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Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells.

Wang W, Lu G, Su X, Tang C, Li H, Xiong Z, Leung CK, Wong MS, Liu H, Ma JL, Cheung HH, Kung HF, Chen ZJ, Chan WY.

Cell Death Dis. 2020 Feb 7;11(2):107. doi: 10.1038/s41419-020-2271-0.


Synthesis and evaluation of novel radioiodinated PSMA targeting ligands for potential radiotherapy of prostate cancer.

Yao X, Zha Z, Ploessl K, Choi SR, Zhao R, Alexoff D, Zhu L, Kung HF.

Bioorg Med Chem. 2020 Mar 1;28(5):115319. doi: 10.1016/j.bmc.2020.115319. Epub 2020 Jan 20.


[68Ga]Ga-HBED-CC-DiAsp: A new renal function imaging agent.

Shi S, Zhang L, Wu Z, Zhang A, Hong H, Choi SR, Zhu L, Kung HF.

Nucl Med Biol. 2019 Dec 16;82-83:17-24. doi: 10.1016/j.nucmedbio.2019.12.005. [Epub ahead of print]


Synthesis of novel technetium-99m tricarbonyl-HBED-CC complexes and structural prediction in solution by density functional theory calculation.

Shi S, Yao L, Li L, Wu Z, Zha Z, Kung HF, Zhu L, Fang DC.

R Soc Open Sci. 2019 Nov 27;6(11):191247. doi: 10.1098/rsos.191247. eCollection 2019 Nov.


An improved preparation of [18 F]AV-45 by simplified solid-phase extraction purification.

Zhang L, Zhang A, Yao X, Zhang Y, Liu F, Hong H, Zha Z, Liu Y, Wu Z, Qiao J, Zhu L, Kung HF.

J Labelled Comp Radiopharm. 2019 Nov 7. doi: 10.1002/jlcr.3813. [Epub ahead of print]


Effect of Vacuum Packaging on Histamine Production in Japanese Spanish Mackerel (Scomberomorus niphonius) Stored at Various Temperatures.

Lee YC, Tseng PH, Hwang CC, Kung HF, Huang YL, Lin CS, Wei CI, Tsai YH.

J Food Prot. 2019 Nov;82(11):1931-1937. doi: 10.4315/0362-028X.JFP-19-143.


Determination of Histamine in Japanese Spanish Mackerel (Scomberomorus niphonius) Meat Implicated in a Foodborne Poisoning.

Hwang CC, Tseng PH, Lee YC, Kung HF, Huang CY, Chen HC, Tsai YH.

J Food Prot. 2019 Oct;82(10):1643-1649. doi: 10.4315/0362-028X.JFP-19-111.


[68Ga]Ga-P16-093 as a PSMA-Targeted PET Radiopharmaceutical for Detection of Cancer: Initial Evaluation and Comparison with [68Ga]Ga-PSMA-11 in Prostate Cancer Patients Presenting with Biochemical Recurrence.

Green MA, Hutchins GD, Bahler CD, Tann M, Mathias CJ, Territo W, Sims J, Polson H, Alexoff D, Eckelman WC, Kung HF, Fletcher JW.

Mol Imaging Biol. 2019 Aug 19. doi: 10.1007/s11307-019-01421-7. [Epub ahead of print]


The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer.

Dong C, Chen Y, Li H, Yang Y, Zhang H, Ke K, Shi XN, Liu X, Li L, Ma J, Kung HF, Chen C, Lin MC.

Int J Biol Sci. 2019 Jun 2;15(7):1523-1532. doi: 10.7150/ijbs.32625. eCollection 2019.


VMAT2 imaging agent, D6-[18F]FP-(+)-DTBZ: Improved radiosynthesis, purification by solid-phase extraction and characterization.

Zhao R, Zha Z, Yao X, Ploessl K, Choi SR, Liu F, Zhu L, Kung HF.

Nucl Med Biol. 2019 May - Jun;72-73:26-35. doi: 10.1016/j.nucmedbio.2019.07.002. Epub 2019 Jul 11.


Decreased Striatal Vesicular Monoamine Transporter Type 2 Correlates With the Nonmotor Symptoms in Parkinson Disease.

