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Items: 16


Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice.

Antoch MP, Wrobel M, Kuropatwinski KK, Gitlin I, Leonova KI, Toshkov I, Gleiberman AS, Hutson AD, Chernova OB, Gudkov AV.

Aging (Albany NY). 2017 Mar 19;9(3):615-626. doi: 10.18632/aging.101206.


Daily rhythms are retained both in spontaneously developed sarcomas and in xenografts grown in immunocompromised SCID mice.

Comas M, Kuropatwinski KK, Wrobel M, Toshkov I, Antoch MP.

Chronobiol Int. 2014 Oct;31(8):901-10. doi: 10.3109/07420528.2014.925469. Epub 2014 Jun 16.


Tissue-specific changes in molecular clocks during the transition from pregnancy to lactation in mice.

Casey TM, Crodian J, Erickson E, Kuropatwinski KK, Gleiberman AS, Antoch MP.

Biol Reprod. 2014 Jun;90(6):127. doi: 10.1095/biolreprod.113.116137. Epub 2014 Apr 23.


Deficiency in PER proteins has no effect on the rate of spontaneous and radiation-induced carcinogenesis.

Antoch MP, Toshkov I, Kuropatwinski KK, Jackson M.

Cell Cycle. 2013 Dec 1;12(23):3673-80. doi: 10.4161/cc.26614. Epub 2013 Oct 2.


New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis.

Comas M, Toshkov I, Kuropatwinski KK, Chernova OB, Polinsky A, Blagosklonny MV, Gudkov AV, Antoch MP.

Aging (Albany NY). 2012 Oct;4(10):715-22.


Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription.

Spengler ML, Kuropatwinski KK, Comas M, Gasparian AV, Fedtsova N, Gleiberman AS, Gitlin II, Artemicheva NM, Deluca KA, Gudkov AV, Antoch MP.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2457-65. doi: 10.1073/pnas.1206274109. Epub 2012 Aug 15.


Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1.

Hu Y, Spengler ML, Kuropatwinski KK, Comas-Soberats M, Jackson M, Chernov MV, Gleiberman AS, Fedtsova N, Rustum YM, Gudkov AV, Antoch MP.

Oncotarget. 2011 Dec;2(12):1279-90.


A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation.

Spengler ML, Kuropatwinski KK, Schumer M, Antoch MP.

Cell Cycle. 2009 Dec 15;8(24):4138-46. Epub 2009 Dec 8.


Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma.

Wang J, Rajput A, Kan JL, Rose R, Liu XQ, Kuropatwinski K, Hauser J, Beko A, Dominquez I, Sharratt EA, Brattain L, Levea C, Sun FL, Keane DM, Gibson NW, Brattain MG.

J Biol Chem. 2009 Apr 17;284(16):10912-22. doi: 10.1074/jbc.M809551200. Epub 2009 Feb 18.


Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells.

Wang J, Yang L, Yang J, Kuropatwinski K, Wang W, Liu XQ, Hauser J, Brattain MG.

Cancer Res. 2008 May 1;68(9):3152-60. doi: 10.1158/0008-5472.CAN-07-5348.


Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model.

Guo XN, Rajput A, Rose R, Hauser J, Beko A, Kuropatwinski K, LeVea C, Hoffman RM, Brattain MG, Wang J.

Cancer Res. 2007 Jun 15;67(12):5851-8.


Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.

Wang J, Kuropatwinski K, Hauser J, Rossi MR, Zhou Y, Conway A, Kan JL, Gibson NW, Willson JK, Cowell JK, Brattain MG.

Mol Cancer Ther. 2007 Mar;6(3):1143-50.


Leptin receptor action in hepatic cells.

Wang Y, Kuropatwinski KK, White DW, Hawley TS, Hawley RG, Tartaglia LA, Baumann H.

J Biol Chem. 1997 Jun 27;272(26):16216-23.


Influence of subunit combinations on signaling by receptors for oncostatin M, leukemia inhibitory factor, and interleukin-6.

Kuropatwinski KK, De Imus C, Gearing D, Baumann H, Mosley B.

J Biol Chem. 1997 Jun 13;272(24):15135-44.


Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization.

White DW, Kuropatwinski KK, Devos R, Baumann H, Tartaglia LA.

J Biol Chem. 1997 Feb 14;272(7):4065-71. Erratum in: J Biol Chem 1997 May 2;272(18):12248.

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