Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 185

1.

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis.

Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W.

Nat Commun. 2018 Nov 15;9(1):4805. doi: 10.1038/s41467-018-07213-x.

2.

The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension.

Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust HJ, Huber TB, Stahl RA, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UO.

Am J Physiol Renal Physiol. 2018 Sep 12. doi: 10.1152/ajprenal.00149.2018. [Epub ahead of print]

PMID:
30207169
3.

Targeting kidney inflammation as a new therapy for primary hyperoxaluria?

Martin-Higueras C, Ludwig-Portugall I, Hoppe B, Kurts C.

Nephrol Dial Transplant. 2018 Aug 29. doi: 10.1093/ndt/gfy239. [Epub ahead of print]

PMID:
30169827
4.

Salt, inflammation, IL-17 and hypertension.

Wenzel UO, Bode M, Kurts C, Ehmke H.

Br J Pharmacol. 2018 May 16. doi: 10.1111/bph.14359. [Epub ahead of print] Review.

PMID:
29767465
5.

The multifaceted role of the renal mononuclear phagocyte system.

Viehmann SF, Böhner AMC, Kurts C, Brähler S.

Cell Immunol. 2018 Aug;330:97-104. doi: 10.1016/j.cellimm.2018.04.009. Epub 2018 Apr 22. Review.

PMID:
29748002
6.

Antigen-specific Helios- , Neuropilin-1- Tregs induce apoptosis of autoreactive B cells via PD-L1.

Gotot J, Dhana E, Yagita H, Kaiser R, Ludwig-Portugall I, Kurts C.

Immunol Cell Biol. 2018 Sep;96(8):852-862. doi: 10.1111/imcb.12053. Epub 2018 May 2.

PMID:
29617057
7.

In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche.

Breitbach M, Kimura K, Luis TC, Fuegemann CJ, Woll PS, Hesse M, Facchini R, Rieck S, Jobin K, Reinhardt J, Ohneda O, Wenzel D, Geisen C, Kurts C, Kastenmüller W, Hölzel M, Jacobsen SEW, Fleischmann BK.

Cell Stem Cell. 2018 Feb 1;22(2):262-276.e7. doi: 10.1016/j.stem.2018.01.008.

PMID:
29451855
8.

Plasmacytoid dendritic cells: important players in human kidney allograft rejection.

Reich B, Viehmann SF, Kurts C.

Kidney Int. 2018 Feb;93(2):301-303. doi: 10.1016/j.kint.2017.10.025.

PMID:
29389394
9.

Role of immune cells in crystal-induced kidney fibrosis.

Dhana E, Ludwig-Portugall I, Kurts C.

Matrix Biol. 2018 Aug;68-69:280-292. doi: 10.1016/j.matbio.2017.11.013. Epub 2017 Dec 6. Review.

PMID:
29221812
10.

Opposing Roles of Dendritic Cell Subsets in Experimental GN.

Brähler S, Zinselmeyer BH, Raju S, Nitschke M, Suleiman H, Saunders BT, Johnson MW, Böhner AMC, Viehmann SF, Theisen DJ, Kretzer NM, Briseño CG, Zaitsev K, Ornatsky O, Chang Q, Carrero JA, Kopp JB, Artyomov MN, Kurts C, Murphy KM, Miner JH, Shaw AS.

J Am Soc Nephrol. 2018 Jan;29(1):138-154. doi: 10.1681/ASN.2017030270. Epub 2017 Dec 7.

PMID:
29217759
11.

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.

Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courrèges CJF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine A, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C.

Cell Rep. 2017 Oct 17;21(3):578-586. doi: 10.1016/j.celrep.2017.09.082.

12.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available.

13.

Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination.

Heine A, Flores C, Gevensleben H, Diehl L, Heikenwalder M, Ringelhan M, Janssen KP, Nitsche U, Garbi N, Brossart P, Knolle PA, Kurts C, Höchst B.

Oncoimmunology. 2017 Jun 16;6(8):e1338995. doi: 10.1080/2162402X.2017.1338995. eCollection 2017.

14.

Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation.

