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Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic.

Azim A, Mistry H, Freeman A, Barber C, Newell C, Gove K, Thirlwall Y, Harvey M, Bentley K, Knight D, Long K, Mitchell F, Cheng Y, Varkonyi-Sepp J, Grabau W, Dennison P, Haitchi HM, Arshad SH, Djukanovic R, Wilkinson T, Howarth P, Kurukulaaratchy RJ.

BMC Pulm Med. 2019 May 24;19(1):99. doi: 10.1186/s12890-019-0862-2.


Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors - a birth cohort study.

Karmaus W, Mukherjee N, Janjanam VD, Chen S, Zhang H, Roberts G, Kurukulaaratchy RJ, Arshad H.

Respir Res. 2019 May 22;20(1):98. doi: 10.1186/s12931-019-1068-0.


Follow-up, 18 months off house dust mite immunotherapy, of a randomized controlled study on the primary prevention of atopy.

Alviani C, Roberts G, Moyses H, Pearson S, Larsson M, Zolkipli Z, Michaelis LJ, Kurukulaaratchy R, Arshad SH.

Allergy. 2019 Feb 9. doi: 10.1111/all.13744. [Epub ahead of print] No abstract available.


A Pediatric Asthma Risk Score to better predict asthma development in young children.

Biagini Myers JM, Schauberger E, He H, Martin LJ, Kroner J, Hill GM, Ryan PH, LeMasters GK, Bernstein DI, Lockey JE, Arshad SH, Kurukulaaratchy R, Khurana Hershey GK.

J Allergy Clin Immunol. 2019 May;143(5):1803-1810.e2. doi: 10.1016/j.jaci.2018.09.037. Epub 2018 Dec 13.


Leptin receptor gene polymorphisms and sex modify the association between acetaminophen use and asthma among young adults: results from two observational studies.

Ziyab AH, Mukherjee N, Kurukulaaratchy RJ, Zhang H, Ewart S, Arshad H, Karmaus W.

Respir Res. 2018 Sep 19;19(1):179. doi: 10.1186/s12931-018-0892-y.


Influence of deprivation on health care use, health care costs, and mortality in COPD.

Collins PF, Stratton RJ, Kurukulaaratchy RJ, Elia M.

Int J Chron Obstruct Pulmon Dis. 2018 Apr 19;13:1289-1296. doi: 10.2147/COPD.S157594. eCollection 2018.


Cohort Profile: The Isle Of Wight Whole Population Birth Cohort (IOWBC).

Arshad SH, Holloway JW, Karmaus W, Zhang H, Ewart S, Mansfield L, Matthews S, Hodgekiss C, Roberts G, Kurukulaaratchy R.

Int J Epidemiol. 2018 Aug 1;47(4):1043-1044i. doi: 10.1093/ije/dyy023. No abstract available.


Prevalence and longitudinal trends of food allergy during childhood and adolescence: Results of the Isle of Wight Birth Cohort study.

Venkataraman D, Erlewyn-Lajeunesse M, Kurukulaaratchy RJ, Potter S, Roberts G, Matthews S, Arshad SH.

Clin Exp Allergy. 2018 Apr;48(4):394-402. doi: 10.1111/cea.13088. Epub 2018 Feb 8.


Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization.

Chan A, Terry W, Zhang H, Karmaus W, Ewart S, Holloway JW, Roberts G, Kurukulaaratchy R, Arshad SH.

Clin Exp Allergy. 2018 Feb;48(2):147-155. doi: 10.1111/cea.13077.


Consistency and Variability of DNA Methylation in Women During Puberty, Young Adulthood, and Pregnancy.

Chen S, Mukherjee N, Janjanam VD, Arshad SH, Kurukulaaratchy RJ, Holloway JW, Zhang H, Karmaus W.

Genet Epigenet. 2017 Jul 28;9:1179237X17721540. doi: 10.1177/1179237X17721540. eCollection 2017.


Relationship between birth weight, maternal smoking during pregnancy and childhood and adolescent lung function: A path analysis.

Balte P, Karmaus W, Roberts G, Kurukulaaratchy R, Mitchell F, Arshad H.

Respir Med. 2016 Dec;121:13-20. doi: 10.1016/j.rmed.2016.10.010. Epub 2016 Oct 19.


Tetanus vaccination is associated with differential DNA-methylation: Reduces the risk of asthma in adolescence.

Janjanam VD, Mukherjee N, Lockett GA, Rezwan FI, Kurukulaaratchy R, Mitchell F, Zhang H, Arshad H, Holloway JW, Karmaus W.

