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Items: 1 to 50 of 341

1.

Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A.

Schreiber R, Buchholz B, Kraus A, Schley G, Scholz J, Ousingsawat J, Kunzelmann K.

J Am Soc Nephrol. 2019 Jan 3. pii: ASN.2018010039. doi: 10.1681/ASN.2018010039. [Epub ahead of print]

PMID:
30606785
2.

TMEM16A is indispensable for basal mucus secretion in airways and intestine.

Benedetto R, Cabrita I, Schreiber R, Kunzelmann K.

FASEB J. 2018 Dec 26:fj201801333RRR. doi: 10.1096/fj.201801333RRR. [Epub ahead of print]

PMID:
30586313
3.

No Effect of Transcranial Direct Current Stimulation of the Auditory Cortex on Auditory-Evoked Potentials.

Kunzelmann K, Meier L, Grieder M, Morishima Y, Dierks T.

Front Neurosci. 2018 Nov 27;12:880. doi: 10.3389/fnins.2018.00880. eCollection 2018.

4.

Anoctamin-6 regulates ADAM sheddase function.

Veit M, Koyro KI, Ahrens B, Bleibaum F, Munz M, Rövekamp H, Andrä J, Schreiber R, Kunzelmann K, Sommer A, Bhakdi S, Reiss K.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt A):1598-1610. doi: 10.1016/j.bbamcr.2018.08.011. Epub 2018 Aug 23.

PMID:
30327201
5.

Effects of boundary condition on shrinkage vectors of a flowable composite in experimental cavity models made of dental substrates.

Kaisarly D, El Gezawi M, Nyamaa I, Rösch P, Kunzelmann KH.

Clin Oral Investig. 2018 Oct 9. doi: 10.1007/s00784-018-2696-3. [Epub ahead of print]

PMID:
30302605
6.

Hydroxyapatite and Self-Assembling Peptide Matrix for Non-Oxidizing Tooth Whitening.

Bommer C, Flessa HP, Xu X, Kunzelmann KH.

J Clin Dent. 2018 Jun;29(2):57-63.

PMID:
30211992
7.

HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease.

Kraus A, Peters DJM, Klanke B, Weidemann A, Willam C, Schley G, Kunzelmann K, Eckardt KU, Buchholz B.

Kidney Int. 2018 Nov;94(5):887-899. doi: 10.1016/j.kint.2018.06.008. Epub 2018 Aug 30.

PMID:
30173898
8.

Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria.

Schenk LK, Buchholz B, Henke SF, Michgehl U, Daniel C, Amann K, Kunzelmann K, Pavenstädt HJ.

Am J Physiol Renal Physiol. 2018 Aug 29. doi: 10.1152/ajprenal.00638.2017. [Epub ahead of print]

PMID:
30156115
9.

Effect of fiber incorporation on the contraction stress of composite materials.

Keßler A, Kaisarly D, Hickel R, Kunzelmann KH.

Clin Oral Investig. 2018 Aug 17. doi: 10.1007/s00784-018-2572-1. [Epub ahead of print]

PMID:
30120604
10.

Surface properties and color stability of dental flowable composites influenced by simulated toothbrushing.

Lai G, Zhao L, Wang J, Kunzelmann KH.

Dent Mater J. 2018 Sep 30;37(5):717-724. doi: 10.4012/dmj.2017-233. Epub 2018 Jul 12.

11.

Decreased blood flow in the right insula and middle temporal gyrus predicts negative formal thought disorder in schizophrenia.

Winkelbeiner S, Cavelti M, Federspiel A, Kunzelmann K, Dierks T, Strik W, Horn H, Homan P.

Schizophr Res. 2018 Nov;201:432-434. doi: 10.1016/j.schres.2018.06.009. Epub 2018 Jun 21. No abstract available.

PMID:
29935888
12.

Regulation and Function of TMEM16F in Renal Podocytes.

Schenk LK, Ousingsawat J, Skryabin BV, Schreiber R, Pavenstädt H, Kunzelmann K.

Int J Mol Sci. 2018 Jun 18;19(6). pii: E1798. doi: 10.3390/ijms19061798.

13.

