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Items: 1 to 50 of 100

1.

The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity.

Digomann D, Kurth I, Tyutyunnykova A, Chen O, Löck S, Gorodetska I, Peitzsch C, Skvortsova II, Negro G, Aschenbrenner B, Eisenhofer G, Richter S, Heiden S, Porrmann J, Klink B, Schwager C, Dowle AA, Hein L, Kunz-Schughart LA, Abdollahi A, Lohaus F, Krause M, Baumann M, Linge A, Dubrovska A.

Clin Cancer Res. 2019 May 15;25(10):3152-3163. doi: 10.1158/1078-0432.CCR-18-2951. Epub 2019 Jan 22.

PMID:
30670494
2.

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy.

Ashton TM, McKenna WG, Kunz-Schughart LA, Higgins GS.

Clin Cancer Res. 2018 Jun 1;24(11):2482-2490. doi: 10.1158/1078-0432.CCR-17-3070. Epub 2018 Feb 2. Review.

3.

A Complex Scenario and Underestimated Challenge: The Tumor Microenvironment, ER Stress, and Cancer Treatment.

Chen OI, Bobak YP, Stasyk OV, Kunz-Schughart LA.

Curr Med Chem. 2018;25(21):2465-2502. doi: 10.2174/0929867325666180117110259. Review.

PMID:
29345569
4.

Arginine Deprivation Therapy: Putative Strategy to Eradicate Glioblastoma Cells by Radiosensitization.

Hinrichs CN, Ingargiola M, Käubler T, Löck S, Temme A, Köhn-Luque A, Deutsch A, Vovk O, Stasyk O, Kunz-Schughart LA.

Mol Cancer Ther. 2018 Feb;17(2):393-406. doi: 10.1158/1535-7163.MCT-16-0807. Epub 2017 Aug 22.

5.

Nanoparticles for radiooncology: Mission, vision, challenges.

Kunz-Schughart LA, Dubrovska A, Peitzsch C, Ewe A, Aigner A, Schellenburg S, Muders MH, Hampel S, Cirillo G, Iemma F, Tietze R, Alexiou C, Stephan H, Zarschler K, Vittorio O, Kavallaris M, Parak WJ, Mädler L, Pokhrel S.

Biomaterials. 2017 Mar;120:155-184. doi: 10.1016/j.biomaterials.2016.12.010. Epub 2016 Dec 14. Review.

PMID:
28063356
6.

The why and how of amino acid analytics in cancer diagnostics and therapy.

Manig F, Kuhne K, von Neubeck C, Schwarzenbolz U, Yu Z, Kessler BM, Pietzsch J, Kunz-Schughart LA.

J Biotechnol. 2017 Jan 20;242:30-54. doi: 10.1016/j.jbiotec.2016.12.001. Epub 2016 Dec 5. Review.

PMID:
27932276
7.

Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability.

Kurlishchuk Y, Vynnytska-Myronovska B, Grosse-Gehling P, Bobak Y, Manig F, Chen O, Merker SR, Henle T, Löck S, Stange DE, Stasyk O, Kunz-Schughart LA.

Oncotarget. 2016 Nov 8;7(45):73292-73308. doi: 10.18632/oncotarget.12320.

8.

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia.

Ashton TM, Fokas E, Kunz-Schughart LA, Folkes LK, Anbalagan S, Huether M, Kelly CJ, Pirovano G, Buffa FM, Hammond EM, Stratford M, Muschel RJ, Higgins GS, McKenna WG.

Nat Commun. 2016 Jul 25;7:12308. doi: 10.1038/ncomms12308.

9.

Efficacy of Beta1 Integrin and EGFR Targeting in Sphere-Forming Human Head and Neck Cancer Cells.

Zscheppang K, Kurth I, Wachtel N, Dubrovska A, Kunz-Schughart LA, Cordes N.

