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Items: 44

1.

AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.

Crim WS, Wu R, Carter JD, Cole BK, Trace AP, Mirmira RG, Kunsch C, Nadler JL, Nunemaker CS.

Mol Cell Endocrinol. 2010 Jul 29;323(2):246-55. doi: 10.1016/j.mce.2010.02.041. Epub 2010 Mar 6.

2.

Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells.

Chen XL, Dodd G, Kunsch C.

Inflamm Res. 2009 Aug;58(8):513-21. doi: 10.1007/s00011-009-0017-7. Epub 2009 Mar 11.

PMID:
19277846
3.

Selective thromboxane inhibition after vascular protectant AGI-1067: results of assessment of lipoprotein profiles (ALPS) biomarkers in vitro and in vivo substudy.

Serebruany V, Malinin A, Qiu FH, Xu XC, Kunsch C, Scott R; ALPS Study Group.

J Thromb Thrombolysis. 2009 May;27(4):438-46. doi: 10.1007/s11239-008-0233-y. Epub 2008 Jun 3.

PMID:
18521540
4.

A novel class of antioxidants inhibit LPS induction of tissue factor by selective inhibition of the activation of ASK1 and MAP kinases.

Luyendyk JP, Piper JD, Tencati M, Reddy KV, Holscher T, Zhang R, Luchoomun J, Chen X, Min W, Kunsch C, Mackman N.

Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1857-63. Epub 2007 Jun 7.

PMID:
17561491
5.

Carboxylated, heteroaryl-substituted chalcones as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

Meng CQ, Ni L, Worsencroft KJ, Ye Z, Weingarten MD, Simpson JE, Skudlarek JW, Marino EM, Suen KL, Kunsch C, Souder A, Howard RB, Sundell CL, Wasserman MA, Sikorski JA.

J Med Chem. 2007 Mar 22;50(6):1304-15. Epub 2007 Feb 27.

PMID:
17323940
6.

Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression.

Chen XL, Dodd G, Thomas S, Zhang X, Wasserman MA, Rovin BH, Kunsch C.

Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1862-70. Epub 2005 Dec 9.

7.

AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression.

Kunsch C, Luchoomun J, Chen XL, Dodd GL, Karu KS, Meng CQ, Marino EM, Olliff LK, Piper JD, Qiu FH, Sikorski JA, Somers PK, Suen KL, Thomas S, Whalen AM, Wasserman MA, Sundell CL.

J Pharmacol Exp Ther. 2005 May;313(2):492-501. Epub 2005 Feb 8.

PMID:
15701708
8.

Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

Meng CQ, Somers PK, Hoong LK, Zheng XS, Ye Z, Worsencroft KJ, Simpson JE, Hotema MR, Weingarten MD, MacDOnald ML, Hill RR, Marino EM, Suen KL, Luchoomun J, Kunsch C, Landers LK, Stefanopoulos D, Howard RB, Sundell CL, Saxena U, Wasserman MA, Sikorski JA.

J Med Chem. 2004 Dec 2;47(25):6420-32.

PMID:
15566311
9.

Sphingosine kinase-1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow.

Chen XL, Grey JY, Thomas S, Qiu FH, Medford RM, Wasserman MA, Kunsch C.

Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1452-8. Epub 2004 Jun 10.

11.

Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-alpha-induced VCAM-1 expression.

Meng CQ, Zheng XS, Ni L, Ye Z, Simpson JE, Worsencroft KJ, Hotema MR, Weingarten MD, Skudlarek JW, Gilmore JM, Hoong LK, Hill RR, Marino EM, Suen KL, Kunsch C, Wasserman MA, Sikorski JA.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1513-7.

PMID:
15006393
12.

Selective inhibition of endothelial and monocyte redox-sensitive genes by AGI-1067: a novel antioxidant and anti-inflammatory agent.

Kunsch C, Luchoomun J, Grey JY, Olliff LK, Saint LB, Arrendale RF, Wasserman MA, Saxena U, Medford RM.

J Pharmacol Exp Ther. 2004 Mar;308(3):820-9. Epub 2003 Nov 14.

PMID:
14617690
13.

Chemistry and pharmacology of vascular protectants: a novel approach to the treatment of atherosclerosis and coronary artery disease.

Wasserman MA, Sundell CL, Kunsch C, Edwards D, Meng CQ, Medford RM.

Am J Cardiol. 2003 Feb 6;91(3A):34A-40A. Review.

PMID:
12645642
14.

Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism.

Chen XL, Varner SE, Rao AS, Grey JY, Thomas S, Cook CK, Wasserman MA, Medford RM, Jaiswal AK, Kunsch C.

J Biol Chem. 2003 Jan 10;278(2):703-11. Epub 2002 Oct 4.

15.

Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis.

Meng CQ, Somers PK, Rachita CL, Holt LA, Hoong LK, Zheng XS, Simpson JE, Hill RR, Olliff LK, Kunsch C, Sundell CL, Parthasarathy S, Saxena U, Sikorski JA, Wasserman MA.

Bioorg Med Chem Lett. 2002 Sep 16;12(18):2545-8.

PMID:
12182856
16.

Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection.

Wizemann TM, Heinrichs JH, Adamou JE, Erwin AL, Kunsch C, Choi GH, Barash SC, Rosen CA, Masure HR, Tuomanen E, Gayle A, Brewah YA, Walsh W, Barren P, Lathigra R, Hanson M, Langermann S, Johnson S, Koenig S.

Infect Immun. 2001 Mar;69(3):1593-8.

