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Items: 1 to 50 of 65

1.

Mild maternal hyperglycemia in INS C93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring.

Renner S, Martins AS, Streckel E, Braun-Reichhart C, Backman M, Prehn C, Klymiuk N, Bähr A, Blutke A, Landbrecht-Schessl C, Wünsch A, Kessler B, Kurome M, Hinrichs A, Koopmans SJ, Krebs S, Kemter E, Rathkolb B, Nagashima H, Blum H, Ritzmann M, Wanke R, Aigner B, Adamski J, Hrabě de Angelis M, Wolf E.

Dis Model Mech. 2019 Aug 12;12(8). pii: dmm039156. doi: 10.1242/dmm.039156.

2.

Author Correction: Consistent success in life-supporting porcine cardiac xenotransplantation.

Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht JM.

Nature. 2019 Apr;568(7752):E7. doi: 10.1038/s41586-019-1108-4.

PMID:
30944481
3.

Consistent success in life-supporting porcine cardiac xenotransplantation.

Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht JM.

Nature. 2018 Dec;564(7736):430-433. doi: 10.1038/s41586-018-0765-z. Epub 2018 Dec 5. Erratum in: Nature. 2019 Apr;568(7752):E7.

PMID:
30518863
4.

Targeting αGal epitopes for multi-species embryo immunosurgery.

Kurome M, Baehr A, Simmet K, Jemiller EM, Egerer S, Dahlhoff M, Zakhartchenko V, Nagashima H, Klymiuk N, Kessler B, Wolf E.

Reprod Fertil Dev. 2019 Apr;31(4):820-826. doi: 10.1071/RD18120.

PMID:
30384878
5.

Early weaning completely eliminates porcine cytomegalovirus from a newly established pig donor facility for xenotransplantation.

Egerer S, Fiebig U, Kessler B, Zakhartchenko V, Kurome M, Reichart B, Kupatt C, Klymiuk N, Wolf E, Denner J, Bähr A.

Xenotransplantation. 2018 Jul;25(4):e12449. doi: 10.1111/xen.12449.

PMID:
30264883
6.

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.

Hinrichs A, Kessler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, de Angelis MH, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M, Wolf E.

Mol Metab. 2018 May;11:113-128. doi: 10.1016/j.molmet.2018.03.006. Epub 2018 Mar 15.

7.

Strong xenoprotective function by single-copy transgenes placed sequentially at a permissive locus.

Rieblinger B, Fischer K, Kind A, Saller BS, Baars W, Schuster M, Wolf-van Buerck L, Schäffler A, Flisikowska T, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Wolf E, Seissler J, Schwinzer R, Schnieke A.

Xenotransplantation. 2018 Mar;25(2):e12382. doi: 10.1111/xen.12382. Epub 2018 Jan 23.

PMID:
29359453
8.

Modeling lethal X-linked genetic disorders in pigs with ensured fertility.

Matsunari H, Watanabe M, Nakano K, Enosawa S, Umeyama K, Uchikura A, Yashima S, Fukuda T, Klymiuk N, Kurome M, Kessler B, Wuensch A, Zakhartchenko V, Wolf E, Hanazono Y, Nagaya M, Umezawa A, Nakauchi H, Nagashima H.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):708-713. doi: 10.1073/pnas.1715940115. Epub 2018 Jan 8.

9.

The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.

Blutke A, Renner S, Flenkenthaler F, Backman M, Haesner S, Kemter E, Ländström E, Braun-Reichhart C, Albl B, Streckel E, Rathkolb B, Prehn C, Palladini A, Grzybek M, Krebs S, Bauersachs S, Bähr A, Brühschwein A, Deeg CA, De Monte E, Dmochewitz M, Eberle C, Emrich D, Fux R, Groth F, Gumbert S, Heitmann A, Hinrichs A, Keßler B, Kurome M, Leipig-Rudolph M, Matiasek K, Öztürk H, Otzdorff C, Reichenbach M, Reichenbach HD, Rieger A, Rieseberg B, Rosati M, Saucedo MN, Schleicher A, Schneider MR, Simmet K, Steinmetz J, Übel N, Zehetmaier P, Jung A, Adamski J, Coskun Ü, Hrabě de Angelis M, Simmet C, Ritzmann M, Meyer-Lindenberg A, Blum H, Arnold GJ, Fröhlich T, Wanke R, Wolf E.

