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Items: 1 to 50 of 274

1.

CD81 as target for B cell lymphomas.

Küppers R.

J Exp Med. 2019 Jul 1;216(7):1469-1470. doi: 10.1084/jem.20190733. Epub 2019 Jun 6.

PMID:
31171705
2.

MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma.

Hüllein J, Słabicki M, Rosolowski M, Jethwa A, Habringer S, Tomska K, Kurilov R, Lu J, Scheinost S, Wagener R, Huang Z, Lukas M, Yavorska O, Helfrich H, Scholtysik R, Bonneau K, Tedesco D, Küppers R, Klapper W, Pott C, Stilgenbauer S, Burkhardt B, Löffler M, Trümper LH, Hummel M, Brors B, Zapatka M, Siebert R, Kreuz M, Keller U, Huber W, Zenz T.

Cancer Res. 2019 Jun 15;79(12):3125-3138. doi: 10.1158/0008-5472.CAN-18-3438. Epub 2019 Apr 18.

PMID:
31000522
3.

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma.

López C, Kleinheinz K, Aukema SM, Rohde M, Bernhart SH, Hübschmann D, Wagener R, Toprak UH, Raimondi F, Kreuz M, Waszak SM, Huang Z, Sieverling L, Paramasivam N, Seufert J, Sungalee S, Russell RB, Bausinger J, Kretzmer H, Ammerpohl O, Bergmann AK, Binder H, Borkhardt A, Brors B, Claviez A, Doose G, Feuerbach L, Haake A, Hansmann ML, Hoell J, Hummel M, Korbel JO, Lawerenz C, Lenze D, Radlwimmer B, Richter J, Rosenstiel P, Rosenwald A, Schilhabel MB, Stein H, Stilgenbauer S, Stadler PF, Szczepanowski M, Weniger MA, Zapatka M, Eils R, Lichter P, Loeffler M, Möller P, Trümper L, Klapper W; ICGC MMML-Seq Consortium, Hoffmann S, Küppers R, Burkhardt B, Schlesner M, Siebert R.

Nat Commun. 2019 Mar 29;10(1):1459. doi: 10.1038/s41467-019-08578-3.

4.
5.

Origin and Pathogenesis of B Cell Lymphomas.

Seifert M, Scholtysik R, Küppers R.

Methods Mol Biol. 2019;1956:1-33. doi: 10.1007/978-1-4939-9151-8_1. Review.

PMID:
30779028
6.

IG-MYC + neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas.

Wagener R, López C, Kleinheinz K, Bausinger J, Aukema SM, Nagel I, Toprak UH, Seufert J, Altmüller J, Thiele H, Schneider C, Kolarova J, Park J, Hübschmann D, Murga Penas EM, Drexler HG, Attarbaschi A, Hovland R, Kjeldsen E, Kneba M, Kontny U, de Leval L, Nürnberg P, Oschlies I, Oscier D, Schlegelberger B, Stilgenbauer S, Wössmann W, Schlesner M, Burkhardt B, Klapper W, Jaffe ES, Küppers R, Siebert R.

Blood. 2018 Nov 22;132(21):2280-2285. doi: 10.1182/blood-2018-03-842088. Epub 2018 Oct 3.

PMID:
30282799
7.

JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma.

Schuhmacher B, Bein J, Rausch T, Benes V, Tousseyn T, Vornanen M, Ponzoni M, Thurner L, Gascoyne R, Steidl C, Küppers R, Hansmann ML, Hartmann S.

Haematologica. 2019 Feb;104(2):330-337. doi: 10.3324/haematol.2018.203224. Epub 2018 Sep 13.

8.

Expression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcome.

Unterluggauer JJ, Prochazka K, Tomazic PV, Huber HJ, Seeboeck R, Fechter K, Steinbauer E, Gruber V, Feichtinger J, Pichler M, Weniger MA, Küppers R, Sill H, Schicho R, Neumeister P, Beham-Schmid C, Deutsch AJA, Haybaeck J.

Blood Cancer J. 2018 Aug 22;8(9):79. doi: 10.1038/s41408-018-0112-5. No abstract available.

9.

CD30 expression in neoplastic T cells of follicular T cell lymphoma is a helpful diagnostic tool in the differential diagnosis of Hodgkin lymphoma.

Hartmann S, Goncharova O, Portyanko A, Sabattini E, Meinel J, Küppers R, Agostinelli C, Pileri SA, Hansmann ML.

