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Items: 1 to 50 of 52

1.

Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.

Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F.

Structure. 2018 Jun 1. pii: S0969-2126(18)30178-3. doi: 10.1016/j.str.2018.05.014. [Epub ahead of print]

2.

Structure of human ADP-ribosyl-acceptor hydrolase 3 bound to ADP-ribose reveals a conformational switch that enables specific substrate recognition.

Pourfarjam Y, Ventura J, Kurinov I, Cho A, Moss J, Kim IK.

J Biol Chem. 2018 Jun 15. pii: jbc.RA118.003586. doi: 10.1074/jbc.RA118.003586. [Epub ahead of print]

3.

Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor.

Huang J, Dey R, Wang Y, Jakoncic J, Kurinov I, Huang XY.

J Mol Biol. 2018 Apr 27;430(9):1324-1335. doi: 10.1016/j.jmb.2018.03.009. Epub 2018 Mar 21.

PMID:
29573988
4.

MEK drives BRAF activation through allosteric control of KSR proteins.

Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M.

Nature. 2018 Feb 22;554(7693):549-553. doi: 10.1038/nature25478. Epub 2018 Feb 12.

PMID:
29433126
5.

Effects of rigidity on the selectivity of protein kinase inhibitors.

Assadieskandar A, Yu C, Maisonneuve P, Liu X, Chen YC, Prakash GKS, Kurinov I, Sicheri F, Zhang C.

Eur J Med Chem. 2018 Feb 25;146:519-528. doi: 10.1016/j.ejmech.2018.01.053. Epub 2018 Jan 31.

PMID:
29407977
6.

Crystal structure of the human Polϵ B-subunit in complex with the C-terminal domain of the catalytic subunit.

Baranovskiy AG, Gu J, Babayeva ND, Kurinov I, Pavlov YI, Tahirov TH.

J Biol Chem. 2017 Sep 22;292(38):15717-15730. doi: 10.1074/jbc.M117.792705. Epub 2017 Jul 26.

PMID:
28747437
7.

MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.

Couzens AL, Xiong S, Knight JDR, Mao DY, Guettler S, Picaud S, Kurinov I, Filippakopoulos P, Sicheri F, Gingras AC.

Mol Cell Proteomics. 2017 Jun;16(6):1098-1110. doi: 10.1074/mcp.M116.065490. Epub 2017 Apr 3.

8.

Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation.

Xiong S, Couzens AL, Kean MJ, Mao DY, Guettler S, Kurinov I, Gingras AC, Sicheri F.

Mol Cell Proteomics. 2017 Jun;16(6):1111-1125. doi: 10.1074/mcp.M117.068130. Epub 2017 Apr 3.

9.

Structural mechanism of ligand activation in human calcium-sensing receptor.

Geng Y, Mosyak L, Kurinov I, Zuo H, Sturchler E, Cheng TC, Subramanyam P, Brown AP, Brennan SC, Mun HC, Bush M, Chen Y, Nguyen TX, Cao B, Chang DD, Quick M, Conigrave AD, Colecraft HM, McDonald P, Fan QR.

Elife. 2016 Jul 19;5. pii: e13662. doi: 10.7554/eLife.13662.

10.

Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.

Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Guarné A, Kurinov I, Durocher D, Sicheri F.

Nucleic Acids Res. 2016 Aug 19;44(14):6971-80. doi: 10.1093/nar/gkw542. Epub 2016 Jun 14.

11.

A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer.

Lim do Y, Shin SH, Lee MH, Malakhova M, Kurinov I, Wu Q, Xu J, Jiang Y, Dong Z, Liu K, Lee KY, Bae KB, Choi BY, Deng Y, Bode A, Dong Z.

Oncotarget. 2016 Jun 7;7(23):35001-14. doi: 10.18632/oncotarget.9223.

12.

Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.

Gorelik M, Orlicky S, Sartori MA, Tang X, Marcon E, Kurinov I, Greenblatt JF, Tyers M, Moffat J, Sicheri F, Sidhu SS.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3527-32. doi: 10.1073/pnas.1519389113. Epub 2016 Mar 14.

13.

Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.

Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AF, Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJ, Guarné A, Greenberg RA, Sicheri F.

Mol Cell. 2015 Sep 17;59(6):970-83. doi: 10.1016/j.molcel.2015.07.028. Epub 2015 Sep 3.

14.