Holland T, Wohlleber D, Marx S, Kreutzberg T, Vento-Asturias S, Schmitt-Mbamunyo C, Welz M, Janas M, Komander K, Eickhoff S, Brewitz A, Hasenberg M, Männ L, Gunzer M, Wilhelm C, Kastenmüller W, Knolle P, Abdullah Z, Kurts C, Garbi N.

J Allergy Clin Immunol. 2018 Jan;141(1):416-419.e10. doi: 10.1016/j.jaci.2017.06.048. Epub 2017 Aug 19. No abstract available.

PMID:
28826775
15.

Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus.

Pohl JM, Gutweiler S, Thiebes S, Volke JK, Klein-Hitpass L, Zwanziger D, Gunzer M, Jung S, Agace WW, Kurts C, Engel DR.

Gut. 2017 Dec;66(12):2110-2120. doi: 10.1136/gutjnl-2017-313856. Epub 2017 Jun 14. Erratum in: Gut. 2018 Feb;67(2):379.

16.

Urinary tract infection: recent insight into the evolutionary arms race between uropathogenic Escherichia coli and our immune system.

Schwab S, Jobin K, Kurts C.

Nephrol Dial Transplant. 2017 Dec 1;32(12):1977-1983. doi: 10.1093/ndt/gfx022. Review.

PMID:
28340252
17.

Immunophysiology: Macrophages as key regulators of homeostasis in various organs.

Jantsch J, L Schultze J, Kurts C.

Pflugers Arch. 2017 Apr;469(3-4):363-364. doi: 10.1007/s00424-017-1963-5. Epub 2017 Mar 15. No abstract available.

PMID:
28299445
18.

Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice.

Rieck M, Kremser C, Jobin K, Mettke E, Kurts C, Gräler M, Willecke K, Kolanus W.

Eur J Immunol. 2017 Apr;47(4):677-684. doi: 10.1002/eji.201646623. Epub 2017 Feb 27.

19.

CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.

Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W.

Immunity. 2017 Feb 21;46(2):205-219. doi: 10.1016/j.immuni.2017.01.003. Epub 2017 Feb 9.

20.

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

Wittlich M, Dudek M, Böttcher JP, Schanz O, Hegenbarth S, Bopp T, Schmitt E, Kurts C, Garbers C, Rose John S, Knolle PA, Wohlleber D.

J Hepatol. 2017 May;66(5):978-986. doi: 10.1016/j.jhep.2016.12.015. Epub 2016 Dec 23.

PMID:
28025060
21.

CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.

Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts C.

J Am Soc Nephrol. 2016 Nov;27(11):3368-3382. Epub 2016 Apr 1.

22.

B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.

Klotz L, Kuzmanov I, Hucke S, Gross CC, Posevitz V, Dreykluft A, Schulte-Mecklenbeck A, Janoschka C, Lindner M, Herold M, Schwab N, Ludwig-Portugall I, Kurts C, Meuth SG, Kuhlmann T, Wiendl H.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6182-E6191. Epub 2016 Sep 26.

23.

Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy.

Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Gunzer M.

J Am Soc Nephrol. 2017 Feb;28(2):452-459. doi: 10.1681/ASN.2016020232. Epub 2016 Aug 3.

24.

Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis.

Hackstein CP, Assmus LM, Welz M, Klein S, Schwandt T, Schultze J, Förster I, Gondorf F, Beyer M, Kroy D, Kurts C, Trebicka J, Kastenmüller W, Knolle PA, Abdullah Z.

Gut. 2017 Mar;66(3):507-518. doi: 10.1136/gutjnl-2015-311224. Epub 2016 Jul 18.

PMID:
27432540
25.

Impact of macrophages on tumor growth characteristics in a murine ocular tumor model.

Stei MM, Loeffler KU, Kurts C, Hoeller T, Pfarrer C, Holz FG, Herwig-Carl MC.

Exp Eye Res. 2016 Oct;151:9-18. doi: 10.1016/j.exer.2016.07.008. Epub 2016 Jul 15.

PMID:
27426931
26.

Recombinant HLA-G as Tolerogenic Immunomodulant in Experimental Small Bowel Transplantation.

von Websky MW, Kitamura K, Ludwig-Portugall I, Kurts C, von Laffert M, LeMaoult J, Carosella ED, Abu-Elmagd K, Kalff JC, Schäfer N.

