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Items: 1 to 50 of 94

1.

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism.

Ruprecht JJ, Kunji ERS.

Trends Biochem Sci. 2019 Nov 28. pii: S0968-0004(19)30229-4. doi: 10.1016/j.tibs.2019.11.001. [Epub ahead of print] Review.

2.

Comment on "Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry".

Hirst J, Kunji ERS, Walker JE.

Science. 2019 Nov 8;366(6466). pii: eaaw9830. doi: 10.1126/science.aaw9830. Epub 2019 Nov 7.

PMID:
31699909
3.

Structural changes in the transport cycle of the mitochondrial ADP/ATP carrier.

Ruprecht JJ, Kunji ER.

Curr Opin Struct Biol. 2019 Aug;57:135-144. doi: 10.1016/j.sbi.2019.03.029. Epub 2019 Apr 28. Review.

4.

Correction: Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease.

Boczonadi V, King MS, Smith AC, Olahova M, Bansagi B, Roos A, Eyassu F, Borchers C, Ramesh V, Lochmüller H, Polvikoski T, Whittaker RG, Pyle A, Griffin H, Taylor RW, Chinnery PF, Robinson AJ, Kunji ERS, Horvath R.

Genet Med. 2019 Sep;21(9):2163-2164. doi: 10.1038/s41436-019-0506-1.

PMID:
31028354
5.

The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state.

Tavoulari S, Thangaratnarajah C, Mavridou V, Harbour ME, Martinou JC, Kunji ER.

EMBO J. 2019 May 15;38(10). pii: e100785. doi: 10.15252/embj.2018100785. Epub 2019 Apr 12.

6.

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier.

Ruprecht JJ, King MS, Zögg T, Aleksandrova AA, Pardon E, Crichton PG, Steyaert J, Kunji ERS.

Cell. 2019 Jan 24;176(3):435-447.e15. doi: 10.1016/j.cell.2018.11.025. Epub 2019 Jan 2.

7.

Screening of candidate substrates and coupling ions of transporters by thermostability shift assays.

Majd H, King MS, Palmer SM, Smith AC, Elbourne LD, Paulsen IT, Sharples D, Henderson PJ, Kunji ER.

Elife. 2018 Oct 15;7. pii: e38821. doi: 10.7554/eLife.38821.

8.

Calcium-regulated mitochondrial ATP-Mg/Pi carriers evolved from a fusion of an EF-hand regulatory domain with a mitochondrial ADP/ATP carrier-like domain.

Harborne SPD, Kunji ERS.

IUBMB Life. 2018 Dec;70(12):1222-1232. doi: 10.1002/iub.1931. Epub 2018 Oct 3. Review.

9.

Publisher Correction: Concerns with yeast mitochondrial ADP/ATP carrier's integrity in DPC.

King MS, Crichton PG, Ruprecht JJ, Kunji ERS.

Nat Struct Mol Biol. 2018 Oct;25(10):988. doi: 10.1038/s41594-018-0138-1.

PMID:
30218104
10.

Concerns with yeast mitochondrial ADP/ATP carrier's integrity in DPC.

King MS, Crichton PG, Ruprecht JJ, Kunji ERS.

Nat Struct Mol Biol. 2018 Sep;25(9):747-749. doi: 10.1038/s41594-018-0125-6. No abstract available. Erratum in: Nat Struct Mol Biol. 2018 Oct;25(10):988.

PMID:
30177757
11.

The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism.

Hofherr A, Seger C, Fitzpatrick F, Busch T, Michel E, Luan J, Osterried L, Linden F, Kramer-Zucker A, Wakimoto B, Schütze C, Wiedemann N, Artati A, Adamski J, Walz G, Kunji ERS, Montell C, Watnick T, Köttgen M.

PLoS Biol. 2018 Aug 6;16(8):e2005651. doi: 10.1371/journal.pbio.2005651. eCollection 2018 Aug.

12.

Expanding the phenotype of de novo SLC25A4-linked mitochondrial disease to include mild myopathy.

King MS, Thompson K, Hopton S, He L, Kunji ERS, Taylor RW, Ortiz-Gonzalez XR.

Neurol Genet. 2018 Jul 20;4(4):e256. doi: 10.1212/NXG.0000000000000256. eCollection 2018 Aug.

13.

Transporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites.

Dean P, Sendra KM, Williams TA, Watson AK, Major P, Nakjang S, Kozhevnikova E, Goldberg AV, Kunji ERS, Hirt RP, Embley TM.

Nat Commun. 2018 Apr 27;9(1):1709. doi: 10.1038/s41467-018-03923-4.

