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Items: 47

1.

DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response.

Liang F, Miller AS, Longerich S, Tang C, Maranon D, Williamson EA, Hromas R, Wiese C, Kupfer GM, Sung P.

Nat Commun. 2019 Jun 28;10(1):2849. doi: 10.1038/s41467-019-10408-5.

2.

Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study.

Rogers ZR, Nakano TA, Olson TS, Bertuch AA, Wang W, Gillio A, Coates TD, Chawla A, Castillo P, Kurre P, Gamper C, Bennett CM, Joshi S, Geddis AE, Boklan J, Nalepa G, Rothman JA, Huang JN, Kupfer GM, Cada M, Glader B, Walkovich KJ, Thompson AA, Hanna R, Vlachos A, Malsch M, Weller EA, Williams DA, Shimamura A.

Haematologica. 2019 Oct;104(10):1974-1983. doi: 10.3324/haematol.2018.206540. Epub 2019 Apr 4.

3.

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination.

Liang Z, Liang F, Teng Y, Chen X, Liu J, Longerich S, Rao T, Green AM, Collins NB, Xiong Y, Lan L, Sung P, Kupfer GM.

Cell Rep. 2019 Jan 15;26(3):564-572.e5. doi: 10.1016/j.celrep.2018.12.084.

4.

Endosome trafficking: blood and more.

Kupfer GM.

Blood. 2018 Aug 9;132(6):557-558. doi: 10.1182/blood-2018-06-854968. No abstract available.

PMID:
30093384
5.

Reprogramming human T cell function and specificity with non-viral genome targeting.

Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A.

Nature. 2018 Jul;559(7714):405-409. doi: 10.1038/s41586-018-0326-5. Epub 2018 Jul 11.

6.

BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.

Zhao W, Steinfeld JB, Liang F, Chen X, Maranon DG, Jian Ma C, Kwon Y, Rao T, Wang W, Sheng C, Song X, Deng Y, Jimenez-Sainz J, Lu L, Jensen RB, Xiong Y, Kupfer GM, Wiese C, Greene EC, Sung P.

Nature. 2017 Oct 19;550(7676):360-365. doi: 10.1038/nature24060. Epub 2017 Oct 4.

7.

A novel role for non-ubiquitinated FANCD2 in response to hydroxyurea-induced DNA damage.

Chen X, Bosques L, Sung P, Kupfer GM.

Oncogene. 2017 Sep 7;36(36):5220. doi: 10.1038/onc.2017.238. Epub 2017 Jul 3.

PMID:
28671668
8.

Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex.

Liang F, Longerich S, Miller AS, Tang C, Buzovetsky O, Xiong Y, Maranon DG, Wiese C, Kupfer GM, Sung P.

Cell Rep. 2016 Jun 7;15(10):2118-2126. doi: 10.1016/j.celrep.2016.05.007. Epub 2016 May 26.

9.

A novel role for non-ubiquitinated FANCD2 in response to hydroxyurea-induced DNA damage.

Chen X, Bosques L, Sung P, Kupfer GM.

Oncogene. 2016 Jan 7;35(1):22-34. doi: 10.1038/onc.2015.68. Epub 2015 Apr 20. Erratum in: Oncogene. 2017 Jul 03;:.

10.

Factor VIII May Predict Catheter-Related Thrombosis in Critically Ill Children: A Preliminary Study.

Faustino EV, Li S, Silva CT, Pinto MG, Qin L, Tala JA, Rinder HM, Kupfer GM, Shapiro ED; Northeast Pediatric Critical Care Research Consortium.

Pediatr Crit Care Med. 2015 Jul;16(6):497-504. doi: 10.1097/PCC.0000000000000409.

11.

Stress and DNA repair biology of the Fanconi anemia pathway.

Longerich S, Li J, Xiong Y, Sung P, Kupfer GM.

Blood. 2014 Oct 30;124(18):2812-9. doi: 10.1182/blood-2014-04-526293. Epub 2014 Sep 18. Review.

12.

The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization.

Chen X, Wilson JB, McChesney P, Williams SA, Kwon Y, Longerich S, Marriott AS, Sung P, Jones NJ, Kupfer GM.

J Biol Chem. 2014 Sep 12;289(37):25774-82. doi: 10.1074/jbc.M114.552570. Epub 2014 Jul 28.

13.

Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA.

Longerich S, Kwon Y, Tsai MS, Hlaing AS, Kupfer GM, Sung P.

Nucleic Acids Res. 2014 May;42(9):5657-70. doi: 10.1093/nar/gku198. Epub 2014 Mar 12.

14.

Fanconi anemia: a signal transduction and DNA repair pathway.

Kupfer GM.

Yale J Biol Med. 2013 Dec 13;86(4):491-7. Review.

