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TNFα regulates diabetic macrophage function through the histone acetyl-transferase, MOF.

denDekker AD, Davis FM, Joshi AD, Wolf SJ, Allen R, Lipinski J, Nguyen B, Kirma J, Nycz D, Bermick JR, Moore BB, Gudjonsson JE, Kunkel SL, Gallagher KA.

JCI Insight. 2020 Feb 18. pii: 132306. doi: 10.1172/jci.insight.132306. [Epub ahead of print]


Pneumococcal conjugate vaccine modulates macrophage-mediated innate immunity in pneumonia caused by Streptococcus pneumoniae following influenza.

Mimura K, Kimura S, Kajiwara C, Nakakubo S, Schaller MA, Ishii Y, Standiford TJ, Kunkel SL, Tateda K.

Microbes Infect. 2020 Jan 17. pii: S1286-4579(20)30008-3. doi: 10.1016/j.micinf.2019.12.005. [Epub ahead of print]


Ly6CLo Monocyte/Macrophages are Essential for Thrombus Resolution in a Murine Model of Venous Thrombosis.

Kimball AS, Obi AT, Luke CE, Dowling AR, Cai Q, Adili R, Jankowski H, Schaller M, Holinstadt M, Jaffer FA, Kunkel SL, Gallagher KA, Henke PK.

Thromb Haemost. 2020 Feb;120(2):289-299. doi: 10.1055/s-0039-3400959. Epub 2019 Dec 30.


Inhibition of the stem cell factor 248 isoform attenuates the development of pulmonary remodeling disease.

Rasky A, Habiel DM, Morris S, Schaller M, Moore BB, Phan S, Kunkel SL, Phillips M, Hogaboam C, Lukacs NW.

Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L200-L211. doi: 10.1152/ajplung.00114.2019. Epub 2019 Nov 20.


Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation.

Agarwal S, Loder SJ, Cholok D, Li J, Bian G, Yalavarthi S, Li S, Carson WF, Hwang C, Marini S, Pagani C, Edwards N, Delano MJ, Standiford TJ, Knight JS, Kunkel SL, Mishina Y, Ward PA, Levi B.

Front Immunol. 2019 Oct 24;10:2148. doi: 10.3389/fimmu.2019.02148. eCollection 2019.


Sepsis Induces Prolonged Epigenetic Modifications in Bone Marrow and Peripheral Macrophages Impairing Inflammation and Wound Healing.

Davis FM, Schaller MA, Dendekker A, Joshi AD, Kimball AS, Evanoff H, Wilke C, Obi AT, Melvin WJ, Cavassani K, Scola M, Carson B, Moser S, Blanc V, Engoren M, Moore BB, Kunkel SL, Gallagher KA.

Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2353-2366. doi: 10.1161/ATVBAHA.119.312754. Epub 2019 Sep 5.


The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair.

Kimball AS, Davis FM, denDekker A, Joshi AD, Schaller MA, Bermick J, Xing X, Burant CF, Obi AT, Nysz D, Robinson S, Allen R, Lukacs NW, Henke PK, Gudjonsson JE, Moore BB, Kunkel SL, Gallagher KA.

Immunity. 2019 Aug 20;51(2):258-271.e5. doi: 10.1016/j.immuni.2019.06.015. Epub 2019 Jul 23.


SIRT3 Regulates Macrophage-Mediated Inflammation in Diabetic Wound Repair.

Boniakowski AM, denDekker AD, Davis FM, Joshi A, Kimball AS, Schaller M, Allen R, Bermick J, Nycz D, Skinner ME, Robinson S, Obi AT, Moore BB, Gudjonsson JE, Lombard D, Kunkel SL, Gallagher KA.

J Invest Dermatol. 2019 Dec;139(12):2528-2537.e2. doi: 10.1016/j.jid.2019.05.017. Epub 2019 Jun 15.


Histone Methylation Directs Myeloid TLR4 Expression and Regulates Wound Healing following Cutaneous Tissue Injury.

