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Items: 1 to 50 of 353

1.

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis.

Nagy M, van Geffen JP, Stegner D, Adams DJ, Braun A, de Witt SM, Elvers M, Geer MJ, Kuijpers MJE, Kunzelmann K, Mori J, Oury C, Pircher J, Pleines I, Poole AW, Senis YA, Verdoold R, Weber C, Nieswandt B, Heemskerk JWM, Baaten CCFMJ.

Front Cardiovasc Med. 2019 Jul 30;6:99. doi: 10.3389/fcvm.2019.00099. eCollection 2019.

2.

Niclosamide repurposed for the treatment of inflammatory airway disease.

Cabrita I, Benedetto R, Schreiber R, Kunzelmann K.

JCI Insight. 2019 Aug 8;4(15). pii: 128414. doi: 10.1172/jci.insight.128414. eCollection 2019 Aug 8.

3.

Fatigue resistance of ultrathin CAD/CAM ceramic and nanoceramic composite occlusal veneers.

Heck K, Paterno H, Lederer A, Litzenburger F, Hickel R, Kunzelmann KH.

Dent Mater. 2019 Oct;35(10):1370-1377. doi: 10.1016/j.dental.2019.07.006. Epub 2019 Jul 25.

PMID:
31351578
4.

TMEM16F/Anoctamin 6 in Ferroptotic Cell Death.

Ousingsawat J, Schreiber R, Kunzelmann K.

Cancers (Basel). 2019 May 5;11(5). pii: E625. doi: 10.3390/cancers11050625.

5.

Plasma membrane-localized TMEM16 proteins are indispensable for expression of CFTR.

Benedetto R, Ousingsawat J, Cabrita I, Pinto M, Lérias JR, Wanitchakool P, Schreiber R, Kunzelmann K.

J Mol Med (Berl). 2019 May;97(5):711-722. doi: 10.1007/s00109-019-01770-4. Epub 2019 Mar 26.

PMID:
30915480
6.

Contribution of Anoctamins to Cell Survival and Cell Death.

Kunzelmann K, Ousingsawat J, Benedetto R, Cabrita I, Schreiber R.

Cancers (Basel). 2019 Mar 19;11(3). pii: E382. doi: 10.3390/cancers11030382. Review.

7.

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.

Miner K, Labitzke K, Liu B, Wang P, Henckels K, Gaida K, Elliott R, Chen JJ, Liu L, Leith A, Trueblood E, Hensley K, Xia XZ, Homann O, Bennett B, Fiorino M, Whoriskey J, Yu G, Escobar S, Wong M, Born TL, Budelsky A, Comeau M, Smith D, Phillips J, Johnston JA, McGivern JG, Weikl K, Powers D, Kunzelmann K, Mohn D, Hochheimer A, Sullivan JK.

Front Pharmacol. 2019 Feb 14;10:51. doi: 10.3389/fphar.2019.00051. eCollection 2019.

8.

Immobilization of Denosumab on Titanium Affects Osteoclastogenesis of Human Peripheral Blood Monocytes.

Beck F, Hartmann ES, Koehler MI, Redeker JI, Schluessel S, Schmitt B, Fottner A, Unger M, van Griensven M, Michael J, Summer B, Kunzelmann KH, Beutner R, Scharnweber D, Kostenuik PJ, Mayer-Wagner S.

Int J Mol Sci. 2019 Feb 26;20(5). pii: E1002. doi: 10.3390/ijms20051002.

9.

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

Kunzelmann K, Ousingsawat J, Cabrita I, Doušová T, Bähr A, Janda M, Schreiber R, Benedetto R.

Front Pharmacol. 2019 Jan 29;10:3. doi: 10.3389/fphar.2019.00003. eCollection 2019. Review.

10.

ADAM10 sheddase activation is controlled by cell membrane asymmetry.

Bleibaum F, Sommer A, Veit M, Rabe B, Andrä J, Kunzelmann K, Nehls C, Correa W, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K.

J Mol Cell Biol. 2019 Feb 12. doi: 10.1093/jmcb/mjz008. [Epub ahead of print]

PMID:
30753537
11.

Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: A randomized, controlled 6-month trial.

Schlagenhauf U, Kunzelmann KH, Hannig C, May TW, Hösl H, Gratza M, Viergutz G, Nazet M, Schamberger S, Proff P.

J Investig Clin Dent. 2019 May;10(2):e12399. doi: 10.1111/jicd.12399. Epub 2019 Jan 30.