Vaccine. 2016 Dec 12;34(51):6493-6501. doi: 10.1016/j.vaccine.2016.10.068. Epub 2016 Nov 17.


The influence of deprivation on malnutrition risk in outpatients with chronic obstructive pulmonary disease (COPD).

Collins PF, Elia M, Kurukulaaratchy RJ, Stratton RJ.

Clin Nutr. 2018 Feb;37(1):144-148. doi: 10.1016/j.clnu.2016.11.005. Epub 2016 Nov 11.


A multidisciplinary team case management approach reduces the burden of frequent asthma admissions.

Burke H, Davis J, Evans S, Flower L, Tan A, Kurukulaaratchy RJ.

ERJ Open Res. 2016 Jul 29;2(3). pii: 00039-2016. eCollection 2016 Jul.


The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart.

Venter C, Maslin K, Patil V, Kurukulaaratchy R, Grundy J, Glasbey G, Twiselton R, Dean T, Arshad SH.

Pediatr Allergy Immunol. 2016 Dec;27(8):804-811. doi: 10.1111/pai.12616. Epub 2016 Sep 19.


An outreaching model of tertiary difficult asthma care reduces adverse asthma outcomes and healthcare utilisation costs.

Patil VK, Townshend C, Mitchell F, Kurukulaaratchy RJ.

Eur Respir J. 2016 Jun;47(6):1857-60. doi: 10.1183/13993003.01689-2015. Epub 2016 Mar 23. No abstract available.


Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1.

Hinks TS, Brown T, Lau LC, Rupani H, Barber C, Elliott S, Ward JA, Ono J, Ohta S, Izuhara K, Djukanović R, Kurukulaaratchy RJ, Chauhan A, Howarth PH.

J Allergy Clin Immunol. 2016 Jul;138(1):61-75. doi: 10.1016/j.jaci.2015.11.020. Epub 2016 Feb 3.


Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood.

Zolkipli Z, Roberts G, Cornelius V, Clayton B, Pearson S, Michaelis L, Djukanovic R, Kurukulaaratchy R, Arshad SH.

J Allergy Clin Immunol. 2015 Dec;136(6):1541-1547.e11. doi: 10.1016/j.jaci.2015.04.045. Epub 2015 Jun 12.


Changing prevalence of wheeze, rhinitis and allergic sensitisation in late childhood: findings from 2 Isle of Wight birth cohorts 12 years apart.

Patil VK, Kurukulaaratchy RJ, Venter C, Grundy J, Roberts G, Dean T, Arshad SH.

Clin Exp Allergy. 2015 Sep;45(9):1430-8. doi: 10.1111/cea.12534.


Case series: the application of "third wave" cognitive behavioural therapies in difficult to treat asthma.

Fellows JL, Flower L, Blakey J, Kurukulaaratchy R, Howard R, Mansur A.

J Asthma. 2015;52(9):905-12. doi: 10.3109/02770903.2014.1003155. Epub 2015 Sep 16.


Pathophysiological characterization of asthma transitions across adolescence.

Arshad SH, Raza A, Lau L, Bawakid K, Karmaus W, Zhang H, Ewart S, Patil V, Roberts G, Kurukulaaratchy R.

Respir Res. 2014 Nov 29;15:153. doi: 10.1186/s12931-014-0153-7.


The natural history of peanut sensitization and allergy in a birth cohort.

Arshad SH, Venter C, Roberts G, Dean T, Kurukulaaratchy R.

J Allergy Clin Immunol. 2014 Dec;134(6):1462-1463.e6. doi: 10.1016/j.jaci.2014.09.026. Epub 2014 Oct 29. No abstract available.


Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence.

Venkataraman D, Soto-Ramírez N, Kurukulaaratchy RJ, Holloway JW, Karmaus W, Ewart SL, Arshad SH, Erlewyn-Lajeunesse M.

J Allergy Clin Immunol. 2014 Oct;134(4):876-882.e4. doi: 10.1016/j.jaci.2014.07.033. Epub 2014 Aug 28.


Identifying the heterogeneity of young adult rhinitis through cluster analysis in the Isle of Wight birth cohort.

Kurukulaaratchy RJ, Zhang H, Patil V, Raza A, Karmaus W, Ewart S, Arshad SH.

J Allergy Clin Immunol. 2015 Jan;135(1):143-50. doi: 10.1016/j.jaci.2014.06.017. Epub 2014 Jul 29.