14.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.

Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28.

15.

Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease.

Boczonadi V, King MS, Smith AC, Olahova M, Bansagi B, Roos A, Eyassu F, Borchers C, Ramesh V, Lochmüller H, Polvikoski T, Whittaker RG, Pyle A, Griffin H, Taylor RW, Chinnery PF, Robinson AJ, Kunji ERS, Horvath R.

Genet Med. 2018 Oct;20(10):1224-1235. doi: 10.1038/gim.2017.251. Epub 2018 Mar 8. Erratum in: Genet Med. 2019 Sep;21(9):2163-2164.

16.

Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies.

Chipot C, Dehez F, Schnell JR, Zitzmann N, Pebay-Peyroula E, Catoire LJ, Miroux B, Kunji ERS, Veglia G, Cross TA, Schanda P.

Chem Rev. 2018 Apr 11;118(7):3559-3607. doi: 10.1021/acs.chemrev.7b00570. Epub 2018 Feb 28. Review.

17.

How Detergent Impacts Membrane Proteins: Atomic-Level Views of Mitochondrial Carriers in Dodecylphosphocholine.

Kurauskas V, Hessel A, Ma P, Lunetti P, Weinhäupl K, Imbert L, Brutscher B, King MS, Sounier R, Dolce V, Kunji ERS, Capobianco L, Chipot C, Dehez F, Bersch B, Schanda P.

J Phys Chem Lett. 2018 Mar 1;9(5):933-938. doi: 10.1021/acs.jpclett.8b00269. Epub 2018 Feb 8.

18.

Cardiolipin dynamics and binding to conserved residues in the mitochondrial ADP/ATP carrier.

Duncan AL, Ruprecht JJ, Kunji ERS, Robinson AJ.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):1035-1045. doi: 10.1016/j.bbamem.2018.01.017. Epub 2018 Jan 31.

19.

Mitochondrial ADP/ATP Carrier in Dodecylphosphocholine Binds Cardiolipins with Non-native Affinity.

Dehez F, Schanda P, King MS, Kunji ERS, Chipot C.

Biophys J. 2017 Dec 5;113(11):2311-2315. doi: 10.1016/j.bpj.2017.09.019. Epub 2017 Oct 20.

20.

Pathogenic mutations of the human mitochondrial citrate carrier SLC25A1 lead to impaired citrate export required for lipid, dolichol, ubiquinone and sterol synthesis.

Majd H, King MS, Smith AC, Kunji ERS.

Biochim Biophys Acta Bioenerg. 2018 Jan;1859(1):1-7. doi: 10.1016/j.bbabio.2017.10.002. Epub 2017 Oct 12.

21.

Modelling the free energy profile of the mitochondrial ADP/ATP carrier.

Springett R, King MS, Crichton PG, Kunji ERS.

Biochim Biophys Acta Bioenerg. 2017 Nov;1858(11):906-914. doi: 10.1016/j.bbabio.2017.05.006. Epub 2017 May 26.

22.

Calcium regulation of the human mitochondrial ATP-Mg/Pi carrier SLC25A24 uses a locking pin mechanism.

Harborne SP, King MS, Crichton PG, Kunji ER.

Sci Rep. 2017 Mar 28;7:45383. doi: 10.1038/srep45383.

23.

Expression and putative role of mitochondrial transport proteins in cancer.

Lytovchenko O, Kunji ERS.

Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):641-654. doi: 10.1016/j.bbabio.2017.03.006. Epub 2017 Mar 22. Review.

24.

The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism.

Crichton PG, Lee Y, Kunji ER.

Biochimie. 2017 Mar;134:35-50. doi: 10.1016/j.biochi.2016.12.016. Epub 2017 Jan 3. Review.

25.

Recurrent De Novo Dominant Mutations in SLC25A4 Cause Severe Early-Onset Mitochondrial Disease and Loss of Mitochondrial DNA Copy Number.

Thompson K, Majd H, Dallabona C, Reinson K, King MS, Alston CL, He L, Lodi T, Jones SA, Fattal-Valevski A, Fraenkel ND, Saada A, Haham A, Isohanni P, Vara R, Barbosa IA, Simpson MA, Deshpande C, Puusepp S, Bonnen PE, Rodenburg RJ, Suomalainen A, Õunap K, Elpeleg O, Ferrero I, McFarland R, Kunji ERS, Taylor RW.

Am J Hum Genet. 2016 Dec 1;99(6):1405. doi: 10.1016/j.ajhg.2016.11.001. No abstract available.