Correction to: Phenytoin inhibits necroptosis.

von Mässenhausen A, Tonnus W, Himmerkus N, Parmentier S, Saleh D, Rodriguez D, Ousingsawat J, Ang RL, Weinberg JM, Sanz AB, Ortiz A, Zierleyn A, Becker JU, Baratte B, Desban N, Bach S, Schiessl IM, Nogusa S, Balachandran S, Anders HJ, Ting AT, Bleich M, Degterev A, Kunzelmann K, Bornstein SR, Green DR, Hugo C, Linkermann A.

Cell Death Dis. 2018 May 24;9(6):622. doi: 10.1038/s41419-018-0638-2.

14.

Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo.

Mycielska ME, Dettmer K, Rümmele P, Schmidt K, Prehn C, Milenkovic VM, Jagla W, Madej GM, Lantow M, Schladt M, Cecil A, Koehl GE, Eggenhofer E, Wachsmuth CJ, Ganapathy V, Schlitt HJ, Kunzelmann K, Ziegler C, Wetzel CH, Gaumann A, Lang SA, Adamski J, Oefner PJ, Geissler EK.

Cancer Res. 2018 May 15;78(10):2513-2523. doi: 10.1158/0008-5472.CAN-17-2959. Epub 2018 Mar 6.

PMID:
29510993
15.

Phenytoin inhibits necroptosis.

von Mässenhausen A, Tonnus W, Himmerkus N, Parmentier S, Saleh D, Rodriguez D, Ousingsawat J, Ang RL, Weinberg JM, Sanz AB, Ortiz A, Zierleyn A, Becker JU, Baratte B, Desban N, Bach S, Schiessl IM, Nogusa S, Balachandran S, Anders HJ, Ting AT, Bleich M, Degterev A, Kunzelmann K, Bornstein SR, Green DR, Hugo C, Linkermann A.

Cell Death Dis. 2018 Mar 2;9(3):359. doi: 10.1038/s41419-018-0394-3. Erratum in: Cell Death Dis. 2018 May 24;9(6):622.

16.

Transillumination and HDR Imaging for Proximal Caries Detection.

Lederer A, Kunzelmann KH, Hickel R, Litzenburger F.

J Dent Res. 2018 Jul;97(7):844-849. doi: 10.1177/0022034518759957. Epub 2018 Feb 26.

PMID:
29481761
17.

Contribution of TMEM16F to pyroptotic cell death.

Ousingsawat J, Wanitchakool P, Schreiber R, Kunzelmann K.

Cell Death Dis. 2018 Feb 20;9(3):300. doi: 10.1038/s41419-018-0373-8.

18.

Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1.

Lérias J, Pinto M, Benedetto R, Schreiber R, Amaral M, Aureli M, Kunzelmann K.

Cell Signal. 2018 Apr;44:10-19. doi: 10.1016/j.cellsig.2018.01.008. Epub 2018 Jan 10.

PMID:
29331508
19.

Effects of occlusal cavity configuration on 3D shrinkage vectors in a flowable composite.

Kaisarly D, El Gezawi M, Lai G, Jin J, Rösch P, Kunzelmann KH.

Clin Oral Investig. 2018 Jun;22(5):2047-2056. doi: 10.1007/s00784-017-2304-y. Epub 2017 Dec 16.

PMID:
29248963
20.
21.

A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic.

Lérias JR, Pinto MC, Botelho HM, Awatade NT, Quaresma MC, Silva IAL, Wanitchakool P, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD.

Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):421-431. doi: 10.1016/j.bbamcr.2017.11.009. Epub 2017 Nov 15.

PMID:
29154949
22.

Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid.

Schreiber R, Ousingsawat J, Wanitchakool P, Sirianant L, Benedetto R, Reiss K, Kunzelmann K.

J Physiol. 2018 Jan 15;596(2):217-229. doi: 10.1113/JP275175. Epub 2017 Dec 18.

23.

Shrinkage vectors of a flowable composite in artificial cavity models with different boundary conditions: Ceramic and Teflon.

Kaisarly D, El Gezawi M, Xu X, Rösch P, Kunzelmann KH.

J Mech Behav Biomed Mater. 2018 Jan;77:414-421. doi: 10.1016/j.jmbbm.2017.10.004. Epub 2017 Oct 3.

PMID:
29020664
24.

Epithelial Chloride Transport by CFTR Requires TMEM16A.

Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K.

Sci Rep. 2017 Sep 29;7(1):12397. doi: 10.1038/s41598-017-10910-0.

25.

Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression.

Hagmann H, Mangold N, Rinschen MM, Koenig T, Kunzelmann K, Schermer B, Benzing T, Brinkkoetter PT.

FASEB J. 2018 Jan;32(1):208-219. doi: 10.1096/fj.201700309R. Epub 2017 Sep 6.

26.

CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6).

Simões F, Ousingsawat J, Wanitchakool P, Fonseca A, Cabrita I, Benedetto R, Schreiber R, Kunzelmann K.

Pflugers Arch. 2018 Feb;470(2):305-314. doi: 10.1007/s00424-017-2065-0. Epub 2017 Sep 5.

PMID:
28875346
27.

Bicarbonate in cystic fibrosis.

Kunzelmann K, Schreiber R, Hadorn HB.

J Cyst Fibros. 2017 Nov;16(6):653-662. doi: 10.1016/j.jcf.2017.06.005. Epub 2017 Jul 18. Review.

PMID:
28732801
28.

Differential effects of anoctamins on intracellular calcium signals.

Cabrita I, Benedetto R, Fonseca A, Wanitchakool P, Sirianant L, Skryabin BV, Schenk LK, Pavenstädt H, Schreiber R, Kunzelmann K.

FASEB J. 2017 May;31(5):2123-2134. doi: 10.1096/fj.201600797RR. Epub 2017 Feb 9.

PMID:
28183802
29.

Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling.

Wanitchakool P, Ousingsawat J, Sirianant L, Cabrita I, Faria D, Schreiber R, Kunzelmann K.

Cell Signal. 2017 Jan;30:41-49. doi: 10.1016/j.cellsig.2016.11.006. Epub 2016 Nov 10.

PMID:
27838374
30.

Expression of anoctamins in retinal pigment epithelium (RPE).

Schreiber R, Kunzelmann K.

Pflugers Arch. 2016 Nov;468(11-12):1921-1929. Epub 2016 Nov 7.

PMID:
27822608
31.

Degradation Potential of Bulk Versus Incrementally Applied and Indirect Composites: Color, Microhardness, and Surface Deterioration.

El Gezawi M, Kaisarly D, Al-Saleh H, ArRejaie A, Al-Harbi F, Kunzelmann KH.

Oper Dent. 2016 Nov/Dec;41(6):e195-e208.

PMID:
27820694
32.

TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report.

Baig AA, Haining EJ, Geuss E, Beck S, Swieringa F, Wanitchakool P, Schuhmann MK, Stegner D, Kunzelmann K, Kleinschnitz C, Heemskerk JW, Braun A, Nieswandt B.

Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2152-2157. Epub 2016 Sep 15.

PMID:
27634832
33.

P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells.

Kraus A, Grampp S, Goppelt-Struebe M, Schreiber R, Kunzelmann K, Peters DJ, Leipziger J, Schley G, Schödel J, Eckardt KU, Buchholz B.

Purinergic Signal. 2016 Dec;12(4):687-695. Epub 2016 Aug 26.

34.

Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis.

Ousingsawat J, Cabrita I, Wanitchakool P, Sirianant L, Krautwald S, Linkermann A, Schreiber R, Kunzelmann K.

Cell Mol Life Sci. 2017 Jan;74(1):173-181. doi: 10.1007/s00018-016-2338-3. Epub 2016 Aug 17.

PMID:
27535660
35.

Relationship between TMEM16A/anoctamin 1 and LRRC8A.

Benedetto R, Sirianant L, Pankonien I, Wanitchakool P, Ousingsawat J, Cabrita I, Schreiber R, Amaral M, Kunzelmann K.

Pflugers Arch. 2016 Oct;468(10):1751-63. doi: 10.1007/s00424-016-1862-1. Epub 2016 Aug 12.

PMID:
27514381
36.

Cl- channels in apoptosis.

Wanitchakool P, Ousingsawat J, Sirianant L, MacAulay N, Schreiber R, Kunzelmann K.

Eur Biophys J. 2016 Oct;45(7):599-610. Epub 2016 Jun 7.

PMID:
27270446
37.

Phosphatidylserine exposure is required for ADAM17 sheddase function.

Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K.

Nat Commun. 2016 May 10;7:11523. doi: 10.1038/ncomms11523.

38.

Ion channels in regulated cell death.

Kunzelmann K.

