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Sorcin a Potential Molecular Target for Cancer Therapy.

Shabnam B, Padmavathi G, Banik K, Girisa S, Monisha J, Sethi G, Fan L, Wang L, Mao X, Kunnumakkara AB.

Transl Oncol. 2018 Sep 11;11(6):1379-1389. doi: 10.1016/j.tranon.2018.08.015. [Epub ahead of print] Review.


Pleiotropic Effect of Mahanine and Girinimbine Analogs: Anticancer Mechanism and its Therapeutic Versatility.

Maruthanila VL, Elancheran R, Kunnumakkara AB, Kabilan S, Kotoky J.

Anticancer Agents Med Chem. 2018 Aug 30. doi: 10.2174/1871520618666180830151720. [Epub ahead of print]


Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases.

Kunnumakkara AB, Banik K, Bordoloi D, Harsha C, Sailo BL, Padmavathi G, Roy NK, Gupta SC, Aggarwal BB.

Front Pharmacol. 2018 Aug 6;9:686. doi: 10.3389/fphar.2018.00686. eCollection 2018. Review.


Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer.

Ranaware AM, Banik K, Deshpande V, Padmavathi G, Roy NK, Sethi G, Fan L, Kumar AP, Kunnumakkara AB.

Int J Mol Sci. 2018 Aug 10;19(8). pii: E2362. doi: 10.3390/ijms19082362. Review.


NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance.

Monisha J, Roy NK, Padmavathi G, Banik K, Bordoloi D, Khwairakpam AD, Arfuso F, Chinnathambi A, Alahmadi TA, Alharbi SA, Sethi G, Kumar AP, Kunnumakkara AB.

Cancers (Basel). 2018 Jul 10;10(7). pii: E228. doi: 10.3390/cancers10070228.


Novel tumor necrosis factor-α induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression.

Padmavathi G, Banik K, Monisha J, Bordoloi D, Shabnam B, Arfuso F, Sethi G, Fan L, Kunnumakkara AB.

Cancer Lett. 2018 Sep 28;432:260-271. doi: 10.1016/j.canlet.2018.06.017. Epub 2018 Jun 18.


Possible use of Punica granatum (Pomegranate) in cancer therapy.

Khwairakpam AD, Bordoloi D, Thakur KK, Monisha J, Arfuso F, Sethi G, Mishra S, Kumar AP, Kunnumakkara AB.

Pharmacol Res. 2018 Jul;133:53-64. doi: 10.1016/j.phrs.2018.04.021. Epub 2018 May 2. Review.


Novel AKT1 mutations associated with cell-cycle abnormalities in gastric carcinoma.

Ghatak S, Lalnunhlimi S, Lalrohlui F, Pautu JL, Zohmingthanga J, Kunnumakkara AB, Kumar NS.

Per Med. 2018 Mar;15(2):79-86. doi: 10.2217/pme-2017-0053. Epub 2018 Jan 30.


Tocotrienols: The promising analogues of vitamin E for cancer therapeutics.

Sailo BL, Banik K, Padmavathi G, Javadi M, Bordoloi D, Kunnumakkara AB.

Pharmacol Res. 2018 Apr;130:259-272. doi: 10.1016/j.phrs.2018.02.017. Epub 2018 Feb 27. Review.


Targeting IκappaB kinases for cancer therapy.

Awasthee N, Rai V, Chava S, Nallasamy P, Kunnumakkara AB, Bishayee A, Chauhan SC, Challagundla KB, Gupta SC.

Semin Cancer Biol. 2018 Feb 24. pii: S1044-579X(17)30046-9. doi: 10.1016/j.semcancer.2018.02.007. [Epub ahead of print] Review.


Acorus calamus: a bio-reserve of medicinal values.

Khwairakpam AD, Damayenti YD, Deka A, Monisha J, Roy NK, Padmavathi G, Kunnumakkara AB.

J Basic Clin Physiol Pharmacol. 2018 Mar 28;29(2):107-122. doi: 10.1515/jbcpp-2016-0132. Review.


Chronic diseases, inflammation, and spices: how are they linked?

