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TAK-071, a novel M1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects.

Sako Y, Kurimoto E, Mandai T, Suzuki A, Tanaka M, Suzuki M, Shimizu Y, Yamada M, Kimura H.

Neuropsychopharmacology. 2018 Aug 1. doi: 10.1038/s41386-018-0168-8. [Epub ahead of print]


Inhibition of tumor formation and metastasis by a monoclonal antibody against lymphatic vessel endothelial hyaluronan receptor 1.

Hara Y, Torii R, Ueda S, Kurimoto E, Ueda E, Okura H, Tatano Y, Yagi H, Ohno Y, Tanaka T, Masuko K, Masuko T.

Cancer Sci. 2018 Oct;109(10):3171-3182. doi: 10.1111/cas.13755. Epub 2018 Aug 26.


Computational studies on the water-catalyzed stereoinversion mechanism of glutamic acid residues in peptides and proteins.

Nakayoshi T, Kato K, Fukuyoshi S, Takahashi O, Kurimoto E, Oda A.

Chirality. 2018 May;30(5):527-535. doi: 10.1002/chir.22841. Epub 2018 Mar 12.


Validation of molecular force field parameters for peptides including isomerized amino acids.

Oda A, Nakayoshi T, Fukuyoshi S, Kurimoto E, Yamaotsu N, Hirono S, Takahashi O.

Chirality. 2018 Apr;30(4):332-341. doi: 10.1002/chir.22821. Epub 2018 Feb 2.


The assembly mechanism of coiled-coil domains of the yeast cargo receptors Emp46p/47p and the mutational alteration of pH-dependency of complex formation.

Kato K, Furuhashi T, Kato K, Oda A, Kurimoto E.

J Biochem. 2018 May 1;163(5):441-446. doi: 10.1093/jb/mvy011.


Influences of conformations of peptides on stereoinversions and/or isomerizations of aspartic acid residues.

Oda A, Nakayoshi T, Fukuyoshi S, Kurimoto E, Takahashi O.

Biochim Biophys Acta Proteins Proteom. 2018 Jul;1866(7):783-788. doi: 10.1016/j.bbapap.2018.01.006. Epub 2018 Jan 11.


Comparison of the activation energy barrier for succinimide formation from α- and β-aspartic acid residues obtained from density functional theory calculations.

Nakayoshi T, Kato K, Fukuyoshi S, Takahashi O, Kurimoto E, Oda A.

Biochim Biophys Acta Proteins Proteom. 2018 Jul;1866(7):759-766. doi: 10.1016/j.bbapap.2017.12.011. Epub 2018 Jan 3.


An Approach to Discovering Novel Muscarinic M1 Receptor Positive Allosteric Modulators with Potent Cognitive Improvement and Minimized Gastrointestinal Dysfunction.

Kurimoto E, Matsuda S, Shimizu Y, Sako Y, Mandai T, Sugimoto T, Sakamoto H, Kimura H.

J Pharmacol Exp Ther. 2018 Jan;364(1):28-37. doi: 10.1124/jpet.117.243774. Epub 2017 Oct 12.


Validation of Molecular Dynamics Simulations for Prediction of Three-Dimensional Structures of Small Proteins.

Kato K, Nakayoshi T, Fukuyoshi S, Kurimoto E, Oda A.

Molecules. 2017 Oct 12;22(10). pii: E1716. doi: 10.3390/molecules22101716.


FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia.

Nishiyama K, Suzuki H, Harasawa T, Suzuki N, Kurimoto E, Kawai T, Maruyama M, Komatsu H, Sakuma K, Shimizu Y, Shimojo M.

J Pharmacol Exp Ther. 2017 Nov;363(2):253-264. doi: 10.1124/jpet.117.242925. Epub 2017 Aug 29.


Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists.

Tokumaru K, Ito Y, Nomura I, Nakahata T, Shimizu Y, Kurimoto E, Aoyama K, Aso K.

Bioorg Med Chem. 2017 Jun 15;25(12):3098-3115. doi: 10.1016/j.bmc.2017.03.064. Epub 2017 Apr 1.


Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation.

Kurimoto E, Satoh T, Ito Y, Ishihara E, Okamoto K, Yagi-Utsumi M, Tanaka K, Kato K.

Protein Sci. 2017 May;26(5):1080-1085. doi: 10.1002/pro.3153. Epub 2017 Mar 16.


IL-23 Is Essential for the Development of Elastase-Induced Pulmonary Inflammation and Emphysema.