Davis FM, Kimball A, denDekker A, Joshi AD, Boniakowski AE, Nysz D, Allen RM, Obi A, Singer K, Henke PK, Moore BB, Kunkel SL, Gallagher KA.

J Immunol. 2019 Mar 15;202(6):1777-1785. doi: 10.4049/jimmunol.1801258. Epub 2019 Feb 1.


Attracting Attention: Discovery of IL-8/CXCL8 and the Birth of the Chemokine Field.

Moore BB, Kunkel SL.

J Immunol. 2019 Jan 1;202(1):3-4. doi: 10.4049/jimmunol.1801485. No abstract available.


GM-CSF Administration Improves Defects in Innate Immunity and Sepsis Survival in Obese Diabetic Mice.

Frydrych LM, Bian G, Fattahi F, Morris SB, O'Rourke RW, Lumeng CN, Kunkel SL, Ward PA, Delano MJ.

J Immunol. 2019 Feb 1;202(3):931-942. doi: 10.4049/jimmunol.1800713. Epub 2018 Dec 21.


Role of Chemokine Receptor CCR4 and Regulatory T Cells in Wound Healing of Diabetic Mice.

Barros JF, Waclawiak I, Pecli C, Borges PA, Georgii JL, Ramos-Junior ES, Canetti C, Courau T, Klatzmann D, Kunkel SL, Penido C, Canto FB, Benjamim CF.

J Invest Dermatol. 2019 May;139(5):1161-1170. doi: 10.1016/j.jid.2018.10.039. Epub 2018 Nov 19.


Targeting epigenetic mechanisms in diabetic wound healing.

den Dekker A, Davis FM, Kunkel SL, Gallagher KA.

Transl Res. 2019 Feb;204:39-50. doi: 10.1016/j.trsl.2018.10.001. Epub 2018 Oct 10. Review.


Murine macrophage chemokine receptor CCR2 plays a crucial role in macrophage recruitment and regulated inflammation in wound healing.

Boniakowski AE, Kimball AS, Joshi A, Schaller M, Davis FM, denDekker A, Obi AT, Moore BB, Kunkel SL, Gallagher KA.

Eur J Immunol. 2018 Sep;48(9):1445-1455. doi: 10.1002/eji.201747400. Epub 2018 Jun 26.


Ly6CHi Blood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes Mellitus.

Kimball A, Schaller M, Joshi A, Davis FM, denDekker A, Boniakowski A, Bermick J, Obi A, Moore B, Henke PK, Kunkel SL, Gallagher KA.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1102-1114. doi: 10.1161/ATVBAHA.118.310703. Epub 2018 Mar 1.


Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα.

Yang X, Fujisawa M, Yoshimura T, Ohara T, Sato M, Mino M, San TH, Gao T, Kunkel SL, Matsukawa A.

Sci Rep. 2018 Jan 9;8(1):188. doi: 10.1038/s41598-017-18380-0.


Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis.

Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O'Reilly C, O'Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC.

QJM. 2018 Apr 1;111(4):217-224. doi: 10.1093/qjmed/hcx243.


CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine-Induced T Cells to Both the Lung Parenchyma and Airway.

Jeyanathan M, Afkhami S, Khera A, Mandur T, Damjanovic D, Yao Y, Lai R, Haddadi S, Dvorkin-Gheva A, Jordana M, Kunkel SL, Xing Z.

J Immunol. 2017 Oct 1;199(7):2555-2569. doi: 10.4049/jimmunol.1700382. Epub 2017 Aug 21.


The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages.

Carson WF 4th, Cavassani KA, Soares EM, Hirai S, Kittan NA, Schaller MA, Scola MM, Joshi A, Matsukawa A, Aronoff DM, Johnson CN, Dou Y, Gallagher KA, Kunkel SL.

J Immunol. 2017 Sep 1;199(5):1865-1874. doi: 10.4049/jimmunol.1601272. Epub 2017 Jul 21.