17.

Human G protein gamma(11) and gamma(14) subtypes define a new functional subclass.

Balcueva EA, Wang Q, Hughes H, Kunsch C, Yu Z, Robishaw JD.

Exp Cell Res. 2000 Jun 15;257(2):310-9.

PMID:
10837145
18.

PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression.

Oettgen P, Finger E, Sun Z, Akbarali Y, Thamrongsak U, Boltax J, Grall F, Dube A, Weiss A, Brown L, Quinn G, Kas K, Endress G, Kunsch C, Libermann TA.

J Biol Chem. 2000 Jan 14;275(2):1216-25.

19.

Oxidative stress as a regulator of gene expression in the vasculature.

Kunsch C, Medford RM.

Circ Res. 1999 Oct 15;85(8):753-66. Review.

PMID:
10521248
20.

Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes.

Oettgen P, Kas K, Dube A, Gu X, Grall F, Thamrongsak U, Akbarali Y, Finger E, Boltax J, Endress G, Munger K, Kunsch C, Libermann TA.

J Biol Chem. 1999 Oct 8;274(41):29439-52.

21.

Identification and characterization of SirA, an iron-regulated protein from Staphylococcus aureus.

Heinrichs JH, Gatlin LE, Kunsch C, Choi GH, Hanson MS.

J Bacteriol. 1999 Mar;181(5):1436-43.

22.

The novel epithelial-specific Ets transcription factor gene ESX maps to human chromosome 1q32.1.

Oettgen P, Carter KC, Augustus M, Barcinski M, Boltax J, Kunsch C, Libermann TA.

Genomics. 1997 Oct 15;45(2):456-7. No abstract available.

PMID:
9463090
23.

The Novel Epithelial-Specific Ets Transcription Factor Gene ESX Maps to Human Chromosome 1q32.1

Oettgen P, Carter KC, Augustus M, Barcinski M, Boltax J, Kunsch C, Libermann TA.

Genomics. 1997 Oct 15;445(2):456-7. No abstract available.

PMID:
9344678
24.

Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family.

Oettgen P, Alani RM, Barcinski MA, Brown L, Akbarali Y, Boltax J, Kunsch C, Munger K, Libermann TA.

Mol Cell Biol. 1997 Aug;17(8):4419-33.

25.

Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1.

Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA.

Mol Cell Biol. 1996 Sep;16(9):5091-106.

27.

Local control of granule cell generation by cerebellar Purkinje cells.

Smeyne RJ, Chu T, Lewin A, Bian F, Sanlioglu S, Kunsch C, Lira SA, Oberdick J.

Mol Cell Neurosci. 1995 Jun;6(3):230-51. Erratum in: Mol Cell Neurosci. 2006 May-Jun;32(1-2):215. S-Crisman, S [corrected to Sanlioglu, S].

PMID:
7496629
28.

Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6.

Kunsch C, Lang RK, Rosen CA, Shannon MF.

J Immunol. 1994 Jul 1;153(1):153-64.

PMID:
8207232
29.
30.

NF-kappa B subunit-specific regulation of the interleukin-8 promoter.

Kunsch C, Rosen CA.

Mol Cell Biol. 1993 Oct;13(10):6137-46.

31.

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM.

J Clin Invest. 1993 Oct;92(4):1866-74.

32.

Acquisition of NFKB1-selective DNA binding by substitution of four amino acid residues from NFKB1 into RelA.

Coleman TA, Kunsch C, Maher M, Ruben SM, Rosen CA.

Mol Cell Biol. 1993 Jul;13(7):3850-9.

33.

A sense phosphorothioate oligonucleotide directed to the initiation codon of transcription factor NF-kappa B p65 causes sequence-specific immune stimulation.

McIntyre KW, Lombard-Gillooly K, Perez JR, Kunsch C, Sarmiento UM, Larigan JD, Landreth KT, Narayanan R.

Antisense Res Dev. 1993 Winter;3(4):309-22.

PMID:
8155973
36.

Human immunodeficiency virus infection and neurologic dysfunction.

Wigdahl B, Kunsch C.

Prog Med Virol. 1990;37:1-46. Review. No abstract available.

PMID:
2244008
37.
40.

Role of HIV in human nervous system dysfunction.

Wigdahl B, Kunsch C.

AIDS Res Hum Retroviruses. 1989 Aug;5(4):369-74. Review. No abstract available.

PMID:
2669896
41.

CD4-independent infection of human neural cells by human immunodeficiency virus type 1.

Harouse JM, Kunsch C, Hartle HT, Laughlin MA, Hoxie JA, Wigdahl B, Gonzalez-Scarano F.

J Virol. 1989 Jun;63(6):2527-33.

42.

Effect of Sodium Chloride on Uptake of Substrate by Staphylococcus aureus 196E.

Smith JL, Maurer MJ, Bencivengo MM, Kunsch CA.

J Food Prot. 1987 Nov;50(11):968-974. doi: 10.4315/0362-028X-50.11.968.

PMID:
30978822
43.

Enterotoxin A synthesis in Staphylococcus aureus: inhibition by glycerol and maltose.

Smith JL, Bencivengo MM, Kunsch CA.

J Gen Microbiol. 1986 Dec;132(12):3375-80.

PMID:
3116155
44.

Enterotoxin A production in Staphylococcus aureus: inhibition by glucose.

Smith JL, Bencivengo MM, Buchanan RL, Kunsch CA.

Arch Microbiol. 1986 Mar;144(2):131-6.

PMID:
3013114

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