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Items: 9

1.

Rifampicin has a profound effect on the pharmacokinetics of oral S-ketamine and less on intravenous S-ketamine.

Peltoniemi MA, Saari TI, Hagelberg NM, Laine K, Kurkinen KJ, Neuvonen PJ, Olkkola KT.

Basic Clin Pharmacol Toxicol. 2012 Nov;111(5):325-32. doi: 10.1111/j.1742-7843.2012.00908.x. Epub 2012 Jun 27.

2.

Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren.

Tapaninen T, Backman JT, Kurkinen KJ, Neuvonen PJ, Niemi M.

J Clin Pharmacol. 2011 Mar;51(3):359-67. doi: 10.1177/0091270010365885. Epub 2010 Apr 16.

PMID:
20400651
3.

Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S-ketamine.

Hagelberg NM, Peltoniemi MA, Saari TI, Kurkinen KJ, Laine K, Neuvonen PJ, Olkkola KT.

Eur J Pain. 2010 Jul;14(6):625-9. doi: 10.1016/j.ejpain.2009.10.003. Epub 2009 Nov 7.

PMID:
19897389
4.

CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe.

Backman JT, Honkalammi J, Neuvonen M, Kurkinen KJ, Tornio A, Niemi M, Neuvonen PJ.

Drug Metab Dispos. 2009 Dec;37(12):2359-66. doi: 10.1124/dmd.109.029728. Epub 2009 Sep 22.

PMID:
19773535
5.

No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.

Keskitalo JE, Kurkinen KJ, Neuvonen M, Backman JT, Neuvonen PJ, Niemi M.

Br J Clin Pharmacol. 2009 Aug;68(2):207-13. doi: 10.1111/j.1365-2125.2009.03440.x.

6.

ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.

Keskitalo JE, Zolk O, Fromm MF, Kurkinen KJ, Neuvonen PJ, Niemi M.

Clin Pharmacol Ther. 2009 Aug;86(2):197-203. doi: 10.1038/clpt.2009.79. Epub 2009 May 27.

PMID:
19474787
7.

Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism.

Kalliokoski A, Backman JT, Kurkinen KJ, Neuvonen PJ, Niemi M.

Clin Pharmacol Ther. 2008 Oct;84(4):488-96.

PMID:
19238654
8.

ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin.

Keskitalo JE, Kurkinen KJ, Neuvoneni PJ, Niemi M.

Clin Pharmacol Ther. 2008 Oct;84(4):457-61.

PMID:
19238649
9.

Voriconazole increases while itraconazole decreases plasma meloxicam concentrations.

Hynninen VV, Olkkola KT, Bertilsson L, Kurkinen KJ, Korhonen T, Neuvonen PJ, Laine K.

Antimicrob Agents Chemother. 2009 Feb;53(2):587-92. doi: 10.1128/AAC.00530-08. Epub 2008 Nov 17.

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