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Items: 41

1.

Recipient mucosal-associated invariant T cells control GVHD within the colon.

Varelias A, Bunting MD, Ormerod KL, Koyama M, Olver SD, Straube J, Kuns RD, Robb RJ, Henden AS, Cooper L, Lachner N, Gartlan KH, Lantz O, Kjer-Nielsen L, Mak JY, Fairlie DP, Clouston AD, McCluskey J, Rossjohn J, Lane SW, Hugenholtz P, Hill GR.

J Clin Invest. 2018 May 1;128(5):1919-1936. doi: 10.1172/JCI91646. Epub 2018 Apr 9.

2.

Conventional dendritic cells are required for the cross-presentation of leukemia-specific antigen in a model of AML relapse post-BMT.

Markey KA, Gartlan KH, Kuns RD, Lane SW, Hill GR.

Bone Marrow Transplant. 2018 Jun;53(6):800-803. doi: 10.1038/s41409-018-0148-y. Epub 2018 Mar 13. No abstract available.

PMID:
29535380
3.

Flt-3L Expansion of Recipient CD8α+ Dendritic Cells Deletes Alloreactive Donor T Cells and Represents an Alternative to Posttransplant Cyclophosphamide for the Prevention of GVHD.

Markey KA, Kuns RD, Browne DJ, Gartlan KH, Robb RJ, Martins JP, Henden AS, Minnie SA, Cheong M, Koyama M, Smyth MJ, Steptoe RJ, Belz GT, Brocker T, Degli-Esposti MA, Lane SW, Hill GR.

Clin Cancer Res. 2018 Apr 1;24(7):1604-1616. doi: 10.1158/1078-0432.CCR-17-2148. Epub 2018 Jan 24.

PMID:
29367429
4.

Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT.

Gartlan KH, Varelias A, Koyama M, Robb RJ, Markey KA, Chang K, Wilkinson AN, Smith D, Ullah MA, Kuns RD, Raffelt NC, Olver SD, Lineburg KE, Teal BE, Cheong M, Teng MWL, Smyth MJ, Tey SK, MacDonald KPA, Hill GR.

Blood Adv. 2017 Jan 26;1(6):341-351. doi: 10.1182/bloodadvances.2016002980. eCollection 2017 Feb 14.

5.

A critical role for donor-derived IL-22 in cutaneous chronic GVHD.

Gartlan KH, Bommiasamy H, Paz K, Wilkinson AN, Owen M, Reichenbach DK, Banovic T, Wehner K, Buchanan F, Varelias A, Kuns RD, Chang K, Fedoriw Y, Shea T, Coghill J, Zaiken M, Plank MW, Foster PS, Clouston AD, Blazar BR, Serody JS, Hill GR.

Am J Transplant. 2018 Apr;18(4):810-820. doi: 10.1111/ajt.14513. Epub 2017 Oct 24.

PMID:
28941323
6.

Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.

Zhang P, Lee JS, Gartlan KH, Schuster IS, Comerford I, Varelias A, Ullah MA, Vuckovic S, Koyama M, Kuns RD, Locke KR, Beckett KJ, Olver SD, Samson LD, Montes de Oca M, de Labastida Rivera F, Clouston AD, Belz GT, Blazar BR, MacDonald KP, McColl SR, Thomas R, Engwerda CR, Degli-Esposti MA, Kallies A, Tey SK, Hill GR.

Sci Immunol. 2017 Apr 7;2(10). pii: eaah7152. doi: 10.1126/sciimmunol.aah7152.

7.

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome.

Varelias A, Ormerod KL, Bunting MD, Koyama M, Gartlan KH, Kuns RD, Lachner N, Locke KR, Lim CY, Henden AS, Zhang P, Clouston AD, Hasnain SZ, McGuckin MA, Blazar BR, MacDonald KP, Hugenholtz P, Hill GR.

Blood. 2017 Apr 13;129(15):2172-2185. doi: 10.1182/blood-2016-08-732628. Epub 2017 Jan 30.

8.

GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity.

Bunting MD, Varelias A, Souza-Fonseca-Guimaraes F, Schuster IS, Lineburg KE, Kuns RD, Fleming P, Locke KR, Huntington ND, Blazar BR, Lane SW, Tey SK, MacDonald KP, Smyth MJ, Degli-Esposti MA, Hill GR.

Blood. 2017 Feb 2;129(5):630-642. doi: 10.1182/blood-2016-08-734020. Epub 2016 Dec 7.

9.

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease.

