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Items: 42


AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression.

Liao SY, Kuo IY, Chen YT, Liao PC, Liu YF, Wu HY, Lai WW, Wang YC.

Oncogene. 2019 Oct;38(41):6723-6736. doi: 10.1038/s41388-019-0928-x. Epub 2019 Aug 9.


Polycystin 2 regulates mitochondrial Ca2+ signaling, bioenergetics, and dynamics through mitofusin 2.

Kuo IY, Brill AL, Lemos FO, Jiang JY, Falcone JL, Kimmerling EP, Cai Y, Dong K, Kaplan DL, Wallace DP, Hofer AM, Ehrlich BE.

Sci Signal. 2019 May 7;12(580). pii: eaat7397. doi: 10.1126/scisignal.aat7397.


TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells.

Arhatte M, Gunaratne GS, El Boustany C, Kuo IY, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N, Couvreux A, Duranton C, Rubera I, Pagnotta S, Lacas-Gervais S, Ehrlich BE, Marchant JS, Savage AM, van Eeden FJM, Wilkinson RN, Demolombe S, Honoré E, Patel A.

Nat Commun. 2019 May 2;10(1):2024. doi: 10.1038/s41467-019-10045-y.


Novel approach for quantification of endoplasmic reticulum Ca2+ transport.

Bovo E, Nikolaienko R, Bhayani S, Kahn D, Cao Q, Martin JL, Kuo IY, Robia SL, Zima AV.

Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1323-H1331. doi: 10.1152/ajpheart.00031.2019. Epub 2019 Mar 22.


SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes.

Kuo IY, Huang YL, Lin CY, Lin CH, Chang WL, Lai WW, Wang YC.

J Biomed Sci. 2019 Feb 18;26(1):20. doi: 10.1186/s12929-019-0510-4.


Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.

Cho SH, Kuo IY, Lu PF, Tzeng HT, Lai WW, Su WC, Wang YC.

Cell Death Dis. 2018 Aug 29;9(9):868. doi: 10.1038/s41419-018-0915-0.


Factor VII-Induced MicroRNA-135a Inhibits Autophagy and Is Associated with Poor Prognosis in Hepatocellular Carcinoma.

Huang KT, Kuo IY, Tsai MC, Wu CH, Hsu LW, Chen LY, Kung CP, Cheng YF, Goto S, Chou YW, Chen CL, Lin CC, Chen KD.

Mol Ther Nucleic Acids. 2017 Dec 15;9:274-283. doi: 10.1016/j.omtn.2017.10.002. Epub 2017 Oct 7.


Polycystin 2-dependent cardio-protective mechanisms revealed by cardiac stress.

Giehl E, Lemos FO, Huang Y, Giordano FJ, Kuo IY, Ehrlich BE.

Pflugers Arch. 2017 Nov;469(11):1507-1517. doi: 10.1007/s00424-017-2042-7. Epub 2017 Jul 31.


Measuring T-Type Calcium Channel Currents in Isolated Vascular Smooth Muscle Cells.

Kuo IY, Hill CE.

Methods Mol Biol. 2017;1527:189-200. doi: 10.1007/978-1-4939-6625-7_15.


Low-dose dasatinib rescues cardiac function in Noonan syndrome.

Yi JS, Huang Y, Kwaczala AT, Kuo IY, Ehrlich BE, Campbell SG, Giordano FJ, Bennett AM.

JCI Insight. 2016 Dec 8;1(20):e90220. doi: 10.1172/jci.insight.90220.


The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function.

Padovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ.

Mol Biol Cell. 2017 Jan 15;28(2):261-269. doi: 10.1091/mbc.E16-08-0597. Epub 2016 Nov 23.


A six-CpG panel with DNA methylation biomarkers predicting treatment response of chemoradiation in esophageal squamous cell carcinoma.

Chang WL, Lai WW, Kuo IY, Lin CY, Lu PJ, Sheu BS, Wang YC.

J Gastroenterol. 2017 Jun;52(6):705-714. doi: 10.1007/s00535-016-1265-2. Epub 2016 Sep 26.


A prognostic predictor panel with DNA methylation biomarkers for early-stage lung adenocarcinoma in Asian and Caucasian populations.