Developmental trajectories of Body Mass Index from infancy to 18 years of age: prenatal determinants and health consequences.

Ziyab AH, Karmaus W, Kurukulaaratchy RJ, Zhang H, Arshad SH.

J Epidemiol Community Health. 2014 Oct;68(10):934-41. doi: 10.1136/jech-2014-203808. Epub 2014 Jun 3.


The diversity of young adult wheeze: a cluster analysis in a longitudinal birth cohort.

Kurukulaaratchy RJ, Zhang H, Raza A, Patil V, Karmaus W, Ewart S, Arshad SH.

Clin Exp Allergy. 2014;44(5):724-35. doi: 10.1111/cea.12306.


Early-life wheeze: "the Child is father of the Man".

Kurukulaaratchy RJ, Evans S, Arshad SH.

Eur Respir J. 2014 Feb;43(2):648-50. doi: 10.1183/09031936.00075313. No abstract available.


Case series reporting the effectiveness of mycophenolate mofetil in treatment-resistant asthma.

Grainge C, Jayasekera N, Dennison P, Rupani H, Kurukulaaratchy R, Howarth P.

Eur Respir J. 2013 Oct;42(4):1134-7. doi: 10.1183/09031936.00026413. No abstract available.


Effect of GSTM2-5 polymorphisms in relation to tobacco smoke exposures on lung function growth: a birth cohort study.

Alexander M, Karmaus W, Holloway JW, Zhang H, Roberts G, Kurukulaaratchy RJ, Arshad SH, Ewart S.

BMC Pulm Med. 2013 Sep 3;13:56. doi: 10.1186/1471-2466-13-56.


Epidemiologic methods of assessing asthma and wheezing episodes in longitudinal studies: measures of change and stability.

Soto-Ramírez N, Ziyab AH, Karmaus W, Zhang H, Kurukulaaratchy RJ, Ewart S, Arshad SH.

J Epidemiol. 2013;23(6):399-410. Epub 2013 Aug 31.


Pneumomediastinum leading to respiratory compromise as a complication of acute severe asthma.

Jones MG, Rae W, Lwin AA, Kurukulaaratchy RJ.

Am J Respir Crit Care Med. 2013 Feb 1;187(3):e5-6. doi: 10.1164/rccm.201202-0250IM. No abstract available.


An unusual bronchial obstruction in a fit young man.

Freeman A, Weeden D, Wilkinson J, Kurukulaaratchy RJ.

BMJ Case Rep. 2013 Jan 9;2013. pii: bcr2012007766. doi: 10.1136/bcr-2012-007766.


The effect of bariatric surgery in the difficult asthma-obesity phenotype: a case report.

Evans S, Kurukulaaratchy RJ.

J Asthma. 2013 Feb;50(1):52-5. doi: 10.3109/02770903.2012.741639. Epub 2012 Nov 22.


Trends in cutaneous sensitization in the first 18 years of life: results from the 1989 Isle of Wight birth cohort study.

Roberts G, Zhang H, Karmaus W, Raza A, Scott M, Matthews S, Kurukulaaratchy RJ, Dean T, Arshad SH.

Clin Exp Allergy. 2012 Oct;42(10):1501-9. doi: 10.1111/j.1365-2222.2012.04074.x.


Multifaceted allergen avoidance during infancy reduces asthma during childhood with the effect persisting until age 18 years.

Scott M, Roberts G, Kurukulaaratchy RJ, Matthews S, Nove A, Arshad SH.

Thorax. 2012 Dec;67(12):1046-51. doi: 10.1136/thoraxjnl-2012-202150. Epub 2012 Aug 2.


Rising to the GINA Asthma Challenge: thinking beyond just asthma.

Pond Z, Burke H, Duffus C, Kurukulaaratchy RJ.

Eur Respir J. 2012 Jul;40(1):280-1; author reply 281. doi: 10.1183/09031936.00036712. No abstract available.


The effect of parental allergy on childhood allergic diseases depends on the sex of the child.

Arshad SH, Karmaus W, Raza A, Kurukulaaratchy RJ, Matthews SM, Holloway JW, Sadeghnejad A, Zhang H, Roberts G, Ewart SL.

J Allergy Clin Immunol. 2012 Aug;130(2):427-34.e6. doi: 10.1016/j.jaci.2012.03.042. Epub 2012 May 18.


What does adolescent undiagnosed wheeze represent? Findings from the Isle of Wight Cohort.

Raza A, Kurukulaaratchy RJ, Grundy JD, Clayton CB, Mitchell FA, Roberts G, Ewart S, Sadeghnejad A, Arshad SH.

