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Items: 1 to 50 of 59

1.

D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels.

Kakumanu R, Kuruppu S, Rash LD, Isbister GK, Hodgson WC, Kemp-Harper BK.

Toxins (Basel). 2019 Apr 1;11(4). pii: E197. doi: 10.3390/toxins11040197.

2.

Powering Amyloid Beta Degrading Enzymes: A Possible Therapy for Alzheimer's Disease.

Sikanyika NL, Parkington HC, Smith AI, Kuruppu S.

Neurochem Res. 2019 Jun;44(6):1289-1296. doi: 10.1007/s11064-019-02756-x. Epub 2019 Feb 26. Review.

PMID:
30806879
3.

Peripheral nerve blocks for above knee amputation in high-risk patients.

Chandran R, Beh ZY, Tsai FC, Kuruppu SD, Lim JY.

J Anaesthesiol Clin Pharmacol. 2018 Oct-Dec;34(4):458-464. doi: 10.4103/joacp.JOACP_346_17.

4.

Clinico-pathological characteristics and outcome of upper urinary tract urothelial carcinoma presenting to a tertiary care urology unit in Sri Lanka

Jayarajah U, Fernando MH, Herath KB, Kuruppu SN, Wickramanayaka UL, Fernando IU, de Silva VC, Goonewardena SAS.

Ceylon Med J. 2018 Sep 30;63(3):129-132.

5.

Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathy.

Giam B, Chu PY, Kuruppu S, Smith AI, Horlock D, Murali A, Kiriazis H, Du XJ, Kaye DM, Rajapakse NW.

Exp Physiol. 2018 Dec;103(12):1593-1602. doi: 10.1113/EP087189. Epub 2018 Nov 5.

PMID:
30311699
6.

A clinico-pathological study of non-urothelial bladder cancers in a cohort of patients from a tertiary care urology unit in Sri Lanka

Jayarajah U, Herath KB, Fernando MH, Kuruppu SN, Wickramanayaka UL, Fernando IU, Lokuhetty DS, de Silva VC, Goonewardena SAS.

Ceylon Med J. 2018 Jun 30;63(2):92-94. No abstract available.

7.

Clinical outcomes in a cohort of patients with T1 high grade urothelial bladder cancer not receiving intravesical bacillus Calmette-Guerin: a 15 year experience

Goonewardena SAS, Jayarajah U, Kuruppu SN, Herath HMKB, Fernando DMH, Vickneswaran K.

Ceylon Med J. 2018 Mar 31;63(1):37-39. No abstract available.

8.

N-Acetylcysteine Attenuates the Development of Renal Fibrosis in Transgenic Mice with Dilated Cardiomyopathy.

Giam B, Kuruppu S, Chu PY, Smith AI, Marques FZ, Fiedler A, Horlock D, Kiriazis H, Du XJ, Kaye DM, Rajapakse NW.

Sci Rep. 2017 Dec 18;7(1):17718. doi: 10.1038/s41598-017-17927-5.

9.
10.

The characteristics of astrocyte on Aβ clearance altered in Alzheimer's disease were reversed by anti-inflammatory agent (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate.

Kuruppu S, Rajapakse NW, Parkington HC, Smith AI.

Am J Transl Res. 2017 Jul 15;9(7):3514-3516. eCollection 2017. No abstract available.

11.

Insulin resistance in a cohort of 5-15 year old children in urban Sri Lanka.

Wickramasinghe VP, Arambepola C, Bandara P, Abeysekera M, Kuruppu S, Dilshan P, Dissanayake BS.

BMC Res Notes. 2017 Jul 28;10(1):347. doi: 10.1186/s13104-017-2658-x.

12.

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes.

Casewell NR, Visser JC, Baumann K, Dobson J, Han H, Kuruppu S, Morgan M, Romilio A, Weisbecker V, Mardon K, Ali SA, Debono J, Koludarov I, Que I, Bird GC, Cooke GM, Nouwens A, Hodgson WC, Wagstaff SC, Cheney KL, Vetter I, van der Weerd L, Richardson MK, Fry BG.

Curr Biol. 2017 May 22;27(10):1549-1550. doi: 10.1016/j.cub.2017.05.009. No abstract available.

13.

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes.

Casewell NR, Visser JC, Baumann K, Dobson J, Han H, Kuruppu S, Morgan M, Romilio A, Weisbecker V, Mardon K, Ali SA, Debono J, Koludarov I, Que I, Bird GC, Cooke GM, Nouwens A, Hodgson WC, Wagstaff SC, Cheney KL, Vetter I, van der Weerd L, Richardson MK, Fry BG.

