant drugs and pesticides in whole blood.

Kusano M, Sakamoto Y, Natori Y, Miyagawa H, Tsuchihashi H, Ishii A, Zaitsu K.

Forensic Sci Int. 2019 Jul;300:125-135. doi: 10.1016/j.forsciint.2019.03.048. Epub 2019 Apr 6.


Tibial insertion of the anterior cruciate ligament and anterior horn of the lateral meniscus share the lateral slope of the medial intercondylar ridge: A computed tomography study in a young, healthy population.

Yonetani Y, Kusano M, Tsujii A, Kinugasa K, Hamada M, Shino K.

Knee. 2019 Jun;26(3):612-618. doi: 10.1016/j.knee.2019.04.009. Epub 2019 May 9. Erratum in: Knee. 2019 Aug;26(4):951.


Relationship between esophageal motility abnormalities and skin or lung involvements in patients with systemic sclerosis.

Kuribayashi S, Motegi SI, Hara K, Shimoyama Y, Hosaka H, Sekiguchi A, Yamaguchi K, Kawamura O, Hisada T, Ishikawa O, Kusano M, Uraoka T.

J Gastroenterol. 2019 Nov;54(11):950-962. doi: 10.1007/s00535-019-01578-6. Epub 2019 Apr 1.


Efficacy of Vonoprazan, a Novel Potassium-Competitive Acid Blocker, in Patients with Proton Pump Inhibitor-Refractory Acid Reflux.

Akiyama J, Hosaka H, Kuribayashi S, Moriyasu S, Hisada Y, Okubo H, Watanabe K, Imbe K, Nagata N, Kojima Y, Yokoi C, Uemura N, Shimoyama Y, Kawamura O, Yamada M, Kusano M.

Digestion. 2020;101(2):174-183. doi: 10.1159/000497775. Epub 2019 Mar 21.


Daikenchuto accelerates the recovery from prolonged postoperative ileus after open abdominal surgery: a subgroup analysis of three randomized controlled trials.

Kono T, Shimada M, Nishi M, Morine Y, Yoshikawa K, Katsuno H, Maeda K, Koeda K, Morita S, Watanabe M, Kusano M, Sakamoto J, Saji S, Sokuoka H, Sato Y, Maehara Y, Kanematsu T, Kitajima M.

Surg Today. 2019 Aug;49(8):704-711. doi: 10.1007/s00595-019-01787-9. Epub 2019 Feb 25.


Reduction in sucrose contents by downregulation of fructose-1,6-bisphosphatase 2 causes tiller outgrowth cessation in rice mutants lacking glutamine synthetase1;2.

Ohashi M, Ishiyama K, Kusano M, Fukushima A, Kojima S, Hayakawa T, Yamaya T.

Rice (N Y). 2018 Dec 22;11(1):65. doi: 10.1186/s12284-018-0261-y.


A Systems Analysis With "Simplified Source-Sink Model" Reveals Metabolic Reprogramming in a Pair of Source-to-Sink Organs During Early Fruit Development in Tomato by LED Light Treatments.

Fukushima A, Hikosaka S, Kobayashi M, Nishizawa T, Saito K, Goto E, Kusano M.

Front Plant Sci. 2018 Oct 9;9:1439. doi: 10.3389/fpls.2018.01439. eCollection 2018.


Loop Length Change of an Adjustable-Length Femoral Cortical Suspension Device in Anatomic Rectangular Tunnel Anterior Cruciate Ligament Reconstruction With a Bone-Patellar Tendon-Bone Graft and Associated Clinical Outcomes.

Kusano M, Kazui A, Uchida R, Mae T, Tsuda T, Toritsuka Y.

Arthroscopy. 2018 Nov;34(11):3063-3070. doi: 10.1016/j.arthro.2018.06.034. Epub 2018 Oct 6.


A randomized phase III study of hepatic arterial infusion chemotherapy with 5-fluorouracil and subsequent systemic chemotherapy versus systemic chemotherapy alone for colorectal cancer patients with curatively resected liver metastases (Japanese Foundation for Multidisciplinary Treatment of Cancer 32).

Kusano M, Aoyama T, Okabayashi K, Hirata K, Tsuji Y, Nakamori S, Asahara T, Ohashi Y, Yoshikawa T, Sakamoto J, Oba K, Saji S.

