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A new [68Ga]Ga-HBED-CC-bisphosphonate as a bone imaging agent.

Zha Z, Wu Z, Choi SR, Ploessl K, Smith M, Alexoff D, Zhu L, Kung HF.

Mol Pharm. 2020 Apr 6. doi: 10.1021/acs.molpharmaceut.0c00103. [Epub ahead of print]


Preclinical evaluation of [18F]D3FSP, deuterated AV-45, for imaging of β-amyloid in the brain.

Zha Z, Ploessl K, Choi SR, Alexoff D, Kung HF.

Nucl Med Biol. 2020 Mar 25. pii: S0969-8051(20)30062-7. doi: 10.1016/j.nucmedbio.2020.03.003. [Epub ahead of print]


Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs.

Yang CP, Yang WS, Wong YH, Wang KH, Teng YC, Chang MH, Liao KH, Nian FS, Chao CC, Tsai JW, Hwang WL, Lin MW, Tzeng TY, Wang PN, Campbell M, Chen LK, Tsai TF, Chang PC, Kung HJ.

Aging Cell. 2020 Mar 31:e13107. doi: 10.1111/acel.13107. [Epub ahead of print]


Ligand-Assisted Reconstruction of Colloidal Quantum Dots Decreases Trap State Density.

Sun B, Vafaie M, Levina L, Wei M, Dong Y, Gao Y, Kung HT, Biondi M, Proppe AH, Chen B, Choi MJ, Sagar LK, Voznyy O, Kelley SO, Laquai F, Lu ZH, Hoogland S, García de Arquer FP, Sargent EH.

Nano Lett. 2020 Apr 6. doi: 10.1021/acs.nanolett.0c00638. [Epub ahead of print]


Dynamic PET/CT imaging of 18F-(2S, 4R)4-fluoroglutamine in healthy volunteers and oncological patients.

Xu X, Zhu H, Liu F, Zhang Y, Yang J, Zhang L, Xie Q, Zhu L, Li N, Kung HF, Yang Z.

Eur J Nucl Med Mol Imaging. 2020 Mar 12. doi: 10.1007/s00259-019-04543-w. [Epub ahead of print]


Inactivation and Damage of Histamine-Forming Bacteria by Treatment with High Hydrostatic Pressure.

Lee YC, Tsai YH, Chen SL, Kung HF, Arakawa O, Wei CI.

Foods. 2020 Mar 2;9(3). pii: E266. doi: 10.3390/foods9030266.


Lower postoperative natural killer cell activity is associated with positive surgical margins after radical prostatectomy.

Lu YC, Kuo MC, Hong JH, Jaw FS, Huang CY, Cheng JC, Kung HN.

J Formos Med Assoc. 2020 Feb 17. pii: S0929-6646(20)30001-2. doi: 10.1016/j.jfma.2019.12.015. [Epub ahead of print]


Noncontact catalysis: Initiation of selective ethylbenzene oxidation by Au cluster-facilitated cyclooctene epoxidation.

Peng A, Kung MC, Brydon RRO, Ross MO, Qian L, Broadbelt LJ, Kung HH.

Sci Adv. 2020 Jan 31;6(5):eaax6637. doi: 10.1126/sciadv.aax6637. eCollection 2020 Jan.


Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells.

Wang W, Lu G, Su X, Tang C, Li H, Xiong Z, Leung CK, Wong MS, Liu H, Ma JL, Cheung HH, Kung HF, Chen ZJ, Chan WY.

Cell Death Dis. 2020 Feb 7;11(2):107. doi: 10.1038/s41419-020-2271-0.


Synthesis and evaluation of novel radioiodinated PSMA targeting ligands for potential radiotherapy of prostate cancer.

Yao X, Zha Z, Ploessl K, Choi SR, Zhao R, Alexoff D, Zhu L, Kung HF.

Bioorg Med Chem. 2020 Mar 1;28(5):115319. doi: 10.1016/j.bmc.2020.115319. Epub 2020 Jan 20.


