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The role of platelets in mediating a response to human influenza infection.

Koupenova M, Corkrey HA, Vitseva O, Manni G, Pang CJ, Clancy L, Yao C, Rade J, Levy D, Wang JP, Finberg RW, Kurt-Jones EA, Freedman JE.

Nat Commun. 2019 Apr 16;10(1):1780. doi: 10.1038/s41467-019-09607-x.


A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection.

Bazzone LE, King M, MacKay CR, Kyawe PP, Meraner P, Lindstrom D, Rojas-Quintero J, Owen CA, Wang JP, Brass AL, Kurt-Jones EA, Finberg RW.

MBio. 2019 Feb 5;10(1). pii: e02734-18. doi: 10.1128/mBio.02734-18.


Micro RNAs from DNA Viruses are Found Widely in Plasma in a Large Observational Human Population.

Koupenova M, Mick E, Corkrey HA, Huan T, Clancy L, Shah R, Benjamin EJ, Levy D, Kurt-Jones EA, Tanriverdi K, Freedman JE.

Sci Rep. 2018 Apr 23;8(1):6397. doi: 10.1038/s41598-018-24765-6.


Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria.

Gallego-Marin C, Schrum JE, Andrade WA, Shaffer SA, Giraldo LF, Lasso AM, Kurt-Jones EA, Fitzgerald KA, Golenbock DT.

J Immunol. 2018 Jan 15;200(2):768-774. doi: 10.4049/jimmunol.1701048. Epub 2017 Dec 6.


Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease.

Kurt-Jones EA, Orzalli MH, Knipe DM.

Adv Anat Embryol Cell Biol. 2017;223:49-75. doi: 10.1007/978-3-319-53168-7_3. Review.


miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).

Kalantari P, Harandi OF, Agarwal S, Rus F, Kurt-Jones EA, Fitzgerald KA, Caffrey DR, Golenbock DT.

J Biol Chem. 2017 Apr 7;292(14):5634-5644. doi: 10.1074/jbc.M116.749325. Epub 2017 Feb 16.


Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.

Iracheta-Vellve A, Petrasek J, Gyongyosi B, Satishchandran A, Lowe P, Kodys K, Catalano D, Calenda CD, Kurt-Jones EA, Fitzgerald KA, Szabo G.

J Biol Chem. 2016 Dec 23;291(52):26794-26805. doi: 10.1074/jbc.M116.736991. Epub 2016 Nov 3.


Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production.

Andrade WA, Firon A, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Trieu-Cuot P, Golenbock DT, Kaminski PA.

Cell Host Microbe. 2016 Jul 13;20(1):49-59. doi: 10.1016/j.chom.2016.06.003.


Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.

Andrade WA, Agarwal S, Mo S, Shaffer SA, Dillard JP, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Golenbock DT.

Cell Rep. 2016 Jun 14;15(11):2438-48. doi: 10.1016/j.celrep.2016.05.030. Epub 2016 Jun 2.


Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2.

Schattgen SA, Gao G, Kurt-Jones EA, Fitzgerald KA.

J Immunol. 2016 Jan 1;196(1):29-33. doi: 10.4049/jimmunol.1501048. Epub 2015 Nov 20.


Virulence of Group A Streptococci Is Enhanced by Human Complement Inhibitors.

Ermert D, Shaughnessy J, Joeris T, Kaplan J, Pang CJ, Kurt-Jones EA, Rice PA, Ram S, Blom AM.

PLoS Pathog. 2015 Jul 22;11(7):e1005043. doi: 10.1371/journal.ppat.1005043. eCollection 2015 Jul.


Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.

Iracheta-Vellve A, Petrasek J, Satishchandran A, Gyongyosi B, Saha B, Kodys K, Fitzgerald KA, Kurt-Jones EA, Szabo G.

J Hepatol. 2015 Nov;63(5):1147-55. doi: 10.1016/j.jhep.2015.06.013. Epub 2015 Jun 20.


Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease.

Petrasek J, Iracheta-Vellve A, Saha B, Satishchandran A, Kodys K, Fitzgerald KA, Kurt-Jones EA, Szabo G.