Mod Pathol. 2019 Jan;32(1):37-47. doi: 10.1038/s41379-018-0108-5. Epub 2018 Aug 23.

PMID:
30140037
10.

Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells.

Weniger MA, Tiacci E, Schneider S, Arnolds J, Rüschenbaum S, Duppach J, Seifert M, Döring C, Hansmann ML, Küppers R.

J Clin Invest. 2018 Jul 2;128(7):2996-3007. doi: 10.1172/JCI95993. Epub 2018 Jun 11.

11.

Critical influences on the pathogenesis of follicular lymphoma.

Küppers R, Stevenson FK.

Blood. 2018 May 24;131(21):2297-2306. doi: 10.1182/blood-2017-11-764365. Epub 2018 Apr 17. Review.

12.

Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model.

Weiser C, Petkova MV, Rengstl B, Döring C, von Laer D, Hartmann S, Küppers R, Hansmann ML, Newrzela S.

Oncotarget. 2018 Mar 23;9(22):15942-15951. doi: 10.18632/oncotarget.24639. eCollection 2018 Mar 23.

13.

CD83 in Hodgkin lymphoma.

Küppers R.

Haematologica. 2018 Apr;103(4):561-562. doi: 10.3324/haematol.2018.188870. No abstract available.

14.

SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.

Johansson P, Klein-Hitpass L, Choidas A, Habenberger P, Mahboubi B, Kim B, Bergmann A, Scholtysik R, Brauser M, Lollies A, Siebert R, Zenz T, Dührsen U, Küppers R, Dürig J.

Blood Cancer J. 2018 Jan 19;8(1):11. doi: 10.1038/s41408-017-0036-5.

15.

Structure and diversification of immunoglobulin genes in African Burkitt lymphoma.

Küppers R.

Blood Adv. 2017 Jul 3;1(16):1259-1260. doi: 10.1182/bloodadvances.2017007401. eCollection 2017 Jul 11. No abstract available.

16.

Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus-infected individuals.

Tucci FA, Kitanovski S, Johansson P, Klein-Hitpass L, Kahraman A, Dürig J, Hoffmann D, Küppers R.

Blood. 2018 Feb 1;131(5):546-557. doi: 10.1182/blood-2017-09-805762. Epub 2017 Dec 14.

17.

Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma.

Wein F, Weniger MA, Höing B, Arnolds J, Hüttmann A, Hansmann ML, Hartmann S, Küppers R.

Cancer Immunol Res. 2017 Dec;5(12):1122-1132. doi: 10.1158/2326-6066.CIR-17-0325. Epub 2017 Oct 25.

18.

An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma.

Lollies A, Hartmann S, Schneider M, Bracht T, Weiß AL, Arnolds J, Klein-Hitpass L, Sitek B, Hansmann ML, Küppers R, Weniger MA.

Leukemia. 2018 Jan;32(1):92-101. doi: 10.1038/leu.2017.203. Epub 2017 Jun 29.

PMID:
28659618
19.

Determining the Origin of Human Germinal Center B Cell-Derived Malignancies.

Seifert M, Küppers R.

Methods Mol Biol. 2017;1623:253-279. doi: 10.1007/978-1-4939-7095-7_20.

PMID:
28589362
20.

TET2 mutations in B cells of patients affected by angioimmunoblastic T-cell lymphoma.

Schwartz FH, Cai Q, Fellmann E, Hartmann S, Mäyränpää MI, Karjalainen-Lindsberg ML, Sundström C, Scholtysik R, Hansmann ML, Küppers R.

J Pathol. 2017 Jun;242(2):129-133. doi: 10.1002/path.4898. Epub 2017 May 3.

PMID:
28337768
21.

Quantitative Comparison of Abundance Structures of Generalized Communities: From B-Cell Receptor Repertoires to Microbiomes.

Saeedghalati M, Farahpour F, Budeus B, Lange A, Westendorf AM, Seifert M, Küppers R, Hoffmann D.

PLoS Comput Biol. 2017 Jan 23;13(1):e1005362. doi: 10.1371/journal.pcbi.1005362. eCollection 2017 Jan.

22.

Alterations of microRNA and microRNA-regulated messenger RNA expression in germinal center B-cell lymphomas determined by integrative sequencing analysis.

