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Highly oxygenated isoprenylated cyclohexanoids from the fungus Parastagonospora nodorum SN15.

El-Demerdash A, Genta-Jouve G, Bärenstrauch M, Kunz C, Baudouin E, Prado S.

Phytochemistry. 2019 Jul 11;166:112056. doi: 10.1016/j.phytochem.2019.112056. [Epub ahead of print]


Prospective target assessment and multimodal prediction of survival for personalized and risk-adapted treatment strategies in multiple myeloma in the GMMG-MM5 multicenter trial.

Hose D, Beck S, Salwender H, Emde M, Bertsch U, Kunz C, Scheid C, Hänel M, Weisel K, Hielscher T, Raab MS, Goldschmidt H, Jauch A, Moreaux J, Seckinger A.

J Hematol Oncol. 2019 Jun 26;12(1):65. doi: 10.1186/s13045-019-0750-5.


Rationale and design of the German-speaking myeloma multicenter group (GMMG) trial HD6: a randomized phase III trial on the effect of elotuzumab in VRD induction/consolidation and lenalidomide maintenance in patients with newly diagnosed myeloma.

Salwender H, Bertsch U, Weisel K, Duerig J, Kunz C, Benner A, Blau IW, Raab MS, Hillengass J, Hose D, Huhn S, Hundemer M, Andrulis M, Jauch A, Seidel-Glaetzer A, Lindemann HW, Hensel M, Fronhoffs S, Martens U, Hansen T, Wattad M, Graeven U, Munder M, Fenk R, Haenel M, Scheid C, Goldschmidt H.

BMC Cancer. 2019 May 28;19(1):504. doi: 10.1186/s12885-019-5600-x.


Metabolic Fate and Distribution of 2´-Fucosyllactose: Direct Influence on Gut Microbial Activity but not on Brain.

Kuntz S, Kunz C, Borsch C, Vazquez E, Buck R, Reutzel M, Eckert GP, Rudloff S.

Mol Nutr Food Res. 2019 May 24:e1900035. doi: 10.1002/mnfr.201900035. [Epub ahead of print]


Nonstandard Treatment of Endophthalmitis after Osteo-Odonto Keratoprothesis.

Eggenschwiler L, Hasler PW, Gatzioufas Z, Waldmann N, Berg I, Kunz C, Brockhaus L, Goldblum D.

Klin Monbl Augenheilkd. 2019 Apr;236(4):382-383. doi: 10.1055/a-0839-3725. Epub 2019 Apr 18. No abstract available.


Milk Oligosaccharides From Different Cattle Breeds Influence Growth-Related Characteristics of Intestinal Cells.

Kuntz S, Rudloff S, Kunz C.

Front Nutr. 2019 Mar 28;6:31. doi: 10.3389/fnut.2019.00031. eCollection 2019.


Addition of cyclophosphamide on insufficient response to pomalidomide and dexamethasone: results of the phase II PERSPECTIVE Multiple Myeloma trial.

Weisel KC, Scheid C, Zago M, Besemer B, Mai EK, Haenel M, Duerig J, Munder M, Lindemann HW, Seckinger A, Kunz C, Benner A, Hose D, Jauch A, Salwender H, Goldschmidt H.

Blood Cancer J. 2019 Apr 8;9(4):45. doi: 10.1038/s41408-019-0206-8. No abstract available.


Translational PBPK Modeling of the Protein Therapeutic and CD95L Inhibitor Asunercept to Develop Dose Recommendations for Its First Use in Pediatric Glioblastoma Patients.

Hanke N, Kunz C, Thiemann M, Fricke H, Lehr T.

Pharmaceutics. 2019 Apr 1;11(4). pii: E152. doi: 10.3390/pharmaceutics11040152.


Metabolism of Milk Oligosaccharides in Preterm Pigs Sensitive to Necrotizing Enterocolitis.

Rudloff S, Kuntz S, Ostenfeldt Rasmussen S, Roggenbuck M, Sprenger N, Kunz C, Sangild PT, Brandt Bering S.