Le Texier L, Lineburg KE, Cao B, McDonald-Hyman C, Leveque-El Mouttie L, Nicholls J, Melino M, Nalkurthi BC, Alexander KA, Teal B, Blake SJ, Souza-Fonseca-Guimaraes F, Engwerda CR, Kuns RD, Lane SW, Teng M, Teh C, Gray D, Clouston AD, Nilsson SK, Blazar BR, Hill GR, MacDonald KP.

JCI Insight. 2016 Sep 22;1(15):e86850.

10.

Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD.

Leveque-El Mouttie L, Koyama M, Le Texier L, Markey KA, Cheong M, Kuns RD, Lineburg KE, Teal BE, Alexander KA, Clouston AD, Blazar BR, Hill GR, MacDonald KP.

Blood. 2016 Aug 11;128(6):794-804. doi: 10.1182/blood-2015-11-680876. Epub 2016 Jun 23.

11.

IL-17A-Producing γδ T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver.

Sheel M, Beattie L, Frame TC, de Labastida Rivera F, Faleiro RJ, Bunn PT, Montes de Oca M, Edwards CL, Ng SS, Kumar R, Amante FH, Best SE, McColl SR, Varelias A, Kuns RD, MacDonald KP, Smyth MJ, Haque A, Hill GR, Engwerda CR.

J Immunol. 2015 Dec 15;195(12):5707-17. doi: 10.4049/jimmunol.1501046. Epub 2015 Nov 4.

12.

Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects.

Gartlan KH, Markey KA, Varelias A, Bunting MD, Koyama M, Kuns RD, Raffelt NC, Olver SD, Lineburg KE, Cheong M, Teal BE, Lor M, Comerford I, Teng MW, Smyth MJ, McCluskey J, Rossjohn J, Stockinger B, Boyle GM, Lane SW, Clouston AD, McColl SR, MacDonald KP, Hill GR.

Blood. 2015 Sep 24;126(13):1609-20. doi: 10.1182/blood-2015-01-622662. Epub 2015 Jul 23.

13.

Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.

Koyama M, Cheong M, Markey KA, Gartlan KH, Kuns RD, Locke KR, Lineburg KE, Teal BE, Leveque-El Mouttie L, Bunting MD, Vuckovic S, Zhang P, Teng MW, Varelias A, Tey SK, Wockner LF, Engwerda CR, Smyth MJ, Belz GT, McColl SR, MacDonald KP, Hill GR.

J Exp Med. 2015 Jul 27;212(8):1303-21. doi: 10.1084/jem.20150329. Epub 2015 Jul 13.

14.

Acute GVHD results in a severe DC defect that prevents T-cell priming and leads to fulminant cytomegalovirus disease in mice.

Wikstrom ME, Fleming P, Kuns RD, Schuster IS, Voigt V, Miller G, Clouston AD, Tey SK, Andoniou CE, Hill GR, Degli-Esposti MA.

Blood. 2015 Sep 17;126(12):1503-14. doi: 10.1182/blood-2015-01-622837. Epub 2015 Jun 30.

15.

Imaging the immunological synapse between dendritic cells and T cells.

Markey KA, Gartlan KH, Kuns RD, MacDonald KP, Hill GR.

J Immunol Methods. 2015 Aug;423:40-4. doi: 10.1016/j.jim.2015.04.029. Epub 2015 May 9.

PMID:
25967948
16.

Autophagy is required for stem cell mobilization by G-CSF.

Leveque-El Mouttie L, Vu T, Lineburg KE, Kuns RD, Bagger FO, Teal BE, Lor M, Boyle GM, Bruedigam C, Mintern JD, Hill GR, MacDonald KP, Lane SW.

Blood. 2015 May 7;125(19):2933-6. doi: 10.1182/blood-2014-03-562660. Epub 2015 Mar 18.

17.

Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation.

Varelias A, Gartlan KH, Kreijveld E, Olver SD, Lor M, Kuns RD, Lineburg KE, Teal BE, Raffelt NC, Cheong M, Alexander KA, Koyama M, Markey KA, Sturgeon E, Leach J, Reddy P, Kennedy GA, Yanik GA, Blazar BR, Tey SK, Clouston AD, MacDonald KP, Cooke KR, Hill GR.

Blood. 2015 Apr 9;125(15):2435-44. doi: 10.1182/blood-2014-07-590232. Epub 2015 Feb 11.

18.

CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease.

Alexander KA, Flynn R, Lineburg KE, Kuns RD, Teal BE, Olver SD, Lor M, Raffelt NC, Koyama M, Leveque L, Le Texier L, Melino M, Markey KA, Varelias A, Engwerda C, Serody JS, Janela B, Ginhoux F, Clouston AD, Blazar BR, Hill GR, MacDonald KP.

J Clin Invest. 2014 Oct;124(10):4266-80. doi: 10.1172/JCI75935. Epub 2014 Aug 26.