Kuo IY, Jen J, Hsu LH, Hsu HS, Lai WW, Wang YC.

J Biomed Sci. 2016 Aug 2;23(1):58. doi: 10.1186/s12929-016-0276-x.


Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging.

Kuo IY, Duong SL, Nguyen L, Ehrlich BE.

PLoS One. 2016 Apr 15;11(4):e0153632. doi: 10.1371/journal.pone.0153632. eCollection 2016.


Coagulation factor VII and malignant progression of hepatocellular carcinoma.

Chen KD, Huang KT, Tsai MC, Wu CH, Kuo IY, Chen LY, Hu TH, Chen CL, Lin CC.

Cell Death Dis. 2016 Feb 25;7:e2110. doi: 10.1038/cddis.2015.395. No abstract available.


The effects of mycoplasma contamination upon the ability to form bioengineered 3D kidney cysts.

DesRochers TM, Kuo IY, Kimmerling EP, Ehrlich BE, Kaplan DL.

PLoS One. 2015 Mar 20;10(3):e0120097. doi: 10.1371/journal.pone.0120097. eCollection 2015.


Oligomerization of the polycystin-2 C-terminal tail and effects on its Ca2+-binding properties.

Yang Y, Keeler C, Kuo IY, Lolis EJ, Ehrlich BE, Hodsdon ME.

J Biol Chem. 2015 Apr 17;290(16):10544-54. doi: 10.1074/jbc.M115.641803. Epub 2015 Feb 25.


Muscling in on the ryanodine receptor.

Kuo IY, Ehrlich BE.

Nat Struct Mol Biol. 2015 Feb;22(2):106-7. doi: 10.1038/nsmb.2960. No abstract available.


Signaling in muscle contraction.

Kuo IY, Ehrlich BE.

Cold Spring Harb Perspect Biol. 2015 Feb 2;7(2):a006023. doi: 10.1101/cshperspect.a006023. Review.


Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels.

Kuo IY, Hu J, Ha Y, Ehrlich BE.

J Biol Chem. 2015 Mar 6;290(10):6419-27. doi: 10.1074/jbc.M114.629584. Epub 2015 Jan 21.


Factor VII promotes hepatocellular carcinoma progression through ERK-TSC signaling.

Tsai MC, Chen KD, Wang CC, Huang KT, Wu CH, Kuo IY, Chen LY, Hu TH, Goto S, Nakano T, Dorling A, McVey JH, Chen CL, Lin CC.

Cell Death Discov. 2015 Nov 30;1:15051. doi: 10.1038/cddiscovery.2015.51. eCollection 2015.


Deregulation of SLIT2-mediated Cdc42 activity is associated with esophageal cancer metastasis and poor prognosis.

Tseng RC, Chang JM, Chen JH, Huang WR, Tang YA, Kuo IY, Yan JJ, Lai WW, Wang YC.

J Thorac Oncol. 2015 Jan;10(1):189-98. doi: 10.1097/JTO.0000000000000369.


Decreased polycystin 2 expression alters calcium-contraction coupling and changes β-adrenergic signaling pathways.

Kuo IY, Kwaczala AT, Nguyen L, Russell KS, Campbell SG, Ehrlich BE.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16604-9. doi: 10.1073/pnas.1415933111. Epub 2014 Nov 3.


Cyst formation following disruption of intracellular calcium signaling.

Kuo IY, DesRochers TM, Kimmerling EP, Nguyen L, Ehrlich BE, Kaplan DL.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14283-8. doi: 10.1073/pnas.1412323111. Epub 2014 Sep 16.


Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.

Tsai CH, Cheng HC, Wang YS, Lin P, Jen J, Kuo IY, Chang YH, Liao PC, Chen RH, Yuan WC, Hsu HS, Yang MH, Hsu MT, Wu CY, Wang YC.

Nat Commun. 2014 Sep 3;5:4804. doi: 10.1038/ncomms5804.


Network-based analysis identifies epigenetic biomarkers of esophageal squamous cell carcinoma progression.

Cheng CP, Kuo IY, Alakus H, Frazer KA, Harismendy O, Wang YC, Tseng VS.

Bioinformatics. 2014 Nov 1;30(21):3054-61. doi: 10.1093/bioinformatics/btu433. Epub 2014 Jul 10.


Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients.

Kuo IY, Chang JM, Jiang SS, Chen CH, Chang IS, Sheu BS, Lu PJ, Chang WL, Lai WW, Wang YC.

Int J Med Sci. 2014 May 30;11(8):779-87. doi: 10.7150/ijms.7405. eCollection 2014.


The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function.

Kuo IY, Keeler C, Corbin R, Ćelić A, Petri ET, Hodsdon ME, Ehrlich BE.

FASEB J. 2014 May;28(5):2332-46. doi: 10.1096/fj.13-247106. Epub 2014 Feb 20.


Role of T-type channels in vasomotor function: team player or chameleon?

Kuo IY, Howitt L, Sandow SL, McFarlane A, Hansen PB, Hill CE.

Pflugers Arch. 2014 Apr;466(4):767-79. doi: 10.1007/s00424-013-1430-x. Epub 2014 Jan 31. Review.


Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression.

Kuo IY, Wu CC, Chang JM, Huang YL, Lin CH, Yan JJ, Sheu BS, Lu PJ, Chang WL, Lai WW, Wang YC.

Int J Cancer. 2014 Aug 1;135(3):563-73. doi: 10.1002/ijc.28695. Epub 2014 Jan 10.


An explicit formulation approach for the analysis of calcium binding to EF-hand proteins using isothermal titration calorimetry.

Keeler C, Poon G, Kuo IY, Ehrlich BE, Hodsdon ME.

Biophys J. 2013 Dec 17;105(12):2843-53. doi: 10.1016/j.bpj.2013.11.017.


Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles.

Howitt L, Kuo IY, Ellis A, Chaston DJ, Shin HS, Hansen PB, Hill CE.

Cardiovasc Res. 2013 Jun 1;98(3):449-57. doi: 10.1093/cvr/cvt043. Epub 2013 Feb 22.


Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy.

Paavola J, Schliffke S, Rossetti S, Kuo IY, Yuan S, Sun Z, Harris PC, Torres VE, Ehrlich BE.

J Mol Cell Cardiol. 2013 May;58:199-208. doi: 10.1016/j.yjmcc.2013.01.015. Epub 2013 Jan 30.


Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.

Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, Hamada H.

Science. 2012 Oct 12;338(6104):226-31. doi: 10.1126/science.1222538. Epub 2012 Sep 13.


Ion channels in renal disease.

Kuo IY, Ehrlich BE.

Chem Rev. 2012 Dec 12;112(12):6353-72. doi: 10.1021/cr3001077. Epub 2012 Jul 18. Review. No abstract available.


T-type calcium channels and vascular function: the new kid on the block?

Kuo IY, Wölfle SE, Hill CE.

J Physiol. 2011 Feb 15;589(Pt 4):783-95. doi: 10.1113/jphysiol.2010.199497. Epub 2010 Dec 20. Review.


Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries.

Kuo IY, Ellis A, Seymour VA, Sandow SL, Hill CE.

J Cereb Blood Flow Metab. 2010 Jun;30(6):1226-39. doi: 10.1038/jcbfm.2010.11. Epub 2010 Feb 3.


Limited intravascular coupling in the rodent brainstem and retina supports a role for glia in regional blood flow.

Kuo IY, Chan-Ling T, Wojcikiewicz RJ, Hill CE.

J Comp Neurol. 2008 Dec 20;511(6):773-87. doi: 10.1002/cne.21873.


Ultrasound scattering from blood with hematocrits up to 100%.

Mo LY, Kuo IY, Shung KK, Ceresne L, Cobbold RS.

IEEE Trans Biomed Eng. 1994 Jan;41(1):91-5.


High frequency ultrasonic backscatter from erythrocyte suspension.

Kuo IY, Shung KK.

IEEE Trans Biomed Eng. 1994 Jan;41(1):29-34.


Analysis of ultrasonic scattering in blood via a continuum approach.

Shung KK, Kuo IY.

Ultrasound Med Biol. 1994;20(7):623-7.


A novel method for the measurement of acoustic speed.

Kuo IY, Hete B, Shung KK.

J Acoust Soc Am. 1990 Oct;88(4):1679-82.


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