12.

In vitro validation of near-infrared transillumination at 780 nm for the detection of caries on proximal surfaces.

Lederer A, Kunzelmann KH, Heck K, Hickel R, Litzenburger F.

Clin Oral Investig. 2019 Jan 28. doi: 10.1007/s00784-019-02824-0. [Epub ahead of print]

PMID:
30693402
13.

Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A.

Schreiber R, Buchholz B, Kraus A, Schley G, Scholz J, Ousingsawat J, Kunzelmann K.

J Am Soc Nephrol. 2019 Feb;30(2):228-242. doi: 10.1681/ASN.2018010039. Epub 2019 Jan 3.

PMID:
30606785
14.

TMEM16A is indispensable for basal mucus secretion in airways and intestine.

Benedetto R, Cabrita I, Schreiber R, Kunzelmann K.

FASEB J. 2019 Mar;33(3):4502-4512. doi: 10.1096/fj.201801333RRR. Epub 2018 Dec 26.

PMID:
30586313
15.

No Effect of Transcranial Direct Current Stimulation of the Auditory Cortex on Auditory-Evoked Potentials.

Kunzelmann K, Meier L, Grieder M, Morishima Y, Dierks T.

Front Neurosci. 2018 Nov 27;12:880. doi: 10.3389/fnins.2018.00880. eCollection 2018.

16.

Anoctamin-6 regulates ADAM sheddase function.

Veit M, Koyro KI, Ahrens B, Bleibaum F, Munz M, Rövekamp H, Andrä J, Schreiber R, Kunzelmann K, Sommer A, Bhakdi S, Reiss K.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt A):1598-1610. doi: 10.1016/j.bbamcr.2018.08.011. Epub 2018 Aug 23.

PMID:
30327201
17.

Effects of boundary condition on shrinkage vectors of a flowable composite in experimental cavity models made of dental substrates.

Kaisarly D, El Gezawi M, Nyamaa I, Rösch P, Kunzelmann KH.

Clin Oral Investig. 2019 May;23(5):2403-2411. doi: 10.1007/s00784-018-2696-3. Epub 2018 Oct 9.

PMID:
30302605
18.

Hydroxyapatite and Self-Assembling Peptide Matrix for Non-Oxidizing Tooth Whitening.

Bommer C, Flessa HP, Xu X, Kunzelmann KH.

J Clin Dent. 2018 Jun;29(2):57-63.

PMID:
30211992
19.

HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease.

Kraus A, Peters DJM, Klanke B, Weidemann A, Willam C, Schley G, Kunzelmann K, Eckardt KU, Buchholz B.

Kidney Int. 2018 Nov;94(5):887-899. doi: 10.1016/j.kint.2018.06.008. Epub 2018 Aug 30.

PMID:
30173898
20.

Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria.

Schenk LK, Buchholz B, Henke SF, Michgehl U, Daniel C, Amann K, Kunzelmann K, Pavenstädt H.

Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1777-F1786. doi: 10.1152/ajprenal.00638.2017. Epub 2018 Aug 29.

PMID:
30156115
21.

Effect of fiber incorporation on the contraction stress of composite materials.

Keßler A, Kaisarly D, Hickel R, Kunzelmann KH.

Clin Oral Investig. 2019 Mar;23(3):1461-1471. doi: 10.1007/s00784-018-2572-1. Epub 2018 Aug 17.

PMID:
30120604
22.

Surface properties and color stability of dental flowable composites influenced by simulated toothbrushing.

Lai G, Zhao L, Wang J, Kunzelmann KH.

Dent Mater J. 2018 Sep 30;37(5):717-724. doi: 10.4012/dmj.2017-233. Epub 2018 Jul 12.

23.

Decreased blood flow in the right insula and middle temporal gyrus predicts negative formal thought disorder in schizophrenia.

Winkelbeiner S, Cavelti M, Federspiel A, Kunzelmann K, Dierks T, Strik W, Horn H, Homan P.

Schizophr Res. 2018 Nov;201:432-434. doi: 10.1016/j.schres.2018.06.009. Epub 2018 Jun 21. No abstract available.

PMID:
29935888
24.

Regulation and Function of TMEM16F in Renal Podocytes.

Schenk LK, Ousingsawat J, Skryabin BV, Schreiber R, Pavenstädt H, Kunzelmann K.

Int J Mol Sci. 2018 Jun 18;19(6). pii: E1798. doi: 10.3390/ijms19061798.

25.