J Cancer Res Ther. 2018 Sep;14(Supplement):S761-S766. doi: 10.4103/0973-1482.179188.


Aberrant Stamen Development is Associated with Parthenocarpic Fruit Set Through Up-Regulation of Gibberellin Biosynthesis in Tomato.

Okabe Y, Yamaoka T, Ariizumi T, Ushijima K, Kojima M, Takebayashi Y, Sakakibara H, Kusano M, Shinozaki Y, Pulungan SI, Kubo Y, Nakano R, Ezura H.

Plant Cell Physiol. 2019 Jan 1;60(1):38-51. doi: 10.1093/pcp/pcy184.


Esophageal cancer practice guidelines 2017 edited by the Japan esophageal society: part 2.

Kitagawa Y, Uno T, Oyama T, Kato K, Kato H, Kawakubo H, Kawamura O, Kusano M, Kuwano H, Takeuchi H, Toh Y, Doki Y, Naomoto Y, Nemoto K, Booka E, Matsubara H, Miyazaki T, Muto M, Yanagisawa A, Yoshida M.

Esophagus. 2019 Jan;16(1):25-43. doi: 10.1007/s10388-018-0642-8. Epub 2018 Aug 31. No abstract available.


Esophageal cancer practice guidelines 2017 edited by the Japan Esophageal Society: part 1.

Kitagawa Y, Uno T, Oyama T, Kato K, Kato H, Kawakubo H, Kawamura O, Kusano M, Kuwano H, Takeuchi H, Toh Y, Doki Y, Naomoto Y, Nemoto K, Booka E, Matsubara H, Miyazaki T, Muto M, Yanagisawa A, Yoshida M.

Esophagus. 2019 Jan;16(1):1-24. doi: 10.1007/s10388-018-0641-9. Epub 2018 Aug 31. No abstract available.


Ethylene biosynthesis controlled by NON-RIPENING: A regulatory conflict between wounding and ripening.

Wang N, Chen H, Nonaka S, Sato-Izawa K, Kusano M, Ezura H.

Plant Physiol Biochem. 2018 Nov;132:720-726. doi: 10.1016/j.plaphy.2018.07.034. Epub 2018 Aug 16.


Corrigendum to "Intact metabolite profiling of mouse brain by probe electrospray ionization/triple quadrupole tandem mass spectrometry (PESI/MS/MS) and its potential use for local distribution analysis of the brain" [ACA 983 (2017) 160-165].

Hayashi Y, Zaitsu K, Murata T, Ohara T, Moreau S, Kusano M, Tanihata H, Tsuchihashi H, Ishii A, Ishikawa T.

Anal Chim Acta. 2018 Nov 15;1031:196. doi: 10.1016/j.aca.2018.08.001. Epub 2018 Aug 5. No abstract available.


Metabolome analysis of the serotonin syndrome rat model: Abnormal muscular contraction is related to metabolic alterations and hyper-thermogenesis.

Zaitsu K, Noda S, Iguchi A, Hayashi Y, Ohara T, Kimura Y, Koketsu Y, Kosaki T, Kusano M, Sato T, Ishikawa T, Tsuchihashi H, Suzuki K, Ishii A.

Life Sci. 2018 Aug 15;207:550-561. doi: 10.1016/j.lfs.2018.06.031. Epub 2018 Jul 2.


Clinical profile of gilteritinib in Japanese patients with relapsed/refractory acute myeloid leukemia: An open-label phase 1 study.

Usuki K, Sakura T, Kobayashi Y, Miyamoto T, Iida H, Morita S, Bahceci E, Kaneko M, Kusano M, Yamada S, Takeshita S, Miyawaki S, Naoe T.

Cancer Sci. 2018 Oct;109(10):3235-3244. doi: 10.1111/cas.13749.


Efficacy and Safety Profile of Z-215 (Azeloprazole Sodium), a Proton Pump Inhibitor, Compared with Rabeprazole Sodium in Patients with Reflux Esophagitis: A Phase II, Multicenter, Randomized, Double-Blind, Comparative Study.

Kinoshita Y, Kusano M, Iwakiri K, Fujishiro M, Tachikawa N, Haruma K.

Curr Ther Res Clin Exp. 2018 Mar 22;88:26-34. doi: 10.1016/j.curtheres.2018.03.004. eCollection 2018.