The Histone Methyltransferase MLL1 Directs Macrophage-Mediated Inflammation in Wound Healing and Is Altered in a Murine Model of Obesity and Type 2 Diabetes.

Kimball AS, Joshi A, Carson WF 4th, Boniakowski AE, Schaller M, Allen R, Bermick J, Davis FM, Henke PK, Burant CF, Kunkel SL, Gallagher KA.

Diabetes. 2017 Sep;66(9):2459-2471. doi: 10.2337/db17-0194. Epub 2017 Jun 29.


Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing.

Boniakowski AE, Kimball AS, Jacobs BN, Kunkel SL, Gallagher KA.

J Immunol. 2017 Jul 1;199(1):17-24. doi: 10.4049/jimmunol.1700223. Review.


Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing.

Kimball AS, Joshi AD, Boniakowski AE, Schaller M, Chung J, Allen R, Bermick J, Carson WF 4th, Henke PK, Maillard I, Kunkel SL, Gallagher KA.

Front Immunol. 2017 Jun 1;8:635. doi: 10.3389/fimmu.2017.00635. eCollection 2017.


Evaluation of Salivary Cytokines for Diagnosis of both Trauma-Induced and Genetic Heterotopic Ossification.

Sung Hsieh HH, Chung MT, Allen RM, Ranganathan K, Habbouche J, Cholok D, Butts J, Kaura A, Tiruvannamalai-Annamalai R, Breuler C, Priest C, Loder SJ, Li J, Li S, Stegemann J, Kunkel SL, Levi B.

Front Endocrinol (Lausanne). 2017 Apr 24;8:74. doi: 10.3389/fendo.2017.00074. eCollection 2017.


Enhancement of macrophage inflammatory responses by CCL2 is correlated with increased miR-9 expression and downregulation of the ERK1/2 phosphatase Dusp6.

Carson WF 4th, Salter-Green SE, Scola MM, Joshi A, Gallagher KA, Kunkel SL.

Cell Immunol. 2017 Apr;314:63-72. doi: 10.1016/j.cellimm.2017.02.005. Epub 2017 Feb 22.


IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and -negative bacterial pneumonia.

Kovach MA, Singer B, Martinez-Colon G, Newstead MW, Zeng X, Mancuso P, Moore TA, Kunkel SL, Peters-Golden M, Moore BB, Standiford TJ.

Mucosal Immunol. 2017 Sep;10(5):1320-1334. doi: 10.1038/mi.2016.130. Epub 2017 Feb 8.


Regulation of Cellular Immune Responses in Sepsis by Histone Modifications.

Carson WF 4th, Kunkel SL.

Adv Protein Chem Struct Biol. 2017;106:191-225. doi: 10.1016/bs.apcsb.2016.08.004. Epub 2016 Sep 21.


IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia.

Aoyagi T, Newstead MW, Zeng X, Kunkel SL, Kaku M, Standiford TJ.

Mucosal Immunol. 2017 Jul;10(4):1043-1055. doi: 10.1038/mi.2016.107. Epub 2016 Dec 14.


Systemic Expression of Notch Ligand Delta-Like 4 during Mycobacterial Infection Alters the T Cell Immune Response.

Schaller MA, Allen RM, Kimura S, Day CL, Kunkel SL.

Front Immunol. 2016 Nov 24;7:527. eCollection 2016.


Intact Toll-like receptor 9 signaling in neutrophils modulates normal thrombogenesis in mice.

El-Sayed OM, Dewyer NA, Luke CE, Elfline M, Laser A, Hogaboam C, Kunkel SL, Henke PK.

J Vasc Surg. 2016 Nov;64(5):1450-1458.e1. doi: 10.1016/j.jvs.2015.08.070. Epub 2015 Oct 23.


Double-Stranded RNA Interacts With Toll-Like Receptor 3 in Driving the Acute Inflammatory Response Following Lung Contusion.