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

Brown NG, Watson ER, Weissmann F, Jarvis MA, VanderLinden R, Grace CRR, Frye JJ, Qiao R, Dube P, Petzold G, Cho SE, Alsharif O, Bao J, Davidson IF, Zheng JJ, Nourse A, Kurinov I, Peters JM, Stark H, Schulman BA.

Mol Cell. 2014 Oct 23;56(2):246-260. doi: 10.1016/j.molcel.2014.09.009. Epub 2014 Oct 9.

15.

Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.

Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F.

Nat Commun. 2014 Aug 28;5:4202. doi: 10.1038/ncomms5202.

16.

Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.

Huo Y, Nam KH, Ding F, Lee H, Wu L, Xiao Y, Farchione MD Jr, Zhou S, Rajashankar K, Kurinov I, Zhang R, Ke A.

Nat Struct Mol Biol. 2014 Sep;21(9):771-7. doi: 10.1038/nsmb.2875. Epub 2014 Aug 17.

17.

Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis.

Yang G, Fu Y, Malakhova M, Kurinov I, Zhu F, Yao K, Li H, Chen H, Li W, Lim DY, Sheng Y, Bode AM, Dong Z, Dong Z.

Cancer Prev Res (Phila). 2014 Oct;7(10):1056-66. doi: 10.1158/1940-6207.CAPR-14-0141. Epub 2014 Aug 7.

18.

Structural basis for the recruitment of glycogen synthase by glycogenin.

Zeqiraj E, Tang X, Hunter RW, García-Rocha M, Judd A, Deak M, von Wilamowitz-Moellendorff A, Kurinov I, Guinovart JJ, Tyers M, Sakamoto K, Sicheri F.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2831-40. doi: 10.1073/pnas.1402926111. Epub 2014 Jun 30.

19.

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3.

Kamadurai HB, Qiu Y, Deng A, Harrison JS, Macdonald C, Actis M, Rodrigues P, Miller DJ, Souphron J, Lewis SM, Kurinov I, Fujii N, Hammel M, Piper R, Kuhlman B, Schulman BA.

Elife. 2013 Aug 8;2:e00828. doi: 10.7554/eLife.00828.

20.

Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism.

Duda DM, Olszewski JL, Schuermann JP, Kurinov I, Miller DJ, Nourse A, Alpi AF, Schulman BA.

Structure. 2013 Jun 4;21(6):1030-41. doi: 10.1016/j.str.2013.04.019. Epub 2013 May 23.

21.

Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.

Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F.

Nucleic Acids Res. 2013 Jul;41(12):6332-46. doi: 10.1093/nar/gkt322. Epub 2013 Apr 25.

22.

Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.

Kaiser SE, Mao K, Taherbhoy AM, Yu S, Olszewski JL, Duda DM, Kurinov I, Deng A, Fenn TD, Klionsky DJ, Schulman BA.

Nat Struct Mol Biol. 2012 Dec;19(12):1242-9. doi: 10.1038/nsmb.2415. Epub 2012 Nov 11.

23.

Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases.

Li J, Malakhova M, Mottamal M, Reddy K, Kurinov I, Carper A, Langfald A, Oi N, Kim MO, Zhu F, Sosa CP, Zhou K, Bode AM, Dong Z.

Cancer Res. 2012 Jan 1;72(1):260-70. doi: 10.1158/0008-5472.CAN-11-2596. Epub 2011 Nov 14.

24.

Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway.

Taherbhoy AM, Tait SW, Kaiser SE, Williams AH, Deng A, Nourse A, Hammel M, Kurinov I, Rock CO, Green DR, Schulman BA.

Mol Cell. 2011 Nov 4;44(3):451-61. doi: 10.1016/j.molcel.2011.08.034.

25.

A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.

Calabrese MF, Scott DC, Duda DM, Grace CR, Kurinov I, Kriwacki RW, Schulman BA.

Nat Struct Mol Biol. 2011 Jul 17;18(8):947-9. doi: 10.1038/nsmb.2086.

26.
27.

The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.

Malakhova M, D'Angelo I, Kim HG, Kurinov I, Bode AM, Dong Z.

J Mol Biol. 2010 May 28;399(1):41-52. doi: 10.1016/j.jmb.2010.03.064. Epub 2010 Apr 9.

28.

Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2.

Malakhova M, Kurinov I, Liu K, Zheng D, D'Angelo I, Shim JH, Steinman V, Bode AM, Dong Z.

PLoS One. 2009 Nov 30;4(11):e8044. doi: 10.1371/journal.pone.0008044.

29.

Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.

Wang J, Dye BT, Rajashankar KR, Kurinov I, Schulman BA.

