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Items: 1 to 50 of 77

1.

Molecular regulation of Snai2 in development and disease.

Zhou W, Gross KM, Kuperwasser C.

J Cell Sci. 2019 Dec 2;132(23). pii: jcs235127. doi: 10.1242/jcs.235127. Review.

PMID:
31792043
2.

Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.

Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C.

Cell Rep. 2019 Sep 24;28(13):3435-3449.e5. doi: 10.1016/j.celrep.2019.08.060.

3.

Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium.

Gross KM, Zhou W, Breindel JL, Ouyang J, Jin DX, Sokol ES, Gupta PB, Huber K, Zou L, Kuperwasser C.

Cell Rep. 2019 Jul 9;28(2):394-407.e6. doi: 10.1016/j.celrep.2019.06.043.

4.

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance.

Gupta PB, Pastushenko I, Skibinski A, Blanpain C, Kuperwasser C.

Cell Stem Cell. 2019 Jan 3;24(1):65-78. doi: 10.1016/j.stem.2018.11.011. Epub 2018 Dec 13. Review.

PMID:
30554963
5.

Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites.

Montesion M, Williams ZH, Subramanian RP, Kuperwasser C, Coffin JM.

Retrovirology. 2018 Aug 20;15(1):57. doi: 10.1186/s12977-018-0441-2.

6.

BCL11B Drives Human Mammary Stem Cell Self-Renewal In Vitro by Inhibiting Basal Differentiation.

Miller DH, Jin DX, Sokol ES, Cabrera JR, Superville DA, Gorelov RA, Kuperwasser C, Gupta PB.

Stem Cell Reports. 2018 Mar 13;10(3):1131-1145. doi: 10.1016/j.stemcr.2018.01.036. Epub 2018 Mar 1.

7.

Premature polyadenylation of MAGI3 is associated with diminished N6-methyladenosine in its large internal exon.

Ni TK, Elman JS, Jin DX, Gupta PB, Kuperwasser C.

Sci Rep. 2018 Jan 23;8(1):1415. doi: 10.1038/s41598-018-19916-8.

8.

Extracellular superoxide dismutase inhibits hepatocyte growth factor-mediated breast cancer-fibroblast interactions.

Golden BO, Griess B, Mir S, Fitzgerald M, Kuperwasser C, Domann F, Teoh-Fitzgerald M.

Oncotarget. 2017 Nov 10;8(64):107390-107408. doi: 10.18632/oncotarget.22379. eCollection 2017 Dec 8.

9.

Mechanisms of HERV-K (HML-2) Transcription during Human Mammary Epithelial Cell Transformation.

Montesion M, Bhardwaj N, Williams ZH, Kuperwasser C, Coffin JM.

J Virol. 2017 Dec 14;92(1). pii: e01258-17. doi: 10.1128/JVI.01258-17. Print 2018 Jan 1.

10.

Epigenetic Reprogramming of Lineage-Committed Human Mammary Epithelial Cells Requires DNMT3A and Loss of DOT1L.

Breindel JL, Skibinski A, Sedic M, Wronski-Campos A, Zhou W, Keller PJ, Mills J, Bradner J, Onder T, Kuperwasser C.

Stem Cell Reports. 2017 Sep 12;9(3):943-955. doi: 10.1016/j.stemcr.2017.06.019. Epub 2017 Aug 3.

11.

Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers.

Olsen SN, Wronski A, Castaño Z, Dake B, Malone C, De Raedt T, Enos M, DeRose YS, Zhou W, Guerra S, Loda M, Welm A, Partridge AH, McAllister SS, Kuperwasser C, Cichowski K.

Cancer Discov. 2017 Feb;7(2):202-217. doi: 10.1158/2159-8290.CD-16-0520. Epub 2016 Dec 14.

12.

Automated quantification of three-dimensional organization of fiber-like structures in biological tissues.

Liu Z, Pouli D, Sood D, Sundarakrishnan A, Hui Mingalone CK, Arendt LM, Alonzo C, Quinn KP, Kuperwasser C, Zeng L, Schnelldorfer T, Kaplan DL, Georgakoudi I.

Biomaterials. 2017 Feb;116:34-47. doi: 10.1016/j.biomaterials.2016.11.041. Epub 2016 Nov 25.

13.

The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer.

Zhou W, Ni TK, Wronski A, Glass B, Skibinski A, Beck A, Kuperwasser C.

Cell Rep. 2016 Oct 25;17(5):1302-1317. doi: 10.1016/j.celrep.2016.10.006.

14.

Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer.

Ni TK, Kuperwasser C.

Elife. 2016 May 20;5. pii: e14730. doi: 10.7554/eLife.14730.

15.

Cell Fate Decisions During Breast Cancer Development.

Gross K, Wronski A, Skibinski A, Phillips S, Kuperwasser C.

J Dev Biol. 2016 Mar 1;4(1):4. Epub 2016 Jan 22.

16.

BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer.

Sedic M, Kuperwasser C.

Cell Cycle. 2016;15(5):621-7. doi: 10.1080/15384101.2016.1141841. Review.