BSA-bounded p-cresyl sulfate potentiates the malignancy of bladder carcinoma by triggering cell migration and EMT through the ROS/Src/FAK signaling pathway.

Peng YS, Syu JP, Wang SD, Pan PC, Kung HN.

Cell Biol Toxicol. 2019 Dec 24. doi: 10.1007/s10565-019-09509-0. [Epub ahead of print]


[68Ga]Ga-HBED-CC-DiAsp: A new renal function imaging agent.

Shi S, Zhang L, Wu Z, Zhang A, Hong H, Choi SR, Zhu L, Kung HF.

Nucl Med Biol. 2019 Dec 16;82-83:17-24. doi: 10.1016/j.nucmedbio.2019.12.005. [Epub ahead of print]


Synthesis of novel technetium-99m tricarbonyl-HBED-CC complexes and structural prediction in solution by density functional theory calculation.

Shi S, Yao L, Li L, Wu Z, Zha Z, Kung HF, Zhu L, Fang DC.

R Soc Open Sci. 2019 Nov 27;6(11):191247. doi: 10.1098/rsos.191247. eCollection 2019 Nov.


Historical Typhoon Search Engine Based on Track Similarity.

Tsai MH, Chan HY, Hsieh CM, Ho CY, Kung HK, Tsai YC, Cho IC.

Int J Environ Res Public Health. 2019 Dec 4;16(24). pii: E4879. doi: 10.3390/ijerph16244879.


Histone Demethylase KDM4C Stimulates the Proliferation of Prostate Cancer Cells via Activation of AKT and c-Myc.

Lin CY, Wang BJ, Chen BC, Tseng JC, Jiang SS, Tsai KK, Shen YY, Yuh CH, Sie ZL, Wang WC, Kung HJ, Chuu CP.

Cancers (Basel). 2019 Nov 13;11(11). pii: E1785. doi: 10.3390/cancers11111785.


Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor.

Wu JY, Huang TW, Hsieh YT, Wang YF, Yen CC, Lee GL, Yeh CC, Peng YJ, Kuo YY, Wen HT, Lin HC, Hsiao CW, Wu KK, Kung HJ, Hsu YJ, Kuo CC.

Mol Cell. 2020 Jan 16;77(2):213-227.e5. doi: 10.1016/j.molcel.2019.10.023. Epub 2019 Nov 14.


An improved preparation of [18 F]AV-45 by simplified solid-phase extraction purification.

Zhang L, Zhang A, Yao X, Zhang Y, Liu F, Hong H, Zha Z, Liu Y, Wu Z, Qiao J, Zhu L, Kung HF.

J Labelled Comp Radiopharm. 2020 Mar;63(3):108-118. doi: 10.1002/jlcr.3813. Epub 2020 Jan 30.


Chromosomal and plasmid-mediated fluoroquinolone resistance in human Salmonella enterica infection in Ghana.

Acheampong G, Owusu M, Owusu-Ofori A, Osei I, Sarpong N, Sylverken A, Kung HJ, Cho ST, Kuo CH, Park SE, Marks F, Adu-Sarkodie Y, Owusu-Dabo E.

BMC Infect Dis. 2019 Oct 28;19(1):898. doi: 10.1186/s12879-019-4522-1.


Effect of Vacuum Packaging on Histamine Production in Japanese Spanish Mackerel (Scomberomorus niphonius) Stored at Various Temperatures.

Lee YC, Tseng PH, Hwang CC, Kung HF, Huang YL, Lin CS, Wei CI, Tsai YH.

J Food Prot. 2019 Nov;82(11):1931-1937. doi: 10.4315/0362-028X.JFP-19-143.


RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype.

Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW.

Nat Commun. 2019 Oct 11;10(1):4621. doi: 10.1038/s41467-019-12529-3.


Determination of Histamine in Japanese Spanish Mackerel (Scomberomorus niphonius) Meat Implicated in a Foodborne Poisoning.

Hwang CC, Tseng PH, Lee YC, Kung HF, Huang CY, Chen HC, Tsai YH.