Fujii U, Miyahara N, Taniguchi A, Waseda K, Morichika D, Kurimoto E, Koga H, Kataoka M, Gelfand EW, Cua DJ, Yoshimura A, Tanimoto M, Kanehiro A.

Am J Respir Cell Mol Biol. 2016 Nov;55(5):697-707.


[HER2-Positive Advanced Gastric Cancer with Disseminated Intravascular Coagulation and Diffuse Bone Marrow Carcinomatosis Successfully Treated with S-1/Trastuzumab Chemotherapy--A Case Report].

Senoo S, Mannami T, Tamura T, Fujiwara N, Ikeda G, Komoda M, Ohtawa Y, Fujimoto Y, Sato N, Kambara T, Waku T, Kenmotsu M, Kurimoto E, Okada T, Harita S, Sonobe H.

Gan To Kagaku Ryoho. 2015 Dec;42(13):2471-5. Japanese.


Contrasting roles for the receptor for advanced glycation end-products on structural cells in allergic airway inflammation vs. airway hyperresponsiveness.

Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fujii U, Tanimoto Y, Kataoka M, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A.

Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L789-800. doi: 10.1152/ajplung.00087.2015. Epub 2015 Aug 21.


pH-Dependent Assembly and Segregation of the Coiled-Coil Segments of Yeast Putative Cargo Receptors Emp46p and Emp47p.

Ishii K, Enda H, Noda M, Kajino M, Kim A, Kurimoto E, Sato K, Nakano A, Kobayashi Y, Yagi H, Uchiyama S, Kato K.

PLoS One. 2015 Oct 8;10(10):e0140287. doi: 10.1371/journal.pone.0140287. eCollection 2015.


Mode of substrate recognition by the Josephin domain of ataxin-3, which has an endo-type deubiquitinase activity.

Satoh T, Sumiyoshi A, Yagi-Utsumi M, Sakata E, Sasakawa H, Kurimoto E, Yamaguchi Y, Li W, Joazeiro CA, Hirokawa T, Kato K.

FEBS Lett. 2014 Nov 28;588(23):4422-30. doi: 10.1016/j.febslet.2014.10.013. Epub 2014 Oct 19.


Emphysema requires the receptor for advanced glycation end-products triggering on structural cells.

Waseda K, Miyahara N, Taniguchi A, Kurimoto E, Ikeda G, Koga H, Fujii U, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A.

Am J Respir Cell Mol Biol. 2015 Apr;52(4):482-91. doi: 10.1165/rcmb.2014-0027OC.


Effect of a cysteinyl leukotriene receptor antagonist on experimental emphysema and asthma combined with emphysema.

Ikeda G, Miyahara N, Koga H, Fuchimoto Y, Waseda K, Kurimoto E, Taniguchi A, Tanimoto Y, Kataoka M, Tanimoto M, Kanehiro A.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):18-29. doi: 10.1165/rcmb.2012-0418OC.


Structural and functional mosaic nature of MHC class I molecules in their peptide-free form.

Kurimoto E, Kuroki K, Yamaguchi Y, Yagi-Utsumi M, Igaki T, Iguchi T, Maenaka K, Kato K.

Mol Immunol. 2013 Oct;55(3-4):393-9. doi: 10.1016/j.molimm.2013.03.014. Epub 2013 Apr 8.


Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric form.

Sugiyama M, Sahashi H, Kurimoto E, Takata S, Yagi H, Kanai K, Sakata E, Minami Y, Tanaka K, Kato K.

Biochem Biophys Res Commun. 2013 Mar 1;432(1):141-5. doi: 10.1016/j.bbrc.2013.01.071. Epub 2013 Jan 29.


IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice.

Kurimoto E, Miyahara N, Kanehiro A, Waseda K, Taniguchi A, Ikeda G, Koga H, Nishimori H, Tanimoto Y, Kataoka M, Iwakura Y, Gelfand EW, Tanimoto M.

Respir Res. 2013 Jan 20;14:5. doi: 10.1186/1465-9921-14-5.


NMR and mutational identification of the collagen-binding site of the chaperone Hsp47.

Yagi-Utsumi M, Yoshikawa S, Yamaguchi Y, Nishi Y, Kurimoto E, Ishida Y, Homma T, Hoseki J, Nishikawa Y, Koide T, Nagata K, Kato K.

PLoS One. 2012;7(9):e45930. doi: 10.1371/journal.pone.0045930. Epub 2012 Sep 25.


Favorable response of heavily treated Wilms' tumor to paclitaxel and carboplatin.