Nat Struct Mol Biol. 2009 Sep;16(9):987-9. doi: 10.1038/nsmb.1645. Epub 2009 Aug 9.

30.

Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.

Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F.

Mol Cell. 2008 Oct 24;32(2):259-75. doi: 10.1016/j.molcel.2008.10.002.

31.

CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.

Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri F.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2836-41. doi: 10.1073/pnas.0709705105. Epub 2008 Feb 19.

32.
33.

A localized specific interaction alters the unfolding pathways of structural homologues.

Xu G, Narayan M, Kurinov I, Ripoll DR, Welker E, Khalili M, Ealick SE, Scheraga HA.

J Am Chem Soc. 2006 Feb 1;128(4):1204-13.

34.

High resolution X-ray structure and potent anti-HIV activity of recombinant dianthin antiviral protein.

Kurinov IV, Rajamohan F, Uckun FM.

Arzneimittelforschung. 2004;54(10):692-702.

PMID:
15553110
35.

High resolution X-ray structure of potent anti-HIV pokeweed antiviral protein-III.

Kurinov IV, Uckun FM.

Biochem Pharmacol. 2003 May 15;65(10):1709-17.

PMID:
12754107
36.

X-ray crystallographic analysis of pokeweed antiviral protein-II after reductive methylation of lysine residues.

Kurinov IV, Mao C, Irvin JD, Uckun FM.

Biochem Biophys Res Commun. 2000 Aug 28;275(2):549-52.

PMID:
10964701
37.

Modeling and alanine scanning mutagenesis studies of recombinant pokeweed antiviral protein.

Rajamohan F, Pugmire MJ, Kurinov IV, Uckun FM.

J Biol Chem. 2000 Feb 4;275(5):3382-90.

38.
40.

Deguanylation of human immunodeficiency virus (HIV-1) RNA by recombinant pokeweed antiviral protein.

Rajamohan F, Kurinov IV, Venkatachalam TK, Uckun FM.

Biochem Biophys Res Commun. 1999 Sep 24;263(2):419-24.

PMID:
10491308
41.
42.

Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate.

Ridky TW, Kikonyogo A, Leis J, Gulnik S, Copeland T, Erickson J, Wlodawer A, Kurinov I, Harrison RW, Weber IT.

Biochemistry. 1998 Sep 29;37(39):13835-45.

PMID:
9753473
43.

[Comparison of dynamic properties of various globular proteins and polyglutamic acid in alpha-helical and coil states. Rayleigh scattering of Mossbauer radiation data].

Krupianskiĭ IuF, Kurinov IV, Kuznetsov SA, Eshchenko GV, Gol'danskiĭ VI.

Biofizika. 1997 Jan-Feb;42(1):39-46. Russian.

PMID:
9181800
44.

Two crystal structures of the leupeptin-trypsin complex.

Kurinov IV, Harrison RW.

Protein Sci. 1996 Apr;5(4):752-8.

45.

The influence of temperature on lysozyme crystals. Structure and dynamics of protein and water.

Kurinov IV, Harrison RW.

Acta Crystallogr D Biol Crystallogr. 1995 Jan 1;51(Pt 1):98-109.

PMID:
15299341
46.

Prediction of new serine proteinase inhibitors.

Kurinov IV, Harrison RW.

Nat Struct Biol. 1994 Oct;1(10):735-43.

PMID:
7634078
47.

[Study of the dynamics of human serum albumin by coherent Rayleigh dispersion of Mossbauer radiation].

Krupianskiĭ IuF, Albaneze D, Gol'danskiĭ VI, Gorbunova IuV, Deriu A, Zhuravleva TV, Kavatorta F, Kurinov IV, Suzdalev IP.

Mol Biol (Mosk). 1992 Nov-Dec;26(6):1389-96. Russian.

PMID:
1491680
48.

[The effect of high pressure of protein dynamics from Rayleigh scattering of Mossbauer irradiation data].

Suzdalev IP, Kurinov IV, Livshits LD, Krupianskiĭ IuF, Gol'danskiĭ VI.

Dokl Akad Nauk SSSR. 1991;321(4):842-5. Russian. No abstract available.

PMID:
1806356
49.

[A study of the effect of solvent composition and viscosity on the molecular dynamics of human serum albumin using Rayleigh scattering of Mössbauer radiation].

Kurinov IV, Krupianskiĭ IuF, Genkin MV, Davydov RM, Suzdalev IP.

Biofizika. 1988 May-Jun;33(3):407-12. Russian.

PMID:
3167105
50.

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