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Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors.

Kuo MT, Long Y, Tsai WB, Li YY, Chen HHW, Feun LG, Savaraj N.

Transl Oncol. 2020 Feb;13(2):355-364. doi: 10.1016/j.tranon.2019.12.003. Epub 2019 Dec 27.


Systematic Analysis of Transcriptomic Profile of the Effects of Low Dose Atropine Treatment on Scleral Fibroblasts using Next-Generation Sequencing and Bioinformatics.

Hsiao YT, Chang WA, Kuo MT, Lo J, Lin HC, Yen MC, Jian SF, Chen YJ, Kuo PL.

Int J Med Sci. 2019 Nov 9;16(12):1652-1667. doi: 10.7150/ijms.38571. eCollection 2019.


An Omics Approach to Diagnosing or Investigating Fungal Keratitis.

Kuo MT, Chen JL, Hsu SL, Chen A, You HL.

Int J Mol Sci. 2019 Jul 25;20(15). pii: E3631. doi: 10.3390/ijms20153631. Review.


Tracking the Reflective Light Particles Spreading on the Cornea: An Emerging Assessment for Tear Film Homeostasis.

Lai HY, Kuo MT, Fang PC, Lin CC, Chien CC, Cho WH, Chen A, Lai IC.

Transl Vis Sci Technol. 2019 Jun 4;8(3):32. doi: 10.1167/tvst.8.3.32. eCollection 2019 May.


Neuroprotective effect of CuATSM on neurotoxin-induced motor neuron loss in an ALS mouse model.

Kuo MTH, Beckman JS, Shaw CA.

Neurobiol Dis. 2019 Oct;130:104495. doi: 10.1016/j.nbd.2019.104495. Epub 2019 Jun 7.


A comparison between non-sedation and general endotracheal anesthesia for retrograde endoscopic common bile duct stone removal: A tertiary center experience.

Liang CM, Kuo CM, Lu LS, Wu CK, Tsai CE, Kuo MT, Chiu YC, Tai WC, Kuo YH, Kuo CH, Chuah SK, Changchien CS.

Biomed J. 2019 Apr;42(2):131-136. doi: 10.1016/ Epub 2019 May 7.


Tear Proteomics Approach to Monitoring Sjögren Syndrome or Dry Eye Disease.

Kuo MT, Fang PC, Chao TL, Chen A, Lai YH, Huang YT, Tseng CY.

Int J Mol Sci. 2019 Apr 19;20(8). pii: E1932. doi: 10.3390/ijms20081932.


Epidemiology and clinical features of viral anterior uveitis in southern Taiwan-diagnosis with polymerase chain reaction.

Hsiao YT, Kuo MT, Chiang WY, Chao TL, Kuo HK.

BMC Ophthalmol. 2019 Apr 3;19(1):87. doi: 10.1186/s12886-019-1093-2.


A Review of Periocular Botulinum Neurotoxin on the Tear Film Homeostasis and the Ocular Surface Change.

Ho RW, Fang PC, Chang CH, Liu YP, Kuo MT.

Toxins (Basel). 2019 Jan 24;11(2). pii: E66. doi: 10.3390/toxins11020066. Review.


Hepatitis B virus relapse rates in chronic hepatitis B patients who discontinue either entecavir or tenofovir.

Kuo MT, Hu TH, Hung CH, Wang JH, Lu SN, Tsai KL, Chen CH.

Aliment Pharmacol Ther. 2019 Jan;49(2):218-228. doi: 10.1111/apt.15053. Epub 2018 Nov 28.


Molecular Bioburden of the Lens Storage Case for Contact Lens-Related Keratitis.

Hsiao YT, Fang PC, Chen JL, Hsu SL, Chao TL, Yu HJ, Lai YH, Huang YT, Kuo MT.

Cornea. 2018 Dec;37(12):1542-1550. doi: 10.1097/ICO.0000000000001699.


Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm.

Ho RW, Fang PC, Chao TL, Chien CC, Kuo MT.