Shi X, Zhang Y, Xu S, Kung HF, Qiao H, Jiang L, Zhu L, Guo Q, Yi C, Luo G, Wu L, Pei Z, Wang J, Zhang X, Chen L.

Clin Nucl Med. 2019 Sep;44(9):707-713. doi: 10.1097/RLU.0000000000002664.


Optimization of solid-phase extraction (SPE) in the preparation of [18F]D3FSP: A new PET imaging agent for mapping Aβ plaques.

Yao X, Zha Z, Zhao R, Choi SR, Ploessl K, Liu F, Zhu L, Kung HF.

Nucl Med Biol. 2019 Apr;71:54-64. doi: 10.1016/j.nucmedbio.2019.05.002. Epub 2019 May 16.


Rapid screening of nine unradiolabeled candidate compounds as PET brain imaging agents using cassette-wave microdosing and LC-MS/MS.

Sun M, Xiao H, Hong H, Zhang A, Zhang Y, Liu Y, Zhu L, Kung HF, Qiao J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jul 15;1121:28-38. doi: 10.1016/j.jchromb.2019.05.006. Epub 2019 May 6.


Synthesis and preliminary evaluation of a novel glutamine derivative: (2S,4S)4-[18F]FEBGln.

Huang Y, Liu S, Wu R, Zhang L, Zhang Y, Hong H, Zhang A, Xiao H, Liu Y, Wu Z, Zhu L, Kung HF.

Bioorg Med Chem Lett. 2019 May 1;29(9):1047-1050. doi: 10.1016/j.bmcl.2019.03.012. Epub 2019 Mar 11.


Initial experience in synthesis of (2S,4R)-4-[18 F]fluoroglutamine for clinical application.

Zhang Y, Zhang L, Yang J, Wu Z, Ploessl K, Zha Z, Liu F, Xu X, Zhu H, Yang Z, Zhu L, Kung HF.

J Labelled Comp Radiopharm. 2019 May 15;62(5):209-214. doi: 10.1002/jlcr.3719. Epub 2019 Apr 1.


(2S,4R)-4-[18F]Fluoroglutamine as a PET Indicator for Bone Marrow Metabolism Dysfunctional: from Animal Experiments to Clinical Application.

Zhu H, Liu F, Zhang Y, Yang J, Xu X, Guo X, Liu T, Li N, Zhu L, Kung HF, Yang Z.

Mol Imaging Biol. 2019 Oct;21(5):945-953. doi: 10.1007/s11307-019-01319-4.


In Vivo Ester Hydrolysis as a New Approach in Development of Positron Emission Tomography Tracers for Imaging Hypoxia.

Zhang L, Yao X, Cao J, Hong H, Zhang A, Zhao R, Zhang Y, Zha Z, Liu Y, Qiao J, Zhu L, Kung HF.

Mol Pharm. 2019 Mar 4;16(3):1156-1166. doi: 10.1021/acs.molpharmaceut.8b01131. Epub 2019 Feb 20.


Imaging Brain Metastasis Patients With 18F-(2S,4R)-4-Fluoroglutamine.

Xu X, Zhu H, Liu F, Zhang Y, Yang J, Zhang L, Zhu L, Li N, Kung HF, Yang Z.

Clin Nucl Med. 2018 Nov;43(11):e392-e399. doi: 10.1097/RLU.0000000000002257.


Novel HDAC5-interacting motifs of Tbx3 are essential for the suppression of E-cadherin expression and for the promotion of metastasis in hepatocellular carcinoma.

Dong L, Dong Q, Chen Y, Li Y, Zhang B, Zhou F, Lyu X, Chen GG, Lai P, Kung HF, He ML.

Signal Transduct Target Ther. 2018 Aug 24;3:22. doi: 10.1038/s41392-018-0025-6. eCollection 2018.


Fluorine-18 labeled diphenyl sulfide derivatives for imaging serotonin transporter (SERT) in the brain.

Zhang Y, Liu F, Xiao H, Yao X, Li G, Choi SR, Ploessl K, Zha Z, Zhu L, Kung HF.

