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Items: 42

1.

Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases.

Mukherjee B, Tessaro F, Vahokoski J, Kursula I, Marq JB, Scapozza L, Soldati-Favre D.

EMBO J. 2018 Apr 3;37(7). pii: e98047. doi: 10.15252/embj.201798047. Epub 2018 Mar 8.

PMID:
29519896
2.

A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress.

Pino P, Caldelari R, Mukherjee B, Vahokoski J, Klages N, Maco B, Collins CR, Blackman MJ, Kursula I, Heussler V, Brochet M, Soldati-Favre D.

Science. 2017 Oct 27;358(6362):522-528. doi: 10.1126/science.aaf8675.

3.

Apicomplexan actin polymerization depends on nucleation.

Kumpula EP, Pires I, Lasiwa D, Piirainen H, Bergmann U, Vahokoski J, Kursula I.

Sci Rep. 2017 Sep 22;7(1):12137. doi: 10.1038/s41598-017-11330-w.

4.

Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability.

Pospich S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I, Raunser S.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10636-10641. doi: 10.1073/pnas.1707506114. Epub 2017 Sep 18.

5.

Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.

Green JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J, Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP, Moon RW, Molloy JE, Kursula I, Tewari R, Holder AA.

J Biol Chem. 2017 Oct 27;292(43):17857-17875. doi: 10.1074/jbc.M117.802769. Epub 2017 Sep 11.

6.

Rapid cadmium SAD phasing at the standard wavelength (1 Å).

Panneerselvam S, Kumpula EP, Kursula I, Burkhardt A, Meents A.

Acta Crystallogr D Struct Biol. 2017 Jul 1;73(Pt 7):581-590. doi: 10.1107/S2059798317006970. Epub 2017 Jun 30.

7.

A unique profilin-actin interface is important for malaria parasite motility.

Moreau CA, Bhargav SP, Kumar H, Quadt KA, Piirainen H, Strauss L, Kehrer J, Streichfuss M, Spatz JP, Wade RC, Kursula I, Frischknecht F.

PLoS Pathog. 2017 May 26;13(5):e1006412. doi: 10.1371/journal.ppat.1006412. eCollection 2017 May.

8.

Structural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPase.

Muruganandam G, Raasakka A, Myllykoski M, Kursula I, Kursula P.

BMC Biochem. 2017 May 16;18(1):7. doi: 10.1186/s12858-017-0084-2.

9.

An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion.

Jacot D, Tosetti N, Pires I, Stock J, Graindorge A, Hung YF, Han H, Tewari R, Kursula I, Soldati-Favre D.

Cell Host Microbe. 2016 Dec 14;20(6):731-743. doi: 10.1016/j.chom.2016.10.020.

10.

Structural and functional dissection of Toxoplasma gondii armadillo repeats only protein.

Mueller C, Samoo A, Hammoudi PM, Klages N, Kallio JP, Kursula I, Soldati-Favre D.

J Cell Sci. 2016 Mar 1;129(5):1031-45. doi: 10.1242/jcs.177386. Epub 2016 Jan 14.

11.

Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase.

Raasakka A, Myllykoski M, Laulumaa S, Lehtimäki M, Härtlein M, Moulin M, Kursula I, Kursula P.

Sci Rep. 2015 Nov 13;5:16520. doi: 10.1038/srep16520.

12.

Two independently folding units of Plasmodium profilin suggest evolution via gene fusion.

Bhargav SP, Vahokoski J, Kallio JP, Torda AE, Kursula P, Kursula I.

Cell Mol Life Sci. 2015 Nov;72(21):4193-203. doi: 10.1007/s00018-015-1932-0. Epub 2015 May 27.

PMID:
26012696
13.

Towards a molecular understanding of the apicomplexan actin motor: on a road to novel targets for malaria remedies?

Kumpula EP, Kursula I.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):500-13. doi: 10.1107/S2053230X1500391X. Epub 2015 Apr 16. Review.

14.

Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress.

Salamun J, Kallio JP, Daher W, Soldati-Favre D, Kursula I.

FASEB J. 2014 Nov;28(11):4729-47. doi: 10.1096/fj.14-252569. Epub 2014 Aug 11.