Sci Rep. 2018 May 30;8(1):8367. doi: 10.1038/s41598-018-26750-5.


Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis.

Lai YH, Kuo C, Kuo MT, Chen HHW.

Int J Mol Sci. 2018 May 16;19(5). pii: E1486. doi: 10.3390/ijms19051486. Review.


The function and morphology of Meibomian glands in patients with thyroid eye disease: a preliminary study.

Wang CY, Ho RW, Fang PC, Yu HJ, Chien CC, Hsiao CC, Kuo MT.

BMC Ophthalmol. 2018 Apr 12;18(1):90. doi: 10.1186/s12886-018-0763-9.


Role of hepatitis B surface antigen in hepatitis B virus relapse after entecavir or tenofovir prophylaxis in patients undergoing cancer chemotherapy.

Kuo MT, Tseng PL, Chou YP, Chang KC, Tsai MC, Kuo YH, Hu TH, Hung CH, Wang JH, Lu SN, Chen CH.

J Gastroenterol Hepatol. 2018 Oct;33(10):1766-1772. doi: 10.1111/jgh.14142. Epub 2018 Apr 17.


First-week clinical responses to dexlansoprazole 60 mg and esomeprazole 40 mg for the treatment of grades A and B gastroesophageal reflux disease.

Liang CM, Kuo MT, Hsu PI, Kuo CH, Tai WC, Yang SC, Wu KL, Wang HM, Yao CC, Tsai CE, Wang YK, Wang JW, Huang CF, Wu DC, Chuah SK; Taiwan Acid-Related Disease Study Group.

World J Gastroenterol. 2017 Dec 21;23(47):8395-8404. doi: 10.3748/wjg.v23.i47.8395.


Meibomian Gland Performance in Glaucomatous Patients With Long-term Instillation of IOP-lowering Medications.

Cho WH, Lai IC, Fang PC, Chien CC, Tseng SL, Lai YH, Huang YT, Kuo MT.

J Glaucoma. 2018 Feb;27(2):176-183. doi: 10.1097/IJG.0000000000000841.


Degradation of AMPK-α1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation.

Li YY, Wu C, Shah SS, Chen SM, Wangpaichitr M, Kuo MT, Feun LG, Han X, Suarez M, Prince J, Savaraj N.

Mol Oncol. 2017 Dec;11(12):1806-1825. doi: 10.1002/1878-0261.12151. Epub 2017 Nov 16.


Improving radiotherapy in cancer treatment: Promises and challenges.

Chen HHW, Kuo MT.

Oncotarget. 2017 Jun 8;8(37):62742-62758. doi: 10.18632/oncotarget.18409. eCollection 2017 Sep 22. Review.


Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression.

Tsai WB, Long Y, Chang JT, Savaraj N, Feun LG, Jung M, Chen HHW, Kuo MT.

Sci Rep. 2017 Sep 7;7(1):10814. doi: 10.1038/s41598-017-11445-0.


A DNA dot hybridization model for molecular diagnosis of parasitic keratitis.

Huang FC, Hsieh HY, Chang TC, Su SL, Tseng SL, Lai YH, Kuo MT.

Mol Vis. 2017 Aug 24;23:614-623. eCollection 2017.


Relationship of Metabolic Alterations and PD-L1 Expression in Cisplatin Resistant Lung Cancer.

Wangpaichitr M, Kandemir H, Li YY, Wu C, Nguyen D, Feun LG, Kuo MT, Savaraj N.

Cell Dev Biol. 2017 Jun;6(2). pii: 183. doi: 10.4172/2168-9296.1000183. Epub 2017 Apr 28.


Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy.

Li YY, Feun LG, Thongkum A, Tu CH, Chen SM, Wangpaichitr M, Wu C, Kuo MT, Savaraj N.

Int J Mol Sci. 2017 Jun 19;18(6). pii: E1297. doi: 10.3390/ijms18061297. Review.


Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer.

Wangpaichitr M, Wu C, Li YY, Nguyen DJM, Kandemir H, Shah S, Chen S, Feun LG, Prince JS, Kuo MT, Savaraj N.