J Food Prot. 2019 Oct;82(10):1643-1649. doi: 10.4315/0362-028X.JFP-19-111.


Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis.

Wang YH, Huang JT, Chen WL, Wang RH, Kao MC, Pan YR, Chan SH, Tsai KW, Kung HJ, Lin KT, Wang LH.

EMBO Rep. 2019 Oct 4;20(10):e45986. doi: 10.15252/embr.201845986. Epub 2019 Aug 29.


[68Ga]Ga-P16-093 as a PSMA-Targeted PET Radiopharmaceutical for Detection of Cancer: Initial Evaluation and Comparison with [68Ga]Ga-PSMA-11 in Prostate Cancer Patients Presenting with Biochemical Recurrence.

Green MA, Hutchins GD, Bahler CD, Tann M, Mathias CJ, Territo W, Sims J, Polson H, Alexoff D, Eckelman WC, Kung HF, Fletcher JW.

Mol Imaging Biol. 2019 Aug 19. doi: 10.1007/s11307-019-01421-7. [Epub ahead of print]


Isoliquiritigenin Suppresses E2-Induced Uterine Leiomyoma Growth through the Modulation of Cell Death Program and the Repression of ECM Accumulation.

Lin PH, Kung HL, Chen HY, Huang KC, Hsia SM.

Cancers (Basel). 2019 Aug 7;11(8). pii: E1131. doi: 10.3390/cancers11081131.


The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer.

Dong C, Chen Y, Li H, Yang Y, Zhang H, Ke K, Shi XN, Liu X, Li L, Ma J, Kung HF, Chen C, Lin MC.

Int J Biol Sci. 2019 Jun 2;15(7):1523-1532. doi: 10.7150/ijbs.32625. eCollection 2019.


VMAT2 imaging agent, D6-[18F]FP-(+)-DTBZ: Improved radiosynthesis, purification by solid-phase extraction and characterization.

Zhao R, Zha Z, Yao X, Ploessl K, Choi SR, Liu F, Zhu L, Kung HF.

Nucl Med Biol. 2019 May - Jun;72-73:26-35. doi: 10.1016/j.nucmedbio.2019.07.002. Epub 2019 Jul 11.


Decreased Striatal Vesicular Monoamine Transporter Type 2 Correlates With the Nonmotor Symptoms in Parkinson Disease.

Shi X, Zhang Y, Xu S, Kung HF, Qiao H, Jiang L, Zhu L, Guo Q, Yi C, Luo G, Wu L, Pei Z, Wang J, Zhang X, Chen L.

Clin Nucl Med. 2019 Sep;44(9):707-713. doi: 10.1097/RLU.0000000000002664.


Optimization of solid-phase extraction (SPE) in the preparation of [18F]D3FSP: A new PET imaging agent for mapping Aβ plaques.

Yao X, Zha Z, Zhao R, Choi SR, Ploessl K, Liu F, Zhu L, Kung HF.

Nucl Med Biol. 2019 Apr;71:54-64. doi: 10.1016/j.nucmedbio.2019.05.002. Epub 2019 May 16.


Rapid screening of nine unradiolabeled candidate compounds as PET brain imaging agents using cassette-wave microdosing and LC-MS/MS.

Sun M, Xiao H, Hong H, Zhang A, Zhang Y, Liu Y, Zhu L, Kung HF, Qiao J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jul 15;1121:28-38. doi: 10.1016/j.jchromb.2019.05.006. Epub 2019 May 6.


Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation.

Chen TJ, Wang HJ, Liu JS, Cheng HH, Hsu SC, Wu MC, Lu CH, Wu YF, Wu JW, Liu YY, Kung HJ, Wang WC.

Commun Biol. 2019 Mar 15;2:105. doi: 10.1038/s42003-019-0343-4. eCollection 2019.


Synthesis and preliminary evaluation of a novel glutamine derivative: (2S,4S)4-[18F]FEBGln.