J Leukoc Biol. 2015 Aug;98(2):249-56. doi: 10.1189/jlb.3AB1214-590R. Epub 2015 May 1.


Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment.

Zeldovich KB, Liu P, Renzette N, Foll M, Pham ST, Venev SV, Gallagher GR, Bolon DN, Kurt-Jones EA, Jensen JD, Caffrey DR, Schiffer CA, Kowalik TF, Wang JP, Finberg RW.

Mol Biol Evol. 2015 Jun;32(6):1519-32. doi: 10.1093/molbev/msv044. Epub 2015 Feb 23.


Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses.

Hendricks GL, Velazquez L, Pham S, Qaisar N, Delaney JC, Viswanathan K, Albers L, Comolli JC, Shriver Z, Knipe DM, Kurt-Jones EA, Fygenson DK, Trevejo JM, Wang JP, Finberg RW.

Antiviral Res. 2015 Apr;116:34-44. doi: 10.1016/j.antiviral.2015.01.008. Epub 2015 Jan 28.


Interferon γ-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses.

Thompson MR, Sharma S, Atianand M, Jensen SB, Carpenter S, Knipe DM, Fitzgerald KA, Kurt-Jones EA.

J Biol Chem. 2014 Aug 22;289(34):23568-81. doi: 10.1074/jbc.M114.554147. Epub 2014 Jul 7.


Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis.

Koupenova M, Vitseva O, MacKay CR, Beaulieu LM, Benjamin EJ, Mick E, Kurt-Jones EA, Ravid K, Freedman JE.

Blood. 2014 Jul 31;124(5):791-802. doi: 10.1182/blood-2013-11-536003. Epub 2014 Apr 22.


Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis.

Csak T, Pillai A, Ganz M, Lippai D, Petrasek J, Park JK, Kodys K, Dolganiuc A, Kurt-Jones EA, Szabo G.

Liver Int. 2014 Oct;34(9):1402-13. doi: 10.1111/liv.12537. Epub 2014 Apr 17.


Dicer's role as an antiviral: still an enigma.

MacKay CR, Wang JP, Kurt-Jones EA.

Curr Opin Immunol. 2014 Feb;26:49-55. doi: 10.1016/j.coi.2013.10.015. Epub 2013 Nov 22. Review.


Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro.

Renzette N, Caffrey DR, Zeldovich KB, Liu P, Gallagher GR, Aiello D, Porter AJ, Kurt-Jones EA, Bolon DN, Poh YP, Jensen JD, Schiffer CA, Kowalik TF, Finberg RW, Wang JP.

J Virol. 2014 Jan;88(1):272-81. doi: 10.1128/JVI.01067-13. Epub 2013 Oct 23.


STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.

Petrasek J, Iracheta-Vellve A, Csak T, Satishchandran A, Kodys K, Kurt-Jones EA, Fitzgerald KA, Szabo G.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16544-9. doi: 10.1073/pnas.1308331110. Epub 2013 Sep 19.


Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice.

Lippai D, Bala S, Csak T, Kurt-Jones EA, Szabo G.

PLoS One. 2013 Aug 9;8(8):e70945. doi: 10.1371/journal.pone.0070945. eCollection 2013.


Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation.

Lippai D, Bala S, Petrasek J, Csak T, Levin I, Kurt-Jones EA, Szabo G.

J Leukoc Biol. 2013 Jul;94(1):171-82. doi: 10.1189/jlb.1212659. Epub 2013 Apr 26.


Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation.

Vaine CA, Patel MK, Zhu J, Lee E, Finberg RW, Hayward RC, Kurt-Jones EA.

J Immunol. 2013 Apr 1;190(7):3525-32. doi: 10.4049/jimmunol.1200492. Epub 2013 Feb 20.


Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus.

Hendricks GL, Weirich KL, Viswanathan K, Li J, Shriver ZH, Ashour J, Ploegh HL, Kurt-Jones EA, Fygenson DK, Finberg RW, Comolli JC, Wang JP.

J Biol Chem. 2013 Mar 22;288(12):8061-73. doi: 10.1074/jbc.M112.437202. Epub 2013 Jan 28.


CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2.