WIND1 induces dynamic metabolomic reprogramming during regeneration in Brassica napus.

Iwase A, Mita K, Favero DS, Mitsuda N, Sasaki R, Kobayshi M, Takebayashi Y, Kojima M, Kusano M, Oikawa A, Sakakibara H, Saito K, Imamura J, Sugimoto K.

Dev Biol. 2018 Oct 1;442(1):40-52. doi: 10.1016/j.ydbio.2018.07.006. Epub 2018 Jul 17.


Metabolomic Evaluation of the Quality of Leaf Lettuce Grown in Practical Plant Factory to Capture Metabolite Signature.

Tamura Y, Mori T, Nakabayashi R, Kobayashi M, Saito K, Okazaki S, Wang N, Kusano M.

Front Plant Sci. 2018 Jun 27;9:665. doi: 10.3389/fpls.2018.00665. eCollection 2018.


Higher frequency of upper gastrointestinal symptoms in healthy young Japanese females compared to males and older generations.

Kawachi K, Sakata Y, Hara M, Takeshita E, Kawakubo H, Yamaguchi D, Okamoto N, Shimoda R, Iwakiri R, Tsuruoka N, Kusano M, Fujimoto K.

Esophagus. 2018 Apr;15(2):83-87. doi: 10.1007/s10388-017-0598-0. Epub 2017 Dec 19.


Metabolic Reprogramming in Leaf Lettuce Grown Under Different Light Quality and Intensity Conditions Using Narrow-Band LEDs.

Kitazaki K, Fukushima A, Nakabayashi R, Okazaki Y, Kobayashi M, Mori T, Nishizawa T, Reyes-Chin-Wo S, Michelmore RW, Saito K, Shoji K, Kusano M.

Sci Rep. 2018 May 21;8(1):7914. doi: 10.1038/s41598-018-25686-0.


Current and future perspectives in the management of gastroesophageal reflux disease.

Akiyama J, Kuribayashi S, Baeg MK, de Bortoli N, Valitova E, Savarino EV, Kusano M, Triadafilopoulos G.

Ann N Y Acad Sci. 2018 Dec;1434(1):70-83. doi: 10.1111/nyas.13850. Epub 2018 May 16. Review.


[Effectiveness of indocyanine green fluorescence in endoscopic marking in gastric cancer surgery:a feasibility study for replacing India ink].

Ono H, Kusano M, Nihei M, Hayashi H, Fukushima H, Kawakami M, Danjo Y, Nagashima K, Shimizu Y, Kawamata F, Honda S, Shimamura T, Nishihara H.

Nihon Shokakibyo Gakkai Zasshi. 2018;115(4):385-393. doi: 10.11405/nisshoshi.115.385. Japanese.


Improvement of Proteinuria due to Combination Therapy with Daclatasvir and Asunaprevir in Hepatitis C Virus-associated Renal Disease without Cryoglobulinemia.

Takakusagi S, Sato K, Suzuki Y, Yamazaki Y, Kosone T, Kakizaki S, Kusano M, Takagi H.

Intern Med. 2018 Aug 1;57(15):2189-2195. doi: 10.2169/internalmedicine.9624-17. Epub 2018 Mar 9.


Metabolomics analysis of 'Housui' Japanese pear flower buds during endodormancy reveals metabolic suppression by thermal fluctuation.

Horikoshi HM, Sekozawa Y, Kobayashi M, Saito K, Kusano M, Sugaya S.

Plant Physiol Biochem. 2018 May;126:134-141. doi: 10.1016/j.plaphy.2018.02.028. Epub 2018 Mar 2.


In Vivo Real-Time Monitoring System Using Probe Electrospray Ionization/Tandem Mass Spectrometry for Metabolites in Mouse Brain.

Zaitsu K, Hayashi Y, Murata T, Yokota K, Ohara T, Kusano M, Tsuchihashi H, Ishikawa T, Ishii A, Ogata K, Tanihata H.

Anal Chem. 2018 Apr 3;90(7):4695-4701. doi: 10.1021/acs.analchem.7b05291. Epub 2018 Mar 19.


Rikkunshito simultaneously improves dyspepsia correlated with anxiety in patients with functional dyspepsia: A randomized clinical trial (the DREAM study).

