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Items: 1 to 50 of 212

1.

Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.

Chung JK, Nocka LM, Decker A, Wang Q, Kadlecek TA, Weiss A, Kuriyan J, Groves JT.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10798-10803. doi: 10.1073/pnas.1819309116. Epub 2019 May 10.

PMID:
31076553
2.

Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+ /calmodulin-dependent protein kinase II.

McSpadden ED, Xia Z, Chi CC, Susa AC, Shah NH, Gee CL, Williams ER, Kuriyan J.

Protein Sci. 2019 Jun;28(6):1071-1082. doi: 10.1002/pro.3614. Epub 2019 Apr 17.

PMID:
30942928
3.

Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.

Simonetta KR, Taygerly J, Boyle K, Basham SE, Padovani C, Lou Y, Cummins TJ, Yung SL, von Soly SK, Kayser F, Kuriyan J, Rape M, Cardozo M, Gallop MA, Bence NF, Barsanti PA, Saha A.

Nat Commun. 2019 Mar 29;10(1):1402. doi: 10.1038/s41467-019-09358-9.

4.

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS.

Huang WYC, Alvarez S, Kondo Y, Lee YK, Chung JK, Lam HYM, Biswas KH, Kuriyan J, Groves JT.

Science. 2019 Mar 8;363(6431):1098-1103. doi: 10.1126/science.aau5721. Epub 2019 Mar 7.

5.

Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation.

Shah NH, Kuriyan J.

Nat Struct Mol Biol. 2019 Jan;26(1):25-34. doi: 10.1038/s41594-018-0175-9. Epub 2018 Dec 31. Review.

6.

The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases.

Shah NH, Amacher JF, Nocka LM, Kuriyan J.

Crit Rev Biochem Mol Biol. 2018 Oct;53(5):535-563. doi: 10.1080/10409238.2018.1495173. Epub 2018 Sep 5. Review.

PMID:
30183386
7.

Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites.

Cantor AJ, Shah NH, Kuriyan J.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7303-E7312. doi: 10.1073/pnas.1803598115. Epub 2018 Jul 16.

8.

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.

Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A.

Nat Immunol. 2018 Jul;19(7):733-741. doi: 10.1038/s41590-018-0131-1. Epub 2018 Jun 18.

9.

The Interdependent Activation of Son-of-Sevenless and Ras.

Bandaru P, Kondo Y, Kuriyan J.

Cold Spring Harb Perspect Med. 2019 Feb 1;9(2). pii: a031534. doi: 10.1101/cshperspect.a031534. Review.

10.

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen.

Shah NH, Löbel M, Weiss A, Kuriyan J.

Elife. 2018 Mar 16;7. pii: e35190. doi: 10.7554/eLife.35190.

11.

Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates.

Amacher JF, Hobbs HT, Cantor AC, Shah L, Rivero MJ, Mulchand SA, Kuriyan J.

Protein Sci. 2018 May;27(5):923-932. doi: 10.1002/pro.3397. Epub 2018 Apr 14.

12.

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.

Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber DL, Kuriyan J, Roose JP.

Elife. 2017 Sep 27;6. pii: e29002. doi: 10.7554/eLife.29002.

13.

Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane.

Karandur D, Nawrotek A, Kuriyan J, Cherfils J.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11416-11421. doi: 10.1073/pnas.1707970114. Epub 2017 Sep 18.

14.

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.

Courtney AH, Amacher JF, Kadlecek TA, Mollenauer MN, Au-Yeung BB, Kuriyan J, Weiss A.

Mol Cell. 2017 Aug 3;67(3):498-511.e6. doi: 10.1016/j.molcel.2017.06.024. Epub 2017 Jul 20.

15.

Deconstruction of the Ras switching cycle through saturation mutagenesis.

Bandaru P, Shah NH, Bhattacharyya M, Barton JP, Kondo Y, Cofsky JC, Gee CL, Chakraborty AK, Kortemme T, Ranganathan R, Kuriyan J.

Elife. 2017 Jul 7;6. pii: e27810. doi: 10.7554/eLife.27810.

16.

Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen.

Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J.

SLAS Discov. 2017 Mar;22(3):324-331. doi: 10.1177/1087057116681407. Epub 2016 Dec 13.

17.

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.

