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Items: 37

1.

A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells.

Kurenova E, Ucar D, Liao J, Yemma M, Gogate P, Bshara W, Sunar U, Seshadri M, Hochwald SN, Cance WG.

Cell Cycle. 2014;13(16):2542-53. doi: 10.4161/15384101.2015.941760.

2.

Pharmacokinetic analysis of the FAK scaffold inhibitor C4 in dogs.

Wilton J, Kurenova E, Pitzonka L, Gaudy A, Curtin L, Sexton S, Cance W, Fetterly G.

Eur J Drug Metab Pharmacokinet. 2016 Feb;41(1):55-67. doi: 10.1007/s13318-014-0233-6. Epub 2014 Nov 7.

3.

Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer.

Gogate PN, Kurenova EV, Ethirajan M, Liao J, Yemma M, Sen A, Pandey RK, Cance WG.

Cancer Lett. 2014 Oct 28;353(2):281-9. doi: 10.1016/j.canlet.2014.07.032. Epub 2014 Jul 24.

4.

Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction.

Gogate PN, Ethirajan M, Kurenova EV, Magis AT, Pandey RK, Cance WG.

Eur J Med Chem. 2014 Jun 10;80:154-166. doi: 10.1016/j.ejmech.2014.04.041. Epub 2014 Apr 15.

5.

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth.

Kurenova E, Liao J, He DH, Hunt D, Yemma M, Bshara W, Seshadri M, Cance WG.

Oncotarget. 2013 Oct;4(10):1632-46.

6.

Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.

Stewart JE, Ma X, Megison M, Nabers H, Cance WG, Kurenova EV, Beierle EA.

Mol Carcinog. 2015 Jan;54(1):9-23. doi: 10.1002/mc.22070. Epub 2013 Jul 19.

7.

Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeutics.

Cance WG, Kurenova E, Marlowe T, Golubovskaya V.

Sci Signal. 2013 Mar 26;6(268):pe10. doi: 10.1126/scisignal.2004021. Review.

8.

Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic cancer cells in vitro and in vivo.

Ucar DA, Magis AT, He DH, Lawrence NJ, Sebti SM, Kurenova E, Zajac-Kaye M, Zhang J, Hochwald SN.

Anticancer Agents Med Chem. 2013 May;13(4):595-602.

9.

Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines.

Beierle EA, Ma X, Stewart JE, Megison M, Cance WG, Kurenova EV.

Mol Carcinog. 2014 Mar;53(3):230-42. doi: 10.1002/mc.21969. Epub 2012 Oct 12.

10.

Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.

Ucar DA, Kurenova E, Garrett TJ, Cance WG, Nyberg C, Cox A, Massoll N, Ostrov DA, Lawrence N, Sebti SM, Zajac-Kaye M, Hochwald SN.

Cell Cycle. 2012 Sep 1;11(17):3250-9. doi: 10.4161/cc.21611. Epub 2012 Aug 16.

11.

A novel small molecule inhibitor of FAK and IGF-1R protein interactions decreases growth of human esophageal carcinoma.

Ucar DA, Cox A, He DH, Ostrov DA, Kurenova E, Hochwald SN.

Anticancer Agents Med Chem. 2011 Sep;11(7):629-37.

PMID:
21707510
12.

Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines.

Beierle EA, Ma X, Trujillo A, Kurenova EV, Cance WG, Golubovskaya VM.

Mol Carcinog. 2010 Mar;49(3):224-34. doi: 10.1002/mc.20592.

13.

A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts.

Zheng D, Golubovskaya V, Kurenova E, Wood C, Massoll NA, Ostrov D, Cance WG, Hochwald SN.

Mol Carcinog. 2010 Feb;49(2):200-9. doi: 10.1002/mc.20590.

14.

Targeting of the protein interaction site between FAK and IGF-1R.

Zheng D, Kurenova E, Ucar D, Golubovskaya V, Magis A, Ostrov D, Cance WG, Hochwald SN.

Biochem Biophys Res Commun. 2009 Oct 16;388(2):301-5. doi: 10.1016/j.bbrc.2009.07.156. Epub 2009 Aug 5.

15.
16.

Vascular endothelial growth factor receptor-3 promotes breast cancer cell proliferation, motility and survival in vitro and tumor formation in vivo.

Kurenova EV, Hunt DL, He D, Fu AD, Massoll NA, Golubovskaya VM, Garces CA, Cance WG.

Cell Cycle. 2009 Jul 15;8(14):2266-80. Epub 2009 Jul 23.

17.

Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase.

Kweh F, Zheng M, Kurenova E, Wallace M, Golubovskaya V, Cance WG.

Mol Carcinog. 2009 Nov;48(11):1005-17. doi: 10.1002/mc.20552.

18.

Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group.