Suresh MV, Thomas B, Machado-Aranda D, Dolgachev VA, Kumar Ramakrishnan S, Talarico N, Cavassani K, Sherman MA, Hemmila MR, Kunkel SL, Walter NG, Hogaboam CM, Raghavendran K.

Crit Care Med. 2016 Nov;44(11):e1054-e1066.


Neonatal monocytes exhibit a unique histone modification landscape.

Bermick JR, Lambrecht NJ, denDekker AD, Kunkel SL, Lukacs NW, Hogaboam CM, Schaller MA.

Clin Epigenetics. 2016 Sep 20;8:99. doi: 10.1186/s13148-016-0265-7. eCollection 2016.


Histone Deacetylase Inhibition Protects Mice Against Lethal Postinfluenza Pneumococcal Infection.

Yagi K, Ishii M, Namkoong H, Fujii H, Asami T, Suzuki S, Asakura T, Mizoguchi K, Kamo T, Tasaka S, Iwata S, Kunkel SL, Hasegawa N, Betsuyaku T.

Crit Care Med. 2016 Oct;44(10):e980-7. doi: 10.1097/CCM.0000000000001821.


IL-36γ is secreted in microparticles and exosomes by lung macrophages in response to bacteria and bacterial components.

Kovach MA, Singer BH, Newstead MW, Zeng X, Moore TA, White ES, Kunkel SL, Peters-Golden M, Standiford TJ.

J Leukoc Biol. 2016 Aug;100(2):413-21. doi: 10.1189/jlb.4A0315-087R. Epub 2016 Feb 10.


Sprouty-Related Ena/Vasodilator-Stimulated Phosphoprotein Homology 1-Domain-Containing Protein-2 Critically Regulates Influenza A Virus-Induced Pneumonia.

Ito T, Itakura J, Takahashi S, Sato M, Mino M, Fushimi S, Yamada M, Morishima T, Kunkel SL, Matsukawa A.

Crit Care Med. 2016 Jul;44(7):e530-43. doi: 10.1097/CCM.0000000000001562.


Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection.

Kroetz DN, Allen RM, Schaller MA, Cavallaro C, Ito T, Kunkel SL.

PLoS Pathog. 2015 Dec 28;11(12):e1005338. doi: 10.1371/journal.ppat.1005338. eCollection 2015 Dec.


Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma.

Carson WF 4th, Guernsey LA, Singh A, Secor ER Jr, Wohlfert EA, Clark RB, Schramm CM, Kunkel SL, Thrall RS.

Front Immunol. 2015 Nov 20;6:592. doi: 10.3389/fimmu.2015.00592. eCollection 2015.


MicroRNA-155 regulates host immune response to postviral bacterial pneumonia via IL-23/IL-17 pathway.

Podsiad A, Standiford TJ, Ballinger MN, Eakin R, Park P, Kunkel SL, Moore BB, Bhan U.

Am J Physiol Lung Cell Mol Physiol. 2016 Mar 1;310(5):L465-75. doi: 10.1152/ajplung.00224.2015. Epub 2015 Nov 20.


Ulcerative Dermatitis in C57BL/6NCrl Mice on a Low-Fat or High-Fat Diet With or Without a Mineralized Red-Algae Supplement.

Hampton AL, Aslam MN, Naik MK, Bergin IL, Allen RM, Craig RA, Kunkel SL, Veerapaneni I, Paruchuri T, Patterson KA, Rothman ED, Hish GA, Varani J, Rush HG.

J Am Assoc Lab Anim Sci. 2015 Sep;54(5):487-96.


Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK-STAT pathway in Sézary syndrome.

Kiel MJ, Sahasrabuddhe AA, Rolland DCM, Velusamy T, Chung F, Schaller M, Bailey NG, Betz BL, Miranda RN, Porcu P, Byrd JC, Medeiros LJ, Kunkel SL, Bahler DW, Lim MS, Elenitoba-Johnson KSJ.

Nat Commun. 2015 Sep 29;6:8470. doi: 10.1038/ncomms9470.


CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis.