Kunnumakkara AB, Sailo BL, Banik K, Harsha C, Prasad S, Gupta SC, Bharti AC, Aggarwal BB.

J Transl Med. 2018 Jan 25;16(1):14. doi: 10.1186/s12967-018-1381-2. Review.


Therapeutic potential of gambogic acid, a caged xanthone, to target cancer.

Banik K, Harsha C, Bordoloi D, Lalduhsaki Sailo B, Sethi G, Leong HC, Arfuso F, Mishra S, Wang L, Kumar AP, Kunnumakkara AB.

Cancer Lett. 2018 Mar 1;416:75-86. doi: 10.1016/j.canlet.2017.12.014. Epub 2017 Dec 13.


Comparative Oral Absorption of Curcumin in a Natural Turmeric Matrix with Two Other Curcumin Formulations: An Open-label Parallel-arm Study.

Gopi S, Jacob J, Varma K, Jude S, Amalraj A, Arundhathy CA, George R, Sreeraj TR, Divya C, Kunnumakkara AB, Stohs SJ.

Phytother Res. 2017 Dec;31(12):1883-1891. doi: 10.1002/ptr.5931. Epub 2017 Oct 13.


Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis.

Gupta SC, Prasad S, Tyagi AK, Kunnumakkara AB, Aggarwal BB.

Phytomedicine. 2017 Oct 15;34:14-20. doi: 10.1016/j.phymed.2017.07.001. Epub 2017 Jul 3. Review.


A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study.

Amalraj A, Varma K, Jacob J, Divya C, Kunnumakkara AB, Stohs SJ, Gopi S.

J Med Food. 2017 Oct;20(10):1022-1030. doi: 10.1089/jmf.2017.3930. Epub 2017 Aug 29.


Alarming Burden of Triple-Negative Breast Cancer in India.

Thakur KK, Bordoloi D, Kunnumakkara AB.

Clin Breast Cancer. 2018 Jun;18(3):e393-e399. doi: 10.1016/j.clbc.2017.07.013. Epub 2017 Jul 20. Review.


Antiulcer properties of fruits and vegetables: A mechanism based perspective.

Harsha C, Banik K, Bordoloi D, Kunnumakkara AB.

Food Chem Toxicol. 2017 Oct;108(Pt A):104-119. doi: 10.1016/j.fct.2017.07.023. Epub 2017 Jul 12. Review.


Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.

Kunnumakkara AB, Bordoloi D, Harsha C, Banik K, Gupta SC, Aggarwal BB.

Clin Sci (Lond). 2017 Jul 5;131(15):1781-1799. doi: 10.1042/CS20160935. Print 2017 Aug 1. Review.


Butein in health and disease: A comprehensive review.

Padmavathi G, Roy NK, Bordoloi D, Arfuso F, Mishra S, Sethi G, Bishayee A, Kunnumakkara AB.

Phytomedicine. 2017 Feb 15;25:118-127. doi: 10.1016/j.phymed.2016.12.002. Epub 2016 Dec 12. Review.


Therapeutic implications of toll-like receptors in peripheral neuropathic pain.

Thakur KK, Saini J, Mahajan K, Singh D, Jayswal DP, Mishra S, Bishayee A, Sethi G, Kunnumakkara AB.

Pharmacol Res. 2017 Jan;115:224-232. doi: 10.1016/j.phrs.2016.11.019. Epub 2016 Nov 25. Review.


Recent development of targeted approaches for the treatment of breast cancer.

Maruthanila VL, Elancheran R, Kunnumakkara AB, Kabilan S, Kotoky J.

Breast Cancer. 2017 Mar;24(2):191-219. doi: 10.1007/s12282-016-0732-1. Epub 2016 Oct 31. Review.


Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.

Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB.

Br J Pharmacol. 2017 Jun;174(11):1325-1348. doi: 10.1111/bph.13621. Epub 2016 Oct 21. Review.


NF-κB Blockers Gifted by Mother Nature: Prospectives in Cancer Cell Chemosensitization.

Monisha J, Padmavathi G, Roy NK, Deka A, Bordoloi D, Anip A, Kunnumakkara AB.