Oncotarget. 2017 Jul 25;8(30):49275-49292. doi: 10.18632/oncotarget.17568.


A dot hybridization assay for the diagnosis of bacterial keratitis.

Fang PC, Chien CC, Yu HJ, Ho RW, Tseng SL, Lai YH, Kuo MT.

Mol Vis. 2017 Apr 28;23:306-317. eCollection 2017.


In Vitro Anticancer Activity and Structural Characterization of Ubiquinones from Antrodia cinnamomea Mycelium.

Yen IC, Lee SY, Lin KT, Lai FY, Kuo MT, Chang WL.

Molecules. 2017 May 6;22(5). pii: E747. doi: 10.3390/molecules22050747.


Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy.

Long Y, Tsai WB, Wang D, Hawke DH, Savaraj N, Feun LG, Hung MC, Chen HH, Kuo MT.

Cancer Lett. 2017 Mar 1;388:54-63. doi: 10.1016/j.canlet.2016.11.028. Epub 2016 Nov 30.


C-Jun N-terminal kinase signalling pathway in response to cisplatin.

Yan D, An G, Kuo MT.

J Cell Mol Med. 2016 Nov;20(11):2013-2019. doi: 10.1111/jcmm.12908. Epub 2016 Jul 4. Review.


Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.

Long Y, Tsai WB, Chang JT, Estecio M, Wangpaichitr M, Savaraj N, Feun LG, Chen HH, Kuo MT.

Oncotarget. 2016 Dec 13;7(50):82658-82670. doi: 10.18632/oncotarget.12308.


Co-existing ligneous conjunctivitis and IgG4-related disease.

Chiang WY, Liu TT, Huang WT, Kuo MT.

Indian J Ophthalmol. 2016 Jul;64(7):532-4. doi: 10.4103/0301-4738.190154.


Isolates and antibiotic susceptibilities of endophthalmitis in postcataract surgery: a 12-year review of culture-proven cases.

Teng YT, Teng MC, Kuo HK, Fang PC, Wu PC, Chen CH, Kuo MT, Yang IH, Chen YJ.

Int Ophthalmol. 2017 Jun;37(3):513-518. doi: 10.1007/s10792-016-0288-2. Epub 2016 Jul 15.


Effects of Cu(II) and cisplatin on the stability of Specific protein 1 (Sp1)-DNA binding: Insights into the regulation of copper homeostasis and platinum drug transport.

Yan D, Aiba I, Chen HH, Kuo MT.

J Inorg Biochem. 2016 Aug;161:37-9. doi: 10.1016/j.jinorgbio.2016.04.030. Epub 2016 Apr 27.


A Multiplex Dot Hybridization Assay For Detection and Differentiation of Acanthamoeba and Herpes Keratitis.

Kuo MT, Fang PC, Yu HJ, Chao TL, Chien CC, Chen SH, Wang JR, Tseng SL, Lai YH, Hsiao CC, Chang TC.

Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2158-63. doi: 10.1167/iovs.15-17741.


PCR analysis for assessment of bacterial bioburden in orthokeratology lens cases.

Lo J, Fang PC, Chien CC, Hsiao CC, Tseng SL, Lai YH, Kuo MT.

Mol Vis. 2016 Jan 14;22:1-8. eCollection 2016.


Bacterial Bioburden Decrease in Orthokeratology Lens Storage Cases After Forewarning: Assessment by the DNA Dot Hybridization Assay.

Fang PC, Lo J, Chang TC, Chien CC, Hsiao CC, Tseng SL, Lai YH, Kuo MT.

Eye Contact Lens. 2017 May;43(3):174-180. doi: 10.1097/ICL.0000000000000252.


BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma.

Li YY, Wu C, Chen SM, Shah SS, Wangpaichitr M, Feun LG, Kuo MT, Suarez M, Prince J, Savaraj N.

Oncotarget. 2016 Apr 5;7(14):17665-80. doi: 10.18632/oncotarget.6882.


Gas6/Axl in arginine-starvation therapy.