Curr Biol. 2017 Apr 24;27(8):1184-1191. doi: 10.1016/j.cub.2017.02.067. Epub 2017 Mar 30. Erratum in: Curr Biol. 2017 May 22;27(10):1549-1550.

14.

The Cardiovascular and Neurotoxic Effects of the  Venoms of Six Bony and Cartilaginous Fish Species.

Han H, Baumann K, Casewell NR, Ali SA, Dobson J, Koludarov I, Debono J, Cutmore SC, Rajapakse NW, Jackson TN, Jones R, Hodgson WC, Fry BG, Kuruppu S.

Toxins (Basel). 2017 Feb 16;9(2). pii: E67. doi: 10.3390/toxins9020067.

15.

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.

Marques FZ, Nelson E, Chu PY, Horlock D, Fiedler A, Ziemann M, Tan JK, Kuruppu S, Rajapakse NW, El-Osta A, Mackay CR, Kaye DM.

Circulation. 2017 Mar 7;135(10):964-977. doi: 10.1161/CIRCULATIONAHA.116.024545. Epub 2016 Dec 7.

PMID:
27927713
16.

Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming.

Silva A, Johnston C, Kuruppu S, Kneisz D, Maduwage K, Kleifeld O, Smith AI, Siribaddana S, Buckley NA, Hodgson WC, Isbister GK.

PLoS Negl Trop Dis. 2016 Dec 2;10(12):e0005172. doi: 10.1371/journal.pntd.0005172. eCollection 2016 Dec.

17.

Stimulating the Activity of Amyloid-Beta Degrading Enzymes: A Novel Approach for the Therapeutic Manipulation of Amyloid-Beta Levels.

Kuruppu S, Rajapakse NW, Spicer AJ, Parkington HC, Smith AI.

J Alzheimers Dis. 2016 Oct 4;54(3):891-895. Review.

PMID:
27567865
18.

Effects of Animal Venoms and Toxins on Hallmarks of Cancer.

Chaisakul J, Hodgson WC, Kuruppu S, Prasongsook N.

J Cancer. 2016 Jul 15;7(11):1571-8. doi: 10.7150/jca.15309. eCollection 2016. Review.

19.

Letter by Rajapakse et al Regarding Article, "Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition".

Rajapakse NW, Kuruppu S, Ian Smith A.

Circulation. 2016 Jul 19;134(3):e9-e10. doi: 10.1161/CIRCULATIONAHA.116.023086. No abstract available.

PMID:
27436888
20.

Neurotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming is Primarily due to U1-viperitoxin-Dr1a, a Pre-Synaptic Neurotoxin.

Silva A, Kuruppu S, Othman I, Goode RJ, Hodgson WC, Isbister GK.

Neurotox Res. 2017 Jan;31(1):11-19. doi: 10.1007/s12640-016-9650-4. Epub 2016 Jul 11.

PMID:
27401825
21.

Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper Venoms.

Debono J, Cochran C, Kuruppu S, Nouwens A, Rajapakse NW, Kawasaki M, Wood K, Dobson J, Baumann K, Jouiaei M, Jackson TN, Koludarov I, Low D, Ali SA, Smith AI, Barnes A, Fry BG.

Toxins (Basel). 2016 Jul 8;8(7). pii: E210. doi: 10.3390/toxins8070210.

22.

Defining Obesity Using a Biological End Point in Sri Lankan Children.

Wickramasinghe VP, Arambepola C, Bandara P, Abeysekera M, Kuruppu S, Dilshan P, Dissanayake BS.

Indian J Pediatr. 2017 Feb;84(2):117-123. doi: 10.1007/s12098-016-2191-2. Epub 2016 Jul 7.

PMID:
27383504
23.

Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects.

Giam B, Kuruppu S, Head GA, Kaye DM, Rajapakse NW.

Nutrients. 2016 Jun 14;8(6). pii: E364. doi: 10.3390/nu8060364.

24.

Corrigendum: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin.

Smith AI, Rajapakse NW, Kleifeld O, Lomonte B, Sikanyika NL, Spicer AJ, Hodgson WC, Conroy PJ, Small DH, Kaye DM, Parkington HC, Whisstock JC, Kuruppu S.

Sci Rep. 2016 Apr 22;6:24333. doi: 10.1038/srep24333. No abstract available.

25.

N-acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure.

Giam B, Chu PY, Kuruppu S, Smith AI, Horlock D, Kiriazis H, Du XJ, Kaye DM, Rajapakse NW.