Mol Metab. 2017 Jun 13;6(8):931-940. doi: 10.1016/j.molmet.2017.06.004. eCollection 2017 Aug.

10.

INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters.

Kemter E, Cohrs CM, Schäfer M, Schuster M, Steinmeyer K, Wolf-van Buerck L, Wolf A, Wuensch A, Kurome M, Kessler B, Zakhartchenko V, Loehn M, Ivashchenko Y, Seissler J, Schulte AM, Speier S, Wolf E.

Diabetologia. 2017 Jun;60(6):1152-1156. doi: 10.1007/s00125-017-4250-2. Epub 2017 Mar 18. No abstract available.

PMID:
28315950
11.

Direct introduction of gene constructs into the pronucleus-like structure of cloned embryos: a new strategy for the generation of genetically modified pigs.

Kurome M, Leuchs S, Kessler B, Kemter E, Jemiller EM, Foerster B, Klymiuk N, Zakhartchenko V, Wolf E.

Transgenic Res. 2017 Apr;26(2):309-318. doi: 10.1007/s11248-016-0004-z. Epub 2016 Dec 10.

PMID:
27943082
12.

Efficient production of multi-modified pigs for xenotransplantation by 'combineering', gene stacking and gene editing.

Fischer K, Kraner-Scheiber S, Petersen B, Rieblinger B, Buermann A, Flisikowska T, Flisikowski K, Christan S, Edlinger M, Baars W, Kurome M, Zakhartchenko V, Kessler B, Plotzki E, Szczerbal I, Switonski M, Denner J, Wolf E, Schwinzer R, Niemann H, Kind A, Schnieke A.

Sci Rep. 2016 Jun 29;6:29081. doi: 10.1038/srep29081.

13.

Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs.

Bähr A, Käser T, Kemter E, Gerner W, Kurome M, Baars W, Herbach N, Witter K, Wünsch A, Talker SC, Kessler B, Nagashima H, Saalmüller A, Schwinzer R, Wolf E, Klymiuk N.

PLoS One. 2016 May 13;11(5):e0155676. doi: 10.1371/journal.pone.0155676. eCollection 2016.

14.

Viable pigs with a conditionally-activated oncogenic KRAS mutation.

Li S, Edlinger M, Saalfrank A, Flisikowski K, Tschukes A, Kurome M, Zakhartchenko V, Kessler B, Saur D, Kind A, Wolf E, Schnieke A, Flisikowska T.

Transgenic Res. 2015 Jun;24(3):509-17. doi: 10.1007/s11248-015-9866-8. Epub 2015 Feb 26.

PMID:
25716163
15.

Nuclear transfer and transgenesis in the pig.

Kurome M, Kessler B, Wuensch A, Nagashima H, Wolf E.

Methods Mol Biol. 2015;1222:37-59. doi: 10.1007/978-1-4939-1594-1_4.

PMID:
25287337
16.

Dual fluorescent reporter pig for Cre recombination: transgene placement at the ROSA26 locus.

Li S, Flisikowska T, Kurome M, Zakhartchenko V, Kessler B, Saur D, Kind A, Wolf E, Flisikowski K, Schnieke A.

PLoS One. 2014 Jul 15;9(7):e102455. doi: 10.1371/journal.pone.0102455. eCollection 2014.

17.

Homologous recombination contributes to the repair of zinc-finger-nuclease induced double strand breaks in pig primary cells and facilitates recombination with exogenous DNA.

Klymiuk N, Fezert P, Wünsch A, Kurome M, Kessler B, Wolf E.

J Biotechnol. 2014 May 10;177:74-81. doi: 10.1016/j.jbiotec.2014.01.018. Epub 2014 Mar 5.

PMID:
24613297
18.

Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs.

Wuensch A, Baehr A, Bongoni AK, Kemter E, Blutke A, Baars W, Haertle S, Zakhartchenko V, Kurome M, Kessler B, Faber C, Abicht JM, Reichart B, Wanke R, Schwinzer R, Nagashima H, Rieben R, Ayares D, Wolf E, Klymiuk N.

Transplantation. 2014 Jan 27;97(2):138-47. doi: 10.1097/TP.0b013e3182a95cbc.

19.

Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle.

Klymiuk N, Blutke A, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, Kemter E, Nagashima H, Schoser B, Herbach N, Blum H, Wanke R, Aartsma-Rus A, Thirion C, Lochmüller H, Walter MC, Wolf E.