15.

The inherited bone marrow failure syndromes.

Chirnomas SD, Kupfer GM.

Pediatr Clin North Am. 2013 Dec;60(6):1291-310. doi: 10.1016/j.pcl.2013.09.007. Review.

16.

Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults.

Omer B, Kadan-Lottick NS, Roberts KB, Wang R, Demsky C, Kupfer GM, Cooper D, Seropian S, Ma X.

Br J Haematol. 2012 Sep;158(5):615-25. doi: 10.1111/j.1365-2141.2012.09211.x. Epub 2012 Jul 6.

PMID:
22775513
17.

Phenotype diversity in type 1 Gaucher disease: discovering the genetic basis of Gaucher disease/hematologic malignancy phenotype by individual genome analysis.

Lo SM, Choi M, Liu J, Jain D, Boot RG, Kallemeijn WW, Aerts JM, Pashankar F, Kupfer GM, Mane S, Lifton RP, Mistry PK.

Blood. 2012 May 17;119(20):4731-40. doi: 10.1182/blood-2011-10-386862. Epub 2012 Apr 4. Erratum in: Blood. 2014 Oct 9;124(15):2469.

18.

Functional and physical interaction between the mismatch repair and FA-BRCA pathways.

Williams SA, Wilson JB, Clark AP, Mitson-Salazar A, Tomashevski A, Ananth S, Glazer PM, Semmes OJ, Bale AE, Jones NJ, Kupfer GM.

Hum Mol Genet. 2011 Nov 15;20(22):4395-410. doi: 10.1093/hmg/ddr366. Epub 2011 Aug 24.

19.

The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI.

Williams SA, Longerich S, Sung P, Vaziri C, Kupfer GM.

Blood. 2011 May 12;117(19):5078-87. doi: 10.1182/blood-2010-10-311761. Epub 2011 Feb 25.

20.

Rad18-mediated translesion synthesis of bulky DNA adducts is coupled to activation of the Fanconi anemia DNA repair pathway.

Song IY, Palle K, Gurkar A, Tateishi S, Kupfer GM, Vaziri C.

J Biol Chem. 2010 Oct 8;285(41):31525-36. doi: 10.1074/jbc.M110.138206. Epub 2010 Jul 30.

21.

Serum response factor is an essential transcription factor in megakaryocytic maturation.

Halene S, Gao Y, Hahn K, Massaro S, Italiano JE Jr, Schulz V, Lin S, Kupfer GM, Krause DS.

Blood. 2010 Sep 16;116(11):1942-50. doi: 10.1182/blood-2010-01-261743. Epub 2010 Jun 4.

22.

Purification of FANCD2 sub-complexes.

Zhi G, Chen X, Newcomb W, Brown J, Semmes OJ, Kupfer GM.

Br J Haematol. 2010 Jul;150(1):88-92. doi: 10.1111/j.1365-2141.2010.08217.x. Epub 2010 Apr 29.

23.

Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance.

Wilson JB, Blom E, Cunningham R, Xiao Y, Kupfer GM, Jones NJ.

Mutat Res. 2010 Jul 7;689(1-2):12-20. doi: 10.1016/j.mrfmmm.2010.04.003. Epub 2010 May 5.

24.

Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction.

Zhi G, Wilson JB, Chen X, Krause DS, Xiao Y, Jones NJ, Kupfer GM.

Cancer Res. 2009 Nov 15;69(22):8775-83. doi: 10.1158/0008-5472.CAN-09-2312. Epub 2009 Oct 27.

25.

Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated.

Noy-Lotan S, Dgany O, Lahmi R, Marcoux N, Krasnov T, Yissachar N, Ginsberg D, Motro B, Resnitzky P, Yaniv I, Kupfer GM, Tamary H.

Haematologica. 2009 May;94(5):629-37. doi: 10.3324/haematol.2008.003327. Epub 2009 Mar 31.

26.

Fanconi anemia.

Green AM, Kupfer GM.

Hematol Oncol Clin North Am. 2009 Apr;23(2):193-214. doi: 10.1016/j.hoc.2009.01.008. Review.

27.

ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function.

Collins NB, Wilson JB, Bush T, Thomashevski A, Roberts KJ, Jones NJ, Kupfer GM.

Blood. 2009 Mar 5;113(10):2181-90. doi: 10.1182/blood-2008-05-154294. Epub 2008 Dec 24.

28.

HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase.

Durkin SS, Guo X, Fryrear KA, Mihaylova VT, Gupta SK, Belgnaoui SM, Haoudi A, Kupfer GM, Semmes OJ.

J Biol Chem. 2008 Dec 26;283(52):36311-20. doi: 10.1074/jbc.M804931200. Epub 2008 Oct 27.

