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Items: 1 to 50 of 93

1.

Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis.

Eustace AD, McNaughton EF, King S, Kehoe O, Kungl A, Mattey D, Nobbs AH, Williams N, Middleton J.

Arthritis Res Ther. 2019 Jul 12;21(1):172. doi: 10.1186/s13075-019-1939-2.

2.

Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex.

Merle DA, Witternigg A, Tam-Amersdorfer C, Hartlmüller C, Spreitzer E, Schrank E, Wagner-Lichtenegger S, Werzer O, Zangger K, Kungl AJ, Madl T, Meyer NH, Falsone SF.

J Mol Biol. 2019 Jun 28;431(14):2581-2598. doi: 10.1016/j.jmb.2019.04.031. Epub 2019 Apr 26.

PMID:
31034892
3.

Demonstrating Advantages of Neuromorphic Computation: A Pilot Study.

Wunderlich T, Kungl AF, Müller E, Hartel A, Stradmann Y, Aamir SA, Grübl A, Heimbrecht A, Schreiber K, Stöckel D, Pehle C, Billaudelle S, Kiene G, Mauch C, Schemmel J, Meier K, Petrovici MA.

Front Neurosci. 2019 Mar 26;13:260. doi: 10.3389/fnins.2019.00260. eCollection 2019.

4.

Molecular dynamics simulations of the chemokine CCL2 in complex with pull down-derived heparan sulfate hexasaccharides.

Winkler S, Derler R, Gesslbauer B, Krieger E, Kungl AJ.

Biochim Biophys Acta Gen Subj. 2019 Mar;1863(3):528-533. doi: 10.1016/j.bbagen.2018.12.014. Epub 2018 Dec 23.

PMID:
30586626
5.

Therapeutic strategies to target microbial protein-glycosaminoglycan interactions.

Almer J, Gesslbauer B, Kungl AJ.

Biochem Soc Trans. 2018 Dec 17;46(6):1505-1515. doi: 10.1042/BST20170485. Epub 2018 Oct 31. Review.

PMID:
30381333
6.

Anti-inflammatory effects of the GAG-binding CXCL9(74-103) peptide in dinitrofluorobenzene-induced contact hypersensitivity in mice.

Vanheule V, Crijns H, Poosti F, Ruytinx P, Berghmans N, Gerlza T, Ronsse I, Pörtner N, Matthys P, Kungl AJ, Opdenakker G, Struyf S, Proost P.

Clin Exp Allergy. 2018 Oct;48(10):1333-1344. doi: 10.1111/cea.13227. Epub 2018 Aug 14.

PMID:
29978510
7.

Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis.

McNaughton EF, Eustace AD, King S, Sessions RB, Kay A, Farris M, Broadbridge R, Kehoe O, Kungl AJ, Middleton J.

J Immunol. 2018 May 1;200(9):3201-3217. doi: 10.4049/jimmunol.1701187. Epub 2018 Mar 23.

8.

Glycosaminoglycan-Mediated Downstream Signaling of CXCL8 Binding to Endothelial Cells.

Derler R, Gesslbauer B, Weber C, Strutzmann E, Miller I, Kungl A.

Int J Mol Sci. 2017 Dec 4;18(12). pii: E2605. doi: 10.3390/ijms18122605.

9.

CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions.

Vanheule V, Boff D, Mortier A, Janssens R, Petri B, Kolaczkowska E, Kubes P, Berghmans N, Struyf S, Kungl AJ, Teixeira MM, Amaral FA, Proost P.

Front Immunol. 2017 May 10;8:530. doi: 10.3389/fimmu.2017.00530. eCollection 2017.

10.

Glycosaminoglycans are important mediators of neutrophilic inflammation in vivo.

Gschwandtner M, Strutzmann E, Teixeira MM, Anders HJ, Diedrichs-Möhring M, Gerlza T, Wildner G, Russo RC, Adage T, Kungl AJ.

Cytokine. 2017 Mar;91:65-73. doi: 10.1016/j.cyto.2016.12.008. Epub 2016 Dec 21.

PMID:
28011398
11.

Profiling the Membrane and Glycosaminoglycan-Binding Proteomes of Moraxella catarrhalis.

Karner A, Gesslbauer B, Spreitzer A, Almer J, Smidt M, Schüler W, Fartmann B, Zimmermann W, Meinke A, Kungl AJ.

J Proteome Res. 2016 Sep 2;15(9):3055-97. doi: 10.1021/acs.jproteome.6b00187. Epub 2016 Jul 29.

PMID:
27403532
12.

Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation.

Gschwandtner M, Piccinini AM, Gerlza T, Adage T, Kungl AJ.