Correction to: Phenytoin inhibits necroptosis.

von Mässenhausen A, Tonnus W, Himmerkus N, Parmentier S, Saleh D, Rodriguez D, Ousingsawat J, Ang RL, Weinberg JM, Sanz AB, Ortiz A, Zierleyn A, Becker JU, Baratte B, Desban N, Bach S, Schiessl IM, Nogusa S, Balachandran S, Anders HJ, Ting AT, Bleich M, Degterev A, Kunzelmann K, Bornstein SR, Green DR, Hugo C, Linkermann A.

Cell Death Dis. 2018 May 24;9(6):622. doi: 10.1038/s41419-018-0638-2.

26.

Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo.

Mycielska ME, Dettmer K, Rümmele P, Schmidt K, Prehn C, Milenkovic VM, Jagla W, Madej GM, Lantow M, Schladt M, Cecil A, Koehl GE, Eggenhofer E, Wachsmuth CJ, Ganapathy V, Schlitt HJ, Kunzelmann K, Ziegler C, Wetzel CH, Gaumann A, Lang SA, Adamski J, Oefner PJ, Geissler EK.

Cancer Res. 2018 May 15;78(10):2513-2523. doi: 10.1158/0008-5472.CAN-17-2959. Epub 2018 Mar 6.

27.

Phenytoin inhibits necroptosis.

von Mässenhausen A, Tonnus W, Himmerkus N, Parmentier S, Saleh D, Rodriguez D, Ousingsawat J, Ang RL, Weinberg JM, Sanz AB, Ortiz A, Zierleyn A, Becker JU, Baratte B, Desban N, Bach S, Schiessl IM, Nogusa S, Balachandran S, Anders HJ, Ting AT, Bleich M, Degterev A, Kunzelmann K, Bornstein SR, Green DR, Hugo C, Linkermann A.

Cell Death Dis. 2018 Mar 2;9(3):359. doi: 10.1038/s41419-018-0394-3. Erratum in: Cell Death Dis. 2018 May 24;9(6):622.

28.

Transillumination and HDR Imaging for Proximal Caries Detection.

Lederer A, Kunzelmann KH, Hickel R, Litzenburger F.

J Dent Res. 2018 Jul;97(7):844-849. doi: 10.1177/0022034518759957. Epub 2018 Feb 26.

PMID:
29481761
29.

Contribution of TMEM16F to pyroptotic cell death.

Ousingsawat J, Wanitchakool P, Schreiber R, Kunzelmann K.

Cell Death Dis. 2018 Feb 20;9(3):300. doi: 10.1038/s41419-018-0373-8.

30.

Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1.

Lérias J, Pinto M, Benedetto R, Schreiber R, Amaral M, Aureli M, Kunzelmann K.

Cell Signal. 2018 Apr;44:10-19. doi: 10.1016/j.cellsig.2018.01.008. Epub 2018 Jan 10.

PMID:
29331508
31.

Effects of occlusal cavity configuration on 3D shrinkage vectors in a flowable composite.

Kaisarly D, El Gezawi M, Lai G, Jin J, Rösch P, Kunzelmann KH.

Clin Oral Investig. 2018 Jun;22(5):2047-2056. doi: 10.1007/s00784-017-2304-y. Epub 2017 Dec 16.

PMID:
29248963
32.
33.

A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic.

Lérias JR, Pinto MC, Botelho HM, Awatade NT, Quaresma MC, Silva IAL, Wanitchakool P, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD.

Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):421-431. doi: 10.1016/j.bbamcr.2017.11.009. Epub 2017 Nov 15.

34.

Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid.

Schreiber R, Ousingsawat J, Wanitchakool P, Sirianant L, Benedetto R, Reiss K, Kunzelmann K.

J Physiol. 2018 Jan 15;596(2):217-229. doi: 10.1113/JP275175. Epub 2017 Dec 18.

35.

Shrinkage vectors of a flowable composite in artificial cavity models with different boundary conditions: Ceramic and Teflon.

Kaisarly D, El Gezawi M, Xu X, Rösch P, Kunzelmann KH.

J Mech Behav Biomed Mater. 2018 Jan;77:414-421. doi: 10.1016/j.jmbbm.2017.10.004. Epub 2017 Oct 3.

PMID:
29020664
36.

Epithelial Chloride Transport by CFTR Requires TMEM16A.

Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K.

Sci Rep. 2017 Sep 29;7(1):12397. doi: 10.1038/s41598-017-10910-0.

37.

Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression.