26.

Corrigendum to "The transport mechanism of the mitochondrial ADP/ATP carrier" [Biochim. Biophys. Acta 1863/10 (2016) 2379-2393].

Kunji ER, Aleksandrova A, King MS, Majd H, Ashton VL, Cerson E, Springett R, Kibalchenko M, Tavoulari S, Crichton PG, Ruprecht JJ.

Biochim Biophys Acta. 2016 Dec;1863(12):3169. doi: 10.1016/j.bbamcr.2016.09.021. Epub 2016 Oct 6. No abstract available.

27.

Corrigendum to "Formation of a cytoplasmic salt bridge network in the matrix state is a fundamental step in the transport mechanism of the mitochondrial ADP/ATP carrier" [Biochim. Biophys. Acta 1857 (2016) 14-22].

King MS, Kerr M, Crichton PG, Springett R, Kunji ER.

Biochim Biophys Acta. 2016 Dec;1857(12):1949. doi: 10.1016/j.bbabio.2016.09.013. Epub 2016 Oct 2. No abstract available.

28.

Recurrent De Novo Dominant Mutations in SLC25A4 Cause Severe Early-Onset Mitochondrial Disease and Loss of Mitochondrial DNA Copy Number.

Thompson K, Majd H, Dallabona C, Reinson K, King MS, Alston CL, He L, Lodi T, Jones SA, Fattal-Valevski A, Fraenkel ND, Saada A, Haham A, Isohanni P, Vara R, Barbosa IA, Simpson MA, Deshpande C, Puusepp S, Bonnen PE, Rodenburg RJ, Suomalainen A, Õunap K, Elpeleg O, Ferrero I, McFarland R, Kunji ER, Taylor RW.

Am J Hum Genet. 2016 Oct 6;99(4):860-876. doi: 10.1016/j.ajhg.2016.08.014. Epub 2016 Sep 29. Erratum in: Am J Hum Genet. 2016 Dec 1;99(6):1405.

29.

Membrane Protein Production in Lactococcus lactis for Functional Studies.

Seigneurin-Berny D, King MS, Sautron E, Moyet L, Catty P, André F, Rolland N, Kunji ER, Frelet-Barrand A.

Methods Mol Biol. 2016;1432:79-101. doi: 10.1007/978-1-4939-3637-3_6.

PMID:
27485331
30.

The transport mechanism of the mitochondrial ADP/ATP carrier.

Kunji ER, Aleksandrova A, King MS, Majd H, Ashton VL, Cerson E, Springett R, Kibalchenko M, Tavoulari S, Crichton PG, Ruprecht JJ.

Biochim Biophys Acta. 2016 Oct;1863(10):2379-93. doi: 10.1016/j.bbamcr.2016.03.015. Epub 2016 Mar 19. Review. Erratum in: Biochim Biophys Acta. 2016 Dec;1863(12 ):3169.

31.

Formation of a cytoplasmic salt bridge network in the matrix state is a fundamental step in the transport mechanism of the mitochondrial ADP/ATP carrier.

King MS, Kerr M, Crichton PG, Springett R, Kunji ERS.

Biochim Biophys Acta. 2016 Jan;1857(1):14-22. doi: 10.1016/j.bbabio.2015.09.013. Epub 2015 Oct 24. Erratum in: Biochim Biophys Acta. 2016 Dec;1857(12 ):1949.

32.

Calcium-induced conformational changes in the regulatory domain of the human mitochondrial ATP-Mg/Pi carrier.

Harborne SP, Ruprecht JJ, Kunji ER.

Biochim Biophys Acta. 2015 Oct;1847(10):1245-53. doi: 10.1016/j.bbabio.2015.07.002. Epub 2015 Jul 9.

33.

Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin.

Lee Y, Willers C, Kunji ER, Crichton PG.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6973-8. doi: 10.1073/pnas.1503833112. Epub 2015 May 18.

34.

Membrane protein expression in Lactococcus lactis.

King MS, Boes C, Kunji ER.

Methods Enzymol. 2015;556:77-97. doi: 10.1016/bs.mie.2014.12.009. Epub 2015 Mar 20.

PMID:
25857778
35.

Trends in thermostability provide information on the nature of substrate, inhibitor, and lipid interactions with mitochondrial carriers.

Crichton PG, Lee Y, Ruprecht JJ, Cerson E, Thangaratnarajah C, King MS, Kunji ER.

J Biol Chem. 2015 Mar 27;290(13):8206-17. doi: 10.1074/jbc.M114.616607. Epub 2015 Feb 4.

36.