Tsai WB, Long Y, Kuo MT.

Oncoscience. 2015 Aug 25;2(8):659-60. eCollection 2015. No abstract available.


Predicting risk factors for rebleeding, infections, mortality following peptic ulcer bleeding in patients with cirrhosis and the impact of antibiotics prophylaxis at different clinical stages of the disease.

Kuo MT, Yang SC, Lu LS, Hsu CN, Kuo YH, Kuo CH, Liang CM, Kuo CM, Wu CK, Tai WC, Chuah SK.

BMC Gastroenterol. 2015 May 20;15:61. doi: 10.1186/s12876-015-0289-z.


Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents.

Tsai WB, Long Y, Park JR, Chang JT, Liu H, Rodriguez-Canales J, Savaraj N, Feun LG, Davies MA, Wistuba II, Kuo MT.

Oncogene. 2016 Mar 31;35(13):1632-42. doi: 10.1038/onc.2015.237. Epub 2015 Jun 22.


Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy.

Chen HH, Chen WC, Liang ZD, Tsai WB, Long Y, Aiba I, Fu S, Broaddus R, Liu J, Feun LG, Savaraj N, Kuo MT.

Expert Opin Ther Targets. 2015;19(10):1307-17. doi: 10.1517/14728222.2015.1043269. Epub 2015 May 25. Review.


Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin.

Savaraj N, Wu C, Li YY, Wangpaichitr M, You M, Bomalaski J, He W, Kuo MT, Feun LG.

Oncotarget. 2015 Mar 20;6(8):6295-309.


Microbial Bioburden of Orthokeratology Contact Lens Care System.

Lo J, Kuo MT, Chien CC, Tseng SL, Lai YH, Fang PC.

Eye Contact Lens. 2016 Jan;42(1):61-7. doi: 10.1097/ICL.0000000000000130.


Anti-cancer agents derived from solid-state fermented Antrodia camphorata mycelium.

Yen IC, Yao CW, Kuo MT, Chao CL, Pai CY, Chang WL.

Fitoterapia. 2015 Apr;102:115-9. doi: 10.1016/j.fitote.2015.02.010. Epub 2015 Feb 23.


Experience of scleritis and episcleritis at a tertiary center in Southern Taiwan.

Chen YW, Poon YC, Yu HJ, Kuo MT, Fan PC.

Taiwan J Ophthalmol. 2015 Jan-Mar;5(1):19-22. doi: 10.1016/j.tjo.2014.10.004. Epub 2015 Jan 22.


A DNA dot hybridization model for assessment of bacterial bioburden in orthokeratology lens storage cases.

Kuo MT, Chien CC, Lo J, Hsiao CC, Tseng SL, Lai YH, Fang PC, Chang TC.

Invest Ophthalmol Vis Sci. 2014 Dec 23;56(1):445-50. doi: 10.1167/iovs.14-15920.


Neutrophil-to-lymphocyte ratio as a predictor of response to peginterferon plus ribavirin therapy for chronic hepatitis C.

Kuo MT, Hu TH, Lu SN, Hung CH, Wang JH, Chen CH, Chiu YC, Lee CM.

Dis Markers. 2014;2014:462958. doi: 10.1155/2014/462958. Epub 2014 Nov 18.


Arginine deprivation in cancer therapy.

Feun LG, Kuo MT, Savaraj N.

Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):78-82. doi: 10.1097/MCO.0000000000000122. Review.


A new method for studying social eavesdropping using male golden hamsters.

Lai WS, Yu WC, Liu CY, Kuo MT, Huang CH.

Physiol Behav. 2014 Apr 10;128:202-11. doi: 10.1016/j.physbeh.2014.01.029. Epub 2014 Feb 11.


Onset aging conditions of adults with an intellectual disability associated with primary caregiver depression.

Lin LP, Hsu SW, Kuo MT, Wu JL, Chu C, Lin JD.

Res Dev Disabil. 2014 Mar;35(3):632-8. doi: 10.1016/j.ridd.2013.12.013. Epub 2014 Jan 24.


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