Physiol Rep. 2016 Apr;4(7). pii: e12757. doi: 10.14814/phy2.12757. Epub 2016 Apr 13.

26.

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin.

Smith AI, Rajapakse NW, Kleifeld O, Lomonte B, Sikanyika NL, Spicer AJ, Hodgson WC, Conroy PJ, Small DH, Kaye DM, Parkington HC, Whisstock JC, Kuruppu S.

Sci Rep. 2016 Mar 2;6:22413. doi: 10.1038/srep22413. Erratum in: Sci Rep. 2016 Apr 22;6:24333.

27.

Prothrombin activator-like toxin appears to mediate cardiovascular collapse following envenoming by Pseudonaja textilis.

Chaisakul J, Isbister GK, O'Leary MA, Parkington HC, Smith AI, Hodgson WC, Kuruppu S.

Toxicon. 2015 Aug;102:48-54. doi: 10.1016/j.toxicon.2015.05.001. Epub 2015 May 7.

PMID:
25959508
28.

Nitric oxide inhibits the production of soluble endothelin converting enzyme-1.

Kuruppu S, Rajapakse NW, Dunstan RA, Smith AI.

Mol Cell Biochem. 2014 Nov;396(1-2):49-54. doi: 10.1007/s11010-014-2141-0. Epub 2014 Sep 17.

PMID:
25226840
29.

In vitro toxic effects of puff adder (Bitis arietans) venom, and their neutralization by antivenom.

Fernandez S, Hodgson W, Chaisakul J, Kornhauser R, Konstantakopoulos N, Smith AI, Kuruppu S.

Toxins (Basel). 2014 May 19;6(5):1586-97. doi: 10.3390/toxins6051586.

30.

Angiotensin (1-7) as a therapy to prevent rupture of intracranial aneurysms?

Kuruppu S, Smith AI, Drummond GR, Sobey CG.

Hypertension. 2014 Aug;64(2):222-3. doi: 10.1161/HYPERTENSIONAHA.114.03551. No abstract available.

PMID:
24799616
31.

Production of soluble Neprilysin by endothelial cells.

Kuruppu S, Rajapakse NW, Minond D, Smith AI.

Biochem Biophys Res Commun. 2014 Apr 4;446(2):423-7. doi: 10.1016/j.bbrc.2014.01.158. Epub 2014 Feb 2.

PMID:
24495806
32.

Inhibition of presynaptic neurotoxins in taipan venom by suramin.

Kuruppu S, Chaisakul J, Smith AI, Hodgson WC.

Neurotox Res. 2014 Apr;25(3):305-10. doi: 10.1007/s12640-013-9426-z. Epub 2013 Oct 16.

PMID:
24129771
33.

An examination of cardiovascular collapse induced by eastern brown snake (Pseudonaja textilis) venom.

Chaisakul J, Isbister GK, Kuruppu S, Konstantakopoulos N, Hodgson WC.

Toxicol Lett. 2013 Aug 29;221(3):205-11. doi: 10.1016/j.toxlet.2013.06.235. Epub 2013 Jul 2.

PMID:
23830990
34.

Soluble and catalytically active endothelin converting enzyme-1 is present in cerebrospinal fluid of subarachnoid hemorrhage patients.

Kuruppu S, Chou SH, Feske SK, Suh S, Hanchapola I, Lo EH, Ning M, Smith AI.

Mol Cell Proteomics. 2014 Apr;13(4):1091-4. doi: 10.1074/mcp.M113.027359. Epub 2013 Jul 1.

35.

Validity of newly-developed BMI and waist cut-off values for Sri Lankan children.

Wickramasinghe VP, Arambepola C, Bandara DM, Abeysekera M, Kuruppu S, Dilshan P, Dissanayake BS.

Ann Hum Biol. 2013 May;40(3):280-5. doi: 10.3109/03014460.2013.769629. Epub 2013 Mar 18.

PMID:
23496777
36.

Endothelin-converting enzyme-1 inhibition and renoprotection in end-stage renal disease.

Kuruppu S, Rajapakse NW, Smith AI.

Pflugers Arch. 2013 Jul;465(7):929-34. doi: 10.1007/s00424-013-1216-1. Epub 2013 Jan 18. Review.

PMID:
23328864
37.

Distribution of obesity-related metabolic markers among 5-15 year old children from an urban area of Sri Lanka.

Wickramasinghe VP, Arambepola C, Bandara P, Abeysekera M, Kuruppu S, Dilshan P, Dissanayake BS.

Ann Hum Biol. 2013 Mar;40(2):168-74. doi: 10.3109/03014460.2012.753109. Epub 2013 Jan 18.