Neurosci Lett. 2016 Jul 28;626:164-73. doi: 10.1016/j.neulet.2016.05.037. Epub 2016 May 19.

PMID:
27212623
13.

Exploring the glycosaminoglycan-protein interaction network by glycan-mediated pull-down proteomics.

Gesslbauer B, Derler R, Handwerker C, Seles E, Kungl AJ.

Electrophoresis. 2016 Jun;37(11):1437-47. doi: 10.1002/elps.201600043. Epub 2016 Apr 9.

PMID:
26970331
14.

Preparation and Characterization of Glycosaminoglycan Chemokine Coreceptors.

Kitic N, Gschwandtner M, Derler R, Gerlza T, Kungl AJ.

Methods Enzymol. 2016;570:517-38. doi: 10.1016/bs.mie.2015.09.018. Epub 2015 Nov 14.

PMID:
26921960
15.

Targeting of CCL2-CCR2-Glycosaminoglycan Axis Using a CCL2 Decoy Protein Attenuates Metastasis through Inhibition of Tumor Cell Seeding.

Roblek M, Strutzmann E, Zankl C, Adage T, Heikenwalder M, Atlic A, Weis R, Kungl A, Borsig L.

Neoplasia. 2016 Jan;18(1):49-59. doi: 10.1016/j.neo.2015.11.013.

16.

PA401, a novel CXCL8-based biologic therapeutic with increased glycosaminoglycan binding, reduces bronchoalveolar lavage neutrophils and systemic inflammatory markers in a murine model of LPS-induced lung inflammation.

Adage T, Del Bene F, Fiorentini F, Doornbos RP, Zankl C, Bartley MR, Kungl AJ.

Cytokine. 2015 Dec;76(2):433-441. doi: 10.1016/j.cyto.2015.08.006. Epub 2015 Aug 21.

PMID:
26303011
17.

Glycosaminoglycan silencing by engineered CXCL12 variants.

Gschwandtner M, Trinker MU, Hecher B, Adage T, Ali S, Kungl AJ.

FEBS Lett. 2015 Sep 14;589(19 Pt B):2819-24. doi: 10.1016/j.febslet.2015.07.052. Epub 2015 Aug 20.

18.

The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74-103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice.

Vanheule V, Janssens R, Boff D, Kitic N, Berghmans N, Ronsse I, Kungl AJ, Amaral FA, Teixeira MM, Van Damme J, Proost P, Mortier A.

J Biol Chem. 2015 Aug 28;290(35):21292-304. doi: 10.1074/jbc.M115.649855. Epub 2015 Jul 16.

19.

Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA.

Gallmetzer A, Silvestrini L, Schinko T, Gesslbauer B, Hortschansky P, Dattenböck C, Muro-Pastor MI, Kungl A, Brakhage AA, Scazzocchio C, Strauss J.

PLoS Genet. 2015 Jul 1;11(7):e1005297. doi: 10.1371/journal.pgen.1005297. eCollection 2015 Jul.

20.

Designing a mutant CCL2-HSA chimera with high glycosaminoglycan-binding affinity and selectivity.

Gerlza T, Winkler S, Atlic A, Zankl C, Konya V, Kitic N, Strutzmann E, Knebl K, Adage T, Heinemann A, Weis R, Kungl AJ.

Protein Eng Des Sel. 2015 Aug;28(8):231-40. doi: 10.1093/protein/gzv025. Epub 2015 May 11.

PMID:
25969511
21.

Targeting glycosaminoglycans in the lung by an engineered CXCL8 as a novel therapeutic approach to lung inflammation.

Adage T, Konya V, Weber C, Strutzmann E, Fuchs T, Zankl C, Gerlza T, Jeremic D, Heinemann A, Kungl AJ.

Eur J Pharmacol. 2015 Feb 5;748:83-92. doi: 10.1016/j.ejphar.2014.12.019. Epub 2014 Dec 29.

PMID:
25554213
22.

The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis.

McElvaney OJ, O'Reilly N, White M, Lacey N, Pohl K, Gerlza T, Bergin DA, Kerr H, McCarthy C, O'Brien ME, Adage T, Kungl AJ, Reeves EP, McElvaney NG.

Mol Immunol. 2015 Feb;63(2):550-8. doi: 10.1016/j.molimm.2014.10.013. Epub 2014 Nov 2.

PMID:
25453468
23.

A combinatorial approach to biophysically characterise chemokine-glycan binding affinities for drug development.

Gerlza T, Hecher B, Jeremic D, Fuchs T, Gschwandtner M, Falsone A, Gesslbauer B, Kungl AJ.

Molecules. 2014 Jul 22;19(7):10618-34. doi: 10.3390/molecules190710618.

24.

Bacterial expression and functional reconstitution of human heparanase.