Eur Respir J. 2012 Sep;40(3):580-8. doi: 10.1183/09031936.00085111. Epub 2012 Jan 20.


Characterisation of asthma that develops during adolescence; findings from the Isle of Wight Birth Cohort.

Kurukulaaratchy RJ, Raza A, Scott M, Williams P, Ewart S, Matthews S, Roberts G, Hasan Arshad S.

Respir Med. 2012 Mar;106(3):329-37. doi: 10.1016/j.rmed.2011.12.006. Epub 2011 Dec 31.


Sex and atopy influences on the natural history of rhinitis.

Kurukulaaratchy RJ, Karmaus W, Arshad SH.

Curr Opin Allergy Clin Immunol. 2012 Feb;12(1):7-12. doi: 10.1097/ACI.0b013e32834ecc4e. Review.


Can the multidisciplinary input of an asthma nurse specialist and respiratory physician improve the discharge management of acute asthma admissions?

Abayaratne D, Babu S, McCulloch A, Dufus C, Kurukulaaratchy R.

Clin Med (Lond). 2011 Aug;11(4):414-5. No abstract available.


Breastfeeding is associated with increased lung function at 18 years of age: a cohort study.

Soto-Ramírez N, Alexander M, Karmaus W, Yousefi M, Zhang H, Kurukulaaratchy RJ, Raza A, Mitchell F, Ewart S, Arshad SH.

Eur Respir J. 2012 Apr;39(4):985-91. doi: 10.1183/09031936.00037011. Epub 2011 Aug 18.


Identification of ATPAF1 as a novel candidate gene for asthma in children.

Schauberger EM, Ewart SL, Arshad SH, Huebner M, Karmaus W, Holloway JW, Friderici KH, Ziegler JT, Zhang H, Rose-Zerilli MJ, Barton SJ, Holgate ST, Kilpatrick JR, Harley JB, Lajoie-Kadoch S, Harley IT, Hamid Q, Kurukulaaratchy RJ, Seibold MA, Avila PC, Rodriguez-Cintrón W, Rodriguez-Santana JR, Hu D, Gignoux C, Romieu I, London SJ, Burchard EG, Langefeld CD, Wills-Karp M.

J Allergy Clin Immunol. 2011 Oct;128(4):753-760.e11. doi: 10.1016/j.jaci.2011.04.058. Epub 2011 Jun 22.


The influence of gender and atopy on the natural history of rhinitis in the first 18 years of life.

Kurukulaaratchy RJ, Karmaus W, Raza A, Matthews S, Roberts G, Arshad SH.

Clin Exp Allergy. 2011 Jun;41(6):851-9. doi: 10.1111/j.1365-2222.2011.03765.x.


Recognising the risk of aspirin-sensitive respiratory disease in a patient with asthma who has previously tolerated aspirin.

Abayaratne D, Kurukulaaratchy RJ.

Prim Care Respir J. 2011 Jun;20(2):214-7. doi: 10.4104/pcrj.2011.00001.


Buckwheat allergy: a potential problem in 21st century Britain.

Sammut D, Dennison P, Venter C, Kurukulaaratchy RJ.

BMJ Case Rep. 2011 Nov 8;2011. pii: bcr0920114882. doi: 10.1136/bcr.09.2011.4882.


Recurrent haemoptysis, left-sided chest pain and an evolving left lower lobe cavity in a 50-year old smoker with prior high ethanol intake.

Taylor M, Butler C, Lekkas A, Kurukulaaratchy RJ.

BMJ Case Rep. 2011 Dec 21;2011. pii: bcr0920114884. doi: 10.1136/bcr.09.2011.4884.


Definitions are important and not all wheeze is asthma.

Scott M, Kurukulaaratchy RJ, Arshad SH.

Thorax. 2011 Jul;66(7):633; author reply 633-4. doi: 10.1136/thx.2010.143941. Epub 2010 Sep 10. No abstract available.


Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable?

Selby A, Clayton B, Grundy J, Pike K, Drew K, Raza A, Kurukulaaratchy R, Arshad SH, Roberts G.

Respir Res. 2010 Apr 23;11:43. doi: 10.1186/1465-9921-11-43.


Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study.

Scott M, Raza A, Karmaus W, Mitchell F, Grundy J, Kurukulaaratchy RJ, Arshad SH, Roberts G.

Thorax. 2010 Mar;65(3):258-62. doi: 10.1136/thx.2009.125443.

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