J Cancer. 2016 Apr 2;7(6):736-45. doi: 10.7150/jca.14232. eCollection 2016.

10.

Arginine starvation in colorectal carcinoma cells: Sensing, impact on translation control and cell cycle distribution.

Vynnytska-Myronovska BO, Kurlishchuk Y, Chen O, Bobak Y, Dittfeld C, Hüther M, Kunz-Schughart LA, Stasyk OV.

Exp Cell Res. 2016 Feb 1;341(1):67-74. doi: 10.1016/j.yexcr.2016.01.002. Epub 2016 Jan 2.

PMID:
26751966
11.

Arginine deprivation induces endoplasmic reticulum stress in human solid cancer cells.

Bobak Y, Kurlishchuk Y, Vynnytska-Myronovska B, Grydzuk O, Shuvayeva G, Redowicz MJ, Kunz-Schughart LA, Stasyk O.

Int J Biochem Cell Biol. 2016 Jan;70:29-38. doi: 10.1016/j.biocel.2015.10.027. Epub 2015 Nov 4.

PMID:
26546743
12.

Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells.

Cojoc M, Peitzsch C, Kurth I, Trautmann F, Kunz-Schughart LA, Telegeev GD, Stakhovsky EA, Walker JR, Simin K, Lyle S, Fuessel S, Erdmann K, Wirth MP, Krause M, Baumann M, Dubrovska A.

Cancer Res. 2015 Apr 1;75(7):1482-94. doi: 10.1158/0008-5472.CAN-14-1924. Epub 2015 Feb 10.

13.

Potential of a Cetuximab-based radioimmunotherapy combined with external irradiation manifests in a 3-D cell assay.

Ingargiola M, Runge R, Heldt JM, Freudenberg R, Steinbach J, Cordes N, Baumann M, Kotzerke J, Brockhoff G, Kunz-Schughart LA.

Int J Cancer. 2014 Aug 15;135(4):968-80. doi: 10.1002/ijc.28735. Epub 2014 Feb 11.

14.

Cytotoxic properties of radionuclide-conjugated Cetuximab without and in combination with external irradiation in head and neck cancer cells in vitro.

Eke I, Ingargiola M, Förster C, Kunz-Schughart LA, Baumann M, Runge R, Freudenberg R, Kotzerke J, Heldt JM, Pietzsch HJ, Steinbach J, Cordes N.

Int J Radiat Biol. 2014 Aug;90(8):678-86. doi: 10.3109/09553002.2014.899446. Epub 2014 Apr 3.

PMID:
24597752
15.

Three-dimensional environment renders cancer cells profoundly less susceptible to a single amino acid starvation.

Vynnytska-Myronovska B, Kurlishchuk Y, Bobak Y, Dittfeld C, Kunz-Schughart LA, Stasyk O.

Amino Acids. 2013 Nov;45(5):1221-30. doi: 10.1007/s00726-013-1586-x. Epub 2013 Sep 14.

PMID:
24036986
16.

Simultaneous PLK1 inhibition improves local tumour control after fractionated irradiation.

Krause M, Kummer B, Deparade A, Eicheler W, Pfitzmann D, Yaromina A, Kunz-Schughart LA, Baumann M.

Radiother Oncol. 2013 Sep;108(3):422-8. doi: 10.1016/j.radonc.2013.06.038. Epub 2013 Jul 25.

PMID:
23891096
17.

Macromolecule extravasation-xenograft size matters: a systematic study using probe-based confocal laser endomicroscopy (pCLE).

Dietrich A, Stewart J, Huether M, Helm M, Schuetze C, Schnittler HJ, Jaffray DA, Kunz-Schughart LA.

Mol Imaging Biol. 2013 Dec;15(6):693-702. doi: 10.1007/s11307-013-0641-z.

18.

EGFR/JIP-4/JNK2 signaling attenuates cetuximab-mediated radiosensitization of squamous cell carcinoma cells.