Winkler S, Schweiger D, Wei Z, Rajkovic E, Kungl AJ.

Carbohydr Res. 2014 May 7;389:72-7. doi: 10.1016/j.carres.2014.01.002. Epub 2014 Jan 14.

PMID:
24656445
25.

Designing CXCL8-based decoy proteins with strong anti-inflammatory activity in vivo.

Falsone A, Wabitsch V, Geretti E, Potzinger H, Gerlza T, Robinson J, Adage T, Teixeira MM, Kungl AJ.

Biosci Rep. 2013 Sep 17;33(5). pii: e00068. doi: 10.1042/BSR20130069.

26.

Your fate is in your hands? Handedness, digit ratio (2D:4D), and selection to a national talent development system.

Baker J, Kungl AM, Pabst J, Strauß B, Büsch D, Schorer J.

Laterality. 2013;18(6):710-8. doi: 10.1080/1357650X.2012.755992. Epub 2013 Feb 28.

PMID:
23444944
27.

New targets for glycosaminoglycans and glycosaminoglycans as novel targets.

Gesslbauer B, Theuer M, Schweiger D, Adage T, Kungl AJ.

Expert Rev Proteomics. 2013 Feb;10(1):77-95. doi: 10.1586/epr.12.75. Review.

PMID:
23414361
28.

Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats.

Nürnberger S, Miller I, Duvigneau JC, Kavanagh ET, Gupta S, Hartl RT, Hori O, Gesslbauer B, Samali A, Kungl A, Redl H, Kozlov AV.

Am J Physiol Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1373-83. doi: 10.1152/ajpgi.00056.2012. Epub 2012 Oct 11.

29.

SERF protein is a direct modifier of amyloid fiber assembly.

Falsone SF, Meyer NH, Schrank E, Leitinger G, Pham CL, Fodero-Tavoletti MT, Holmberg M, Dulle M, Scicluna B, Gesslbauer B, Rückert HM, Wagner GE, Merle DA, Nollen EA, Kungl AJ, Hill AF, Cappai R, Zangger K.

Cell Rep. 2012 Aug 30;2(2):358-71. doi: 10.1016/j.celrep.2012.06.012. Epub 2012 Jul 26.

30.

Structure-based design of decoy chemokines as a way to explore the pharmacological potential of glycosaminoglycans.

Adage T, Piccinini AM, Falsone A, Trinker M, Robinson J, Gesslbauer B, Kungl AJ.

Br J Pharmacol. 2012 Nov;167(6):1195-205. doi: 10.1111/j.1476-5381.2012.02089.x. Review.

31.

Comparative membrane proteome analysis of three Borrelia species.

Gesslbauer B, Poljak A, Handwerker C, Schüler W, Schwendenwein D, Weber C, Lundberg U, Meinke A, Kungl AJ.

Proteomics. 2012 Mar;12(6):845-58. doi: 10.1002/pmic.201100211.

PMID:
22539435
32.

The neurotransmitter serotonin interrupts α-synuclein amyloid maturation.

Falsone SF, Leitinger G, Karner A, Kungl AJ, Kosol S, Cappai R, Zangger K.

Biochim Biophys Acta. 2011 May;1814(5):553-61. doi: 10.1016/j.bbapap.2011.02.008. Epub 2011 Mar 2.

33.

A new monocyte chemotactic protein-1/chemokine CC motif ligand-2 competitor limiting neointima formation and myocardial ischemia/reperfusion injury in mice.

Liehn EA, Piccinini AM, Koenen RR, Soehnlein O, Adage T, Fatu R, Curaj A, Popescu A, Zernecke A, Kungl AJ, Weber C.

J Am Coll Cardiol. 2010 Nov 23;56(22):1847-57. doi: 10.1016/j.jacc.2010.04.066.

34.

Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans.

Severin IC, Gaudry JP, Johnson Z, Kungl A, Jansma A, Gesslbauer B, Mulloy B, Power C, Proudfoot AE, Handel T.

J Biol Chem. 2010 Jun 4;285(23):17713-24. doi: 10.1074/jbc.M109.082552. Epub 2010 Apr 2.

35.

Rationally evolving MCP-1/CCL2 into a decoy protein with potent anti-inflammatory activity in vivo.

Piccinini AM, Knebl K, Rek A, Wildner G, Diedrichs-Möhring M, Kungl AJ.

J Biol Chem. 2010 Mar 19;285(12):8782-92. doi: 10.1074/jbc.M109.043299. Epub 2010 Jan 22.

36.

A novel CXCL8 protein-based antagonist in acute experimental renal allograft damage.

Bedke J, Nelson PJ, Kiss E, Muenchmeier N, Rek A, Behnes CL, Gretz N, Kungl AJ, Gröne HJ.