Hezaveh K, Kloetgen A, Bernhart SH, Mahapatra KD, Lenze D, Richter J, Haake A, Bergmann AK, Brors B, Burkhardt B, Claviez A, Drexler HG, Eils R, Haas S, Hoffmann S, Karsch D, Klapper W, Kleinheinz K, Korbel J, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Leich E, Loeffler M, Mantovani-Loeffler L, López C, McHardy AC, Möller P, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schlesner M, Scholz I, Stadler PF, Stilgenbauer S, Sungalee S, Szczepanowski M, Trümper L, Weniger MA, Siebert R, Borkhardt A, Hummel M, Hoell JI; ICGC MMML-Seq Project.

Haematologica. 2016 Nov;101(11):1380-1389. Epub 2016 Jul 6.

23.

A strong host response and lack of MYC expression are characteristic for diffuse large B cell lymphoma transformed from nodular lymphocyte predominant Hodgkin lymphoma.

Schuhmacher B, Rengstl B, Döring C, Bein J, Newrzela S, Brunnberg U, Kvasnicka HM, Vornanen M, Küppers R, Hansmann ML, Hartmann S.

Oncotarget. 2016 Nov 1;7(44):72197-72210. doi: 10.18632/oncotarget.12363.

24.

Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma.

Mansouri L, Noerenberg D, Young E, Mylonas E, Abdulla M, Frick M, Asmar F, Ljungström V, Schneider M, Yoshida K, Skaftason A, Pandzic T, Gonzalez B, Tasidou A, Waldhueter N, Rivas-Delgado A, Angelopoulou M, Ziepert M, Arends CM, Couronné L, Lenze D, Baldus CD, Bastard C, Okosun J, Fitzgibbon J, Dörken B, Drexler HG, Roos-Weil D, Schmitt CA, Munch-Petersen HD, Zenz T, Hansmann ML, Strefford JC, Enblad G, Bernard OA, Ralfkiaer E, Erlanson M, Korkolopoulou P, Hultdin M, Papadaki T, Grønbæk K, Lopez-Guillermo A, Ogawa S, Küppers R, Stamatopoulos K, Stavroyianni N, Kanellis G, Rosenwald A, Campo E, Amini RM, Ott G, Vassilakopoulos TP, Hummel M, Rosenquist R, Damm F.

Blood. 2016 Dec 8;128(23):2666-2670. Epub 2016 Sep 26.

25.

Concepts in mature T-cell lymphomas - highlights from an international joint symposium on T-cell immunology and oncology<sup/>.

Herling M, Rengstl B, Scholtysik R, Hartmann S, Küppers R, Hansmann ML, Diebner HH, Roeder I, Abken H, Newrzela S, Kirberg J.

Leuk Lymphoma. 2017 Apr;58(4):788-796. doi: 10.1080/10428194.2016.1222381. Epub 2016 Sep 19.

PMID:
27643643
26.

Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas.

Johansson P, Klein-Hitpass L, Grabellus F, Arnold G, Klapper W, Pförtner R, Dührsen U, Eckstein A, Dürig J, Küppers R.

Oncotarget. 2016 Sep 20;7(38):62627-62639. doi: 10.18632/oncotarget.11548.

27.

Human memory B cells.

Seifert M, Küppers R.

Leukemia. 2016 Dec;30(12):2283-2292. doi: 10.1038/leu.2016.226. Epub 2016 Aug 8. Review.

PMID:
27499139
28.

Hodgkin lymphoma: Pathology and biology.

Mathas S, Hartmann S, Küppers R.

Semin Hematol. 2016 Jul;53(3):139-47. doi: 10.1053/j.seminhematol.2016.05.007. Epub 2016 May 13. Review.

PMID:
27496304
29.

Tumor-infiltrating HLA-matched CD4(+) T cells retargeted against Hodgkin and Reed-Sternberg cells.

Rengstl B, Schmid F, Weiser C, Döring C, Heinrich T, Warner K, Becker PS, Wistinghausen R, Kameh-Var S, Werling E, Billmeier A, Seidl C, Hartmann S, Abken H, Küppers R, Hansmann ML, Newrzela S.

Oncoimmunology. 2016 Mar 16;5(6):e1160186. doi: 10.1080/2162402X.2016.1160186. eCollection 2016 Jun.

30.

Novel IGH and MYC Translocation Partners in Diffuse Large B-Cell Lymphomas.

Otto C, Scholtysik R, Schmitz R, Kreuz M, Becher C, Hummel M, Rosenwald A, Trümper L, Klapper W, Siebert R, Küppers R; “Molecular Mechanisms in Malignant Lymphomas” Network Project.

Genes Chromosomes Cancer. 2016 Dec;55(12):932-943. doi: 10.1002/gcc.22391. Epub 2016 Jul 12.