Curr Pharm Des. 2016;22(27):4173-200. Review.


The potential role of boswellic acids in cancer prevention and treatment.

Roy NK, Deka A, Bordoloi D, Mishra S, Kumar AP, Sethi G, Kunnumakkara AB.

Cancer Lett. 2016 Jul 10;377(1):74-86. doi: 10.1016/j.canlet.2016.04.017. Epub 2016 Apr 14. Review.


Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer.

Roy NK, Bordoloi D, Monisha J, Padmavathi G, Kotoky J, Golla R, Kunnumakkara AB.

Curr Drug Targets. 2017;18(4):421-435. doi: 10.2174/1389450117666160307145236. Review.


Retraction notice to "Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo" [Biochem. Pharmacol. 79 (2010) 330-338].

Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB.

Biochem Pharmacol. 2016 Feb 15;102:143. doi: 10.1016/j.bcp.2015.11.008. Epub 2016 Feb 20. No abstract available.


Nuclear Factor Kappa B: A Potential Target to Persecute Head and Neck Cancer.

Monisha J, Roy NK, Bordoloi D, Kumar A, Golla R, Kotoky J, Padmavathi G, Kunnumakkara AB.

Curr Drug Targets. 2017;18(2):232-253. doi: 10.2174/1389450117666160201112330. Review.


Potential of butein, a tetrahydroxychalcone to obliterate cancer.

Padmavathi G, Rathnakaram SR, Monisha J, Bordoloi D, Roy NK, Kunnumakkara AB.

Phytomedicine. 2015 Dec 1;22(13):1163-71. doi: 10.1016/j.phymed.2015.08.015. Epub 2015 Oct 13. Review.


Multi-Targeted Agents in Cancer Cell Chemosensitization: What We Learnt from Curcumin Thus Far.

Bordoloi D, Roy NK, Monisha J, Padmavathi G, Kunnumakkara AB.

Recent Pat Anticancer Drug Discov. 2016;11(1):67-97. Review.


Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress.

Thomas D, Govindhan S, Baiju EC, Padmavathi G, Kunnumakkara AB, Padikkala J.

J Basic Clin Physiol Pharmacol. 2015 Sep;26(5):485-90. doi: 10.1515/jbcpp-2014-0093.


ATP citrate lyase (ACLY): a promising target for cancer prevention and treatment.

Khwairakpam AD, Shyamananda MS, Sailo BL, Rathnakaram SR, Padmavathi G, Kotoky J, Kunnumakkara AB.

Curr Drug Targets. 2015;16(2):156-63. Review.


Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling.

Quinn BJ, Dallos M, Kitagawa H, Kunnumakkara AB, Memmott RM, Hollander MC, Gills JJ, Dennis PA.

Cancer Prev Res (Phila). 2013 Aug;6(8):801-10. doi: 10.1158/1940-6207.CAPR-13-0058-T. Epub 2013 Jun 14.


Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets.

Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB.

Int J Cancer. 2012 Aug 1;131(3):E292-303. doi: 10.1002/ijc.26442. Epub 2011 Nov 9.


Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors.

Anand P, Sung B, Kunnumakkara AB, Rajasekharan KN, Aggarwal BB.

Biochem Pharmacol. 2011 Dec 15;82(12):1901-9. doi: 10.1016/j.bcp.2011.09.001. Epub 2011 Sep 8. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:144.


Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer.

Heymach JV, Shackleford TJ, Tran HT, Yoo SY, Do KA, Wergin M, Saintigny P, Vollmer RT, Polascik TJ, Snyder DC, Ruffin MT 4th, Yan S, Dewhirst M, Kunnumakkara AB, Aggarwal BB, Demark-Wahnefried W.

Cancer Prev Res (Phila). 2011 Oct;4(10):1590-8. doi: 10.1158/1940-6207.CAPR-10-0136. Epub 2011 Jul 15.


{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.

Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Yadav VR, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB.

Cancer Res. 2010 Nov 1;70(21):8695-705. doi: 10.1158/0008-5472.CAN-10-2318. Epub 2010 Sep 23. Erratum in: Cancer Res. 2018 Sep 1;78(17):5181.