Hagmann H, Mangold N, Rinschen MM, Koenig T, Kunzelmann K, Schermer B, Benzing T, Brinkkoetter PT.

FASEB J. 2018 Jan;32(1):208-219. doi: 10.1096/fj.201700309R. Epub 2017 Sep 6.

38.

CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6).

Simões F, Ousingsawat J, Wanitchakool P, Fonseca A, Cabrita I, Benedetto R, Schreiber R, Kunzelmann K.

Pflugers Arch. 2018 Feb;470(2):305-314. doi: 10.1007/s00424-017-2065-0. Epub 2017 Sep 5.

PMID:
28875346
39.

Bicarbonate in cystic fibrosis.

Kunzelmann K, Schreiber R, Hadorn HB.

J Cyst Fibros. 2017 Nov;16(6):653-662. doi: 10.1016/j.jcf.2017.06.005. Epub 2017 Jul 18. Review.

PMID:
28732801
40.

Differential effects of anoctamins on intracellular calcium signals.

Cabrita I, Benedetto R, Fonseca A, Wanitchakool P, Sirianant L, Skryabin BV, Schenk LK, Pavenstädt H, Schreiber R, Kunzelmann K.

FASEB J. 2017 May;31(5):2123-2134. doi: 10.1096/fj.201600797RR. Epub 2017 Feb 9.

PMID:
28183802
41.

Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling.

Wanitchakool P, Ousingsawat J, Sirianant L, Cabrita I, Faria D, Schreiber R, Kunzelmann K.

Cell Signal. 2017 Jan;30:41-49. doi: 10.1016/j.cellsig.2016.11.006. Epub 2016 Nov 10.

PMID:
27838374
42.

Expression of anoctamins in retinal pigment epithelium (RPE).

Schreiber R, Kunzelmann K.

Pflugers Arch. 2016 Nov;468(11-12):1921-1929. Epub 2016 Nov 7.

PMID:
27822608
43.

Degradation Potential of Bulk Versus Incrementally Applied and Indirect Composites: Color, Microhardness, and Surface Deterioration.

El Gezawi M, Kaisarly D, Al-Saleh H, ArRejaie A, Al-Harbi F, Kunzelmann KH.

Oper Dent. 2016 Nov/Dec;41(6):e195-e208.

PMID:
27820694
44.

TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report.

Baig AA, Haining EJ, Geuss E, Beck S, Swieringa F, Wanitchakool P, Schuhmann MK, Stegner D, Kunzelmann K, Kleinschnitz C, Heemskerk JW, Braun A, Nieswandt B.

Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2152-2157. Epub 2016 Sep 15.

PMID:
27634832
45.

P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells.

Kraus A, Grampp S, Goppelt-Struebe M, Schreiber R, Kunzelmann K, Peters DJ, Leipziger J, Schley G, Schödel J, Eckardt KU, Buchholz B.

Purinergic Signal. 2016 Dec;12(4):687-695. Epub 2016 Aug 26.

46.

Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis.

Ousingsawat J, Cabrita I, Wanitchakool P, Sirianant L, Krautwald S, Linkermann A, Schreiber R, Kunzelmann K.

Cell Mol Life Sci. 2017 Jan;74(1):173-181. doi: 10.1007/s00018-016-2338-3. Epub 2016 Aug 17.

PMID:
27535660
47.

Relationship between TMEM16A/anoctamin 1 and LRRC8A.

Benedetto R, Sirianant L, Pankonien I, Wanitchakool P, Ousingsawat J, Cabrita I, Schreiber R, Amaral M, Kunzelmann K.

Pflugers Arch. 2016 Oct;468(10):1751-63. doi: 10.1007/s00424-016-1862-1. Epub 2016 Aug 12.

PMID:
27514381
48.

Cl- channels in apoptosis.

Wanitchakool P, Ousingsawat J, Sirianant L, MacAulay N, Schreiber R, Kunzelmann K.

Eur Biophys J. 2016 Oct;45(7):599-610. Epub 2016 Jun 7.

PMID:
27270446
49.

Phosphatidylserine exposure is required for ADAM17 sheddase function.

Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K.

Nat Commun. 2016 May 10;7:11523. doi: 10.1038/ncomms11523.

50.

Ion channels in regulated cell death.

Kunzelmann K.

Cell Mol Life Sci. 2016 Jun;73(11-12):2387-403. doi: 10.1007/s00018-016-2208-z. Epub 2016 Apr 18. Review.

PMID:
27091155

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