Ozaki S, Takigawa N, Ichihara E, Hotta K, Oze I, Kurimoto E, Fushimi S, Ogino T, Tabata M, Tanimoto M, Kiura K.

Onkologie. 2012;35(5):283-6. doi: 10.1159/000338532. Epub 2012 Apr 24.


A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex.

Yagi H, Ishimoto K, Hiromoto T, Fujita H, Mizushima T, Uekusa Y, Yagi-Utsumi M, Kurimoto E, Noda M, Uchiyama S, Tokunaga F, Iwai K, Kato K.

EMBO Rep. 2012 May 1;13(5):462-8. doi: 10.1038/embor.2012.24.


Backbone and side chain 1H, 13C, and 15N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex.

Uekusa Y, Mimura S, Sasakawa H, Kurimoto E, Sakata E, Olivier S, Yagi H, Tokunaga F, Iwai K, Kato K.

Biomol NMR Assign. 2012 Oct;6(2):177-80. doi: 10.1007/s12104-011-9350-1. Epub 2011 Nov 30.


Kinetic asymmetry of subunit exchange of homooligomeric protein as revealed by deuteration-assisted small-angle neutron scattering.

Sugiyama M, Kurimoto E, Yagi H, Mori K, Fukunaga T, Hirai M, Zaccai G, Kato K.

Biophys J. 2011 Oct 19;101(8):2037-42. doi: 10.1016/j.bpj.2011.09.004.


Functional characterization of human cyclin T1 N-terminal region for human immunodeficiency virus-1 Tat transcriptional activation.

Asamitsu K, Hibi Y, Imai K, Victoriano AF, Kurimoto E, Kato K, Okamoto T.

J Mol Biol. 2011 Jul 29;410(5):887-95. doi: 10.1016/j.jmb.2011.04.061.


Blocking the leukotriene B4 receptor 1 inhibits late-phase airway responses in established disease.

Waseda K, Miyahara N, Kanehiro A, Ikeda G, Koga H, Fuchimoto Y, Kurimoto E, Tanimoto Y, Kataoka M, Tanimoto M, Gelfand EW.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):851-7. doi: 10.1165/rcmb.2010-0455OC. Epub 2011 Mar 18.


Redox-dependent domain rearrangement of protein disulfide isomerase from a thermophilic fungus.

Nakasako M, Maeno A, Kurimoto E, Harada T, Yamaguchi Y, Oka T, Takayama Y, Iwata A, Kato K.

Biochemistry. 2010 Aug 17;49(32):6953-62. doi: 10.1021/bi1006089.


NMR characterization of intramolecular interaction of osteopontin, an intrinsically disordered protein with cryptic integrin-binding motifs.

Yamaguchi Y, Hanashima S, Yagi H, Takahashi Y, Sasakawa H, Kurimoto E, Iguchi T, Kon S, Uede T, Kato K.

Biochem Biophys Res Commun. 2010 Mar 12;393(3):487-91. doi: 10.1016/j.bbrc.2010.02.030. Epub 2010 Feb 10.


Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates.

Sakata E, Satoh T, Yamamoto S, Yamaguchi Y, Yagi-Utsumi M, Kurimoto E, Tanaka K, Wakatsuki S, Kato K.

Structure. 2010 Jan 13;18(1):138-47. doi: 10.1016/j.str.2009.11.007.


Redox-dependent domain rearrangement of protein disulfide isomerase coupled with exposure of its substrate-binding hydrophobic surface.

Serve O, Kamiya Y, Maeno A, Nakano M, Murakami C, Sasakawa H, Yamaguchi Y, Harada T, Kurimoto E, Yagi-Utsumi M, Iguchi T, Inaba K, Kikuchi J, Asami O, Kajino T, Oka T, Nakasako M, Kato K.

J Mol Biol. 2010 Feb 19;396(2):361-74. doi: 10.1016/j.jmb.2009.11.049. Epub 2009 Nov 26.


Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling.

Katsuki H, Kurimoto E, Takemori S, Kurauchi Y, Hisatsune A, Isohama Y, Izumi Y, Kume T, Shudo K, Akaike A.

J Neurochem. 2009 Jul;110(2):707-18. doi: 10.1111/j.1471-4159.2009.06171.x. Epub 2009 May 15.


Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes.

Yashiroda H, Mizushima T, Okamoto K, Kameyama T, Hayashi H, Kishimoto T, Niwa S, Kasahara M, Kurimoto E, Sakata E, Takagi K, Suzuki A, Hirano Y, Murata S, Kato K, Yamane T, Tanaka K.