A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

Harikumar KB, Kunnumakkara AB, Ochi N, Tong Z, Deorukhkar A, Sung B, Kelland L, Jamieson S, Sutherland R, Raynham T, Charles M, Bagherzadeh A, Foxton C, Boakes A, Farooq M, Maru D, Diagaradjane P, Matsuo Y, Sinnett-Smith J, Gelovani J, Krishnan S, Aggarwal BB, Rozengurt E, Ireson CR, Guha S.

Mol Cancer Ther. 2010 May;9(5):1136-46. doi: 10.1158/1535-7163.MCT-09-1145. Epub 2010 May 4. Erratum in: Mol Cancer Ther. 2010 Jul;9(7):2153. Bagherazadeh, Azadeh [corrected to Bagherzadeh, Azadeh].


Expression of nuclear transcription factor kappa B in locally advanced human cervical cancer treated with definitive chemoradiation.

Garg AK, Jhingran A, Klopp AH, Aggarwal BB, Kunnumakkara AB, Broadus RR, Eifel PJ, Buchholz TA.

Int J Radiat Oncol Biol Phys. 2010 Dec 1;78(5):1331-6. doi: 10.1016/j.ijrobp.2009.09.044. Epub 2010 Mar 16.


Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.

Harikumar KB, Kunnumakkara AB, Sethi G, Diagaradjane P, Anand P, Pandey MK, Gelovani J, Krishnan S, Guha S, Aggarwal BB.

Int J Cancer. 2010 Jul 15;127(2):257-68. doi: 10.1002/ijc.25041. Erratum in: Int J Cancer. 2015 Dec 15;137(12):E21.


Targeting TNF for Treatment of Cancer and Autoimmunity.

Sethi G, Sung B, Kunnumakkara AB, Aggarwal BB.

Adv Exp Med Biol. 2009;647:37-51. doi: 10.1007/978-0-387-89520-8_3. Review.


Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo.

Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB.

Biochem Pharmacol. 2010 Feb 1;79(3):330-8. doi: 10.1016/j.bcp.2009.09.003. Epub 2009 Sep 6. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:143.


Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.

Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, Dey S, Sung B.

Ann N Y Acad Sci. 2009 Aug;1171:59-76. doi: 10.1111/j.1749-6632.2009.04911.x. Review.


Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.

Kunnumakkara AB, Diagaradjane P, Anand P, Harikumar KB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB.

Int J Cancer. 2009 Nov 1;125(9):2187-97. doi: 10.1002/ijc.24593. Erratum in: Int J Cancer. 2010 Feb 1;126(3):799. Kuzhuvelil, Harikumar B [corrected to Harikumar, Kuzhuvelil B].


Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.

Sung B, Kunnumakkara AB, Sethi G, Anand P, Guha S, Aggarwal BB.

Mol Cancer Ther. 2009 Apr;8(4):959-70. doi: 10.1158/1535-7163.MCT-08-0905. Erratum in: Mol Cancer Ther. 2009 May;8(5):1398.


Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.

Kunnumakkara AB, Nair AS, Sung B, Pandey MK, Aggarwal BB.

Mol Cancer Res. 2009 Jan;7(1):118-28. doi: 10.1158/1541-7786.MCR-08-0154. Retraction in: Mol Cancer Res. 2018 Sep;16(9):1444.


Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells.

Muralimanoharan SB, Kunnumakkara AB, Shylesh B, Kulkarni KH, Haiyan X, Ming H, Aggarwal BB, Rita G, Kumar AP.

Prostate. 2009 Apr 1;69(5):494-504. doi: 10.1002/pros.20899.


Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.

Anand P, Kunnumakkara AB, Harikumar KB, Ahn KS, Badmaev V, Aggarwal BB.

Cancer Res. 2008 Nov 1;68(21):8861-70. doi: 10.1158/0008-5472.CAN-08-1902. Retraction in: Cancer Res. 2018 Sep 1;78(17):5187.


Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.

Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB.

Blood. 2009 Feb 26;113(9):2003-13. doi: 10.1182/blood-2008-04-151944. Epub 2008 Oct 24.

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