PLoS One. 2016 Jul 12;11(7):e0158907. doi: 10.1371/journal.pone.0158907. eCollection 2016.

27.

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice.

Ludwig-Portugall I, Bartok E, Dhana E, Evers BD, Primiano MJ, Hall JP, Franklin BS, Knolle PA, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.

Kidney Int. 2016 Sep;90(3):525-39. doi: 10.1016/j.kint.2016.03.035. Epub 2016 Jun 2.

PMID:
27262364
28.

More trouble with FGF23: a novel role in systemic immunosuppression.

Abdullah Z, Kurts C.

Kidney Int. 2016 Jun;89(6):1176-7. doi: 10.1016/j.kint.2016.04.002.

PMID:
27181769
29.

The Hierarchy of Antigen Delivery.

Garbi N, Kurts C.

EBioMedicine. 2016 Feb 18;5:7-8. doi: 10.1016/j.ebiom.2016.02.031. eCollection 2016 Mar. No abstract available.

30.

The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension.

Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UO.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1356-65. doi: 10.1152/ajprenal.00040.2016. Epub 2016 Apr 6.

31.

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.

Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL.

Nat Immunol. 2016 May;17(5):593-603. doi: 10.1038/ni.3399. Epub 2016 Mar 7.

PMID:
26950238
32.

Macrophages: sentinels and regulators of the immune system.

Franken L, Schiwon M, Kurts C.

Cell Microbiol. 2016 Apr;18(4):475-87. doi: 10.1111/cmi.12580. Epub 2016 Mar 16. Review.

PMID:
26880038
33.

Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages.

Zec K, Volke J, Vijitha N, Thiebes S, Gunzer M, Kurts C, Engel DR.

Pathogens. 2016 Feb 4;5(1). pii: E15. doi: 10.3390/pathogens5010015.

34.

German Society for Immunology and Australasian Society for Immunology joint Workshop 3(rd) -4(th) December 2015 - Meeting report.

Kurts C, Gottschalk C, Bedoui S, Heinzel S, Godfrey D, Enders A.

Eur J Immunol. 2016 Feb;46(2):265-8. doi: 10.1002/eji.201670024.

35.

Cutting Edge: The RIG-I Ligand 3pRNA Potently Improves CTL Cross-Priming and Facilitates Antiviral Vaccination.

Hochheiser K, Klein M, Gottschalk C, Hoss F, Scheu S, Coch C, Hartmann G, Kurts C.

J Immunol. 2016 Mar 15;196(6):2439-43. doi: 10.4049/jimmunol.1501958. Epub 2016 Jan 27.

36.

Mitochondrial DNA: An Endogenous Trigger for Immune Paralysis.

Schäfer ST, Franken L, Adamzik M, Schumak B, Scherag A, Engler A, Schönborn N, Walden J, Koch S, Baba HA, Steinmann J, Westendorf AM, Fandrey J, Bieber T, Kurts C, Frede S, Peters J, Limmer A.

Anesthesiology. 2016 Apr;124(4):923-33. doi: 10.1097/ALN.0000000000001008.

PMID:
26808636
37.

The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib.

Heine A, Schilling J, Grünwald B, Krüger A, Gevensleben H, Held SA, Garbi N, Kurts C, Brossart P, Knolle P, Diehl L, Höchst B.

Cancer Immunol Immunother. 2016 Mar;65(3):273-82. doi: 10.1007/s00262-015-1790-5. Epub 2016 Jan 19.

PMID:
26786874
38.

A grain of salt on kidney dendritic cell function in allograft rejection.

Jobin K, Heuser C, Kurts C.

Kidney Int. 2016 Jan;89(1):14-6. doi: 10.1016/j.kint.2015.10.006.

PMID:
26759039
39.

Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Aggravates the Progression of Crescentic GN.

Gotot J, Piotrowski E, Otte MS, Tittel AP, Linlin G, Yao C, Ziegelbauer K, Panzer U, Garbi N, Kurts C, Thaiss F.

J Am Soc Nephrol. 2016 Jul;27(7):1917-24. doi: 10.1681/ASN.2015060699. Epub 2015 Nov 16.