Eke I, Schneider L, Förster C, Zips D, Kunz-Schughart LA, Cordes N.

Cancer Res. 2013 Jan 1;73(1):297-306. doi: 10.1158/0008-5472.CAN-12-2021. Epub 2012 Oct 16.

19.

[Tumor pathophysiology].

Kunz-Schughart LA, Mueller-Klieser W, Vaupel P.

Strahlenther Onkol. 2012 Nov;188 Suppl 3:299-303. doi: 10.1007/s00066-012-0203-3. Review. German. No abstract available.

PMID:
23053151
20.

Sodium-iodide symporter positive cells after intracellular uptake of (99m)Tc versus α-emitter 211At. Reduction of clonogenic survival and characterization of DNA damage.

Kotzerke J, Wendisch M, Freudenberg R, Runge R, Oehme L, Meyer GJ, Kunz-Schughart LA, Wunderlich G.

Nuklearmedizin. 2012;51(5):170-8. doi: 10.3413/Nukmed-0506-12-05.

PMID:
23037134
21.

Rapid re-expression of CD133 protein in colorectal cancer cell lines in vitro and in vivo.

Peickert S, Waurig J, Dittfeld C, Dietrich A, Garbe Y, Kabus L, Baumann M, Grade M, Ried T, Kunz-Schughart LA.

Lab Invest. 2012 Nov;92(11):1607-22. doi: 10.1038/labinvest.2012.124. Epub 2012 Sep 10.

22.

Flow cytometric cell-based assay to preselect antibody constructs for radionuclide conjugation.

Ingargiola M, Dittfeld C, Runge R, Zenker M, Heldt JM, Steinbach J, Cordes N, Baumann M, Kotzerke J, Kunz-Schughart LA.

Cytometry A. 2012 Oct;81(10):865-73. doi: 10.1002/cyto.a.22110. Epub 2012 Aug 28.

23.

CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges.

Grosse-Gehling P, Fargeas CA, Dittfeld C, Garbe Y, Alison MR, Corbeil D, Kunz-Schughart LA.

J Pathol. 2013 Feb;229(3):355-78. doi: 10.1002/path.4086. Epub 2012 Nov 20. Review.

PMID:
22899341
24.

Cancer stem cells as a predictive factor in radiotherapy.

Brunner TB, Kunz-Schughart LA, Grosse-Gehling P, Baumann M.

Semin Radiat Oncol. 2012 Apr;22(2):151-74. doi: 10.1016/j.semradonc.2011.12.003. Review.

PMID:
22385922
25.

Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo.

Yaromina A, Meyer S, Fabian C, Zaleska K, Sattler UG, Kunz-Schughart LA, Mueller-Klieser W, Zips D, Baumann M.

Strahlenther Onkol. 2012 May;188(5):431-7. doi: 10.1007/s00066-011-0054-3. Epub 2012 Feb 16.

PMID:
22349632
26.

Single amino acid arginine starvation efficiently sensitizes cancer cells to canavanine treatment and irradiation.

Vynnytska-Myronovska B, Bobak Y, Garbe Y, Dittfeld C, Stasyk O, Kunz-Schughart LA.

Int J Cancer. 2012 May 1;130(9):2164-75. doi: 10.1002/ijc.26221. Epub 2011 Aug 8.

27.

Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release.

Goetze K, Walenta S, Ksiazkiewicz M, Kunz-Schughart LA, Mueller-Klieser W.

Int J Oncol. 2011 Aug;39(2):453-63. doi: 10.3892/ijo.2011.1055. Epub 2011 May 25.

PMID:
21617859
28.

Genome and transcriptome profiles of CD133-positive colorectal cancer cells.

Gaiser T, Camps J, Meinhardt S, Wangsa D, Nguyen QT, Varma S, Dittfeld C, Kunz-Schughart LA, Kemmerling R, Becker MR, Heselmeyer-Haddad K, Ried T.