PMID:
25114175
15.

Structural differences explain diverse functions of Plasmodium actins.

Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Sidén-Kiamos I, Sachse C, Kursula I.

PLoS Pathog. 2014 Apr 17;10(4):e1004091. doi: 10.1371/journal.ppat.1004091. eCollection 2014 Apr.

16.

Recombinant production, purification and crystallization of the Toxoplasma gondii coronin WD40 domain.

Kallio JP, Kursula I.

Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):517-21. doi: 10.1107/S2053230X14005196. Epub 2014 Mar 25.

17.

Atomic resolution view into the structure-function relationships of the human myelin peripheral membrane protein P2.

Ruskamo S, Yadav RP, Sharma S, Lehtimäki M, Laulumaa S, Aggarwal S, Simons M, Bürck J, Ulrich AS, Juffer AH, Kursula I, Kursula P.

Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):165-76. doi: 10.1107/S1399004713027910. Epub 2013 Dec 31.

18.

Lipid membrane association of myelin proteins and peptide segments studied by oriented and synchrotron radiation circular dichroism spectroscopy.

Muruganandam G, Bürck J, Ulrich AS, Kursula I, Kursula P.

J Phys Chem B. 2013 Dec 5;117(48):14983-93. doi: 10.1021/jp4098588. Epub 2013 Nov 22.

PMID:
24236572
19.

Recombinant production, crystallization and preliminary structural characterization of Schistosoma japonicum profilin.

Vervaet N, Kallio JP, Meier S, Salmivaara E, Eberhardt M, Zhang S, Sun X, Wu Z, Kursula P, Kursula I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11):1264-7. doi: 10.1107/S174430911302647X. Epub 2013 Oct 30.

20.

Crystallization and preliminary structural characterization of the two actin isoforms of the malaria parasite.

Bhargav SP, Vahokoski J, Kumpula EP, Kursula I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Oct;69(Pt 10):1171-6. doi: 10.1107/S174430911302441X. Epub 2013 Sep 30.

21.

Iron binding at specific sites within the octameric HbpS protects streptomycetes from iron-mediated oxidative stress.

Wedderhoff I, Kursula I, Groves MR, Ortiz de Orué Lucana D.

PLoS One. 2013 Aug 27;8(8):e71579. doi: 10.1371/journal.pone.0071579. eCollection 2013.

22.

Crystallographic analysis of the reaction cycle of 2',3'-cyclic nucleotide 3'-phosphodiesterase, a unique member of the 2H phosphoesterase family.

Myllykoski M, Raasakka A, Lehtimäki M, Han H, Kursula I, Kursula P.

J Mol Biol. 2013 Nov 15;425(22):4307-22. doi: 10.1016/j.jmb.2013.06.012. Epub 2013 Jul 2.

PMID:
23831225
23.

Juxtanodin is an intrinsically disordered F-actin-binding protein.

Ruskamo S, Chukhlieb M, Vahokoski J, Bhargav SP, Liang F, Kursula I, Kursula P.

Sci Rep. 2012;2:899. doi: 10.1038/srep00899. Epub 2012 Nov 29.

24.

The N-terminal domain of the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase: direct molecular interaction with the calcium sensor calmodulin.

Myllykoski M, Itoh K, Kangas SM, Heape AM, Kang SU, Lubec G, Kursula I, Kursula P.

J Neurochem. 2012 Nov;123(4):515-24. doi: 10.1111/jnc.12000. Epub 2012 Sep 28.

25.

The lasso segment is required for functional dimerization of the Plasmodium formin 1 FH2 domain.

Ignatev A, Bhargav SP, Vahokoski J, Kursula P, Kursula I.

PLoS One. 2012;7(3):e33586. doi: 10.1371/journal.pone.0033586. Epub 2012 Mar 13.

26.

Characterization of the Duffy-Binding-Like Domain of Plasmodium falciparum Blood-Stage Antigen 332.

Nilsson S, Moll K, Angeletti D, Albrecht L, Kursula I, Jiang N, Sun X, Berzins K, Wahlgren M, Chen Q.

Malar Res Treat. 2011;2011:671439. doi: 10.4061/2011/671439. Epub 2011 Sep 19.

27.

Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite.