PMID:
27356265
31.

NF-κB deregulation in Hodgkin lymphoma.

Weniger MA, Küppers R.

Semin Cancer Biol. 2016 Aug;39:32-9. doi: 10.1016/j.semcancer.2016.05.001. Epub 2016 May 21. Review.

PMID:
27221964
32.

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.

Oakes CC, Seifert M, Assenov Y, Gu L, Przekopowitz M, Ruppert AS, Wang Q, Imbusch CD, Serva A, Koser SD, Brocks D, Lipka DB, Bogatyrova O, Weichenhan D, Brors B, Rassenti L, Kipps TJ, Mertens D, Zapatka M, Lichter P, Döhner H, Küppers R, Zenz T, Stilgenbauer S, Byrd JC, Plass C.

Nat Genet. 2016 Mar;48(3):253-64. doi: 10.1038/ng.3488. Epub 2016 Jan 18.

33.

IRAK4 inhibition to shut down TLR signaling in autoimmunity and MyD88-dependent lymphomas.

Küppers R.

J Exp Med. 2015 Dec 14;212(13):2184. doi: 10.1084/jem.21213insight1. No abstract available.

34.

Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma.

Hartmann S, Schuhmacher B, Rausch T, Fuller L, Döring C, Weniger M, Lollies A, Weiser C, Thurner L, Rengstl B, Brunnberg U, Vornanen M, Pfreundschuh M, Benes V, Küppers R, Newrzela S, Hansmann ML.

Leukemia. 2016 Apr;30(4):844-53. doi: 10.1038/leu.2015.328. Epub 2015 Dec 10.

PMID:
26658840
35.

Whole exome sequencing of microdissected splenic marginal zone lymphoma: a study to discover novel tumor-specific mutations.

Peveling-Oberhag J, Wolters F, Döring C, Walter D, Sellmann L, Scholtysik R, Lucioni M, Schubach M, Paulli M, Biskup S, Zeuzem S, Küppers R, Hansmann ML.

BMC Cancer. 2015 Oct 24;15:773. doi: 10.1186/s12885-015-1766-z.

36.

DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.

Kretzmer H, Bernhart SH, Wang W, Haake A, Weniger MA, Bergmann AK, Betts MJ, Carrillo-de-Santa-Pau E, Doose G, Gutwein J, Richter J, Hovestadt V, Huang B, Rico D, Jühling F, Kolarova J, Lu Q, Otto C, Wagener R, Arnolds J, Burkhardt B, Claviez A, Drexler HG, Eberth S, Eils R, Flicek P, Haas S, Humme M, Karsch D, Kerstens HHD, Klapper W, Kreuz M, Lawerenz C, Lenzek D, Loeffler M, López C, MacLeod RAF, Martens JHA, Kulis M, Martín-Subero JI, Möller P, Nage I, Picelli S, Vater I, Rohde M, Rosenstiel P, Rosolowski M, Russell RB, Schilhabel M, Schlesner M, Stadler PF, Szczepanowski M, Trümper L, Stunnenberg HG, Küppers R, Ammerpohl O, Lichter P, Siebert R, Hoffmann S, Radlwimmer B.

Nat Genet. 2015 Nov;47(11):1316-1325. doi: 10.1038/ng.3413. Epub 2015 Oct 5.

37.

MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells.

Doose G, Haake A, Bernhart SH, López C, Duggimpudi S, Wojciech F, Bergmann AK, Borkhardt A, Burkhardt B, Claviez A, Dimitrova L, Haas S, Hoell JI, Hummel M, Karsch D, Klapper W, Kleo K, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Lenze D, Loeffler M, Mantovani-Löffler L, Möller P, Ott G, Richter J, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schneider M, Scholz I, Stilgenbauer S, Stunnenberg HG, Szczepanowski M, Trümper L, Weniger MA; ICGC MMML-Seq Consortium, Hoffmann S, Siebert R, Iaccarino I.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5261-70. doi: 10.1073/pnas.1505753112. Epub 2015 Sep 8.

38.

Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers.

Budeus B, Schweigle de Reynoso S, Przekopowitz M, Hoffmann D, Seifert M, Küppers R.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5281-9. doi: 10.1073/pnas.1511270112. Epub 2015 Aug 31.

39.

The role of T cells in the microenvironment of Hodgkin lymphoma.

Wein F, Küppers R.

J Leukoc Biol. 2016 Jan;99(1):45-50. doi: 10.1189/jlb.3MR0315-136R. Epub 2015 Aug 28. Review.