Front Nutr. 2019 Mar 12;6:23. doi: 10.3389/fnut.2019.00023. eCollection 2019.


Transfer of total phenols from a grapeseed-supplemented diet to dairy sheep and goat milk, and effects on performance and milk quality1.

Leparmarai PT, Sinz S, Kunz C, Liesegang A, Ortmann S, Kreuzer M, Marquardt S.

J Anim Sci. 2019 Feb 6. pii: skz046. doi: 10.1093/jas/skz046. [Epub ahead of print]


Transfer of total phenols from a grapeseed-supplemented diet to dairy sheep and goat milk, and effects on performance and milk quality.

Leparmarai PT, Sinz S, Kunz C, Liesegang A, Ortmann S, Kreuzer M, Marquardt S.

J Anim Sci. 2019 Feb 6. pii: skz046. doi: 10.1093/jas/skz046. [Epub ahead of print]


Interim analysis incorporating short- and long-term binary endpoints.

Niewczas J, Kunz CU, König F.

Biom J. 2019 May;61(3):665-687. doi: 10.1002/bimj.201700281. Epub 2019 Jan 29.


Polysialic acid interacts with lactoferrin and supports its activity to inhibit the release of neutrophil extracellular traps.

Kühnle A, Veelken R, Galuska CE, Saftenberger M, Verleih M, Schuppe HC, Rudloff S, Kunz C, Galuska SP.

Carbohydr Polym. 2019 Mar 15;208:32-41. doi: 10.1016/j.carbpol.2018.12.033. Epub 2018 Dec 12.


Comparison of an Er: YAG laser osteotome versus a conventional drill for the use in osteo- odonto-keratoprosthesis (OOKP).

Berg BI, Peyer M, Kuske L, Augello M, Schötzau A, Steineck M, Deibel W, Mathys D, Jürgens P, Kunz C, Goldblum D.

Lasers Surg Med. 2019 Aug;51(6):531-537. doi: 10.1002/lsm.23053. Epub 2019 Jan 15.


Association of Maternal Secretor Status and Human Milk Oligosaccharides With Milk Microbiota: An Observational Pilot Study.

Cabrera-Rubio R, Kunz C, Rudloff S, García-Mantrana I, Crehuá-Gaudiza E, Martínez-Costa C, Collado MC.

J Pediatr Gastroenterol Nutr. 2019 Feb;68(2):256-263. doi: 10.1097/MPG.0000000000002216.


Confidence regions for treatment effects in subgroups in biomarker stratified designs.

Wan F, Kunz CU, Jaki TF.

Biom J. 2019 Jan;61(1):27-39. doi: 10.1002/bimj.201700303. Epub 2018 Nov 25.


An alternative method to analyse the biomarker-strategy design.

Kunz CU, Jaki T, Stallard N.

Stat Med. 2018 Dec 30;37(30):4636-4651. doi: 10.1002/sim.7940. Epub 2018 Sep 9.


Fucosylated oligosaccharides in mother's milk alleviate the effects of caesarean birth on infant gut microbiota.

Korpela K, Salonen A, Hickman B, Kunz C, Sprenger N, Kukkonen K, Savilahti E, Kuitunen M, de Vos WM.

Sci Rep. 2018 Sep 13;8(1):13757. doi: 10.1038/s41598-018-32037-6.


Femtosecond Laser-Induced Periodic Surface Structures on Fused Silica: The Impact of the Initial Substrate Temperature.

Gräf S, Kunz C, Engel S, Derrien TJ, Müller FA.

Materials (Basel). 2018 Aug 2;11(8). pii: E1340. doi: 10.3390/ma11081340.


Freeze-Drying From Organic Co-Solvent Systems, Part 2: Process Modifications to Reduce Residual Solvent Levels and Improve Product Quality Attributes.

Kunz C, Schuldt-Lieb S, Gieseler H.