Cell Mol Life Sci. 2016 Jun;73(11-12):2387-403. doi: 10.1007/s00018-016-2208-z. Epub 2016 Apr 18. Review.

PMID:
27091155
39.

Non-essential contribution of LRRC8A to volume regulation.

Sirianant L, Wanitchakool P, Ousingsawat J, Benedetto R, Zormpa A, Cabrita I, Schreiber R, Kunzelmann K.

Pflugers Arch. 2016 May;468(5):805-16. doi: 10.1007/s00424-016-1789-6. Epub 2016 Feb 13.

PMID:
26873248
40.

Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC.

Kunzelmann K, Cabrita I, Wanitchakool P, Ousingsawat J, Sirianant L, Benedetto R, Schreiber R.

Pflugers Arch. 2016 Mar;468(3):475-90. doi: 10.1007/s00424-015-1767-4. Epub 2015 Dec 23. Review.

PMID:
26700940
41.

Polishing mechanism of light-initiated dental composite: Geometric optics approach.

Chiang YC, Lai EH, Kunzelmann KH.

J Formos Med Assoc. 2016 Dec;115(12):1053-1060. doi: 10.1016/j.jfma.2015.10.010. Epub 2015 Dec 11.

42.

Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis.

Liu G, Liu G, Chen H, Borst O, Gawaz M, Vortkamp A, Schreiber R, Kunzelmann K, Lang F.

Cell Physiol Biochem. 2015;37(5):1934-44. doi: 10.1159/000438554. Epub 2015 Nov 20.

43.

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage.

Mattheij NJ, Braun A, van Kruchten R, Castoldi E, Pircher J, Baaten CC, Wülling M, Kuijpers MJ, Köhler R, Poole AW, Schreiber R, Vortkamp A, Collins PW, Nieswandt B, Kunzelmann K, Cosemans JM, Heemskerk JW.

FASEB J. 2016 Feb;30(2):727-37. doi: 10.1096/fj.15-280446. Epub 2015 Oct 19.

PMID:
26481309
44.

Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation.

Forschbach V, Goppelt-Struebe M, Kunzelmann K, Schreiber R, Piedagnel R, Kraus A, Eckardt KU, Buchholz B.

Cell Death Dis. 2015 Oct 8;6:e1899. doi: 10.1038/cddis.2015.273.

45.

Cellular volume regulation by anoctamin 6: Ca²⁺, phospholipase A2 and osmosensing.

Sirianant L, Ousingsawat J, Wanitchakool P, Schreiber R, Kunzelmann K.

Pflugers Arch. 2016 Feb;468(2):335-49. doi: 10.1007/s00424-015-1739-8. Epub 2015 Oct 6.

PMID:
26438191
46.

Shear bond strength of two adhesives to bovine dentin contaminated with various astringents.

Xu X, Chen Q, Lederer A, Bernau C, Lai G, Kaisarly D, Dent DM, Kunzelmann KH.

Am J Dent. 2015 Aug;28(4):229-34.

PMID:
26437505
47.

Glucose promotes secretion-dependent renal cyst growth.

Kraus A, Schley G, Kunzelmann K, Schreiber R, Peters DJ, Stadler R, Eckardt KU, Buchholz B.

J Mol Med (Berl). 2016 Jan;94(1):107-17. doi: 10.1007/s00109-015-1337-4. Epub 2015 Sep 3.

PMID:
26334260
48.

TMEM16, LRRC8A, bestrophin: chloride channels controlled by Ca(2+) and cell volume.

Kunzelmann K.

Trends Biochem Sci. 2015 Sep;40(9):535-43. doi: 10.1016/j.tibs.2015.07.005. Epub 2015 Aug 4. Review.

PMID:
26254230
49.

Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells.

Milenkovic A, Brandl C, Milenkovic VM, Jendryke T, Sirianant L, Wanitchakool P, Zimmermann S, Reiff CM, Horling F, Schrewe H, Schreiber R, Kunzelmann K, Wetzel CH, Weber BH.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2630-9. doi: 10.1073/pnas.1418840112. Epub 2015 May 4.

50.

Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery.

Botelho HM, Uliyakina I, Awatade NT, Proença MC, Tischer C, Sirianant L, Kunzelmann K, Pepperkok R, Amaral MD.

Sci Rep. 2015 Mar 12;5:9038. doi: 10.1038/srep09038.

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