Nat Struct Mol Biol. 2008 Mar;15(3):228-36. doi: 10.1038/nsmb.1386. Epub 2008 Feb 17.


Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of alpha-synuclein.

Sasakawa H, Sakata E, Yamaguchi Y, Masuda M, Mori T, Kurimoto E, Iguchi T, Hisanaga S, Iwatsubo T, Hasegawa M, Kato K.

Biochem Biophys Res Commun. 2007 Nov 23;363(3):795-9. Epub 2007 Sep 21.


Curculin exhibits sweet-tasting and taste-modifying activities through its distinct molecular surfaces.

Kurimoto E, Suzuki M, Amemiya E, Yamaguchi Y, Nirasawa S, Shimba N, Xu N, Kashiwagi T, Kawai M, Suzuki E, Kato K.

J Biol Chem. 2007 Nov 16;282(46):33252-6. Epub 2007 Sep 25.


Dynamics of group II chaperonin and prefoldin probed by 13C NMR spectroscopy.

Kurimoto E, Nishi Y, Yamaguchi Y, Zako T, Iizuka R, Ide N, Yohda M, Kato K.

Proteins. 2008 Mar;70(4):1257-63.


Fbs1 protects the malfolded glycoproteins from the attack of peptide:N-glycanase.

Yamaguchi Y, Hirao T, Sakata E, Kamiya Y, Kurimoto E, Yoshida Y, Suzuki T, Tanaka K, Kato K.

Biochem Biophys Res Commun. 2007 Oct 26;362(3):712-6. Epub 2007 Aug 20.


Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults.

Okawara M, Katsuki H, Kurimoto E, Shibata H, Kume T, Akaike A.

Biochem Pharmacol. 2007 Feb 15;73(4):550-60. Epub 2006 Nov 9.


Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d).

Shiroishi M, Kuroki K, Rasubala L, Tsumoto K, Kumagai I, Kurimoto E, Kato K, Kohda D, Maenaka K.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16412-7. Epub 2006 Oct 20.


NMR assignments of the b' and a' domains of thermophilic fungal protein disulfide isomerase.

Nakano M, Murakami C, Yamaguchi Y, Sasakawa H, Harada T, Kurimoto E, Asami O, Kajino T, Kato K.

J Biomol NMR. 2006;36 Suppl 1:44. No abstract available.


Disulfide bond formation in refolding of thermophilic fungal protein disulfide isomerase.

Harada T, Kurimoto E, Tokuhiro K, Asami O, Sakai T, Nohara D, Kato K.

J Biosci Bioeng. 2001;91(6):596-8.


[A case of a young woman with tuberculous peritonitis diagnosed owing to high value of ADA].

Rai K, Kurimoto E, Kusano N, Koide N, Nishii K.

Kansenshogaku Zasshi. 2004 Oct;78(10):916-22. Japanese.


Recombinant curculin heterodimer exhibits taste-modifying and sweet-tasting activities.

Suzuki M, Kurimoto E, Nirasawa S, Masuda Y, Hori K, Kurihara Y, Shimba N, Kawai M, Suzuki E, Kato K.

FEBS Lett. 2004 Aug 27;573(1-3):135-8.


[Multi-dimensional HPLC method in glycomics].

Takahashi N, Kurimoto E, Yamaguchi Y, Kato K.

Tanpakushitsu Kakusan Koso. 2003 Aug;48(10):1412-8. Review. Japanese. No abstract available.


Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain.

Sakata E, Yamaguchi Y, Kurimoto E, Kikuchi J, Yokoyama S, Yamada S, Kawahara H, Yokosawa H, Hattori N, Mizuno Y, Tanaka K, Kato K.

EMBO Rep. 2003 Mar;4(3):301-6.


Application of combined reagent solution to the oxidative refolding of recombinant human interleukin 6.

Harada T, Kurimoto E, Moriyama Y, Ejima D, Sakai T, Nohara D, Kato K.

Chem Pharm Bull (Tokyo). 2001 Sep;49(9):1128-31.


In vitro refolding of porcine pepsin immobilized on agarose beads.

Kurimoto E, Harada T, Akiyama A, Sakai T, Kato K.

J Biochem. 2001 Aug;130(2):295-7.


Ability of paralyzed flagella mutants of Chlamydomonas to move.

Omoto CK, Yagi T, Kurimoto E, Kamiya R.

Cell Motil Cytoskeleton. 1996;33(2):88-94.


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