40.

Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia.

Johansson P, Bergmann A, Rahmann S, Wohlers I, Scholtysik R, Przekopowitz M, Seifert M, Tschurtschenthaler G, Webersinke G, Jäger U, Siebert R, Klein-Hitpass L, Dührsen U, Dürig J, Küppers R.

Int J Cancer. 2016 Jan 1;138(1):121-4. doi: 10.1002/ijc.29697. Epub 2015 Jul 30.

41.

Alterations of the CD58 gene in classical Hodgkin lymphoma.

Schneider M, Schneider S, Zühlke-Jenisch R, Klapper W, Sundström C, Hartmann S, Hansmann ML, Siebert R, Küppers R, Giefing M.

Genes Chromosomes Cancer. 2015 Oct;54(10):638-45. doi: 10.1002/gcc.22276. Epub 2015 Jul 21.

PMID:
26194173
42.

Potential role of hypoxia in early stages of Hodgkin lymphoma pathogenesis.

Wein F, Otto T, Lambertz P, Fandrey J, Hansmann ML, Küppers R.

Haematologica. 2015 Oct;100(10):1320-6. doi: 10.3324/haematol.2015.127498. Epub 2015 Jul 9.

43.

Whole-genome fingerprint of the DNA methylome during human B cell differentiation.

Kulis M, Merkel A, Heath S, Queirós AC, Schuyler RP, Castellano G, Beekman R, Raineri E, Esteve A, Clot G, Verdaguer-Dot N, Duran-Ferrer M, Russiñol N, Vilarrasa-Blasi R, Ecker S, Pancaldi V, Rico D, Agueda L, Blanc J, Richardson D, Clarke L, Datta A, Pascual M, Agirre X, Prosper F, Alignani D, Paiva B, Caron G, Fest T, Muench MO, Fomin ME, Lee ST, Wiemels JL, Valencia A, Gut M, Flicek P, Stunnenberg HG, Siebert R, Küppers R, Gut IG, Campo E, Martín-Subero JI.

Nat Genet. 2015 Jul;47(7):746-56. doi: 10.1038/ng.3291. Epub 2015 Jun 8.

44.

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS.

Nat Commun. 2015 Feb 18;6:6217. doi: 10.1038/ncomms7217.

45.

A large fraction of human tonsillar B cells expressing CD27 are germinal center B cells.

Przekopowitz M, Küppers R, Weniger MA.

Immunol Cell Biol. 2015 May-Jun;93(5):429-30. doi: 10.1038/icb.2015.6. Epub 2015 Feb 3. No abstract available.

PMID:
25643614
46.

Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions.

Seifert M, Przekopowitz M, Taudien S, Lollies A, Ronge V, Drees B, Lindemann M, Hillen U, Engler H, Singer BB, Küppers R.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E546-55. doi: 10.1073/pnas.1416276112. Epub 2015 Jan 26.

47.

Immunoglobulin repertoire of primary lymphomas of the central nervous system.

Montesinos-Rongen M, Purschke F, Küppers R, Deckert M.

J Neuropathol Exp Neurol. 2014 Dec;73(12):1116-25. doi: 10.1097/NEN.0000000000000133.

PMID:
25383641
48.

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.

Kreher S, Bouhlel MA, Cauchy P, Lamprecht B, Li S, Grau M, Hummel F, Köchert K, Anagnostopoulos I, Jöhrens K, Hummel M, Hiscott J, Wenzel SS, Lenz P, Schneider M, Küppers R, Scheidereit C, Giefing M, Siebert R, Rajewsky K, Lenz G, Cockerill PN, Janz M, Dörken B, Bonifer C, Mathas S.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4513-22. doi: 10.1073/pnas.1406985111. Epub 2014 Oct 6.

49.

Pathogenesis, diagnosis, and treatment of composite lymphomas.

Küppers R, Dührsen U, Hansmann ML.

Lancet Oncol. 2014 Sep;15(10):e435-46. doi: 10.1016/S1470-2045(14)70153-6. Review.

PMID:
25186047
50.

Characterization of genomic imbalances in diffuse large B-cell lymphoma by detailed SNP-chip analysis.

Scholtysik R, Kreuz M, Hummel M, Rosolowski M, Szczepanowski M, Klapper W, Loeffler M, Trümper L, Siebert R, Küppers R; Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe.

Int J Cancer. 2015 Mar 1;136(5):1033-42. doi: 10.1002/ijc.29072. Epub 2014 Jul 22.

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