Hum Mol Genet. 2013 Nov 1;22(21):4368-82. doi: 10.1093/hmg/ddt287. Epub 2013 Jun 19.

PMID:
23784375
20.

Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set.

Kurome M, Geistlinger L, Kessler B, Zakhartchenko V, Klymiuk N, Wuensch A, Richter A, Baehr A, Kraehe K, Burkhardt K, Flisikowski K, Flisikowska T, Merkl C, Landmann M, Durkovic M, Tschukes A, Kraner S, Schindelhauer D, Petri T, Kind A, Nagashima H, Schnieke A, Zimmer R, Wolf E.

BMC Biotechnol. 2013 May 20;13:43. doi: 10.1186/1472-6750-13-43.

21.

Permanent neonatal diabetes in INS(C94Y) transgenic pigs.

Renner S, Braun-Reichhart C, Blutke A, Herbach N, Emrich D, Streckel E, Wünsch A, Kessler B, Kurome M, Bähr A, Klymiuk N, Krebs S, Puk O, Nagashima H, Graw J, Blum H, Wanke R, Wolf E.

Diabetes. 2013 May;62(5):1505-11. doi: 10.2337/db12-1065. Epub 2012 Dec 28.

22.

Potential of primary kidney cells for somatic cell nuclear transfer mediated transgenesis in pig.

Richter A, Kurome M, Kessler B, Zakhartchenko V, Klymiuk N, Nagashima H, Wolf E, Wuensch A.

BMC Biotechnol. 2012 Nov 9;12:84. doi: 10.1186/1472-6750-12-84.

23.

Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs.

Leuchs S, Saalfrank A, Merkl C, Flisikowska T, Edlinger M, Durkovic M, Rezaei N, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Kind A, Wolf E, Schnieke A.

PLoS One. 2012;7(10):e43323. doi: 10.1371/journal.pone.0043323. Epub 2012 Oct 5.

24.

A porcine model of familial adenomatous polyposis.

Flisikowska T, Merkl C, Landmann M, Eser S, Rezaei N, Cui X, Kurome M, Zakhartchenko V, Kessler B, Wieland H, Rottmann O, Schmid RM, Schneider G, Kind A, Wolf E, Saur D, Schnieke A.

Gastroenterology. 2012 Nov;143(5):1173-1175.e7. doi: 10.1053/j.gastro.2012.07.110. Epub 2012 Aug 1.

PMID:
22864254
25.

Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice.

Klymiuk N, van Buerck L, Bähr A, Offers M, Kessler B, Wuensch A, Kurome M, Thormann M, Lochner K, Nagashima H, Herbach N, Wanke R, Seissler J, Wolf E.

Diabetes. 2012 Jun;61(6):1527-32. doi: 10.2337/db11-1325. Epub 2012 Apr 20.

26.

Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses.

Kemter E, Lieke T, Kessler B, Kurome M, Wuensch A, Summerfield A, Ayares D, Nagashima H, Baars W, Schwinzer R, Wolf E.

Xenotransplantation. 2012 Jan-Feb;19(1):40-51. doi: 10.1111/j.1399-3089.2011.00688.x.

PMID:
22360752
27.

Characterization of the ICSI-mediated gene transfer method in the production of transgenic pigs.

Umeyama K, Saito H, Kurome M, Matsunari H, Watanabe M, Nakauchi H, Nagashima H.

Mol Reprod Dev. 2012 Mar;79(3):218-28. doi: 10.1002/mrd.22015. Epub 2011 Dec 29.

PMID:
22213433
28.

Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis.

Klymiuk N, Mundhenk L, Kraehe K, Wuensch A, Plog S, Emrich D, Langenmayer MC, Stehr M, Holzinger A, Kröner C, Richter A, Kessler B, Kurome M, Eddicks M, Nagashima H, Heinritzi K, Gruber AD, Wolf E.

J Mol Med (Berl). 2012 May;90(5):597-608. doi: 10.1007/s00109-011-0839-y. Epub 2011 Dec 15.

PMID:
22170306
29.

First inducible transgene expression in porcine large animal models.

Klymiuk N, Böcker W, Schönitzer V, Bähr A, Radic T, Fröhlich T, Wünsch A, Keßler B, Kurome M, Schilling E, Herbach N, Wanke R, Nagashima H, Mutschler W, Arnold GJ, Schwinzer R, Schieker M, Wolf E.