29.

Human T-cell leukemia virus I tax protein sensitizes p53-mutant cells to DNA damage.

Mihaylova VT, Green AM, Khurgel M, Semmes OJ, Kupfer GM.

Cancer Res. 2008 Jun 15;68(12):4843-52. doi: 10.1158/0008-5472.CAN-07-5070.

30.

Serum protein expression profiling in pediatric Hodgkin lymphoma: a report from the Children's Oncology Group.

Qi L, Cazares L, Johnson C, de Alarcon P, Kupfer GM, Semmes OJ.

Pediatr Blood Cancer. 2008 Aug;51(2):216-21. doi: 10.1002/pbc.21581.

PMID:
18421715
31.

FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.

Wilson JB, Yamamoto K, Marriott AS, Hussain S, Sung P, Hoatlin ME, Mathew CG, Takata M, Thompson LH, Kupfer GM, Jones NJ.

Oncogene. 2008 Jun 12;27(26):3641-52. doi: 10.1038/sj.onc.1211034. Epub 2008 Jan 21.

PMID:
18212739
32.

UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.

Machida YJ, Machida Y, Chen Y, Gurtan AM, Kupfer GM, D'Andrea AD, Dutta A.

Mol Cell. 2006 Aug;23(4):589-96.

33.

Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2.

Hussain S, Wilson JB, Blom E, Thompson LH, Sung P, Gordon SM, Kupfer GM, Joenje H, Mathew CG, Jones NJ.

DNA Repair (Amst). 2006 May 10;5(5):629-40. Epub 2006 Apr 18.

PMID:
16621732
34.

Molecular pathogenesis of Fanconi anemia.

Collins N, Kupfer GM.

Int J Hematol. 2005 Oct;82(3):176-83. Review.

PMID:
16207587
35.

FANCG is phosphorylated at serines 383 and 387 during mitosis.

Mi J, Qiao F, Wilson JB, High AA, Schroeder MJ, Stukenberg PT, Moss A, Shabanowitz J, Hunt DF, Jones NJ, Kupfer GM.

Mol Cell Biol. 2004 Oct;24(19):8576-85.

36.

Phosphorylation of fanconi anemia (FA) complementation group G protein, FANCG, at serine 7 is important for function of the FA pathway.

Qiao F, Mi J, Wilson JB, Zhi G, Bucheimer NR, Jones NJ, Kupfer GM.

J Biol Chem. 2004 Oct 29;279(44):46035-45. Epub 2004 Aug 6.

37.

The Fanconi anemia core complex associates with chromatin during S phase.

Mi J, Kupfer GM.

Blood. 2005 Jan 15;105(2):759-66. Epub 2004 Jul 15.

PMID:
15256425
38.

The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments.

Thomashevski A, High AA, Drozd M, Shabanowitz J, Hunt DF, Grant PA, Kupfer GM.

J Biol Chem. 2004 Jun 18;279(25):26201-9. Epub 2004 Apr 13.

39.

Fanconi anemia proteins localize to chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner.

Qiao F, Moss A, Kupfer GM.

J Biol Chem. 2001 Jun 29;276(26):23391-6. Epub 2001 Apr 10.

40.

The fanconi anemia pathway requires FAA phosphorylation and FAA/FAC nuclear accumulation.

Yamashita T, Kupfer GM, Naf D, Suliman A, Joenje H, Asano S, D'Andrea AD.

Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13085-90.

41.

Functional activity of the fanconi anemia protein FAA requires FAC binding and nuclear localization.

Näf D, Kupfer GM, Suliman A, Lambert K, D'Andrea AD.

Mol Cell Biol. 1998 Oct;18(10):5952-60.

42.

Subtyping analysis of Fanconi anemia by immunoblotting and retroviral gene transfer.

Pulsipher M, Kupfer GM, Naf D, Suliman A, Lee JS, Jakobs P, Grompe M, Joenje H, Sieff C, Guinan E, Mulligan R, D'Andrea AD.

Mol Med. 1998 Jul;4(7):468-79.

43.

Molecular biology of Fanconi anemia.

Kupfer GM, Näf D, D'Andrea AD.

Hematol Oncol Clin North Am. 1997 Dec;11(6):1045-60. Review.

PMID:
9443045
44.

The Fanconi anaemia proteins, FAA and FAC, interact to form a nuclear complex.

Kupfer GM, Näf D, Suliman A, Pulsipher M, D'Andrea AD.

Nat Genet. 1997 Dec;17(4):487-90.

PMID:
9398857
45.

The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2.

Kupfer GM, Yamashita T, Naf D, Suliman A, Asano S, D'Andrea AD.

Blood. 1997 Aug 1;90(3):1047-54.

PMID:
9242535
46.
47.

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