J Pharm Sci. 2019 Jan;108(1):399-415. doi: 10.1016/j.xphs.2018.07.002. Epub 2018 Jul 12.


Effects of Live and Heat-Inactivated E. coli Strains and Their Supernatants on Immune Regulation in HT-29 Cells.

Zimmermann C, Schild M, Kunz C, Zimmermann K, Kuntz S.

Eur J Microbiol Immunol (Bp). 2018 May 5;8(2):41-46. doi: 10.1556/1886.2018.00004. eCollection 2018 Jun 25.


Avidity of α-fucose on human milk oligosaccharides and blood group-unrelated oligo/polyfucoses is essential for potent norovirus-binding targets.

Hanisch FG, Hansman GS, Morozov V, Kunz C, Schroten H.

J Biol Chem. 2018 Jul 27;293(30):11955-11965. doi: 10.1074/jbc.RA117.001369. Epub 2018 Jun 1.


No improvement in vitamin D status in German infants and adolescents between 2009 and 2014 despite public recommendations to increase vitamin D intake in 2012.

Kunz C, Hower J, Knoll A, Ritzenthaler KL, Lamberti T.

Eur J Nutr. 2019 Jun;58(4):1711-1722. doi: 10.1007/s00394-018-1717-y. Epub 2018 May 18.


Multifunctional Hierarchical Surface Structures by Femtosecond Laser Processing.

Kunz C, Müller FA, Gräf S.

Materials (Basel). 2018 May 12;11(5). pii: E789. doi: 10.3390/ma11050789.


Merits and Limitations of Dynamic Vapor Sorption Studies on the Morphology and Physicochemical State of Freeze-Dried Products.

Kunz C, Gieseler H.

J Pharm Sci. 2018 Aug;107(8):2179-2191. doi: 10.1016/j.xphs.2018.04.016. Epub 2018 Apr 24.


Factors Influencing the Retention of Organic Solvents in Products Freeze-Dried From Co-Solvent Systems.

Kunz C, Gieseler H.

J Pharm Sci. 2018 Aug;107(8):2005-2012. doi: 10.1016/j.xphs.2018.04.001. Epub 2018 Apr 9. Review.


Safety and efficacy of the CD95-ligand inhibitor asunercept in transfusion-dependent patients with low and intermediate risk MDS.

Boch T, Luft T, Metzgeroth G, Mossner M, Jann JC, Nowak D, Meir F, Schumann C, Klemmer J, Brendel S, Fricke H, Kunz C, Weiß C, Hofmann WK, Nolte F.

Leuk Res. 2018 May;68:62-69. doi: 10.1016/j.leukres.2018.03.007. Epub 2018 Mar 10.


A systematic classification of death causes in multiple myeloma.

Mai EK, Haas EM, Lücke S, Löpprich M, Kunz C, Pritsch M, Knaup-Gregori P, Raab MS, Schlenzka J, Bertsch U, Hillengass J, Goldschmidt H.

Blood Cancer J. 2018 Mar 8;8(3):30. doi: 10.1038/s41408-018-0068-5. No abstract available.


Inhibition of CD95/CD95L (FAS/FASLG) Signaling with APG101 Prevents Invasion and Enhances Radiation Therapy for Glioblastoma.

Blaes J, Thomé CM, Pfenning PN, Rübmann P, Sahm F, Wick A, Bunse T, Schmenger T, Sykora J, von Deimling A, Wiestler B, Merz C, Jugold M, Haberkorn U, Abdollahi A, Debus J, Gieffers C, Kunz C, Bendszus M, Kluge M, Platten M, Fricke H, Wick W, Lemke D.

Mol Cancer Res. 2018 May;16(5):767-776. doi: 10.1158/1541-7786.MCR-17-0563. Epub 2018 Feb 16.


Human Milk Oligosaccharides as Promising Antivirals.

Morozov V, Hansman G, Hanisch FG, Schroten H, Kunz C.

Mol Nutr Food Res. 2018 Mar;62(6):e1700679. doi: 10.1002/mnfr.201700679. Epub 2018 Mar 1. Review.