FASEB J. 2012 Mar;26(3):1086-99. doi: 10.1096/fj.11-185041. Epub 2011 Dec 1.

PMID:
22138035
30.

The creation of transgenic pigs expressing human proteins using BAC-derived, full-length genes and intracytoplasmic sperm injection-mediated gene transfer.

Watanabe M, Kurome M, Matsunari H, Nakano K, Umeyema K, Shiota A, Nakauchi H, Nagashima H.

Transgenic Res. 2012 Jun;21(3):605-18. doi: 10.1007/s11248-011-9561-3. Epub 2011 Oct 25.

PMID:
22038447
31.

[Cerebral sinus thrombosis complicating ulcerative colitis].

Nakarai A, Ohe H, Uchida D, Numata N, Kominami Y, Matsushita H, Nanba S, Ota S, Ogawa T, Kurome M, Ueki T, Nakagawa M, Araki Y, Mizuno M.

Nihon Shokakibyo Gakkai Zasshi. 2011 Mar;108(3):451-7. Japanese.

PMID:
21389667
32.

[Dynamic computed tomography is useful for the diagnosis and colonoscopic treatment of colonic diverticular bleeding].

Kominami Y, Ohe H, Kobayashi S, Uchida D, Numata N, Matsushita H, Morimoto Y, Nakarai A, Nanba S, Ohta S, Ogawa T, Kurome M, Ueki T, Nakagawa M, Araki Y, Mizuno M.

Nihon Shokakibyo Gakkai Zasshi. 2011 Feb;108(2):223-30. Japanese.

PMID:
21307626
33.

Cloned porcine embryos can maintain developmental ability after cryopreservation at the morula stage.

Nakano K, Matsunari H, Nakayama N, Ogawa B, Kurome M, Takahashi M, Matsumoto M, Murakami H, Kaji Y, Nagashima H.

J Reprod Dev. 2011 Apr;57(2):312-6. Epub 2011 Jan 14.

34.

[A case of gangliocytic paraganglioma with lymphoid metastasis].

Uchida D, Ogawa T, Ueki T, Kominami Y, Numata N, Matsusita H, Morimoto Y, Nakarai A, Ota S, Nanba S, Takada S, Iwado S, Kurome M, Ohe H, Okamoto R, Uematsu S, Nakagawa M, Ishida K, Araki Y, Mizuno M.

Nihon Shokakibyo Gakkai Zasshi. 2010 Sep;107(9):1456-65. Review. Japanese.

PMID:
20827042
35.

Carbon dioxide insufflation is useful for obtaining clear images of the bile duct during peroral cholangioscopy (with video).

Ueki T, Mizuno M, Ota S, Ogawa T, Matsushita H, Uchida D, Numata N, Ueda A, Morimoto Y, Kominami Y, Nanba S, Kurome M, Ohe H, Nakagawa M, Araki Y.

Gastrointest Endosc. 2010 May;71(6):1046-51. doi: 10.1016/j.gie.2010.01.015.

PMID:
20438891
36.

Transgenic pigs as models for translational biomedical research.

Aigner B, Renner S, Kessler B, Klymiuk N, Kurome M, Wünsch A, Wolf E.

J Mol Med (Berl). 2010 Jul;88(7):653-64. doi: 10.1007/s00109-010-0610-9. Epub 2010 Mar 26. Review.

PMID:
20339830
37.

Gender-dependent differences in the incidence of ochratoxin A-induced neural tube defects in the Pdn/Pdn mouse.

Ueta E, Kodama M, Sumino Y, Kurome M, Ohta K, Katagiri R, Naruse I.

Congenit Anom (Kyoto). 2010 Mar;50(1):29-39. doi: 10.1111/j.1741-4520.2009.00255.x.

PMID:
20201966
38.

Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs.

Umeyama K, Watanabe M, Saito H, Kurome M, Tohi S, Matsunari H, Miki K, Nagashima H.

Transgenic Res. 2009 Oct;18(5):697-706. doi: 10.1007/s11248-009-9262-3. Epub 2009 Apr 9.

PMID:
19357985
39.

Production of cloned pigs by nuclear transfer of preadipocytes following cell cycle synchronization by differentiation induction.

Tomii R, Kurome M, Wako N, Ochiai T, Matsunari H, Kano K, Nagashima H.