Nucl Med Biol. 2018 Nov;66:1-9. doi: 10.1016/j.nucmedbio.2018.06.008. Epub 2018 Jul 4.


FMNL1 mediates nasopharyngeal carcinoma cell aggressiveness by epigenetically upregulating MTA1.

Chen WH, Cai MY, Zhang JX, Wang FW, Tang LQ, Liao YJ, Jin XH, Wang CY, Guo L, Jiang YG, Ren CP, Mai HQ, Zeng MS, Kung HF, Qian CN, Xie D.

Oncogene. 2018 Nov;37(48):6243-6258. doi: 10.1038/s41388-018-0351-8. Epub 2018 Jul 16.


PET Imaging of 18F-(2 S,4 R)4-Fluoroglutamine Accumulation in Breast Cancer: From Xenografts to Patients.

Liu F, Xu X, Zhu H, Zhang Y, Yang J, Zhang L, Li N, Zhu L, Kung HF, Yang Z.

Mol Pharm. 2018 Aug 6;15(8):3448-3455. doi: 10.1021/acs.molpharmaceut.8b00430. Epub 2018 Jul 20.


Discovery of rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer.

Shi X, Li H, Shi A, Yao H, Ke K, Dong C, Zhu Y, Qin Y, Ding Y, He YH, Liu X, Li L, Lei L, Hai Q, Chen W, Leung KS, Wong MH, Kung HF, Lin MC.

Oncol Rep. 2018 Sep;40(3):1592-1600. doi: 10.3892/or.2018.6533. Epub 2018 Jun 27.


Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance.

Shi Y, Guryanova OA, Zhou W, Liu C, Huang Z, Fang X, Wang X, Chen C, Wu Q, He Z, Wang W, Zhang W, Jiang T, Liu Q, Chen Y, Wang W, Wu J, Kim L, Gimple RC, Feng H, Kung HF, Yu JS, Rich JN, Ping YF, Bian XW, Bao S.

Sci Transl Med. 2018 May 30;10(443). pii: eaah6816. doi: 10.1126/scitranslmed.aah6816.


Microvascular fractal dimension predicts prognosis and response to chemotherapy in glioblastoma: an automatic image analysis study.

Chen C, He ZC, Shi Y, Zhou W, Zhang X, Xiao HL, Wu HB, Yao XH, Luo WC, Cui YH, Bao S, Kung HF, Bian XW, Ping YF.

Lab Invest. 2018 Jul;98(7):924-934. doi: 10.1038/s41374-018-0055-2. Epub 2018 May 15.


Deuterium-substituted 2-(2'-((dimethylamino)methyl)-4'-[18 F](fluoropropoxy)phenylthio)benzenamine as a serotonin transporter imaging agent.

Liu F, Zhu L, Choi SR, Plössl K, Zha Z, Kung HF.

J Labelled Comp Radiopharm. 2018 Jun 30;61(8):576-585. doi: 10.1002/jlcr.3626. Epub 2018 May 16.


Large Intergenic Non-coding RNA-RoR Inhibits Aerobic Glycolysis of Glioblastoma Cells via Akt Pathway.

Li Y, He ZC, Liu Q, Zhou K, Shi Y, Yao XH, Zhang X, Kung HF, Ping YF, Bian XW.

J Cancer. 2018 Feb 23;9(5):880-889. doi: 10.7150/jca.20869. eCollection 2018.


Developing a cassette microdosing approach to enhance the throughput of PET imaging agent screening.

Xiao H, Sun M, Zhao R, Hong H, Zhang A, Zhang S, Liu F, Zhang Y, Liu Y, Zhu L, Kung HF, Qiao J.

J Pharm Biomed Anal. 2018 May 30;154:48-56. doi: 10.1016/j.jpba.2018.02.063. Epub 2018 Mar 3.


Alanine and glycine conjugates of (2S,4R)-4-[18F]fluoroglutamine for tumor imaging.

Zha Z, Ploessl K, Lieberman BP, Wang L, Kung HF.

Nucl Med Biol. 2018 May;60:19-28. doi: 10.1016/j.nucmedbio.2018.02.001. Epub 2018 Feb 13.