Facial asymmetry correction with moulded helmet therapy in infants with deformational skull base plagiocephaly.

Kreutz M, Fitze B, Blecher C, Marcello A, Simon R, Cremer R, Zeilhofer HF, Kunz C, Mayr J.

J Craniomaxillofac Surg. 2018 Jan;46(1):28-34. doi: 10.1016/j.jcms.2017.10.013. Epub 2017 Oct 16.


Freeze-Drying From Organic Cosolvent Systems, Part 1: Thermal Analysis of Cosolvent-Based Placebo Formulations in the Frozen State.

Kunz C, Schuldt-Lieb S, Gieseler H.

J Pharm Sci. 2018 Mar;107(3):887-896. doi: 10.1016/j.xphs.2017.11.003. Epub 2017 Nov 10.


Formation and Properties of Laser-Induced Periodic Surface Structures on Different Glasses.

Gräf S, Kunz C, Müller FA.

Materials (Basel). 2017 Aug 10;10(8). pii: E933. doi: 10.3390/ma10080933.


Compositional Analysis and Metabolism of Human Milk Oligosaccharides in Infants.

Kunz C, Rudloff S.

Nestle Nutr Inst Workshop Ser. 2017;88:137-147. doi: 10.1159/000455398. Epub 2017 Mar 27. Review.


Osteo-Odonto-Keratoprosthesis in Severe Ocular Graft versus Host Disease.

Plattner K, Goldblum D, Halter J, Kunz C, Koeppl R, Gerber-Hollbach N.

Klin Monbl Augenheilkd. 2017 Apr;234(4):455-456. doi: 10.1055/s-0042-123148. Epub 2017 Mar 22. No abstract available.


Heterogeneous treatment effects in stratified clinical trials with time-to-event endpoints.

Beisel C, Benner A, Kunz C, Kopp-Schneider A.

Biom J. 2017 May;59(3):511-530. doi: 10.1002/bimj.201600047. Epub 2017 Mar 6.


In Vitro, Ex Vivo, and In Vivo Activities of Diamidines against Trypanosoma congolense and Trypanosoma vivax.

Gillingwater K, Kunz C, Braghiroli C, Boykin DW, Tidwell RR, Brun R.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02356-16. doi: 10.1128/AAC.02356-16. Print 2017 May.


Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia.

Bochtler T, Granzow M, Stölzel F, Kunz C, Mohr B, Kartal-Kaess M, Hinderhofer K, Heilig CE, Kramer M, Thiede C, Endris V, Kirchner M, Stenzinger A, Benner A, Bornhäuser M, Ehninger G, Ho AD, Jauch A, Krämer A; Study Alliance Leukemia Investigators.

Blood. 2017 Mar 9;129(10):1333-1342. doi: 10.1182/blood-2016-09-738161. Epub 2017 Jan 24.


Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations.

Kunz CU, Stallard N, Parsons N, Todd S, Friede T.

Biom J. 2017 Mar;59(2):344-357. doi: 10.1002/bimj.201500233. Epub 2016 Nov 25.


Neutral oligosaccharides in feces of breastfed and formula-fed infants at different ages.

Dotz V, Adam R, Lochnit G, Schroten H, Kunz C.

Glycobiology. 2016 Dec;26(12):1308-1316. Epub 2016 Sep 9.


Influence of Gestational Age, Secretor, and Lewis Blood Group Status on the Oligosaccharide Content of Human Milk.

Kunz C, Meyer C, Collado MC, Geiger L, García-Mantrana I, Bertua-Ríos B, Martínez-Costa C, Borsch C, Rudloff S.

J Pediatr Gastroenterol Nutr. 2017 May;64(5):789-798. doi: 10.1097/MPG.0000000000001402.


First Total Synthesis, Structure Revision, and Natural History of the Smallest Cytochalasin: (+)-Periconiasin G.

Zaghouani M, Kunz C, Guédon L, Blanchard F, Nay B.