Huang Y, Liu S, Wu R, Zhang L, Zhang Y, Hong H, Zhang A, Xiao H, Liu Y, Wu Z, Zhu L, Kung HF.

Bioorg Med Chem Lett. 2019 May 1;29(9):1047-1050. doi: 10.1016/j.bmcl.2019.03.012. Epub 2019 Mar 11.


Initial experience in synthesis of (2S,4R)-4-[18 F]fluoroglutamine for clinical application.

Zhang Y, Zhang L, Yang J, Wu Z, Ploessl K, Zha Z, Liu F, Xu X, Zhu H, Yang Z, Zhu L, Kung HF.

J Labelled Comp Radiopharm. 2019 May 15;62(5):209-214. doi: 10.1002/jlcr.3719. Epub 2019 Apr 1.


(2S,4R)-4-[18F]Fluoroglutamine as a PET Indicator for Bone Marrow Metabolism Dysfunctional: from Animal Experiments to Clinical Application.

Zhu H, Liu F, Zhang Y, Yang J, Xu X, Guo X, Liu T, Li N, Zhu L, Kung HF, Yang Z.

Mol Imaging Biol. 2019 Oct;21(5):945-953. doi: 10.1007/s11307-019-01319-4.


Unveiling the role of microRNA-7 in linking TGF-β-Smad-mediated epithelial-mesenchymal transition with negative regulation of trophoblast invasion.

Shih JC, Lin HH, Hsiao AC, Su YT, Tsai S, Chien CL, Kung HN.

FASEB J. 2019 May;33(5):6281-6295. doi: 10.1096/fj.201801898RR. Epub 2019 Feb 21.


Observation of chiral surface excitons in a topological insulator Bi2Se3.

Kung HH, Goyal AP, Maslov DL, Wang X, Lee A, Kemper AF, Cheong SW, Blumberg G.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4006-4011. doi: 10.1073/pnas.1813514116. Epub 2019 Feb 20.


KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis.

Wu MC, Cheng HH, Yeh TS, Li YC, Chen TJ, Sit WY, Chuu CP, Kung HJ, Chien S, Wang WC.

Cell Death Dis. 2019 Jan 25;10(2):68. doi: 10.1038/s41419-019-1305-y.


In Vivo Ester Hydrolysis as a New Approach in Development of Positron Emission Tomography Tracers for Imaging Hypoxia.

Zhang L, Yao X, Cao J, Hong H, Zhang A, Zhao R, Zhang Y, Zha Z, Liu Y, Qiao J, Zhu L, Kung HF.

Mol Pharm. 2019 Mar 4;16(3):1156-1166. doi: 10.1021/acs.molpharmaceut.8b01131. Epub 2019 Feb 20.


Dietary wild bitter gourd displays selective androgen receptor modulator like activity and improves the muscle decline of orchidectomized mice.

Wang CL, Kung HN, Wu CH, Huang CJ.

Food Funct. 2019 Jan 22;10(1):125-139. doi: 10.1039/c8fo01777h.


Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction.

Cheng CT, Qi Y, Wang YC, Chi KK, Chung Y, Ouyang C, Chen YR, Oh ME, Sheng X, Tang Y, Liu YR, Lin HH, Kuo CY, Schones D, Vidal CM, Chu JC, Wang HJ, Chen YH, Miller KM, Chu P, Yen Y, Jiang L, Kung HJ, Ann DK.

Commun Biol. 2018 Oct 26;1:178. doi: 10.1038/s42003-018-0178-4. eCollection 2018.


Estimation of the Fe and Cu Contents of the Surface Water in the Ebinur Lake Basin Based on LIBS and a Machine Learning Algorithm.

Zhang X, Zhang F, Kung HT, Shi P, Yushanjiang A, Zhu S.

Int J Environ Res Public Health. 2018 Oct 28;15(11). pii: E2390. doi: 10.3390/ijerph15112390.


Imaging Brain Metastasis Patients With 18F-(2S,4R)-4-Fluoroglutamine.

Xu X, Zhu H, Liu F, Zhang Y, Yang J, Zhang L, Zhu L, Li N, Kung HF, Yang Z.