19.

Cross-dressing by donor dendritic cells after allogeneic bone marrow transplantation contributes to formation of the immunological synapse and maximizes responses to indirectly presented antigen.

Markey KA, Koyama M, Gartlan KH, Leveque L, Kuns RD, Lineburg KE, Teal BE, MacDonald KP, Hill GR.

J Immunol. 2014 Jun 1;192(11):5426-33. doi: 10.4049/jimmunol.1302490. Epub 2014 Apr 30.

20.

Modification of T cell responses by stem cell mobilization requires direct signaling of the T cell by G-CSF and IL-10.

MacDonald KP, Le Texier L, Zhang P, Morris H, Kuns RD, Lineburg KE, Leveque L, Don AL, Markey KA, Vuckovic S, Bagger FO, Boyle GM, Blazar BR, Hill GR.

J Immunol. 2014 Apr 1;192(7):3180-9. doi: 10.4049/jimmunol.1302315. Epub 2014 Feb 28.

21.

Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo.

Zhang P, Tey SK, Koyama M, Kuns RD, Olver SD, Lineburg KE, Lor M, Teal BE, Raffelt NC, Raju J, Leveque L, Markey KA, Varelias A, Clouston AD, Lane SW, MacDonald KP, Hill GR.

J Immunol. 2013 Nov 15;191(10):5291-303. doi: 10.4049/jimmunol.1301181. Epub 2013 Oct 11.

22.

Promoting regulation via the inhibition of DNAM-1 after transplantation.

Koyama M, Kuns RD, Olver SD, Lineburg KE, Lor M, Teal BE, Raffelt NC, Leveque L, Chan CJ, Robb RJ, Markey KA, Alexander KA, Varelias A, Clouston AD, Smyth MJ, MacDonald KP, Hill GR.

Blood. 2013 Apr 25;121(17):3511-20. doi: 10.1182/blood-2012-07-444026. Epub 2013 Feb 21.

23.

Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.

Robb RJ, Lineburg KE, Kuns RD, Wilson YA, Raffelt NC, Olver SD, Varelias A, Alexander KA, Teal BE, Sparwasser T, Hammerling GJ, Markey KA, Koyama M, Clouston AD, Engwerda CR, Hill GR, MacDonald KP.

Blood. 2012 Jun 14;119(24):5898-908. doi: 10.1182/blood-2011-12-396119. Epub 2012 Apr 26.

24.

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets.

Markey KA, Koyama M, Kuns RD, Lineburg KE, Wilson YA, Olver SD, Raffelt NC, Don AL, Varelias A, Robb RJ, Cheong M, Engwerda CR, Steptoe RJ, Ramshaw HS, Lopez AF, Vega-Ramos J, Lew AM, Villadangos JA, Hill GR, MacDonald KP.

Blood. 2012 Jun 14;119(24):5918-30. doi: 10.1182/blood-2011-12-398164. Epub 2012 Mar 13.

25.

Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease.

Koyama M, Kuns RD, Olver SD, Raffelt NC, Wilson YA, Don AL, Lineburg KE, Cheong M, Robb RJ, Markey KA, Varelias A, Malissen B, Hämmerling GJ, Clouston AD, Engwerda CR, Bhat P, MacDonald KP, Hill GR.

Nat Med. 2011 Nov 29;18(1):135-42. doi: 10.1038/nm.2597.

PMID:
22127134
26.

Type I-IFNs control GVHD and GVL responses after transplantation.

Robb RJ, Kreijveld E, Kuns RD, Wilson YA, Olver SD, Don AL, Raffelt NC, De Weerd NA, Lineburg KE, Varelias A, Markey KA, Koyama M, Clouston AD, Hertzog PJ, Macdonald KP, Hill GR.

Blood. 2011 Sep 22;118(12):3399-409. doi: 10.1182/blood-2010-12-325746. Epub 2011 Jun 30.

27.

SOCS3 regulates graft-versus-host disease.

Hill GR, Kuns RD, Raffelt NC, Don AL, Olver SD, Markey KA, Wilson YA, Tocker J, Alexander WS, Clouston AD, Roberts AW, MacDonald KP.

Blood. 2010 Jul 15;116(2):287-96. doi: 10.1182/blood-2009-12-259598. Epub 2010 Apr 30.

28.

Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma.

Hill GR, Olver SD, Kuns RD, Varelias A, Raffelt NC, Don AL, Markey KA, Wilson YA, Smyth MJ, Iwakura Y, Tocker J, Clouston AD, Macdonald KP.

Blood. 2010 Aug 5;116(5):819-28. doi: 10.1182/blood-2009-11-256495. Epub 2010 Apr 30.

29.