Tominaga K, Sakata Y, Kusunoki H, Odaka T, Sakurai K, Kawamura O, Nagahara A, Takeuchi T, Fujikawa Y, Oshima T, Kato M, Furuta T, Murakami K, Chiba T, Miwa H, Kinoshita Y, Higuchi K, Kusano M, Iwakiri R, Fujimoto K, Tack JF, Arakawa T.

Neurogastroenterol Motil. 2018 Jul;30(7):e13319. doi: 10.1111/nmo.13319. Epub 2018 Mar 2.


High-throughput determination of valproate in human samples by modified QuEChERS extraction and GC-MS/MS.

Mizuno S, Lee XP, Fujishiro M, Matsuyama T, Yamada M, Sakamoto Y, Kusano M, Zaitsu K, Hasegawa C, Hasegawa I, Kumazawa T, Ishii A, Sato K.

Leg Med (Tokyo). 2018 Mar;31:66-73. doi: 10.1016/j.legalmed.2018.01.002. Epub 2018 Feb 3.


Transcriptomic and Metabolomic Reprogramming from Roots to Haustoria in the Parasitic Plant, Thesium chinense.

Ichihashi Y, Kusano M, Kobayashi M, Suetsugu K, Yoshida S, Wakatake T, Kumaishi K, Shibata A, Saito K, Shirasu K.

Plant Cell Physiol. 2018 Apr 1;59(4):724-733. doi: 10.1093/pcp/pcx200. Erratum in: Plant Cell Physiol. 2018 Apr 1;59(4):876.


Mid-infrared pulsed laser ultrasonic testing for carbon fiber reinforced plastics.

Kusano M, Hatano H, Watanabe M, Takekawa S, Yamawaki H, Oguchi K, Enoki M.

Ultrasonics. 2018 Mar;84:310-318. doi: 10.1016/j.ultras.2017.11.015. Epub 2017 Nov 24.


Efficacy and safety of twice-daily rabeprazole maintenance therapy for patients with reflux esophagitis refractory to standard once-daily proton pump inhibitor: the Japan-based EXTEND study.

Kinoshita Y, Kato M, Fujishiro M, Masuyama H, Nakata R, Abe H, Kumagai S, Fukushima Y, Okubo Y, Hojo S, Kusano M.

J Gastroenterol. 2018 Jul;53(7):834-844. doi: 10.1007/s00535-017-1417-z. Epub 2017 Nov 29.


Light Controls Protein Localization through Phytochrome-Mediated Alternative Promoter Selection.

Ushijima T, Hanada K, Gotoh E, Yamori W, Kodama Y, Tanaka H, Kusano M, Fukushima A, Tokizawa M, Yamamoto YY, Tada Y, Suzuki Y, Matsushita T.

Cell. 2017 Nov 30;171(6):1316-1325.e12. doi: 10.1016/j.cell.2017.10.018. Epub 2017 Nov 9.


eQTLs Regulating Transcript Variations Associated with Rapid Internode Elongation in Deepwater Rice.

Kuroha T, Nagai K, Kurokawa Y, Nagamura Y, Kusano M, Yasui H, Ashikari M, Fukushima A.

Front Plant Sci. 2017 Oct 13;8:1753. doi: 10.3389/fpls.2017.01753. eCollection 2017.


Sodium Glucose Cotransporter 2 Inhibition Combined With Cetuximab Significantly Reduced Tumor Size and Carcinoembryonic Antigen Level in Colon Cancer Metastatic to Liver.

Okada J, Matsumoto S, Kaira K, Saito T, Yamada E, Yokoo H, Katoh R, Kusano M, Okada S, Yamada M.

Clin Colorectal Cancer. 2018 Mar;17(1):e45-e48. doi: 10.1016/j.clcc.2017.09.005. Epub 2017 Sep 28. No abstract available.


Effects of Combined Low Glutathione with Mild Oxidative and Low Phosphorus Stress on the Metabolism of Arabidopsis thaliana.

Fukushima A, Iwasa M, Nakabayashi R, Kobayashi M, Nishizawa T, Okazaki Y, Saito K, Kusano M.

Front Plant Sci. 2017 Aug 28;8:1464. doi: 10.3389/fpls.2017.01464. eCollection 2017.

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