Singh BK, Sattler JM, Chatterjee M, Huttu J, Schüler H, Kursula I.

J Biol Chem. 2011 Aug 12;286(32):28256-64. doi: 10.1074/jbc.M111.211730.

28.

Structure of the dimeric autoinhibited conformation of DAPK2, a pro-apoptotic protein kinase.

Patel AK, Yadav RP, Majava V, Kursula I, Kursula P.

J Mol Biol. 2011 Jun 10;409(3):369-83. doi: 10.1016/j.jmb.2011.03.065. Epub 2011 Apr 8.

PMID:
21497605
29.

Crystallization and preliminary structural characterization of the two actin-depolymerization factors of the malaria parasite.

Huttu J, Singh BK, Bhargav SP, Sattler JM, Schüler H, Kursula I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt 5):583-7. doi: 10.1107/S1744309110011589. Epub 2010 Apr 30.

30.

Structural and functional characterization of human peripheral nervous system myelin protein P2.

Majava V, Polverini E, Mazzini A, Nanekar R, Knoll W, Peters J, Natali F, Baumgärtel P, Kursula I, Kursula P.

PLoS One. 2010 Apr 22;5(4):e10300. doi: 10.1371/journal.pone.0010300.

31.

Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII.

Wigren E, Bourhis JM, Kursula I, Guy JE, Lindqvist Y.

FEBS Lett. 2010 Mar 5;584(5):878-82. doi: 10.1016/j.febslet.2010.02.009. Epub 2010 Feb 9.

32.

Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum.

Kursula I, Kursula P, Ganter M, Panjikar S, Matuschewski K, Schüler H.

Structure. 2008 Nov 12;16(11):1638-48. doi: 10.1016/j.str.2008.09.008.

33.

High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP.

Kursula P, Kursula I, Massimi M, Song YH, Downer J, Stanley WA, Witke W, Wilmanns M.

J Mol Biol. 2008 Jan 4;375(1):270-90. Epub 2007 Oct 24.

PMID:
18001770
34.

Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning.

Sultana A, Alexeev I, Kursula I, Mäntsälä P, Niemi J, Schneider G.

Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):149-59. Epub 2007 Jan 16.

PMID:
17242508
35.

Crystal structure of non-fused glutathione S-transferase from Schistosoma japonicum in complex with glutathione.

Kursula I, Heape AM, Kursula P.

Protein Pept Lett. 2005 Oct;12(7):709-12.

PMID:
16522189
36.

Crystal structure of the PB1 domain of NBR1.

Müller S, Kursula I, Zou P, Wilmanns M.

FEBS Lett. 2006 Jan 9;580(1):341-4. Epub 2005 Dec 19.

37.

Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase.

Kursula I, Salin M, Sun J, Norledge BV, Haapalainen AM, Sampson NS, Wierenga RK.

Protein Eng Des Sel. 2004 Apr;17(4):375-82. Epub 2004 May 27.

PMID:
15166315
38.

Crystal structure of triosephosphate isomerase complexed with 2-phosphoglycolate at 0.83-A resolution.

Kursula I, Wierenga RK.

J Biol Chem. 2003 Mar 14;278(11):9544-51. Epub 2003 Jan 9.

39.
40.

Structural determinants for ligand binding and catalysis of triosephosphate isomerase.

Kursula I, Partanen S, Lambeir AM, Antonov DM, Augustyns K, Wierenga RK.

Eur J Biochem. 2001 Oct;268(19):5189-96.

41.

The ionization of a buried glutamic acid is thermodynamically linked to the stability of Leishmania mexicana triose phosphate isomerase.

Lambeir AM, Backmann J, Ruiz-Sanz J, Filimonov V, Nielsen JE, Kursula I, Norledge BV, Wierenga RK.

Eur J Biochem. 2000 May;267(9):2516-24.

42.

A neutralizing antibody against human DNA polymerase epsilon inhibits cellular but not SV40 DNA replication.

Pospiech H, Kursula I, Abdel-Aziz W, Malkas L, Uitto L, Kastelli M, Vihinen-Ranta M, Eskelinen S, Syväoja JE.

Nucleic Acids Res. 1999 Oct 1;27(19):3799-804.

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