Mol Immunol. 2010 Feb;47(5):1047-57. doi: 10.1016/j.molimm.2009.11.012. Epub 2009 Dec 11.

PMID:
20004976
37.

The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein.

Falsone SF, Kungl AJ, Rek A, Cappai R, Zangger K.

J Biol Chem. 2009 Nov 6;284(45):31190-9. doi: 10.1074/jbc.M109.057240. Epub 2009 Sep 15.

38.

Chemokine degradation by the Group A streptococcal serine proteinase ScpC can be reconstituted in vitro and requires two separate domains.

Fritzer A, Noiges B, Schweiger D, Rek A, Kungl AJ, von Gabain A, Nagy E, Meinke AL.

Biochem J. 2009 Aug 27;422(3):533-42. doi: 10.1042/BJ20090278.

PMID:
19552626
39.

The basic residue cluster (55)KKWVR(59) in CCL5 is required for in vivo biologic function.

Segerer S, Johnson Z, Rek A, Baltus T, von Hundelshausen P, Kungl AJ, Proudfoot AE, Weber C, Nelson PJ.

Mol Immunol. 2009 Aug;46(13):2533-8. doi: 10.1016/j.molimm.2009.05.015. Epub 2009 Jun 12.

PMID:
19524301
40.

A biophysical insight into the RANTES-glycosaminoglycan interaction.

Rek A, Brandner B, Geretti E, Kungl AJ.

Biochim Biophys Acta. 2009 Apr;1794(4):577-82. doi: 10.1016/j.bbapap.2009.01.001.

PMID:
19455751
41.

Physical activity and successful aging in Canadian older adults.

Baker J, Meisner BA, Logan AJ, Kungl AM, Weir P.

J Aging Phys Act. 2009 Apr;17(2):223-35.

PMID:
19451670
42.

Engineering the glycosaminoglycan-binding affinity, kinetics and oligomerization behavior of RANTES: a tool for generating chemokine-based glycosaminoglycan antagonists.

Brandner B, Rek A, Diedrichs-Möhring M, Wildner G, Kungl AJ.

Protein Eng Des Sel. 2009 Jun;22(6):367-73. doi: 10.1093/protein/gzp013. Epub 2009 May 4.

PMID:
19414521
43.

Therapeutically targeting protein-glycan interactions.

Rek A, Krenn E, Kungl AJ.

Br J Pharmacol. 2009 Jul;157(5):686-94. doi: 10.1111/j.1476-5381.2009.00226.x. Epub 2009 Apr 9. Review.

44.

Endotoxin causes functional endoplasmic reticulum failure, possibly mediated by mitochondria.

Kozlov AV, Duvigneau JC, Miller I, Nürnberger S, Gesslbauer B, Kungl A, Ohlinger W, Hartl RT, Gille L, Staniek K, Gregor W, Haindl S, Redl H.

Biochim Biophys Acta. 2009 Jun;1792(6):521-30. doi: 10.1016/j.bbadis.2009.03.004. Epub 2009 Mar 25.

45.

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice.

Koenen RR, von Hundelshausen P, Nesmelova IV, Zernecke A, Liehn EA, Sarabi A, Kramp BK, Piccinini AM, Paludan SR, Kowalska MA, Kungl AJ, Hackeng TM, Mayo KH, Weber C.

Nat Med. 2009 Jan;15(1):97-103. doi: 10.1038/nm.1898. Epub 2009 Jan 4.

PMID:
19122657
46.

Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives.

Weis R, Schweiger K, Faist J, Rajkovic E, Kungl AJ, Fabian WM, Schunack W, Seebacher W.

Bioorg Med Chem. 2008 Dec 15;16(24):10326-31. doi: 10.1016/j.bmc.2008.10.042. Epub 2008 Oct 22.

PMID:
18977145
47.

Glycanogenomics: a qPCR-approach to investigate biological glycan function.

Krenn EC, Wille I, Gesslbauer B, Poteser M, van Kuppevelt TH, Kungl AJ.

Biochem Biophys Res Commun. 2008 Oct 24;375(3):297-302. doi: 10.1016/j.bbrc.2008.07.144. Epub 2008 Aug 8.

PMID:
18692483
48.

Coimmunoprecipitation and proteomic analyses.

Falsone SF, Gesslbauer B, Kungl AJ.

Methods Mol Biol. 2008;439:291-308. doi: 10.1007/978-1-59745-188-8_20.

PMID:
18370111
49.

Lessons from the stem cell proteome.

Gesslbauer B, Krenn E, Zenzmaier C, Preisegger KH, Kungl AJ.

Curr Stem Cell Res Ther. 2006 Sep;1(3):395-409. Review.

PMID:
18220883
50.

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