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Efficacy, Retention, and Tolerability of Brivaracetam in Patients With Epileptic Encephalopathies: A Multicenter Cohort Study From Germany.

Willems LM, Bertsche A, Bösebeck F, Hornemann F, Immisch I, Klein KM, Knake S, Kunz R, Kurlemann G, Langenbruch L, Möddel G, Müller-Schlüter K, von Podewils F, Reif PS, Steinhoff BJ, Steinig I, Rosenow F, Schubert-Bast S, Strzelczyk A.

Front Neurol. 2018 Jul 23;9:569. doi: 10.3389/fneur.2018.00569. eCollection 2018.


Use of brivaracetam in genetic generalized epilepsies and for acute, intravenous treatment of absence status epilepticus.

Strzelczyk A, Kay L, Bauer S, Immisch I, Klein KM, Knake S, Kowski A, Kunz R, Kurlemann G, Langenbruch L, Möddel G, Müller-Schlüter K, Reif PS, Schubert-Bast S, Steinhoff BJ, Steinig I, Willems LM, von Podewils F, Rosenow F.

Epilepsia. 2018 Aug;59(8):1549-1556. doi: 10.1111/epi.14476. Epub 2018 Jun 25.


Rapid Quantitative Analysis of Multiple Explosive Compound Classes on a Single Instrument via Flow-Injection Analysis Tandem Mass Spectrometry.

Ostrinskaya A, Kunz RR, Clark M, Kingsborough RP, Ong TH, Deneault S.

J Forensic Sci. 2018 May 24. doi: 10.1111/1556-4029.13827. [Epub ahead of print]


Sericin and swimming on histomorphometric parameters of denervated plantar muscle in Wistar rats.

Santana AJ, Debastiani JC, Buratti P, Peretti AL, Kunz RI, Brancalhão RMC, Ribeiro LFC, Torrejais MM, Bertolini GRF.

Einstein (Sao Paulo). 2018;16(1):eAO4137. doi: 10.1590/s1679-45082018ao4137. Epub 2018 Apr 26. Portuguese, English.


Association of sericin and swimming on the phenotype, motor plate, and functionality of the denervated plantar muscle of Wistar rats.

Santana A Junior, Debastiani JC, Kunz RI, Buratti P, Brancalhão RMC, de Fátima Chasko Ribeiro L, Torrejais MM, Bertolini GRF.

J Exerc Rehabil. 2018 Feb 26;14(1):24-31. doi: 10.12965/jer.1835138.569. eCollection 2018 Feb.


Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation.

Vildhede A, Nguyen C, Erickson BK, Kunz RC, Jones R, Kimoto E, Bourbonais F, Rodrigues AD, Varma MVS.

Drug Metab Dispos. 2018 May;46(5):692-696. doi: 10.1124/dmd.117.079285. Epub 2018 Feb 8.


GRADE guidelines: 18. How ROBINS-I and other tools to assess risk of bias in nonrandomized studies should be used to rate the certainty of a body of evidence.

Schünemann HJ, Cuello C, Akl EA, Mustafa RA, Meerpohl JJ, Thayer K, Morgan RL, Gartlehner G, Kunz R, Katikireddi SV, Sterne J, Higgins JP, Guyatt G; GRADE Working Group.

J Clin Epidemiol. 2018 Feb 9. pii: S0895-4356(17)31031-4. doi: 10.1016/j.jclinepi.2018.01.012. [Epub ahead of print]


Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis.

Nath S, Koziarz A, Badhiwala JH, Alhazzani W, Jaeschke R, Sharma S, Banfield L, Shoamanesh A, Singh S, Nassiri F, Oczkowski W, Belley-Côté E, Truant R, Reddy K, Meade MO, Farrokhyar F, Bala MM, Alshamsi F, Krag M, Etxeandia-Ikobaltzeta I, Kunz R, Nishida O, Matouk C, Selim M, Rhodes A, Hawryluk G, Almenawer SA.

Lancet. 2018 Mar 24;391(10126):1197-1204. doi: 10.1016/S0140-6736(17)32451-0. Epub 2017 Dec 7.


Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg.

Presler M, Van Itallie E, Klein AM, Kunz R, Coughlin ML, Peshkin L, Gygi SP, Wühr M, Kirschner MW.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10838-E10847. doi: 10.1073/pnas.1709207114. Epub 2017 Nov 28.


S-Nitrosoglutathione Reductase Dysfunction Contributes to Obesity-Associated Hepatic Insulin Resistance via Regulating Autophagy.

Qian Q, Zhang Z, Orwig A, Chen S, Ding WX, Xu Y, Kunz RC, Lind NRL, Stamler JS, Yang L.

Diabetes. 2018 Feb;67(2):193-207. doi: 10.2337/db17-0223. Epub 2017 Oct 26.


