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Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence.

Maxwell JH, Kumar B, Feng FY, Worden FP, Lee JS, Eisbruch A, Wolf GT, Prince ME, Moyer JS, Teknos TN, Chepeha DB, McHugh JB, Urba SG, Stoerker J, Walline HM, Kurnit DM, Cordell KG, Davis SJ, Ward PD, Bradford CR, Carey TE.

Clin Cancer Res. 2010 Feb 15;16(4):1226-35. doi: 10.1158/1078-0432.CCR-09-2350. Epub 2010 Feb 9.


Development and evaluation of a PCR and mass spectroscopy (PCR-MS)-based method for quantitative, type-specific detection of human papillomavirus.

Patel DA, Shih YJ, Newton DW, Michael CW, Oeth PA, Kane MD, Opipari AW, Ruffin MT 4th, Kalikin LM, Kurnit DM.

J Virol Methods. 2009 Sep;160(1-2):78-84. doi: 10.1016/j.jviromet.2009.04.024. Epub 2009 May 3.


Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number.

Worden FP, Kumar B, Lee JS, Wolf GT, Cordell KG, Taylor JM, Urba SG, Eisbruch A, Teknos TN, Chepeha DB, Prince ME, Tsien CI, D'Silva NJ, Yang K, Kurnit DM, Mason HL, Miller TH, Wallace NE, Bradford CR, Carey TE.

J Clin Oncol. 2008 Jul 1;26(19):3138-46. doi: 10.1200/JCO.2007.12.7597. Epub 2008 May 12.


EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer.

Kumar B, Cordell KG, Lee JS, Worden FP, Prince ME, Tran HH, Wolf GT, Urba SG, Chepeha DB, Teknos TN, Eisbruch A, Tsien CI, Taylor JM, D'Silva NJ, Yang K, Kurnit DM, Bauer JA, Bradford CR, Carey TE.

J Clin Oncol. 2008 Jul 1;26(19):3128-37. doi: 10.1200/JCO.2007.12.7662. Epub 2008 May 12.


Recombination-based assay (RBA) for screening bacteriophage lambda libraries.

Kurnit DM.

Curr Protoc Mol Biol. 2001 May;Chapter 6:Unit6.12. doi: 10.1002/0471142727.mb0612s27.


Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor, gender, and smoking.

Kumar B, Cordell KG, Lee JS, Prince ME, Tran HH, Wolf GT, Urba SG, Worden FP, Chepeha DB, Teknos TN, Eisbruch A, Tsien CI, Taylor JM, D'Silva NJ, Yang K, Kurnit DM, Bradford CR, Carey TE.

Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S109-11.


Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies.

Yang H, Yang K, Khafagi A, Tang Y, Carey TE, Opipari AW, Lieberman R, Oeth PA, Lancaster W, Klinger HP, Kaseb AO, Metwally A, Khaled H, Kurnit DM.

Proc Natl Acad Sci U S A. 2005 May 24;102(21):7683-8.


Overexpression of cyclin D1 correlates with sensitivity to cisplatin in squamous cell carcinoma cell lines of the head and neck.

Akervall J, Kurnit DM, Adams M, Zhu S, Fisher SG, Bradford CR, Carey TE.

Acta Otolaryngol. 2004 Sep;124(7):851-7.


Study of dosage compensation in Drosophila.

Chiang PW, Kurnit DM.

Genetics. 2003 Nov;165(3):1167-81.


Rapid response of cardiac obscurin gene cluster to aortic stenosis: differential activation of Rho-GEF and MLCK and involvement in hypertrophic growth.

Borisov AB, Raeker MO, Kontrogianni-Konstantopoulos A, Yang K, Kurnit DM, Bloch RJ, Russell MW.

Biochem Biophys Res Commun. 2003 Oct 24;310(3):910-8.


Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form.

Mitra RS, Zhang Z, Henson BS, Kurnit DM, Carey TE, D'Silva NJ.

Oncogene. 2003 Sep 18;22(40):6243-56.


Rap1, a small GTP-binding protein is upregulated during arrest of proliferation in human keratinocytes.

D'Silva NJ, Mitra RS, Zhang Z, Kurnit DM, Babcock CR, Polverini PJ, Carey TE.

J Cell Physiol. 2003 Sep;196(3):532-40.


The gene ratios c-MYC:cyclin-dependent kinase (CDK)N2A and CCND1:CDKN2A correlate with poor prognosis in squamous cell carcinoma of the head and neck.

Akervall J, Bockmühl U, Petersen I, Yang K, Carey TE, Kurnit DM.

Clin Cancer Res. 2003 May;9(5):1750-5.


Food deprivation-induced expression of minoxidil sulfotransferase in the hypothalamus uncovered by microarray analysis.