Am J Pathol. 2011 Apr;178(4):1478-88. doi: 10.1016/j.ajpath.2010.12.036.

29.

Characterization and modulation of fibroblast/endothelial cell co-cultures for the in vitro preformation of three-dimensional tubular networks.

Eckermann CW, Lehle K, Schmid SA, Wheatley DN, Kunz-Schughart LA.

Cell Biol Int. 2011 Nov;35(11):1097-110. doi: 10.1042/CBI20100718.

PMID:
21418038
30.

Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits.

Hardelauf H, Frimat JP, Stewart JD, Schormann W, Chiang YY, Lampen P, Franzke J, Hengstler JG, Cadenas C, Kunz-Schughart LA, West J.

Lab Chip. 2011 Feb 7;11(3):419-28. doi: 10.1039/c0lc00089b. Epub 2010 Nov 16.

PMID:
21079873
31.

Relevance of disease- and organ-specific endothelial cells for in vitro research.

Lehle K, Straub RH, Morawietz H, Kunz-Schughart LA.

Cell Biol Int. 2010 Dec;34(12):1231-8. doi: 10.1042/CBI20100531. Review.

PMID:
21067521
32.

Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts.

Ksiazkiewicz M, Gottfried E, Kreutz M, Mack M, Hofstaedter F, Kunz-Schughart LA.

Immunobiology. 2010 Sep-Oct;215(9-10):737-47. doi: 10.1016/j.imbio.2010.05.019. Epub 2010 Jun 4.

PMID:
20605053
33.

CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell line HCT-116.

Dittfeld C, Dietrich A, Peickert S, Hering S, Baumann M, Grade M, Ried T, Kunz-Schughart LA.

Radiother Oncol. 2010 Mar;94(3):375-83.

PMID:
20344822
34.

Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids.

Gottfried E, Rogenhofer S, Waibel H, Kunz-Schughart LA, Reichle A, Wehrstein M, Peuker A, Peter K, Hartmannsgruber G, Andreesen R, Kreutz M.

Cancer Chemother Pharmacol. 2011 Jan;67(1):117-26. doi: 10.1007/s00280-010-1294-0. Epub 2010 Mar 9.

PMID:
20217088
35.

Multicellular tumor spheroids: an underestimated tool is catching up again.

Hirschhaeuser F, Menne H, Dittfeld C, West J, Mueller-Klieser W, Kunz-Schughart LA.

J Biotechnol. 2010 Jul 1;148(1):3-15. doi: 10.1016/j.jbiotec.2010.01.012. Epub 2010 Jan 25. Review.

PMID:
20097238
36.

Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes.

Dietl K, Renner K, Dettmer K, Timischl B, Eberhart K, Dorn C, Hellerbrand C, Kastenberger M, Kunz-Schughart LA, Oefner PJ, Andreesen R, Gottfried E, Kreutz MP.

J Immunol. 2010 Feb 1;184(3):1200-9. doi: 10.4049/jimmunol.0902584. Epub 2009 Dec 21.

37.

Fibroblastic reaction and vascular maturation in human colon cancers.

Schmid SA, Dietrich A, Schulte S, Gaumann A, Kunz-Schughart LA.

Int J Radiat Biol. 2009 Nov;85(11):1013-25. doi: 10.3109/09553000903258897.

PMID:
19895278
38.

Impact of exogenous lactate on survival and radioresponse of carcinoma cells in vitro.

Grotius J, Dittfeld C, Huether M, Mueller-Klieser W, Baumann M, Kunz-Schughart LA.

Int J Radiat Biol. 2009 Nov;85(11):989-1001. doi: 10.3109/09553000903242156.

PMID:
19895276
39.

CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell lines HCT-116.

Dittfeld C, Dietrich A, Peickert S, Hering S, Baumann M, Grade M, Ried T, Kunz-Schughart LA.