Radiographic evaluation of cementation technique using polished, conical, triple-tapered femoral stem in hip arthroplasty.

Schuroff AA, Deeke M, Pedroni MA, Lupselo FS, Kunz RE, Lima AM.

Rev Bras Ortop. 2017 Sep 5;52(Suppl 1):40-45. doi: 10.1016/j.rboe.2017.08.019. eCollection 2017.


Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.

Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH.

Elife. 2017 Sep 8;6. pii: e26509. doi: 10.7554/eLife.26509.


Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury.

Peretti AL, Antunes JS, Lovison K, Kunz RI, Castor LRG, Brancalhão RMC, Bertolini GRF, Ribeiro LFC.

Einstein (Sao Paulo). 2017 Apr-Jun;15(2):186-191. doi: 10.1590/S1679-45082017AO3967. English, Portuguese.


Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients.

Yin S, Lopez-Gonzalez R, Kunz RC, Gangopadhyay J, Borufka C, Gygi SP, Gao FB, Reed R.

Cell Rep. 2017 Jun 13;19(11):2244-2256. doi: 10.1016/j.celrep.2017.05.056.


Use of Mass Spectrometric Vapor Analysis To Improve Canine Explosive Detection Efficiency.

Ong TH, Mendum T, Geurtsen G, Kelley J, Ostrinskaya A, Kunz R.

Anal Chem. 2017 Jun 20;89(12):6482-6490. doi: 10.1021/acs.analchem.7b00451. Epub 2017 Jun 9.


Postmarketing experience with brivaracetam in the treatment of epilepsies: A multicenter cohort study from Germany.

Steinig I, von Podewils F, Möddel G, Bauer S, Klein KM, Paule E, Reif PS, Willems LM, Zöllner JP, Kunz R, Runge U, Kurlemann G, Schubert-Bast S, Rosenow F, Strzelczyk A.

Epilepsia. 2017 Jul;58(7):1208-1216. doi: 10.1111/epi.13768. Epub 2017 May 8.


Return-to-work coordination programmes for improving return to work in workers on sick leave.

Vogel N, Schandelmaier S, Zumbrunn T, Ebrahim S, de Boer WE, Busse JW, Kunz R.

Cochrane Database Syst Rev. 2017 Mar 30;3:CD011618. doi: 10.1002/14651858.CD011618.pub2. Review.


Dalfampridine effects on cognition, fatigue, and dexterity.

Korsen M, Kunz R, Schminke U, Runge U, Kohlmann T, Dressel A.

Brain Behav. 2016 Nov 11;7(1):e00559. doi: 10.1002/brb3.559. eCollection 2017 Jan.


Inter-rater agreement in evaluation of disability: systematic review of reproducibility studies.

Barth J, de Boer WE, Busse JW, Hoving JL, Kedzia S, Couban R, Fischer K, von Allmen DY, Spanjer J, Kunz R.

BMJ. 2017 Jan 25;356:j14. doi: 10.1136/bmj.j14. Review.


Silkworm Sericin: Properties and Biomedical Applications.

Kunz RI, Brancalhão RM, Ribeiro LF, Natali MR.

Biomed Res Int. 2016;2016:8175701. Epub 2016 Nov 14. Review.


Characterization of nitrated sugar alcohols by atmospheric-pressure chemical-ionization mass spectrometry.

Ostrinskaya A, Kelley JA, Kunz RR.

Rapid Commun Mass Spectrom. 2017 Feb 28;31(4):333-343. doi: 10.1002/rcm.7803.


Biomimetic Sniffing Improves the Detection Performance of a 3D Printed Nose of a Dog and a Commercial Trace Vapor Detector.

Staymates ME, MacCrehan WA, Staymates JL, Kunz RR, Mendum T, Ong TH, Geurtsen G, Gillen GJ, Craven BA.

Sci Rep. 2016 Dec 1;6:36876. doi: 10.1038/srep36876.


Use of photoacoustic excitation and laser vibrometry to remotely detect trace explosives.

Wynn CM, Haupt RW, Doherty JH, Kunz RR, Bai W, Diebold G.

Appl Opt. 2016 Nov 10;55(32):9054-9059. doi: 10.1364/AO.55.009054.


Protonation of the Hydroperoxo Intermediate of Cytochrome P450 2B4 Is Slower in the Presence of Cytochrome P450 Reductase Than in the Presence of Cytochrome b5.

Pearl NM, Wilcoxen J, Im S, Kunz R, Darty J, Britt RD, Ragsdale SW, Waskell L.

Biochemistry. 2016 Nov 29;55(47):6558-6567. Epub 2016 Nov 8.


Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis.