Soberman RJ, MacKay CR, Vaine CA, Ryan GB, Cerny AM, Thompson MR, Nikolic B, Primo V, Christmas P, Sheiffele P, Aronov L, Knipe DM, Kurt-Jones EA.

PLoS One. 2012;7(10):e47740. doi: 10.1371/journal.pone.0047740. Epub 2012 Oct 17.


Methods for in vivo and in vitro analysis of innate immune responses to Helicobacter pylori infection.

Patel MK, Ryan GN, Cerny AM, Kurt-Jones EA.

Methods Mol Biol. 2012;921:209-25.


Innate immune responses to Helicobacter pylori infection: an overview.

Patel MK, Trombly MI, Kurt-Jones EA.

Methods Mol Biol. 2012;921:205-7. Review.


IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice.

Petrasek J, Bala S, Csak T, Lippai D, Kodys K, Menashy V, Barrieau M, Min SY, Kurt-Jones EA, Szabo G.

J Clin Invest. 2012 Oct;122(10):3476-89. doi: 10.1172/JCI60777. Epub 2012 Sep 4. Review.


Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.

Zhou S, Cerny AM, Fitzgerald KA, Kurt-Jones EA, Finberg RW.

J Virol. 2012 Oct;86(20):11254-65. Epub 2012 Aug 8.


Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection.

Wills-Karp M, Rani R, Dienger K, Lewkowich I, Fox JG, Perkins C, Lewis L, Finkelman FD, Smith DE, Bryce PJ, Kurt-Jones EA, Wang TC, Sivaprasad U, Hershey GK, Herbert DR.

J Exp Med. 2012 Mar 12;209(3):607-22. doi: 10.1084/jem.20110079. Epub 2012 Feb 13.


CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone.

Young JL, Mora A, Cerny A, Czech MP, Woda B, Kurt-Jones EA, Finberg RW, Corvera S.

PLoS One. 2012;7(1):e29688. doi: 10.1371/journal.pone.0029688. Epub 2012 Jan 13.


Role of specific innate immune responses in herpes simplex virus infection of the central nervous system.

Wang JP, Bowen GN, Zhou S, Cerny A, Zacharia A, Knipe DM, Finberg RW, Kurt-Jones EA.

J Virol. 2012 Feb;86(4):2273-81. doi: 10.1128/JVI.06010-11. Epub 2011 Dec 14.


C21orf91 genotypes correlate with herpes simplex labialis (cold sore) frequency: description of a cold sore susceptibility gene.

Kriesel JD, Jones BB, Matsunami N, Patel MK, St Pierre CA, Kurt-Jones EA, Finberg RW, Leppert M, Hobbs MR.

J Infect Dis. 2011 Dec 1;204(11):1654-62. doi: 10.1093/infdis/jir633.


Pattern recognition receptors and the innate immune response to viral infection.

Thompson MR, Kaminski JJ, Kurt-Jones EA, Fitzgerald KA.

Viruses. 2011 Jun;3(6):920-40. doi: 10.3390/v3060920. Epub 2011 Jun 23. Review.


Antibodies to cell surface proteins redirect intracellular trafficking pathways.

St Pierre CA, Leonard D, Corvera S, Kurt-Jones EA, Finberg RW.

Exp Mol Pathol. 2011 Dec;91(3):723-32. doi: 10.1016/j.yexmp.2011.05.011. Epub 2011 Jul 23.


Assembly and immunological properties of Newcastle disease virus-like particles containing the respiratory syncytial virus F and G proteins.

McGinnes LW, Gravel KA, Finberg RW, Kurt-Jones EA, Massare MJ, Smith G, Schmidt MR, Morrison TG.

J Virol. 2011 Jan;85(1):366-77. doi: 10.1128/JVI.01861-10. Epub 2010 Oct 27.


Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles.

St Pierre CA, Chan M, Iwakura Y, Ayers DC, Kurt-Jones EA, Finberg RW.

J Orthop Res. 2010 Nov;28(11):1418-24. doi: 10.1002/jor.21149. Erratum in: J Orthop Res. 2011 Jan;29(1):154.


UNC93B1 mediates host resistance to infection with Toxoplasma gondii.