J Reprod Dev. 2009 Apr;55(2):121-7. Epub 2008 Dec 24.

40.

Transgenic-cloned pigs systemically expressing red fluorescent protein, Kusabira-Orange.

Matsunari H, Onodera M, Tada N, Mochizuki H, Karasawa S, Haruyama E, Nakayama N, Saito H, Ueno S, Kurome M, Miyawaki A, Nagashima H.

Cloning Stem Cells. 2008 Sep;10(3):313-23. doi: 10.1089/clo.2008.0024.

PMID:
18729767
41.

Production efficiency and telomere length of the cloned pigs following serial somatic cell nuclear transfer.

Kurome M, Hisatomi H, Matsumoto S, Tomii R, Ueno S, Hiruma K, Saito H, Nakamura K, Okumura K, Matsumoto M, Kaji Y, Endo F, Nagashima H.

J Reprod Dev. 2008 Aug;54(4):254-8. Epub 2008 May 19.

42.

[Case of pseudoaneurysm ruptured into gallbladder and successfully treated with arterial embolization].

Miyahara K, Ueki T, Mizuno M, Kobayashi S, Kajikawa N, Iwado S, Kurome M, Ohe H, Uematsu S, Okamoto R, Shiraga K, Nakagawa M, Nouso K, Araki Y, Urashima M.

Nihon Shokakibyo Gakkai Zasshi. 2008 May;105(5):699-704. Japanese.

PMID:
18460859
43.

Altered signaling pathway in the dysmorphogenesis of telencephalon in the Gli3 depressed mouse embryo, Pdn/Pdn.

Ueta E, Kurome M, Teshima Y, Kodama M, Otsuka Y, Naruse I.

Congenit Anom (Kyoto). 2008 Jun;48(2):74-80. doi: 10.1111/j.1741-4520.2008.00182.x.

PMID:
18452488
44.

Production of cloned pigs from salivary gland-derived progenitor cells.

Kurome M, Tomii R, Ueno S, Hiruma K, Matsumoto S, Okumura K, Nakamura K, Matsumoto M, Kaji Y, Endo F, Nagashima H.

Cloning Stem Cells. 2008 Jun;10(2):277-86. doi: 10.1089/clo.2007.0074.

PMID:
18373475
45.

Production of transgenic and non-transgenic clones in miniature pigs by somatic cell nuclear transfer.

Kurome M, Ishikawa T, Tomii R, Ueno S, Shimada A, Yazawa H, Nagashima H.

J Reprod Dev. 2008 Jun;54(3):156-63. Epub 2008 Feb 25.

46.

Risk factors for high-grade dysplasia or carcinoma in colorectal adenoma cases treated with endoscopic polypectomy.

Kurome M, Kato J, Nawa T, Fujimoto T, Yamamoto H, Shiode J, Wato M, Kuwaki K, Okada H, Sakaguchi K, Shiratori Y.

Eur J Gastroenterol Hepatol. 2008 Feb;20(2):111-7. doi: 10.1097/MEG.0b013e3282f1cbef.

PMID:
18188030
47.

Effects of recloning on the efficiency of production of alpha 1,3-galactosyltransferase knockout pigs.

Fujimura T, Murakami H, Kurome M, Takahagi Y, Shigehisa T, Nagashima H.

J Reprod Dev. 2008 Feb;54(1):58-62. Epub 2007 Dec 18.

48.

Effects of sperm pretreatment on efficiency of ICSI-mediated gene transfer in pigs.

Kurome M, Saito H, Tomii R, Ueno S, Hiruma K, Nagashima H.

J Reprod Dev. 2007 Dec;53(6):1217-26. Epub 2007 Oct 15.

49.

Prevention of ochratoxin A-induced neural tube defects by folic acid in the genetic polydactyly/arhinencephaly mouse, Pdn/Pdn.

Katagiri R, Kurome M, Teshima Y, Ueta E, Naruse I.

Congenit Anom (Kyoto). 2007 Sep;47(3):90-6.

PMID:
17688467
50.

Association between embryonic loss and damage to the zona pellucida by invasive micromanipulation during oviductal transfer of early-stage embryos in pigs.

Ueno S, Kurome M, Tomii R, Hiruma K, Saitoh H, Nagashima H.

J Reprod Dev. 2007 Oct;53(5):1113-8. Epub 2007 Jun 29.

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