Shah NH, Wang Q, Yan Q, Karandur D, Kadlecek TA, Fallahee IR, Russ WP, Ranganathan R, Weiss A, Kuriyan J.

Elife. 2016 Oct 4;5. pii: e20105. doi: 10.7554/eLife.20105.

18.

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.

Huang WY, Yan Q, Lin WC, Chung JK, Hansen SD, Christensen SM, Tu HL, Kuriyan J, Groves JT.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8218-23. doi: 10.1073/pnas.1602602113. Epub 2016 Jul 1.

19.

Molecular basis for multimerization in the activation of the epidermal growth factor receptor.

Huang Y, Bharill S, Karandur D, Peterson SM, Marita M, Shi X, Kaliszewski MJ, Smith AW, Isacoff EY, Kuriyan J.

Elife. 2016 Mar 28;5. pii: e14107. doi: 10.7554/eLife.14107.

20.

Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II.

Bhattacharyya M, Stratton MM, Going CC, McSpadden ED, Huang Y, Susa AC, Elleman A, Cao YM, Pappireddi N, Burkhardt P, Gee CL, Barros T, Schulman H, Williams ER, Kuriyan J.

Elife. 2016 Mar 7;5. pii: e13405. doi: 10.7554/eLife.13405.

21.

Crystal Structure of a Ube2S-Ubiquitin Conjugate.

Lorenz S, Bhattacharyya M, Feiler C, Rape M, Kuriyan J.

PLoS One. 2016 Feb 1;11(2):e0147550. doi: 10.1371/journal.pone.0147550. eCollection 2016.

22.

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.

Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM.

J Exp Med. 2016 Feb 8;213(2):155-65. doi: 10.1084/jem.20150888. Epub 2016 Jan 18.

23.

Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.

Kovacs E, Das R, Wang Q, Collier TS, Cantor A, Huang Y, Wong K, Mirza A, Barros T, Grob P, Jura N, Bose R, Kuriyan J.

Mol Cell Biol. 2015 Sep 1;35(17):3083-102. doi: 10.1128/MCB.00248-15. Epub 2015 Jun 29.

24.

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.

Goodfellow HS, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon A, Weiss A.

Sci Signal. 2015 May 19;8(377):ra49. doi: 10.1126/scisignal.2005596.

25.

Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220).

Zorn JA, Wang Q, Fujimura E, Barros T, Kuriyan J.

PLoS One. 2015 Apr 2;10(4):e0121177. doi: 10.1371/journal.pone.0121177. eCollection 2015.

26.

Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.

Lorenz S, Deng P, Hantschel O, Superti-Furga G, Kuriyan J.

Biochem J. 2015 Jun 1;468(2):283-91. doi: 10.1042/BJ20141492.

27.

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.

Wang Q, Vogan EM, Nocka LM, Rosen CE, Zorn JA, Harrison SC, Kuriyan J.

Elife. 2015 Feb 20;4. doi: 10.7554/eLife.06074.

28.

A structural perspective on the regulation of the epidermal growth factor receptor.

Kovacs E, Zorn JA, Huang Y, Barros T, Kuriyan J.

Annu Rev Biochem. 2015;84:739-64. doi: 10.1146/annurev-biochem-060614-034402. Epub 2015 Jan 26. Review.

29.

A structural atlas of kinases inhibited by clinically approved drugs.

Wang Q, Zorn JA, Kuriyan J.

Methods Enzymol. 2014;548:23-67. doi: 10.1016/B978-0-12-397918-6.00002-1. Review.

PMID:
25399641
30.

Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.

Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J.

Biochem J. 2015 Jan 1;465(1):149-61. doi: 10.1042/BJ20140793.

31.

Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins.

Herzik MA Jr, Jonnalagadda R, Kuriyan J, Marletta MA.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4156-64. doi: 10.1073/pnas.1416936111. Epub 2014 Sep 24.

32.

Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases.

Endres NF, Barros T, Cantor AJ, Kuriyan J.

Trends Biochem Sci. 2014 Oct;39(10):437-46. doi: 10.1016/j.tibs.2014.08.001. Epub 2014 Sep 18. Review.

PMID:
25242369
33.

Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.

Iversen L, Tu HL, Lin WC, Christensen SM, Abel SM, Iwig J, Wu HJ, Gureasko J, Rhodes C, Petit RS, Hansen SD, Thill P, Yu CH, Stamou D, Chakraborty AK, Kuriyan J, Groves JT.