Chemistry. 2016 Oct 17;22(43):15257-15260. doi: 10.1002/chem.201603734. Epub 2016 Sep 9.


Peripheral neuropathy associated with subcutaneous or intravenous bortezomib in patients with newly diagnosed myeloma treated within the GMMG MM5 phase III trial.

Merz M, Salwender H, Haenel M, Mai EK, Bertsch U, Kunz C, Hielscher T, Blau IW, Scheid C, Hose D, Seckinger A, Jauch A, Hillengass J, Raab MS, Schurich B, Munder M, Brossart P, Gerecke C, Lindemann HW, Zeis M, Weisel K, Duerig J, Goldschmidt H.

Haematologica. 2016 Dec;101(12):e485-e487. Epub 2016 Aug 18. No abstract available.


Myeloid cells do not contribute to gender-dependent differences in disease outcome in murine cutaneous leishmaniasis.

Fischer MR, Kunz C, Dietze-Schwonberg K, Lorenz B, von Stebut E.

Cell Immunol. 2016 Oct;308:13-18. doi: 10.1016/j.cellimm.2016.07.009. Epub 2016 Jul 15.


Inhibition of Low-Grade Inflammation by Anthocyanins after Microbial Fermentation in Vitro.

Kuntz S, Kunz C, Domann E, Würdemann N, Unger F, Römpp A, Rudloff S.

Nutrients. 2016 Jul 2;8(7). pii: E411. doi: 10.3390/nu8070411.


Bio-Inspired Functional Surfaces Based on Laser-Induced Periodic Surface Structures.

Müller FA, Kunz C, Gräf S.

Materials (Basel). 2016 Jun 15;9(6). pii: E476. doi: 10.3390/ma9060476. Review.


Prognostic impact of cytogenetic aberrations in AL amyloidosis patients after high-dose melphalan: a long-term follow-up study.

Bochtler T, Hegenbart U, Kunz C, Benner A, Kimmich C, Seckinger A, Hose D, Goldschmidt H, Granzow M, Dreger P, Ho AD, Jauch A, Schönland SO.

Blood. 2016 Jul 28;128(4):594-602. doi: 10.1182/blood-2015-10-676361. Epub 2016 Jun 2.


Model-based evaluation of pulmonary pharmacokinetics in asthmatic and COPD patients after oral olodaterol inhalation.

Borghardt JM, Weber B, Staab A, Kunz C, Kloft C.

Br J Clin Pharmacol. 2016 Sep;82(3):739-53. doi: 10.1111/bcp.12999. Epub 2016 Jun 23.


Rationale and design of the German-Speaking Myeloma Multicenter Group (GMMG) trial ReLApsE: a randomized, open, multicenter phase III trial of lenalidomide/dexamethasone versus lenalidomide/dexamethasone plus subsequent autologous stem cell transplantation and lenalidomide maintenance in patients with relapsed multiple myeloma.

Baertsch MA, Schlenzka J, Mai EK, Merz M, Hillengaß J, Raab MS, Hose D, Wuchter P, Ho AD, Jauch A, Hielscher T, Kunz C, Luntz S, Klein S, Schmidt-Wolf IG, Goerner M, Schmidt-Hieber M, Reimer P, Graeven U, Fenk R, Salwender H, Scheid C, Nogai A, Haenel M, Lindemann HW, Martin H, Noppeney R, Weisel K, Goldschmidt H.

BMC Cancer. 2016 Apr 25;16:290. doi: 10.1186/s12885-016-2321-2.


Effects of the neurokinin-1 antagonist maropitant on canine gastric emptying assessed by radioscintigraphy and breath test.

Schmitz S, Fink T, Failing K, Borsch C, Kunz C, Clemence R, Savary-Bataille K, Neiger R.

Tierarztl Prax Ausg K Kleintiere Heimtiere. 2016 Jun 16;44(3):163-9. doi: 10.15654/TPK-150039. Epub 2016 Apr 19.


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