Radiother Oncol. 2009 Sep;92(3):353-61. doi: 10.1016/j.radonc.2009.06.034. Epub 2009 Aug 21.

PMID:
19699546
40.

Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma.

Meyer S, Vogt T, Landthaler M, Berand A, Reichle A, Bataille F, Marx AH, Menz A, Hartmann A, Kunz-Schughart LA, Wild PJ.

PPAR Res. 2009;2009:848645. doi: 10.1155/2010/848645. Epub 2009 Jul 20.

41.

Spheroid-based drug screen: considerations and practical approach.

Friedrich J, Seidel C, Ebner R, Kunz-Schughart LA.

Nat Protoc. 2009;4(3):309-24. doi: 10.1038/nprot.2008.226. Epub 2009 Feb 12.

PMID:
19214182
42.

Temozolomide preferentially depletes cancer stem cells in glioblastoma.

Beier D, Röhrl S, Pillai DR, Schwarz S, Kunz-Schughart LA, Leukel P, Proescholdt M, Brawanski A, Bogdahn U, Trampe-Kieslich A, Giebel B, Wischhusen J, Reifenberger G, Hau P, Beier CP.

Cancer Res. 2008 Jul 15;68(14):5706-15. doi: 10.1158/0008-5472.CAN-07-6878.

43.

Fates of genetically engineered haematopoietic and mesenchymal stem cell grafts in normal and injured rat hearts.

Schierling W, Kunz-Schughart LA, Muders F, Riegger GA, Griese DP.

J Tissue Eng Regen Med. 2008 Aug;2(6):354-64. doi: 10.1002/term.104.

PMID:
18618869
44.

Basophils enhance immunological memory responses.

Denzel A, Maus UA, Rodriguez Gomez M, Moll C, Niedermeier M, Winter C, Maus R, Hollingshead S, Briles DE, Kunz-Schughart LA, Talke Y, Mack M.

Nat Immunol. 2008 Jul;9(7):733-42. doi: 10.1038/ni.1621. Epub 2008 May 30.

PMID:
18516038
45.

Hepatic progenitor cells from adult human livers for cell transplantation.

Weiss TS, Lichtenauer M, Kirchner S, Stock P, Aurich H, Christ B, Brockhoff G, Kunz-Schughart LA, Jauch KW, Schlitt HJ, Thasler WE.

Gut. 2008 Aug;57(8):1129-38. doi: 10.1136/gut.2007.143321. Epub 2008 Apr 16.

PMID:
18417531
46.

Expression of CD68 in non-myeloid cell types.

Gottfried E, Kunz-Schughart LA, Weber A, Rehli M, Peuker A, Müller A, Kastenberger M, Brockhoff G, Andreesen R, Kreutz M.

Scand J Immunol. 2008 May;67(5):453-63. doi: 10.1111/j.1365-3083.2008.02091.x.

47.

mTOR inhibitors and calcineurin inhibitors do not affect adhesion molecule expression of human macro- and microvascular endothelial cells.

Lehle K, Schreml S, Kunz-Schughart LA, Rupprecht L, Birnbaum DE, Schmid C, Preuner JG.

J Vasc Res. 2008;45(4):333-42. doi: 10.1159/000119199. Epub 2008 Mar 4.

PMID:
18319592
48.

Experimental anti-tumor therapy in 3-D: spheroids--old hat or new challenge?

Friedrich J, Ebner R, Kunz-Schughart LA.

Int J Radiat Biol. 2007 Nov-Dec;83(11-12):849-71. Review.

PMID:
18058370
49.
50.

A reliable tool to determine cell viability in complex 3-d culture: the acid phosphatase assay.

Friedrich J, Eder W, Castaneda J, Doss M, Huber E, Ebner R, Kunz-Schughart LA.

J Biomol Screen. 2007 Oct;12(7):925-37. Erratum in: J Biomol Screen. 2007 Dec;12(8):1115-9.

PMID:
17942785

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