Melo MB, Kasperkovitz P, Cerny A, Könen-Waisman S, Kurt-Jones EA, Lien E, Beutler B, Howard JC, Golenbock DT, Gazzinelli RT.

PLoS Pathog. 2010 Aug 26;6(8):e1001071. doi: 10.1371/journal.ppat.1001071.


Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice.

Petrasek J, Dolganiuc A, Csak T, Kurt-Jones EA, Szabo G.

Gastroenterology. 2011 Feb;140(2):697-708.e4. doi: 10.1053/j.gastro.2010.08.020. Epub 2010 Aug 19.


Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.

van Lint AL, Murawski MR, Goodbody RE, Severa M, Fitzgerald KA, Finberg RW, Knipe DM, Kurt-Jones EA.

J Virol. 2010 Oct;84(20):10802-11. doi: 10.1128/JVI.00063-10. Epub 2010 Aug 4.


Discovery of a novel TLR2 signaling inhibitor with anti-viral activity.

Zhou S, Cerny AM, Bowen G, Chan M, Knipe DM, Kurt-Jones EA, Finberg RW.

Antiviral Res. 2010 Sep;87(3):295-306. doi: 10.1016/j.antiviral.2010.06.011. Epub 2010 Jul 23.


Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus.

Zhou S, Cerny AM, Zacharia A, Fitzgerald KA, Kurt-Jones EA, Finberg RW.

J Virol. 2010 Sep;84(18):9452-62. doi: 10.1128/JVI.00155-10. Epub 2010 Jun 30.


Mutations in bone marrow-derived stromal stem cells unmask latent malignancy.

Houghton J, Li H, Fan X, Liu Y, Liu JH, Rao VP, Poutahidis T, Taylor CL, Jackson EA, Hewes C, Lyle S, Cerny A, Bowen G, Cerny J, Moore N, Kurt-Jones EA, Erdman SE.

Stem Cells Dev. 2010 Aug;19(8):1153-66. doi: 10.1089/scd.2009.0439.


Newcastle disease virus-like particles containing respiratory syncytial virus G protein induced protection in BALB/c mice, with no evidence of immunopathology.

Murawski MR, McGinnes LW, Finberg RW, Kurt-Jones EA, Massare MJ, Smith G, Heaton PM, Fraire AE, Morrison TG.

J Virol. 2010 Jan;84(2):1110-23. doi: 10.1128/JVI.01709-09. Epub 2009 Nov 4.


MDA5 and MAVS mediate type I interferon responses to coxsackie B virus.

Wang JP, Cerny A, Asher DR, Kurt-Jones EA, Bronson RT, Finberg RW.

J Virol. 2010 Jan;84(1):254-60. doi: 10.1128/JVI.00631-09.


MyD88 intrinsically regulates CD4 T-cell responses.

Zhou S, Kurt-Jones EA, Cerny AM, Chan M, Bronson RT, Finberg RW.

J Virol. 2009 Feb;83(4):1625-34. doi: 10.1128/JVI.01770-08. Epub 2008 Dec 3.


Respiratory syncytial virus activates innate immunity through Toll-like receptor 2.

Murawski MR, Bowen GN, Cerny AM, Anderson LJ, Haynes LM, Tripp RA, Kurt-Jones EA, Finberg RW.

J Virol. 2009 Feb;83(3):1492-500. doi: 10.1128/JVI.00671-08. Epub 2008 Nov 19.


Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.

Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, Betz KS, Penz-Oesterreicher M, Bjorkdahl O, Fox JG, Wang TC.

Cancer Cell. 2008 Nov 4;14(5):408-19. doi: 10.1016/j.ccr.2008.10.011. Erratum in: Cancer Cell. 2008 Dec 9;14(6):494. Cancer Cell. 2011 Jan 18;19(1):154.


Toll-like receptor-mediated activation of neutrophils by influenza A virus.

Wang JP, Bowen GN, Padden C, Cerny A, Finberg RW, Newburger PE, Kurt-Jones EA.

Blood. 2008 Sep 1;112(5):2028-34. doi: 10.1182/blood-2008-01-132860. Epub 2008 Jun 10.

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