PMID:
23327188
38.

Applicability of green fluorescence protein in the study of endothelin converting enzyme-1c trafficking.

Kuruppu S, Tochon-Danguy N, Smith AI.

Protein Sci. 2013 Mar;22(3):306-13. doi: 10.1002/pro.2212. Epub 2013 Feb 1.

39.

Protein Kinase C recognition sites in the cytoplasmic domain of Endothelin Converting Enzyme-1c.

Kuruppu S, Tochon-Danguy N, Smith AI.

Biochem Biophys Res Commun. 2012 Oct 26;427(3):606-10. doi: 10.1016/j.bbrc.2012.09.105. Epub 2012 Sep 27.

PMID:
23022525
40.

Endothelin Converting Enzyme-1 phosphorylation and trafficking.

Kuruppu S, Smith AI.

FEBS Lett. 2012 Jul 30;586(16):2212-7. doi: 10.1016/j.febslet.2012.06.020. Epub 2012 Jun 21. Review.

41.

Toxinology of venoms from five Australian lesser known elapid snakes.

Pycroft K, Fry BG, Isbister GK, Kuruppu S, Lawrence J, Ian Smith A, Hodgson WC.

Basic Clin Pharmacol Toxicol. 2012 Oct;111(4):268-74. doi: 10.1111/j.1742-7843.2012.00907.x. Epub 2012 Jul 4.

42.

Evidence that renal arginine transport is impaired in spontaneously hypertensive rats.

Rajapakse NW, Kuruppu S, Hanchapola I, Venardos K, Mattson DL, Smith AI, Kaye DM, Evans RG.

Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1554-62. doi: 10.1152/ajprenal.00084.2011. Epub 2012 Mar 21.

43.

Iterative dictionary construction for compression of large DNA data sets.

Kuruppu S, Beresford-Smith B, Conway T, Zobel J.

IEEE/ACM Trans Comput Biol Bioinform. 2012 Jan-Feb;9(1):137-49. doi: 10.1109/TCBB.2011.82. Epub 2011 Apr 27.

PMID:
21576758
44.

Functional and structural diversification of the Anguimorpha lizard venom system.

Fry BG, Winter K, Norman JA, Roelants K, Nabuurs RJ, van Osch MJ, Teeuwisse WM, van der Weerd L, McNaughtan JE, Kwok HF, Scheib H, Greisman L, Kochva E, Miller LJ, Gao F, Karas J, Scanlon D, Lin F, Kuruppu S, Shaw C, Wong L, Hodgson WC.

Mol Cell Proteomics. 2010 Nov;9(11):2369-90. doi: 10.1074/mcp.M110.001370. Epub 2010 Jul 14.

45.

Role of Protein Kinase C in Endothelin Converting Enzyme-1 trafficking and shedding from endothelial cells.

Kuruppu S, Tochon-Danguy N, Smith AI.

Biochem Biophys Res Commun. 2010 Jul 23;398(2):173-7. doi: 10.1016/j.bbrc.2010.06.045. Epub 2010 Jun 15.

PMID:
20558134
46.

Neurotoxins from Australo-Papuan elapids: a biochemical and pharmacological perspective.

Kuruppu S, Smith AI, Isbister GK, Hodgson WC.

Crit Rev Toxicol. 2008;38(1):73-86. Review.

PMID:
18161503
47.

The in vitro neurotoxic and myotoxic effects of the venom from the Suta genus (curl snakes) of elapid snakes.

Kuruppu S, Robinson S, Hodgson WC, Fry BG.

Basic Clin Pharmacol Toxicol. 2007 Dec;101(6):407-10.

48.

Characterisation of endothelin converting enzyme-1 shedding from endothelial cells.

Kuruppu S, Reeve S, Ian Smith A.

FEBS Lett. 2007 Sep 18;581(23):4501-6. Epub 2007 Aug 22.

49.

Isolation and characterization of rufoxin, a novel protein exhibiting neurotoxicity from venom of the psammophiine, Rhamphiophis oxyrhynchus (Rufous beaked snake).

Lumsden NG, Banerjee Y, Kini RM, Kuruppu S, Hodgson WC.

Neuropharmacology. 2007 Mar;52(4):1065-70. Epub 2006 Dec 27.

PMID:
17194464
50.

Oxylepitoxin-1, a reversible neurotoxin from the venom of the inland taipan (Oxyuranus microlepidotus).

Clarke C, Kuruppu S, Reeve S, Ian Smith A, Hodgson WC.

Peptides. 2006 Nov;27(11):2655-60. Epub 2006 Aug 1.

PMID:
16879898

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