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Items: 16

1.

Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays.

Danthi SJ, Liang B, Smicker O, Coupland B, Gregory J, Gefteas E, Tietz D, Klodnitsky H, Randall K, Belanger A, Kuntzweiler TA.

SLAS Discov. 2019 Feb;24(2):111-120. doi: 10.1177/2472555218794627. Epub 2018 Dec 27.

PMID:
30589598
2.

Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice.

Holladay MW, Bai H, Li Y, Lin NH, Daanen JF, Ryther KB, Wasicak JT, Kincaid JF, He Y, Hettinger AM, Huang P, Anderson DJ, Bannon AW, Buckley MJ, Campbell JE, Donnelly-Roberts DL, Gunther KL, Kim DJ, Kuntzweiler TA, Sullivan JP, Decker MW, Arneric SP.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2797-802.

PMID:
9873625
3.

The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594.

Decker MW, Curzon P, Holladay MW, Nikkel AL, Bitner RS, Bannon AW, Donnelly-Roberts DL, Puttfarcken PS, Kuntzweiler TA, Briggs CA, Williams M, Arneric SP.

J Physiol Paris. 1998 Jun-Aug;92(3-4):221-4. Review.

PMID:
9789812
4.

ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.

Donnelly-Roberts DL, Puttfarcken PS, Kuntzweiler TA, Briggs CA, Anderson DJ, Campbell JE, Piattoni-Kaplan M, McKenna DG, Wasicak JT, Holladay MW, Williams M, Arneric SP.

J Pharmacol Exp Ther. 1998 May;285(2):777-86.

PMID:
9580626
5.

Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling.

Barlocco D, Cignarella G, Tondi D, Vianello P, Villa S, Bartolini A, Ghelardini C, Galeotti N, Anderson DJ, Kuntzweiler TA, Colombo D, Toma L.

J Med Chem. 1998 Feb 26;41(5):674-81.

PMID:
9513595
6.

Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.

Holladay MW, Wasicak JT, Lin NH, He Y, Ryther KB, Bannon AW, Buckley MJ, Kim DJ, Decker MW, Anderson DJ, Campbell JE, Kuntzweiler TA, Donnelly-Roberts DL, Piattoni-Kaplan M, Briggs CA, Williams M, Arneric SP.

J Med Chem. 1998 Feb 12;41(4):407-12.

PMID:
9484491
7.

Cation and cardiac glycoside binding sites of the Na,K-ATPase.

Lingrel JB, Argüello JM, Van Huysse J, Kuntzweiler TA.

Ann N Y Acad Sci. 1997 Nov 3;834:194-206. Review.

PMID:
9405808
8.

Asp804 and Asp808 in the transmembrane domain of the Na,K-ATPase alpha subunit are cation coordinating residues.

Kuntzweiler TA, Argüello JM, Lingrel JB.

J Biol Chem. 1996 Nov 22;271(47):29682-7.

9.

Amino acid substitutions in the rat Na+, K(+)-ATPase alpha 2-subunit alter the cation regulation of pump current expressed in HeLa cells.

Yamamoto S, Kuntzweiler TA, Wallick ET, Sperelakis N, Yatani A.

J Physiol. 1996 Sep 15;495 ( Pt 3):733-42.

10.
11.

Ouabain interactions with the H5-H6 hairpin of the Na,K-ATPase reveal a possible inhibition mechanism via the cation binding domain.

Palasis M, Kuntzweiler TA, Argüello JM, Lingrel JB.

J Biol Chem. 1996 Jun 14;271(24):14176-82.

13.

Glutamic acid 327 in the sheep alpha 1 isoform of Na+,K(+)-ATPase is a pivotal residue for cation-induced conformational changes.

Johnson CL, Kuntzweiler TA, Lingrel JB, Johnson CG, Wallick ET.

Biochem J. 1995 Jul 1;309 ( Pt 1):187-94.

14.

Glutamic acid 327 in the sheep alpha 1 isoform of Na+,K(+)-ATPase stabilizes a K(+)-induced conformational change.

Kuntzweiler TA, Wallick ET, Johnson CL, Lingrel JB.

J Biol Chem. 1995 Feb 17;270(7):2993-3000.

15.
16.

Structural features of intermediate states of sheep kidney Na,K-ATPase.

Stewart JM, Kuntzweiler TA, Klevickis C, Grisham CM.

Soc Gen Physiol Ser. 1991;46:143-58. No abstract available.

PMID:
1653975

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