Therapeutic glucocorticoid-induced TNF receptor-mediated amplification of CD4+ T cell responses enhances antiparasitic immunity.

Haque A, Stanley AC, Amante FH, Rivera Fde L, Zhou Y, Kuns RD, Yardley V, Sakaguchi S, Hill GR, Engwerda CR.

J Immunol. 2010 Mar 1;184(5):2583-92. doi: 10.4049/jimmunol.0903080. Epub 2010 Feb 5.

30.

Soluble lymphotoxin is an important effector molecule in GVHD and GVL.

Markey KA, Burman AC, Banovic T, Kuns RD, Raffelt NC, Rowe V, Olver SD, Don AL, Morris ES, Pettit AR, Wilson YA, Robb RJ, Randall LM, Korner H, Engwerda CR, Clouston AD, Macdonald KP, Hill GR.

Blood. 2010 Jan 7;115(1):122-32. doi: 10.1182/blood-2009-01-199927. Epub 2009 Sep 29.

31.

Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration.

Kuns RD, Morris ES, Macdonald KP, Markey KA, Morris HM, Raffelt NC, Banovic T, Don AL, Rowe V, Burman AC, Clouston AD, Farah C, Besra GS, Illarionov PA, Smyth MJ, Porcelli SA, Hill GR.

Blood. 2009 Jun 4;113(23):5999-6010. doi: 10.1182/blood-2008-10-183335. Epub 2009 Apr 15.

32.

Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation.

Markey KA, Banovic T, Kuns RD, Olver SD, Don AL, Raffelt NC, Wilson YA, Raggatt LJ, Pettit AR, Bromberg JS, Hill GR, MacDonald KP.

Blood. 2009 May 28;113(22):5644-9. doi: 10.1182/blood-2008-12-191833. Epub 2009 Mar 31.

33.

Induction of natural killer T cell-dependent alloreactivity by administration of granulocyte colony-stimulating factor after bone marrow transplantation.

Morris ES, MacDonald KP, Kuns RD, Morris HM, Banovic T, Don AL, Rowe V, Wilson YA, Raffelt NC, Engwerda CR, Burman AC, Markey KA, Godfrey DI, Smyth MJ, Hill GR.

Nat Med. 2009 Apr;15(4):436-41. doi: 10.1038/nm.1948. Epub 2009 Mar 29.

PMID:
19330008
34.

Donor treatment with a multipegylated G-CSF maximizes graft-versus-leukemia effects.

Banovic T, MacDonald KP, Markey KA, Morris ES, Kuns RD, Varelias A, Hill GR.

Biol Blood Marrow Transplant. 2009 Jan;15(1):126-30. doi: 10.1016/j.bbmt.2008.11.019.

35.

Graft-versus-host disease prevents the maturation of plasmacytoid dendritic cells.

Banovic T, Markey KA, Kuns RD, Olver SD, Raffelt NC, Don AL, Degli-Esposti MA, Engwerda CR, MacDonald KP, Hill GR.

J Immunol. 2009 Jan 15;182(2):912-20. Erratum in: J Immunol. 2009 Mar 1;182(5):3327.

36.

Cutting edge: conventional dendritic cells are the critical APC required for the induction of experimental cerebral malaria.

deWalick S, Amante FH, McSweeney KA, Randall LM, Stanley AC, Haque A, Kuns RD, MacDonald KP, Hill GR, Engwerda CR.

J Immunol. 2007 May 15;178(10):6033-7.

37.

IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract.

Burman AC, Banovic T, Kuns RD, Clouston AD, Stanley AC, Morris ES, Rowe V, Bofinger H, Skoczylas R, Raffelt N, Fahy O, McColl SR, Engwerda CR, McDonald KP, Hill GR.

Blood. 2007 Aug 1;110(3):1064-72. Epub 2007 Apr 20.

38.

Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD.

MacDonald KP, Kuns RD, Rowe V, Morris ES, Banovic T, Bofinger H, O'Sullivan B, Markey KA, Don AL, Thomas R, Hill GR.

Blood. 2007 Jun 1;109(11):5049-57. Epub 2007 Feb 27.

39.

NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs.

Morris ES, MacDonald KP, Rowe V, Banovic T, Kuns RD, Don AL, Bofinger HM, Burman AC, Olver SD, Kienzle N, Porcelli SA, Pellicci DG, Godfrey DI, Smyth MJ, Hill GR.

J Clin Invest. 2005 Nov;115(11):3093-103. Epub 2005 Oct 13.

41.

Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells.

MacDonald KP, Rowe V, Clouston AD, Welply JK, Kuns RD, Ferrara JL, Thomas R, Hill GR.

J Immunol. 2005 Feb 15;174(4):1841-50.

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