Magis AT, Bailey KM, Kurenova EV, Hernández Prada JA, Cance WG, Ostrov DA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):564-6. doi: 10.1107/S1744309108011421. Epub 2008 May 30.

19.

Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses.

Beierle EA, Massoll NA, Hartwich J, Kurenova EV, Golubovskaya VM, Cance WG, McGrady P, London WB.

Clin Cancer Res. 2008 Jun 1;14(11):3299-305. doi: 10.1158/1078-0432.CCR-07-1511.

20.

FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells.

Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN.

Carcinogenesis. 2008 Jun;29(6):1096-107. doi: 10.1093/carcin/bgn026. Epub 2008 Feb 7.

21.

TAE226 inhibits human neuroblastoma cell survival.

Beierle EA, Trujillo A, Nagaram A, Golubovskaya VM, Cance WG, Kurenova EV.

Cancer Invest. 2008 Mar;26(2):145-51. doi: 10.1080/07357900701577475.

PMID:
18259944
22.

The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning.

Golubovskaya VM, Finch R, Zheng M, Kurenova EV, Cance WG.

Biochem J. 2008 Apr 1;411(1):151-60. doi: 10.1042/BJ20071657.

PMID:
18215142
23.

Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo.

Funa NS, Reddy K, Bhandarkar S, Kurenova EV, Yang L, Cance WG, Welsh M, Arbiser JL.

J Invest Dermatol. 2008 Mar;128(3):710-6. Epub 2007 Oct 4.

24.

N-MYC regulates focal adhesion kinase expression in human neuroblastoma.

Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM.

J Biol Chem. 2007 Apr 27;282(17):12503-16. Epub 2007 Feb 27.

25.

Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells.

Garces CA, Kurenova EV, Golubovskaya VM, Cance WG.

Cancer Res. 2006 Feb 1;66(3):1446-54.

26.

Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein.

Kurenova E, Xu LH, Yang X, Baldwin AS Jr, Craven RJ, Hanks SK, Liu ZG, Cance WG.

Mol Cell Biol. 2004 May;24(10):4361-71.

27.

Control of telomere elongation and telomeric silencing in Drosophila melanogaster.

Mason JM, Haoudi A, Konev AY, Kurenova E, Walter MF, Biessmann H.

Genetica. 2000;109(1-2):61-70. Review.

PMID:
11293796
28.

Directional gene silencing induced by a complex subtelomeric satellite from Drosophila.

Kurenova E, Champion L, Biessmann H, Mason JM.

Chromosoma. 1998 Nov;107(5):311-20.

PMID:
9880764
29.

Telomere functions. A review.

Kurenova EV, Mason JM.

Biochemistry (Mosc). 1997 Nov;62(11):1242-53. Review.

PMID:
9467848
30.

The Y chromosome of Drosophila melanogaster contains a distinctive subclass of Het-A-related repeats.

Danilevskaya O, Lofsky A, Kurenova EV, Pardue ML.

Genetics. 1993 Jun;134(2):531-43.

31.

A repetitive DNA element, associated with telomeric sequences in Drosophila melanogaster, contains open reading frames.

Danilevskaya ON, Petrov DA, Pavlova MN, Koga A, Kurenova EV, Hartl DL.

Chromosoma. 1992 Dec;102(1):32-40.

PMID:
1291227
32.

He-T family DNA sequences in the Y chromosome of Drosophila melanogaster share homology with the X-linked stellate genes.

Danilevskaya ON, Kurenova EV, Pavlova MN, Bebehov DV, Link AJ, Koga A, Vellek A, Hartl DL.

Chromosoma. 1991 Feb;100(2):118-24.

PMID:
1672635
33.

[Hoppel-family of mobile elements of Drosophila melanogaster, flanked by short inverted repeats and having preferential localization in the heterochromatin regions of the genome].

Kurenova EV, Leĭbovich BA, Bass IA, Bebikhov DV, Pavlova MN, Danilevskaia ON.

Genetika. 1990 Oct;26(10):1701-12. Russian.

PMID:
2178142
34.

[A family of repeated sequences in Drosophila genome with telomeric localization: properties and polymorphism].

Danilevskaia ON, Kurenova EV, Leĭbovich BA, Bass IA, Pavlova MN.

Genetika. 1990 Mar;26(3):474-84. Russian.

PMID:
2113022
35.
36.

[Localization in the P-element of Drosophila melanogaster of sequences ensuring the autonomic replication of plasmids in yeasts].

Danilevskaia ON, Kurenova EV, Kaverina EN.

Mol Gen Mikrobiol Virusol. 1988 Apr;(4):41-4. Russian.

PMID:
2841596
37.

[Cloning of the promoter of the RNA polymerase operon located before the structural gene of the beta-subunit].

Bass IA, Kurenova EV, Mekhedov SL.

Mol Biol (Mosk). 1982 May-Jun;16(3):575-80. Russian.

PMID:
6285178

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