Li JY, Lescure PA, Misek DE, Lai YM, Chai BX, Kuick R, Thompson RC, Demo RM, Kurnit DM, Michailidis G, Hanash SM, Gantz I.

J Biol Chem. 2002 Mar 15;277(11):9069-76. Epub 2002 Jan 8.


Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.

Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ.

Cell. 2001 Dec 28;107(7):893-903.


Matroshka and ectopic polymorphisms: Two new classes of DNA sequence variation identified at the Van der Woude syndrome locus on 1q32-q41.

Watanabe Y, Murray JC, Bjork BC, Bird CP, Chiang PW, Gregory SG, Kurnit DM, Schutte BC.

Hum Mutat. 2001 Nov;18(5):422-34.


Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis.

Rickman DS, Bobek MP, Misek DE, Kuick R, Blaivas M, Kurnit DM, Taylor J, Hanash SM.

Cancer Res. 2001 Sep 15;61(18):6885-91.


Down syndrome congenital heart disease: a narrowed region and a candidate gene.

Barlow GM, Chen XN, Shi ZY, Lyons GE, Kurnit DM, Celle L, Spinner NB, Zackai E, Pettenati MJ, Van Riper AJ, Vekemans MJ, Mjaatvedt CH, Korenberg JR.

Genet Med. 2001 Mar-Apr;3(2):91-101.


The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas.

Rickman DS, Tyagi R, Zhu XX, Bobek MP, Song S, Blaivas M, Misek DE, Israel MA, Kurnit DM, Ross DA, Kish PE, Hanash SM.

Cancer Res. 2001 Mar 1;61(5):2162-8.


Molecular analysis of urine sediment for follow-up of urinary tract cancers.

Chiang PW, Schneider A, Borgnat S, Gaub MP, Oudet P, Kurnit DM, Jacqmin D.

J Natl Cancer Inst. 2000 Nov 1;92(21):1779-80. No abstract available.


A fluorescent quantitative PCR approach to map gene deletions in the Drosophila genome.

Chiang PW, Wei WL, Gibson K, Bodmer R, Kurnit DM.

Genetics. 1999 Nov;153(3):1313-6.


Detection of erbB-2 amplifications in tumors and sera from esophageal carcinoma patients.

Chiang PW, Beer DG, Wei WL, Orringer MB, Kurnit DM.

Clin Cancer Res. 1999 Jun;5(6):1381-6.


A comparison between microsatellite and quantitative PCR analyses to detect frequent p16 copy number changes in primary bladder tumors.

Cairns JP, Chiang PW, Ramamoorthy S, Kurnit DM, Sidransky D.

Clin Cancer Res. 1998 Feb;4(2):441-4.


Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13.

Nothwang HG, Strahm B, Denich D, Kübler M, Schwabe J, Gingrich JC, Jauch A, Cox A, Nicklin MJ, Kurnit DM, Hildebrandt F.

Genomics. 1997 May 1;41(3):370-8.


Multiple independent molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins.

Richard I, Brenguier L, Dinçer P, Roudaut C, Bady B, Burgunder JM, Chemaly R, Garcia CA, Halaby G, Jackson CE, Kurnit DM, Lefranc G, Legum C, Loiselet J, Merlini L, Nivelon-Chevallier A, Ollagnon-Roman E, Restagno G, Topaloglu H, Beckmann JS.

Am J Hum Genet. 1997 May;60(5):1128-38.


The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers.

Song WJ, Chung SH, Kurnit DM.

Biochem Biophys Res Commun. 1997 Feb 24;231(3):640-4.


Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5.

Chiang PW, Fogel E, Jackson CL, Lieuallen K, Lennon G, Qu X, Wang SQ, Kurnit DM.

Genomics. 1996 Dec 15;38(3):421-4.


Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region".

Song WJ, Sternberg LR, Kasten-Sportès C, Keuren ML, Chung SH, Slack AC, Miller DE, Glover TW, Chiang PW, Lou L, Kurnit DM.

Genomics. 1996 Dec 15;38(3):331-9.


Use of a fluorescent-PCR reaction to detect genomic sequence copy number and transcriptional abundance.

Chiang PW, Song WJ, Wu KY, Korenberg JR, Fogel EJ, Van Keuren ML, Lashkari D, Kurnit DM.

Genome Res. 1996 Oct;6(10):1013-26.


Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene.

Chiang PW, Wang SQ, Smithivas P, Song WJ, Crombez E, Akhtar A, Im R, Greenfield J, Ramamoorthy S, Van Keuren M, Blackburn CC, Tsai CH, Kurnit DM.

Genomics. 1996 Jun 15;34(3):368-75.


Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h.