17.

The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis.

Xu K, Tian X, Oh SY, Movassaghi M, Naber SP, Kuperwasser C, Buchsbaum RJ.

Breast Cancer Res. 2016 Jan 28;18(1):14. doi: 10.1186/s13058-016-0674-8.

18.

Working stiff: how obesity boosts cancer risk.

Arendt LM, Kuperwasser C.

Sci Transl Med. 2015 Aug 19;7(301):301fs34. doi: 10.1126/scitranslmed.aac9446.

19.

Rapid three-dimensional quantification of voxel-wise collagen fiber orientation.

Liu Z, Quinn KP, Speroni L, Arendt L, Kuperwasser C, Sonnenschein C, Soto AM, Georgakoudi I.

Biomed Opt Express. 2015 Jun 3;6(7):2294-310. doi: 10.1364/BOE.6.002294. eCollection 2015 Jul 1.

20.

Form and function: how estrogen and progesterone regulate the mammary epithelial hierarchy.

Arendt LM, Kuperwasser C.

J Mammary Gland Biol Neoplasia. 2015 Jun;20(1-2):9-25. doi: 10.1007/s10911-015-9337-0. Epub 2015 Jul 19. Review.

21.

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.

Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, Keller PJ, Glover E, Richardson AL, Cowan J, Toland AE, Ravichandran K, Riethman H, Naber SP, Näär AM, Blasco MA, Hinds PW, Kuperwasser C.

Nat Commun. 2015 Jun 24;6:7505. doi: 10.1038/ncomms8505.

22.

Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring.

Schubert SM, Arendt LM, Zhou W, Baig S, Walter SR, Buchsbaum RJ, Kuperwasser C, Walt DR.

Sci Rep. 2015 Jun 8;5:11034. doi: 10.1038/srep11034.

23.

Humanization of the mouse mammary gland.

Wronski A, Arendt LM, Kuperwasser C.

Methods Mol Biol. 2015;1293:173-86. doi: 10.1007/978-1-4939-2519-3_10.

PMID:
26040688
24.

CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.

Mazumdar S, Arendt LM, Phillips S, Sedic M, Kuperwasser C, Gill G.

PLoS One. 2015 Mar 20;10(3):e0121281. doi: 10.1371/journal.pone.0121281. eCollection 2015.

25.

The origin of breast tumor heterogeneity.

Skibinski A, Kuperwasser C.

Oncogene. 2015 Oct 16;34(42):5309-16. doi: 10.1038/onc.2014.475. Epub 2015 Feb 23. Review.

26.

SLUG: Critical regulator of epithelial cell identity in breast development and cancer.

Phillips S, Kuperwasser C.

Cell Adh Migr. 2014;8(6):578-87. doi: 10.4161/19336918.2014.972740. Review.

27.

Human breast progenitor cell numbers are regulated by WNT and TBX3.

Arendt LM, St Laurent J, Wronski A, Caballero S, Lyle SR, Naber SP, Kuperwasser C.

PLoS One. 2014 Oct 28;9(10):e111442. doi: 10.1371/journal.pone.0111442. eCollection 2014.

28.

Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules.

Arendt LM, Keller PJ, Skibinski A, Goncalves K, Naber SP, Buchsbaum RJ, Gilmore H, Come SE, Kuperwasser C.

Breast Cancer Res. 2014 Oct 15;16(5):453. doi: 10.1186/s13058-014-0453-3.

29.

Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation.

Phillips S, Prat A, Sedic M, Proia T, Wronski A, Mazumdar S, Skibinski A, Shirley SH, Perou CM, Gill G, Gupta PB, Kuperwasser C.

Stem Cell Reports. 2014 Apr 24;2(5):633-47. doi: 10.1016/j.stemcr.2014.03.008. eCollection 2014 May 6.

30.

NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.

Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel E, Kuperwasser C, Tsichlis PN.

Cancer Res. 2014 Jul 15;74(14):3935-46. doi: 10.1158/0008-5472.CAN-13-2733. Epub 2014 May 22.

31.

The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment.

Skibinski A, Breindel JL, Prat A, Galván P, Smith E, Rolfs A, Gupta PB, LaBaer J, Kuperwasser C.

Cell Rep. 2014 Mar 27;6(6):1059-1072. doi: 10.1016/j.celrep.2014.02.038. Epub 2014 Mar 6.

32.

Pregnancy-associated breast cancers are driven by differences in adipose stromal cells present during lactation.

McCready J, Arendt LM, Glover E, Iyer V, Briendel JL, Lyle SR, Naber SP, Jay DG, Kuperwasser C.

Breast Cancer Res. 2014 Jan 9;16(1):R2. doi: 10.1186/bcr3594.

33.

The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.

McLaughlin SK, Olsen SN, Dake B, De Raedt T, Lim E, Bronson RT, Beroukhim R, Polyak K, Brown M, Kuperwasser C, Cichowski K.

Cancer Cell. 2013 Sep 9;24(3):365-78. doi: 10.1016/j.ccr.2013.08.004.

34.

Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis.