The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione.

Booty LM, King MS, Thangaratnarajah C, Majd H, James AM, Kunji ER, Murphy MP.

FEBS Lett. 2015 Feb 27;589(5):621-8. doi: 10.1016/j.febslet.2015.01.027. Epub 2015 Jan 28.

37.

Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites.

Heinz E, Hacker C, Dean P, Mifsud J, Goldberg AV, Williams TA, Nakjang S, Gregory A, Hirt RP, Lucocq JM, Kunji ER, Embley TM.

PLoS Pathog. 2014 Dec 4;10(12):e1004547. doi: 10.1371/journal.ppat.1004547. eCollection 2014 Dec.

38.

Mitochondrial pyruvate import and its effects on homeostasis.

Vanderperre B, Bender T, Kunji ER, Martinou JC.

Curr Opin Cell Biol. 2015 Apr;33:35-41. doi: 10.1016/j.ceb.2014.10.008. Epub 2014 Nov 15. Review.

PMID:
25463844
39.

Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.

Thangaratnarajah C, Ruprecht JJ, Kunji ER.

Nat Commun. 2014 Nov 20;5:5491. doi: 10.1038/ncomms6491.

40.

Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism.

Ruprecht JJ, Hellawell AM, Harding M, Crichton PG, McCoy AJ, Kunji ER.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E426-34. doi: 10.1073/pnas.1320692111. Epub 2014 Jan 13.

41.

Lipid, detergent, and Coomassie Blue G-250 affect the migration of small membrane proteins in blue native gels: mitochondrial carriers migrate as monomers not dimers.

Crichton PG, Harding M, Ruprecht JJ, Lee Y, Kunji ER.

J Biol Chem. 2013 Jul 26;288(30):22163-73. doi: 10.1074/jbc.M113.484329. Epub 2013 Jun 6.

42.

The substrate specificity of the human ADP/ATP carrier AAC1.

Mifsud J, Ravaud S, Krammer EM, Chipot C, Kunji ER, Pebay-Peyroula E, Dehez F.

Mol Membr Biol. 2013 Mar;30(2):160-8. doi: 10.3109/09687688.2012.745175. Epub 2012 Nov 23.

PMID:
23173940
43.

The substrate specificity of mitochondrial carriers: mutagenesis revisited.

Monné M, Palmieri F, Kunji ER.

Mol Membr Biol. 2013 Mar;30(2):149-59. doi: 10.3109/09687688.2012.737936. Epub 2012 Nov 5.

PMID:
23121155
44.

Identification and functional expression of the mitochondrial pyruvate carrier.

Herzig S, Raemy E, Montessuit S, Veuthey JL, Zamboni N, Westermann B, Kunji ER, Martinou JC.

Science. 2012 Jul 6;337(6090):93-6. doi: 10.1126/science.1218530. Epub 2012 May 24.

45.

Online monitoring of biomass accumulation in recombinant yeast cultures.

Palmer SM, Kunji ER.

Methods Mol Biol. 2012;866:165-79. doi: 10.1007/978-1-61779-770-5_14.

PMID:
22454122
46.

Monitoring the biomass accumulation of recombinant yeast cultures: offline estimations of dry cell mass and cell counts.

Palmer SM, Kunji ER.

Methods Mol Biol. 2012;866:157-63. doi: 10.1007/978-1-61779-770-5_13.

PMID:
22454121
47.

Online analysis and process control in recombinant protein production (review).

Palmer SM, Kunji ER.

Methods Mol Biol. 2012;866:129-55. doi: 10.1007/978-1-61779-770-5_12. Review.

PMID:
22454120
48.

Mitochondrial carrier homolog 2 (MTCH2): the recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis.

Robinson AJ, Kunji ER, Gross A.

Exp Cell Res. 2012 Jul 1;318(11):1316-23. doi: 10.1016/j.yexcr.2012.01.026. Epub 2012 Feb 3. Review.

PMID:
22326460
49.

Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site.

Monné M, Miniero DV, Daddabbo L, Robinson AJ, Kunji ER, Palmieri F.

J Biol Chem. 2012 Mar 9;287(11):7925-34. doi: 10.1074/jbc.M111.324855. Epub 2012 Jan 19.

50.

Overcoming barriers to membrane protein structure determination.

Bill RM, Henderson PJ, Iwata S, Kunji ER, Michel H, Neutze R, Newstead S, Poolman B, Tate CG, Vogel H.

Nat Biotechnol. 2011 Apr;29(4):335-40. doi: 10.1038/nbt.1833. Review.

PMID:
21478852

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