Clin Nucl Med. 2018 Nov;43(11):e392-e399. doi: 10.1097/RLU.0000000000002257.


Novel HDAC5-interacting motifs of Tbx3 are essential for the suppression of E-cadherin expression and for the promotion of metastasis in hepatocellular carcinoma.

Dong L, Dong Q, Chen Y, Li Y, Zhang B, Zhou F, Lyu X, Chen GG, Lai P, Kung HF, He ML.

Signal Transduct Target Ther. 2018 Aug 24;3:22. doi: 10.1038/s41392-018-0025-6. eCollection 2018.


Fluorine-18 labeled diphenyl sulfide derivatives for imaging serotonin transporter (SERT) in the brain.

Zhang Y, Liu F, Xiao H, Yao X, Li G, Choi SR, Ploessl K, Zha Z, Zhu L, Kung HF.

Nucl Med Biol. 2018 Nov;66:1-9. doi: 10.1016/j.nucmedbio.2018.06.008. Epub 2018 Jul 4.


KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC.

Wang HJ, Pochampalli M, Wang LY, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Hsieh CL, Sung SY, Li CF, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, Kung HJ.

Oncogene. 2019 Jan;38(1):17-32. doi: 10.1038/s41388-018-0414-x. Epub 2018 Aug 2.


FMNL1 mediates nasopharyngeal carcinoma cell aggressiveness by epigenetically upregulating MTA1.

Chen WH, Cai MY, Zhang JX, Wang FW, Tang LQ, Liao YJ, Jin XH, Wang CY, Guo L, Jiang YG, Ren CP, Mai HQ, Zeng MS, Kung HF, Qian CN, Xie D.

Oncogene. 2018 Nov;37(48):6243-6258. doi: 10.1038/s41388-018-0351-8. Epub 2018 Jul 16.


PET Imaging of 18F-(2 S,4 R)4-Fluoroglutamine Accumulation in Breast Cancer: From Xenografts to Patients.

Liu F, Xu X, Zhu H, Zhang Y, Yang J, Zhang L, Li N, Zhu L, Kung HF, Yang Z.

Mol Pharm. 2018 Aug 6;15(8):3448-3455. doi: 10.1021/acs.molpharmaceut.8b00430. Epub 2018 Jul 20.


Discovery of rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer.

Shi X, Li H, Shi A, Yao H, Ke K, Dong C, Zhu Y, Qin Y, Ding Y, He YH, Liu X, Li L, Lei L, Hai Q, Chen W, Leung KS, Wong MH, Kung HF, Lin MC.

Oncol Rep. 2018 Sep;40(3):1592-1600. doi: 10.3892/or.2018.6533. Epub 2018 Jun 27.


Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis.

Lin HH, Chung Y, Cheng CT, Ouyang C, Fu Y, Kuo CY, Chi KK, Sadeghi M, Chu P, Kung HJ, Li CF, Limesand KH, Ann DK.

Autophagy. 2018;14(9):1481-1498. doi: 10.1080/15548627.2018.1450708. Epub 2018 Aug 21.


HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer.

Chang YT, Lin TP, Tang JT, Campbell M, Luo YL, Lu SY, Yang CP, Cheng TY, Chang CH, Liu TT, Lin CH, Kung HJ, Pan CC, Chang PC.

Cancer Lett. 2018 Oct 1;433:43-52. doi: 10.1016/j.canlet.2018.06.029. Epub 2018 Jun 23.


Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance.

Shi Y, Guryanova OA, Zhou W, Liu C, Huang Z, Fang X, Wang X, Chen C, Wu Q, He Z, Wang W, Zhang W, Jiang T, Liu Q, Chen Y, Wang W, Wu J, Kim L, Gimple RC, Feng H, Kung HF, Yu JS, Rich JN, Ping YF, Bian XW, Bao S.

Sci Transl Med. 2018 May 30;10(443). pii: eaah6816. doi: 10.1126/scitranslmed.aah6816.

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