Arendt LM, McCready J, Keller PJ, Baker DD, Naber SP, Seewaldt V, Kuperwasser C.

Cancer Res. 2013 Oct 1;73(19):6080-93. doi: 10.1158/0008-5472.CAN-13-0926. Epub 2013 Aug 19.

35.

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.

Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM.

EMBO Mol Med. 2013 Apr;5(4):488-508. doi: 10.1002/emmm.201202078. Epub 2013 Feb 21.

36.

Using defined finger-finger interfaces as units of assembly for constructing zinc-finger nucleases.

Zhu C, Gupta A, Hall VL, Rayla AL, Christensen RG, Dake B, Lakshmanan A, Kuperwasser C, Stormo GD, Wolfe SA.

Nucleic Acids Res. 2013 Feb 1;41(4):2455-65. doi: 10.1093/nar/gks1357. Epub 2013 Jan 8.

37.

Cyclin D1 activity regulates autophagy and senescence in the mammary epithelium.

Brown NE, Jeselsohn R, Bihani T, Hu MG, Foltopoulou P, Kuperwasser C, Hinds PW.

Cancer Res. 2012 Dec 15;72(24):6477-89. doi: 10.1158/0008-5472.CAN-11-4139. Epub 2012 Oct 4.

38.
39.

Stromal biomarkers in breast cancer development and progression.

Rudnick JA, Kuperwasser C.

Clin Exp Metastasis. 2012 Oct;29(7):663-72. doi: 10.1007/s10585-012-9499-8. Epub 2012 Jun 10. Review.

PMID:
22684404
40.

Estrogen promotes ER-negative tumor growth and angiogenesis through mobilization of bone marrow-derived monocytes.

Iyer V, Klebba I, McCready J, Arendt LM, Betancur-Boissel M, Wu MF, Zhang X, Lewis MT, Kuperwasser C.

Cancer Res. 2012 Jun 1;72(11):2705-13. doi: 10.1158/0008-5472.CAN-11-3287. Epub 2012 Mar 30.

41.

Stem cell maintenance of the mammary gland: it takes two.

Keller PJ, Arendt LM, Kuperwasser C.

Cell Stem Cell. 2011 Dec 2;9(6):496-7. doi: 10.1016/j.stem.2011.11.008.

42.

Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells.

Rudnick JA, Arendt LM, Klebba I, Hinds JW, Iyer V, Gupta PB, Naber SP, Kuperwasser C.

PLoS One. 2011;6(9):e24605. doi: 10.1371/journal.pone.0024605. Epub 2011 Sep 21.

43.

Defining the cellular precursors to human breast cancer.

Keller PJ, Arendt LM, Skibinski A, Logvinenko T, Klebba I, Dong S, Smith AE, Prat A, Perou CM, Gilmore H, Schnitt S, Naber SP, Garlick JA, Kuperwasser C.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2772-7. doi: 10.1073/pnas.1017626108. Epub 2011 Sep 21.

44.

Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells.

Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, Kuperwasser C, Lander ES.

Cell. 2011 Aug 19;146(4):633-44. doi: 10.1016/j.cell.2011.07.026. Erratum in: Cell. 2011 Nov 23;147(5):1197. Cell. 2011 Sep 16;146(6):1042.

45.

Assessment of the role of circulating breast cancer cells in tumor formation and metastatic potential using in vivo flow cytometry.

Hwu D, Boutrus S, Greiner C, DiMeo T, Kuperwasser C, Georgakoudi I.

J Biomed Opt. 2011 Apr;16(4):040501. doi: 10.1117/1.3560624.

46.

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state.

Chaffer CL, Brueckmann I, Scheel C, Kaestli AJ, Wiggins PA, Rodrigues LO, Brooks M, Reinhardt F, Su Y, Polyak K, Arendt LM, Kuperwasser C, Bierie B, Weinberg RA.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7950-5. doi: 10.1073/pnas.1102454108. Epub 2011 Apr 15.

47.

Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.

Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, Sedic M, Gilmore H, Tung N, Naber SP, Schnitt S, Lander ES, Kuperwasser C.

Cell Stem Cell. 2011 Feb 4;8(2):149-63. doi: 10.1016/j.stem.2010.12.007.

48.

The tumor stromal microenvironment as modulator of malignant behavior.

Kuperwasser C.

J Mammary Gland Biol Neoplasia. 2010 Dec;15(4):377-9. doi: 10.1007/s10911-010-9198-5. No abstract available.

PMID:
21184152
49.

Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling.

Fillmore CM, Gupta PB, Rudnick JA, Caballero S, Keller PJ, Lander ES, Kuperwasser C.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21737-42. doi: 10.1073/pnas.1007863107. Epub 2010 Nov 22.

50.

Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines.

Keller PJ, Lin AF, Arendt LM, Klebba I, Jones AD, Rudnick JA, DiMeo TA, Gilmore H, Jefferson DM, Graham RA, Naber SP, Schnitt S, Kuperwasser C.

Breast Cancer Res. 2010;12(5):R87. doi: 10.1186/bcr2755. Epub 2010 Oct 21.

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