Synthesis and evaluation of a novel urea-based 68Ga-complex for imaging PSMA binding in tumor.

Zha Z, Ploessl K, Choi SR, Wu Z, Zhu L, Kung HF.

Nucl Med Biol. 2018 Apr;59:36-47. doi: 10.1016/j.nucmedbio.2017.12.007. Epub 2017 Dec 27.


In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of 18F-(2S,4R)-4-Fluoroglutamine.

Dunphy MPS, Harding JJ, Venneti S, Zhang H, Burnazi EM, Bromberg J, Omuro AM, Hsieh JJ, Mellinghoff IK, Staton K, Pressl C, Beattie BJ, Zanzonico PB, Gerecitano JF, Kelsen DP, Weber W, Lyashchenko SK, Kung HF, Lewis JS.

Radiology. 2018 May;287(2):667-675. doi: 10.1148/radiol.2017162610. Epub 2018 Jan 31.


Deuterated 18F-9-O-hexadeutero-3-fluoropropoxyl-(+)-dihydrotetrabenazine (D6-FP-(+)-DTBZ): A vesicular monoamine transporter 2 (VMAT2) imaging agent.

Liu F, Choi SR, Zha Z, Ploessl K, Zhu L, Kung HF.

Nucl Med Biol. 2018 Feb;57:42-49. doi: 10.1016/j.nucmedbio.2017.11.009. Epub 2017 Dec 6.


Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells.

Dong C, Yang R, Li H, Ke K, Luo C, Yang F, Shi XN, Zhu Y, Liu X, Wong MH, Lin G, Wang X, Leung KS, Kung HF, Chen C, Lin MC.

Sci Rep. 2017 Dec 21;7(1):17987. doi: 10.1038/s41598-017-18178-0.


Does the "freeze-all" policy allow for a better outcome in assisted reproductive techniques than the use of fresh embryo transfers? - A retrospective study on cumulative live birth rates.

Chang JC, Chen MJ, Guu HF, Chen YF, Yi YC, Kung HF, Chen LY, Chou MM.

Taiwan J Obstet Gynecol. 2017 Dec;56(6):775-780. doi: 10.1016/j.tjog.2017.10.013.


Stanniocalcin-1 augments stem-like traits of glioblastoma cells through binding and activating NOTCH1.

Li Y, He ZC, Zhang XN, Liu Q, Chen C, Zhu Z, Chen Q, Shi Y, Yao XH, Cui YH, Zhang X, Wang Y, Kung HF, Ping YF, Bian XW.

Cancer Lett. 2018 Mar 1;416:66-74. doi: 10.1016/j.canlet.2017.11.033. Epub 2017 Nov 28.


A glycolysis-based ten-gene signature correlates with the clinical outcome, molecular subtype and IDH1 mutation in glioblastoma.

Chen C, Shi Y, Li Y, He ZC, Zhou K, Zhang XN, Yang KD, Wu JR, Kung HF, Ping YF, Bian XW.

J Genet Genomics. 2017 Nov 20;44(11):519-530. doi: 10.1016/j.jgg.2017.05.007. Epub 2017 Sep 21.


Plasma miR-124 Is a Promising Candidate Biomarker for Human Intracerebral Hemorrhage Stroke.

Wang Z, Lu G, Sze J, Liu Y, Lin S, Yao H, Zhang J, Xie D, Liu Q, Kung HF, Lin MC, Poon WS.

Mol Neurobiol. 2018 Jul;55(7):5879-5888. doi: 10.1007/s12035-017-0808-8. Epub 2017 Nov 3.


The effect of vacuum packaging on histamine changes of milkfish sticks at various storage temperatures.

Kung HF, Lee YC, Lin CW, Huang YR, Cheng CA, Lin CM, Tsai YH.

J Food Drug Anal. 2017 Oct;25(4):812-818. doi: 10.1016/j.jfda.2016.12.009. Epub 2017 Feb 14.


Hygienic quality, adulteration of pork and histamine production by Raoultella ornithinolytica in milkfish dumpling.

Lee YC, Chen YF, Huang YL, Kung HF, Chen TY, Tsai YH.