Kugadas A, Christiansen SH, Sankaranarayanan S, Surana NK, Gauguet S, Kunz R, Fichorova R, Vorup-Jensen T, Gadjeva M.

PLoS Pathog. 2016 Sep 22;12(9):e1005855. doi: 10.1371/journal.ppat.1005855. eCollection 2016 Sep.


Are nursing home care workers' health and presenteeism associated with implicit rationing of care? A cross-sectional multi-site study.

Dhaini SR, Zúñiga F, Ausserhofer D, Simon M, Kunz R, De Geest S, Schwendimann R.

Geriatr Nurs. 2017 Jan - Feb;38(1):33-38. doi: 10.1016/j.gerinurse.2016.07.003. Epub 2016 Aug 1.


Use of a structured functional evaluation process for independent medical evaluations of claimants presenting with disabling mental illness: rationale and design for a multi-center reliability study.

Bachmann M, de Boer W, Schandelmaier S, Leibold A, Marelli R, Jeger J, Hoffmann-Richter U, Mager R, Schaad H, Zumbrunn T, Vogel N, Bänziger O, Busse JW, Fischer K, Kunz R.

BMC Psychiatry. 2016 Jul 29;16:271. doi: 10.1186/s12888-016-0967-6.


Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical Studies.

Hu E, Chen N, Kunz RK, Hwang DR, Michelsen K, Davis C, Ma J, Shi J, Lester-Zeiner D, Hungate R, Treanor J, Chen H, Allen JR.

ACS Med Chem Lett. 2016 May 19;7(7):719-23. doi: 10.1021/acsmedchemlett.6b00185. eCollection 2016 Jul 14.


Histopathological grading systems analysis of oral squamous cell carcinomas of young patients.

Frare JC, Sawazaki-Calone I, Ayroza-Rangel AL, Bueno AG, de Morais CF, Nagai HM, Kunz R, Lopes MA.

Med Oral Patol Oral Cir Bucal. 2016 May 1;21(3):e285-98.


Swimming does not alter nociception threshold in obese rats submitted to median nerve compression.

Coradini JG, Kunz RI, Kakihata CM, Errero TK, Bonfleur ML, Ribeiro Lde F, Brancalhão RM, Bertolini GR.

Neurol Res. 2015;37(12):1118-24. doi: 10.1080/01616412.2015.1114742.


Effects of physical exercise on the cartilage of ovariectomized rats submitted to immobilization.

Simas JM, Kunz RI, Brancalhão RM, Ribeiro Lde F, Bertolini GR.

Einstein (Sao Paulo). 2015 Oct-Dec;13(4):574-9. doi: 10.1590/S1679-45082015AO3418. English, Portuguese.


Expectation of sickness absence duration: a review on statements and methods used in guidelines in Europe and North America.

de Boer WE, Mousavi SM, Delclos GL, Benavides FG, Lorente M, Kunz R.

Eur J Public Health. 2016 Apr;26(2):306-11. doi: 10.1093/eurpub/ckv222. Epub 2015 Dec 24.


Reagent approaches for improved detection of chlorate and perchlorate salts via thermal desorption and ionization.

Kelley JA, Ostrinskaya A, Geurtsen G, Kunz RR.

Rapid Commun Mass Spectrom. 2016 Jan 15;30(1):191-8. doi: 10.1002/rcm.7427.


Unified analysis of ensemble and single-complex optical spectral data from light-harvesting complex-2 chromoproteins for gaining deeper insight into bacterial photosynthesis.

Pajusalu M, Kunz R, Rätsep M, Timpmann K, Köhler J, Freiberg A.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015;92(5):052709. doi: 10.1103/PhysRevE.92.052709. Epub 2015 Nov 9.


Absenteeism and Presenteeism among Care Workers in Swiss Nursing Homes and Their Association with Psychosocial Work Environment: A Multi-Site Cross-Sectional Study.

Dhaini S, Zúñiga F, Ausserhofer D, Simon M, Kunz R, De Geest S, Schwendimann R.

Gerontology. 2016;62(4):386-95. doi: 10.1159/000442088. Epub 2015 Dec 1.


Sickness certification in primary care: a survey on views and practices among Swiss physicians.

Kedzia S, Kunz R, Zeller A, Rosemann T, Frey P, Sommer J, Herzig L, Alexanderson K, de Boer WE.

Swiss Med Wkly. 2015 Nov 20;145:w14201. doi: 10.4414/smw.2015.14201. eCollection 2015.


Vapor Pressure of Hexamethylene Triperoxide Diamine (HMTD) Estimated Using Secondary Electrospray Ionization Mass Spectrometry.

Aernecke MJ, Mendum T, Geurtsen G, Ostrinskaya A, Kunz RR.