Molinaro R, Pecli C, Guilherme RF, Alves-Filho JC, Cunha FQ, Canetti C, Kunkel SL, Bozza MT, Benjamim CF.

PLoS One. 2015 Jul 21;10(7):e0133227. doi: 10.1371/journal.pone.0133227. eCollection 2015.


Divergent effects of Tlr9 deletion in experimental late venous thrombosis resolution and vein wall injury.

Dewyer NA, El-Sayed OM, Luke CE, Elfline M, Kittan N, Allen R, Laser A, Oostra C, Comerota A, Hogaboam C, Kunkel SL, Henke PK.

Thromb Haemost. 2015 Nov;114(5):1028-37. doi: 10.1160/TH14-12-1031. Epub 2015 Jul 16.


RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo.

Ptaschinski C, Mukherjee S, Moore ML, Albert M, Helin K, Kunkel SL, Lukacs NW.

PLoS Pathog. 2015 Jun 17;11(6):e1004978. doi: 10.1371/journal.ppat.1004978. eCollection 2015 Jun.


Epigenetic regulation of IL-12-dependent T cell proliferation.

Schaller M, Ito T, Allen RM, Kroetz D, Kittan N, Ptaschinski C, Cavassani K, Carson WF 4th, Godessart N, Grembecka J, Cierpicki T, Dou Y, Kunkel SL.

J Leukoc Biol. 2015 Oct;98(4):601-13. doi: 10.1189/jlb.1A0814-375RR. Epub 2015 Jun 9.


MDI 301 suppresses myeloid leukemia cell growth in vitro and in vivo without the toxicity associated with all-trans retinoic acid therapy.

Aslam MN, McClintock S, Khan SP, Perone P, Allen R, Ouillette PD, Dame MK, Cheng JX, Kunkel SL, Varani J.

Anticancer Drugs. 2015 Aug;26(7):763-73. doi: 10.1097/CAD.0000000000000248.


Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection.

Nagata DE, Ting HA, Cavassani KA, Schaller MA, Mukherjee S, Ptaschinski C, Kunkel SL, Lukacs NW.

Mucosal Immunol. 2015 Sep;8(5):1131-43. doi: 10.1038/mi.2015.4. Epub 2015 Feb 11.


IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury.

Ballinger MN, Newstead MW, Zeng X, Bhan U, Mo XM, Kunkel SL, Moore BB, Flavell R, Christman JW, Standiford TJ.

J Immunol. 2015 Feb 15;194(4):1894-904. doi: 10.4049/jimmunol.1402377. Epub 2015 Jan 16.


Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes.

Gallagher KA, Joshi A, Carson WF, Schaller M, Allen R, Mukerjee S, Kittan N, Feldman EL, Henke PK, Hogaboam C, Burant CF, Kunkel SL.

Diabetes. 2015 Apr;64(4):1420-30. doi: 10.2337/db14-0872. Epub 2014 Nov 3.


Viral disruption of olfactory progenitors is exacerbated in allergic mice.

Ueha R, Mukherjee S, Ueha S, de Almeida Nagata DE, Sakamoto T, Kondo K, Yamasoba T, Lukacs NW, Kunkel SL.

Int Immunopharmacol. 2014 Sep;22(1):242-7. doi: 10.1016/j.intimp.2014.06.034. Epub 2014 Jul 2.


Role of growth arrest-specific gene 6 in the development of fungal allergic airway disease in mice.

Shibata T, Ismailoglu UB, Kittan NA, Moreira AP, Coelho AL, Chupp GL, Kunkel SL, Lukacs NW, Hogaboam CM.

Am J Respir Cell Mol Biol. 2014 Nov;51(5):615-25. doi: 10.1165/rcmb.2014-0049OC.


Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.

Shibata T, Habiel DM, Coelho AL, Kunkel SL, Lukacs NW, Hogaboam CM.

J Immunol. 2014 Apr 15;192(8):3569-81. doi: 10.4049/jimmunol.1302766. Epub 2014 Mar 21.

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