Chiang PW, Wang S, Smithivas P, Song WJ, Ramamoorthy S, Hillman J, Puett S, Van Keuren ML, Crombez E, Kumar A, Glover TW, Miller DE, Tsai CH, Blackburn CC, Chen XN, Sun Z, Cheng JF, Korenberg JR, Kurnit DM.

Genomics. 1996 Jun 15;34(3):328-33.


Linkage mapping of murine homolog of the yeast SPT6 gene to MMU11B1.

Chiang PW, Baldacci PA, Babinet C, Camper SA, Watkins-Chow D, Baker DD, Tsai CH, Ramamoorthy S, King E, Slack AC, Fogel E, Morahan G, Ashworth A, Blackburn CC, Kurnit DM.

Mamm Genome. 1996 Jun;7(6):459-60. No abstract available.


Assignment of the human slow twitch skeletal muscle/cardiac troponin C gene (TNNC1) to human chromosome 3p21.3-->3p14.3 using somatic cell hybrids.

Song WJ, Van Keuren ML, Drabkin HA, Cypser JR, Gemmill RM, Kurnit DM.

Cytogenet Cell Genet. 1996;75(1):36-7. No abstract available.


Expressed sequence tags from the long arm of human chromosome 21.

Chiang PW, Dzida G, Grumet J, Cheng JF, Song WJ, Crombez E, Van Keuren ML, Kurnit DM.

Genomics. 1995 Sep 20;29(2):383-9.


Rapid PCR-based method to directionally pull out longer cDNA fragments from cDNA libraries.

Chiang PW, Trbusek M, Osemlak-Hanzlik M, Kurnit DM.

Biotechniques. 1995 Jan;18(1):36, 38, 40. No abstract available.


Transcription patterns of sequences on human chromosome 21.

Kurnit DM, Cheng J, Zhu Y, Van Keuren ML, Jiang Y, Pan Y, Whitley K, Crombez E.

Cytogenet Cell Genet. 1995;71(2):203-6.


Construction of human embryonic cDNA libraries: HD, PKD1 and BRCA1 are transcribed widely during embryogenesis.

Buraczynska MJ, Van Keuren ML, Buraczynska KM, Chang YS, Crombez E, Kurnit DM.

Cytogenet Cell Genet. 1995;71(2):197-202.


Expression of the IV (reversed and/or heterotaxic) phenotype in SWV mice.

Layton WM, Layton MW, Binder M, Kurnit DM, Hanzlik AJ, Van Keuren M, Biddle FG.

Teratology. 1993 Jun;47(6):595-602.


A recombination-based assay demonstrates that the fragile X sequence is transcribed widely during development.

Hanzlik AJ, Osemlak-Hanzlik MM, Hauser MA, Kurnit DM.

Nat Genet. 1993 Jan;3(1):44-8.


Efficient large-scale sequencing of the Escherichia coli genome: implementation of a transposon- and PCR-based strategy for the analysis of ordered lambda phage clones.

Kasai H, Isono S, Kitakawa M, Mineno J, Akiyama H, Kurnit DM, Berg DE, Isono K.

Nucleic Acids Res. 1992 Dec 25;20(24):6509-15.


A small plasmid for recombination-based screening.

Hanzlik AJ, Osemlak-Hanzlik MM, Kurnit DM.

Gene. 1992 Dec 1;122(1):171-4.


Sequence-tagged sites (STSs) for a set of mapped markers on chromosome 21.

Tanzi RE, Romano DM, Berger R, Buraczynska MJ, Gaston SM, Kurnit DM, Patterson D, Gusella JF, Stewart GD.

Genomics. 1992 Oct;14(2):498-502.


Identifying transcribed sequences: the state of the art.

Kurnit DM.

Biotechnology (N Y). 1992 Jan;10(1):36-9. Review. No abstract available.


Plasmids for recombination-based screening.

Stewart GD, Hauser MA, Kang H, McCann DP, Osemlak MM, Kurnit DM, Hanzlik AJ.

Gene. 1991 Sep 30;106(1):97-101.


Situs inversus in the developing mouse: proteins affected by the iv mutation (genocopy) and the teratogen retinoic acid (phenocopy).

Van Keuren ML, Layton WM, Iacob RA, Kurnit DM.

Mol Reprod Dev. 1991 Jun;29(2):136-44.


Analysis of proteins expressed at the time of murine organogenesis.

Van Keuren ML, Iacob RA, Kurnit DM.

Mol Reprod Dev. 1991 Jun;29(2):129-35.


Developmental appearance of proteins identified by two-dimensional gel electrophoresis in mouse gonadal tissue.

Durbin EJ, Erickson RP, Van Keuren ML, Iacob RA, Kurnit DM.

Mol Reprod Dev. 1991 Mar;28(3):245-8.

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