J Phys Chem A. 2015 Nov 25;119(47):11514-22. doi: 10.1021/acs.jpca.5b08929. Epub 2015 Nov 12.


Localized Modeling of Biochemical and Flow Interactions during Cancer Cell Adhesion.

Behr J, Gaskin B, Fu C, Dong C, Kunz R.

PLoS One. 2015 Sep 14;10(9):e0136926. doi: 10.1371/journal.pone.0136926. eCollection 2015.


Care workers health in Swiss nursing homes and its association with psychosocial work environment: A cross-sectional study.

Dhaini SR, Zúñiga F, Ausserhofer D, Simon M, Kunz R, De Geest S, Schwendimann R.

Int J Nurs Stud. 2016 Jan;53:105-15. doi: 10.1016/j.ijnurstu.2015.08.011. Epub 2015 Aug 31.


Attitudes towards evaluation of psychiatric disability claims: a survey of Swiss stakeholders.

Schandelmaier S, Leibold A, Fischer K, Mager R, Hoffmann-Richter U, Bachmann MS, Kedzia S, Busse JW, Guyatt GH, Jeger J, Marelli R, De Boer WE, Kunz R.

Swiss Med Wkly. 2015 Aug 21;145:w14160. doi: 10.4414/smw.2015.14160. eCollection 2015.


Body mass index as a prognostic factor for fracturing of the proximal extremity of the femur: a case-control study.

Pagani RC, Kunz RE, Girardi R, Guerra M.

Rev Bras Ortop. 2014 Sep 19;49(5):461-7. doi: 10.1016/j.rboe.2014.09.004. eCollection 2014 Sep-Oct.


A randomized controlled bicenter trial of yoga for patients with colorectal cancer.

Cramer H, Pokhrel B, Fester C, Meier B, Gass F, Lauche R, Eggleston B, Walz M, Michalsen A, Kunz R, Dobos G, Langhorst J.

Psychooncology. 2016 Apr;25(4):412-20. doi: 10.1002/pon.3927. Epub 2015 Jul 29.


METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

Yang L, Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamisligil GS.

Science. 2015 Jul 31;349(6247):500-6. doi: 10.1126/science.aaa0079.


Assessment of Intrathecal Pressure in Chondrodystrophic Dogs With Acute Thoracolumbar Disk Disease.

Kunz RE, Rohrbach H, Gorgas D, Gendron K, Henke D, Forterre F.

Vet Surg. 2015 Aug;44(6):687-93. doi: 10.1111/j.1532-950X.2014.12319.x.


Reporting of IMMPACT-recommended core outcome domains among trials assessing opioids for chronic non-cancer pain.

Mulla SM, Maqbool A, Sivananthan L, Lopes LC, Schandelmaier S, Kamaleldin M, Hsu S, Riva JJ, Vandvik PO, Tsoi L, Lam T, Ebrahim S, Johnston BC, Olivieri L, Montoya L, Kunz R, Scheidecker A, Buckley DN, Sessler DI, Guyatt GH, Busse JW.

Pain. 2015 Sep;156(9):1615-9. doi: 10.1097/j.pain.0000000000000241.


A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.

Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GS.

Cell Rep. 2015 Apr 14;11(2):295-307. doi: 10.1016/j.celrep.2015.03.021. Epub 2015 Apr 2.


The prognostic value of histopathological grading systems in oral squamous cell carcinomas.

Sawazaki-Calone I, Rangel A, Bueno AG, Morais CF, Nagai HM, Kunz RP, Souza RL, Rutkauskis L, Salo T, Almangush A, Coletta RD.

Oral Dis. 2015 Sep;21(6):755-61. doi: 10.1111/odi.12343. Epub 2015 Apr 24.


Assessment of Intrathecal Pressure in Chondrodystrophic Dogs With Acute Thoracolumbar Disk Disease.

Kunz RE, Rohrbach H, Gorgas D, Gendron K, Henke D, Forterre F.

Vet Surg. 2015 Feb 4. doi: 10.1111/vsu.12319. [Epub ahead of print]


Trace aerosol detection and identification by dynamic photoacoustic spectroscopy.

Sullenberger RM, Clark ML, Kunz RR, Samuels AC, Emge DK, Ellzy MW, Wynn CM.

Opt Express. 2014 Dec 15;22 Suppl 7:A1810-7. doi: 10.1364/OE.22.0A1810.


Evaluating multiplexed quantitative phosphopeptide analysis on a hybrid quadrupole mass filter/linear ion trap/orbitrap mass spectrometer.

Erickson BK, Jedrychowski MP, McAlister GC, Everley RA, Kunz R, Gygi SP.

Anal Chem. 2015 Jan 20;87(2):1241-9. doi: 10.1021/ac503934f. Epub 2015 Jan 6.

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