J Food Drug Anal. 2016 Oct;24(4):762-770. doi: 10.1016/j.jfda.2016.04.005. Epub 2016 Jun 2.


Degradation of Histamine by Lactobacillus plantarum Isolated from Miso Products.

Kung HF, Lee YC, Huang YL, Huang YR, Su YC, Tsai YH.

J Food Prot. 2017 Oct;80(10):1682-1688. doi: 10.4315/0362-028X.JFP-17-135.


High-mobility group box 1 released by autophagic cancer-associated fibroblasts maintains the stemness of luminal breast cancer cells.

Zhao XL, Lin Y, Jiang J, Tang Z, Yang S, Lu L, Liang Y, Liu X, Tan J, Hu XG, Niu Q, Fu WJ, Yan ZX, Guo DY, Ping YF, Wang JM, Zhang X, Kung HF, Bian XW, Yao XH.

J Pathol. 2017 Nov;243(3):376-389. doi: 10.1002/path.4958. Epub 2017 Sep 21.


miR-181d regulates human dendritic cell maturation through NF-κB pathway.

Su XW, Lu G, Leung CK, Liu Q, Li Y, Tsang KS, Zhao SD, Chan DTM, Kung HF, Poon WS.

Cell Prolif. 2017 Oct;50(5). doi: 10.1111/cpr.12358. Epub 2017 Jul 21.


Maternal outcome after conservative management of abnormally invasive placenta.

Su HW, Yi YC, Tseng JJ, Chen WC, Chen YF, Kung HF, Chou MM.

Taiwan J Obstet Gynecol. 2017 Jun;56(3):353-357. doi: 10.1016/j.tjog.2017.04.016.


Fluorination at the 4 position alters the substrate behavior of L-glutamine and L-glutamate: Implications for positron emission tomography of neoplasias.

Jeitner TM, Kristoferson E, Azcona JA, Pinto JT, Stalnecker C, Erickson JW, Kung HF, Li J, Ploessl K, Cooper AJL.

J Fluor Chem. 2016 Dec;192(A):58-67. doi: 10.1016/j.jfluchem.2016.10.008. Epub 2016 Oct 20.


Ubiquitin specific peptidase 5 mediates Histidine-rich protein Hpn induced cell apoptosis in hepatocellular carcinoma through P14-P53 signaling.

Liu Y, Wang WM, Zou LY, Li L, Feng L, Pan MZ, Lv MY, Cao Y, Wang H, Kung HF, Pang JX, Fu WM, Zhang JF.

Proteomics. 2017 Jun;17(12). doi: 10.1002/pmic.201600350.


Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity.

Cheung DH, Ho ST, Lau KF, Jin R, Wang YN, Kung HF, Huang JJ, Shaw PC.

Sci Rep. 2017 Mar 3;7:43650. doi: 10.1038/srep43650.


Metabolic Imaging of Glutamine in Cancer.

Zhu L, Ploessl K, Zhou R, Mankoff D, Kung HF.

J Nucl Med. 2017 Apr;58(4):533-537. doi: 10.2967/jnumed.116.182345. Epub 2017 Feb 23. Review.


Reduction of Biogenic Amines during Miso Fermentation by Lactobacillus plantarum as a Starter Culture.

Lee YC, Kung HF, Huang YL, Wu CH, Huang YR, Tsai YH.

J Food Prot. 2016 Sep;79(9):1556-1561. doi: 10.4315/0362-028X.JFP-16-060.


[18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition.

Zhou R, Pantel AR, Li S, Lieberman BP, Ploessl K, Choi H, Blankemeyer E, Lee H, Kung HF, Mach RH, Mankoff DA.

Cancer Res. 2017 Mar 15;77(6):1476-1484. doi: 10.1158/0008-5472.CAN-16-1945. Epub 2017 Feb 15.


MiR-34a modulates ErbB2 in breast cancer.

Wang Y, Zhang X, Chao Z, Kung HF, Lin MC, Dress A, Wardle F, Jiang BH, Lai L.

Cell Biol Int. 2017 Jan;41(1):93-101. doi: 10.1002/cbin.10700. Epub 2016 Dec 1.


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