40.

Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.

Djudjaj S, Lue H, Rong S, Papasotiriou M, Klinkhammer BM, Zok S, Klaener O, Braun GS, Lindenmeyer MT, Cohen CD, Bucala R, Tittel AP, Kurts C, Moeller MJ, Floege J, Ostendorf T, Bernhagen J, Boor P.

J Am Soc Nephrol. 2016 Jun;27(6):1650-64. doi: 10.1681/ASN.2015020149. Epub 2015 Oct 9.

41.

Functional classification of memory CD8(+) T cells by CX3CR1 expression.

Böttcher JP, Beyer M, Meissner F, Abdullah Z, Sander J, Höchst B, Eickhoff S, Rieckmann JC, Russo C, Bauer T, Flecken T, Giesen D, Engel D, Jung S, Busch DH, Protzer U, Thimme R, Mann M, Kurts C, Schultze JL, Kastenmüller W, Knolle PA.

Nat Commun. 2015 Sep 25;6:8306. doi: 10.1038/ncomms9306.

42.

The Debate about Dendritic Cells and Macrophages in the Kidney.

Gottschalk C, Kurts C.

Front Immunol. 2015 Sep 1;6:435. doi: 10.3389/fimmu.2015.00435. eCollection 2015. Review.

43.

B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway.

Herold M, Posevitz V, Chudyka D, Hucke S, Groß C, Kurth F, Leder C, Loser K, Kurts C, Knolle P, Klotz L, Wiendl H.

J Immunol. 2015 Oct 15;195(8):3584-95. doi: 10.4049/jimmunol.1402746. Epub 2015 Sep 16.

44.

Selective Dependence of Kidney Dendritic Cells on CX3CR1--Implications for Glomerulonephritis Therapy.

Hochheiser K, Kurts C.

Adv Exp Med Biol. 2015;850:55-71. doi: 10.1007/978-3-319-15774-0_5. Review.

PMID:
26324346
45.

Immune Mechanisms in Arterial Hypertension.

Wenzel U, Turner JE, Krebs C, Kurts C, Harrison DG, Ehmke H.

J Am Soc Nephrol. 2016 Mar;27(3):677-86. doi: 10.1681/ASN.2015050562. Epub 2015 Aug 28. Review.

46.

The Role of Invariant Natural Killer T Cells in Dendritic Cell Licensing, Cross-Priming, and Memory CD8(+) T Cell Generation.

Gottschalk C, Mettke E, Kurts C.

Front Immunol. 2015 Jul 28;6:379. doi: 10.3389/fimmu.2015.00379. eCollection 2015. Review.

47.

Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates.

Franken L, Klein M, Spasova M, Elsukova A, Wiedwald U, Welz M, Knolle P, Farle M, Limmer A, Kurts C.

Sci Rep. 2015 Aug 11;5:12940. doi: 10.1038/srep12940.

48.

The VEGF-Receptor Inhibitor Axitinib Impairs Dendritic Cell Phenotype and Function.

Heine A, Held SA, Daecke SN, Riethausen K, Kotthoff P, Flores C, Kurts C, Brossart P.

PLoS One. 2015 Jun 4;10(6):e0128897. doi: 10.1371/journal.pone.0128897. eCollection 2015.

49.

Liver inflammation abrogates immunological tolerance induced by Kupffer cells.

Heymann F, Peusquens J, Ludwig-Portugall I, Kohlhepp M, Ergen C, Niemietz P, Martin C, van Rooijen N, Ochando JC, Randolph GJ, Luedde T, Ginhoux F, Kurts C, Trautwein C, Tacke F.

Hepatology. 2015 Jul;62(1):279-91. doi: 10.1002/hep.27793. Epub 2015 Apr 22.

PMID:
25810240
50.

Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis.

Höchst B, Mikulec J, Baccega T, Metzger C, Welz M, Peusquens J, Tacke F, Knolle P, Kurts C, Diehl L, Ludwig-Portugall I.

PLoS One. 2015 Mar 4;10(3):e0119662. doi: 10.1371/journal.pone.0119662. eCollection 2015.

Supplemental Content

Support Center