Science. 2014 Jul 4;345(6192):50-4. doi: 10.1126/science.1250373.

34.

Crenolanib is a selective type I pan-FLT3 inhibitor.

Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5319-24. doi: 10.1073/pnas.1320661111. Epub 2014 Mar 12.

35.

Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity.

Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J.

Elife. 2014 Feb 11;3:e02490. doi: 10.7554/eLife.02490. No abstract available.

36.

Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity.

Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J.

Elife. 2014 Jan 28;3:e01610. doi: 10.7554/eLife.01610. Erratum in: Elife. 2014;3:e02490.

37.

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.

Iwig JS, Vercoulen Y, Das R, Barros T, Limnander A, Che Y, Pelton JG, Wemmer DE, Roose JP, Kuriyan J.

Elife. 2013 Jul 30;2:e00813. doi: 10.7554/eLife.00813.

38.

Macromolecular juggling by ubiquitylation enzymes.

Lorenz S, Cantor AJ, Rape M, Kuriyan J.

BMC Biol. 2013 Jun 25;11:65. doi: 10.1186/1741-7007-11-65. Review.

39.

Fixing a hole where the Ras gets in.

Iwig JS, Kuriyan J.

Cell. 2013 Jun 6;153(6):1191-3. doi: 10.1016/j.cell.2013.05.029.

40.

A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation.

Engel K, Sasaki T, Wang Q, Kuriyan J.

Biochem J. 2013 Aug 1;453(3):337-44. doi: 10.1042/BJ20130537.

41.

A structural role for the PHP domain in E. coli DNA polymerase III.

Barros T, Guenther J, Kelch B, Anaya J, Prabhakar A, O'Donnell M, Kuriyan J, Lamers MH.

BMC Struct Biol. 2013 May 14;13:8. doi: 10.1186/1472-6807-13-8.

42.

Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.

Stratton MM, Chao LH, Schulman H, Kuriyan J.

Curr Opin Struct Biol. 2013 Apr;23(2):292-301. doi: 10.1016/j.sbi.2013.04.002. Epub 2013 Apr 27. Review.

43.

Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.

Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J.

Mol Cell Biol. 2013 Jun;33(11):2188-201. doi: 10.1128/MCB.01637-12. Epub 2013 Mar 25.

44.

Architecture and membrane interactions of the EGF receptor.

Arkhipov A, Shan Y, Das R, Endres NF, Eastwood MP, Wemmer DE, Kuriyan J, Shaw DE.

Cell. 2013 Jan 31;152(3):557-69. doi: 10.1016/j.cell.2012.12.030.

45.

Conformational coupling across the plasma membrane in activation of the EGF receptor.

Endres NF, Das R, Smith AW, Arkhipov A, Kovacs E, Huang Y, Pelton JG, Shan Y, Shaw DE, Wemmer DE, Groves JT, Kuriyan J.

Cell. 2013 Jan 31;152(3):543-56. doi: 10.1016/j.cell.2012.12.032.

46.

Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.

Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A.

Sci Signal. 2013 Jan 1;6(256):ra1. doi: 10.1126/scisignal.2003220.

47.

Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization.

Shan Y, Eastwood MP, Zhang X, Kim ET, Arkhipov A, Dror RO, Jumper J, Kuriyan J, Shaw DE.

Cell. 2012 May 11;149(4):860-70. doi: 10.1016/j.cell.2012.02.063.

48.

Clamp loader ATPases and the evolution of DNA replication machinery.

Kelch BA, Makino DL, O'Donnell M, Kuriyan J.

BMC Biol. 2012 Apr 20;10:34. doi: 10.1186/1741-7007-10-34.

49.

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.

Smith CC, Wang Q, Chin CS, Salerno S, Damon LE, Levis MJ, Perl AE, Travers KJ, Wang S, Hunt JP, Zarrinkar PP, Schadt EE, Kasarskis A, Kuriyan J, Shah NP.

Nature. 2012 Apr 15;485(7397):260-3. doi: 10.1038/nature11016.

50.

How a DNA polymerase clamp loader opens a sliding clamp.

Kelch BA, Makino DL, O'Donnell M, Kuriyan J.

Science. 2011 Dec 23;334(6063):1675-80. doi: 10.1126/science.1211884.

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