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RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype.

Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW.

Nat Commun. 2019 Oct 11;10(1):4621. doi: 10.1038/s41467-019-12529-3.


Determination of Histamine in Japanese Spanish Mackerel (Scomberomorus niphonius) Meat Implicated in a Foodborne Poisoning.

Hwang CC, Tseng PH, Lee YC, Kung HF, Huang CY, Chen HC, Tsai YH.

J Food Prot. 2019 Oct;82(10):1643-1649. doi: 10.4315/0362-028X.JFP-19-111.


Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis.

Wang YH, Huang JT, Chen WL, Wang RH, Kao MC, Pan YR, Chan SH, Tsai KW, Kung HJ, Lin KT, Wang LH.

EMBO Rep. 2019 Oct 4;20(10):e45986. doi: 10.15252/embr.201845986. Epub 2019 Aug 29.


[68Ga]Ga-P16-093 as a PSMA-Targeted PET Radiopharmaceutical for Detection of Cancer: Initial Evaluation and Comparison with [68Ga]Ga-PSMA-11 in Prostate Cancer Patients Presenting with Biochemical Recurrence.

Green MA, Hutchins GD, Bahler CD, Tann M, Mathias CJ, Territo W, Sims J, Polson H, Alexoff D, Eckelman WC, Kung HF, Fletcher JW.

Mol Imaging Biol. 2019 Aug 19. doi: 10.1007/s11307-019-01421-7. [Epub ahead of print]


Isoliquiritigenin Suppresses E2-Induced Uterine Leiomyoma Growth through the Modulation of Cell Death Program and the Repression of ECM Accumulation.

Lin PH, Kung HL, Chen HY, Huang KC, Hsia SM.

Cancers (Basel). 2019 Aug 7;11(8). pii: E1131. doi: 10.3390/cancers11081131.


The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer.

Dong C, Chen Y, Li H, Yang Y, Zhang H, Ke K, Shi XN, Liu X, Li L, Ma J, Kung HF, Chen C, Lin MC.

Int J Biol Sci. 2019 Jun 2;15(7):1523-1532. doi: 10.7150/ijbs.32625. eCollection 2019.


VMAT2 imaging agent, D6-[18F]FP-(+)-DTBZ: Improved radiosynthesis, purification by solid-phase extraction and characterization.

Zhao R, Zha Z, Yao X, Ploessl K, Choi SR, Liu F, Zhu L, Kung HF.

Nucl Med Biol. 2019 May - Jun;72-73:26-35. doi: 10.1016/j.nucmedbio.2019.07.002. Epub 2019 Jul 11.


In Memoriam: Monte Blau, PhD, 1926-2019.

Kung HF, Rosenspire KC, Mach RH.

J Nucl Med. 2019 Jul;60(7):11N-12N. No abstract available.


Decreased Striatal Vesicular Monoamine Transporter Type 2 Correlates With the Nonmotor Symptoms in Parkinson Disease.

Shi X, Zhang Y, Xu S, Kung HF, Qiao H, Jiang L, Zhu L, Guo Q, Yi C, Luo G, Wu L, Pei Z, Wang J, Zhang X, Chen L.

Clin Nucl Med. 2019 Sep;44(9):707-713. doi: 10.1097/RLU.0000000000002664.


Optimization of solid-phase extraction (SPE) in the preparation of [18F]D3FSP: A new PET imaging agent for mapping Aβ plaques.

Yao X, Zha Z, Zhao R, Choi SR, Ploessl K, Liu F, Zhu L, Kung HF.

Nucl Med Biol. 2019 Apr;71:54-64. doi: 10.1016/j.nucmedbio.2019.05.002. Epub 2019 May 16.


Rapid screening of nine unradiolabeled candidate compounds as PET brain imaging agents using cassette-wave microdosing and LC-MS/MS.

Sun M, Xiao H, Hong H, Zhang A, Zhang Y, Liu Y, Zhu L, Kung HF, Qiao J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jul 15;1121:28-38. doi: 10.1016/j.jchromb.2019.05.006. Epub 2019 May 6.


Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation.

Chen TJ, Wang HJ, Liu JS, Cheng HH, Hsu SC, Wu MC, Lu CH, Wu YF, Wu JW, Liu YY, Kung HJ, Wang WC.

Commun Biol. 2019 Mar 15;2:105. doi: 10.1038/s42003-019-0343-4. eCollection 2019.


Synthesis and preliminary evaluation of a novel glutamine derivative: (2S,4S)4-[18F]FEBGln.

Huang Y, Liu S, Wu R, Zhang L, Zhang Y, Hong H, Zhang A, Xiao H, Liu Y, Wu Z, Zhu L, Kung HF.

Bioorg Med Chem Lett. 2019 May 1;29(9):1047-1050. doi: 10.1016/j.bmcl.2019.03.012. Epub 2019 Mar 11.


Initial experience in synthesis of (2S,4R)-4-[18 F]fluoroglutamine for clinical application.

Zhang Y, Zhang L, Yang J, Wu Z, Ploessl K, Zha Z, Liu F, Xu X, Zhu H, Yang Z, Zhu L, Kung HF.

J Labelled Comp Radiopharm. 2019 May 15;62(5):209-214. doi: 10.1002/jlcr.3719. Epub 2019 Apr 1.


(2S,4R)-4-[18F]Fluoroglutamine as a PET Indicator for Bone Marrow Metabolism Dysfunctional: from Animal Experiments to Clinical Application.

Zhu H, Liu F, Zhang Y, Yang J, Xu X, Guo X, Liu T, Li N, Zhu L, Kung HF, Yang Z.

Mol Imaging Biol. 2019 Oct;21(5):945-953. doi: 10.1007/s11307-019-01319-4.


Unveiling the role of microRNA-7 in linking TGF-β-Smad-mediated epithelial-mesenchymal transition with negative regulation of trophoblast invasion.

Shih JC, Lin HH, Hsiao AC, Su YT, Tsai S, Chien CL, Kung HN.

FASEB J. 2019 May;33(5):6281-6295. doi: 10.1096/fj.201801898RR. Epub 2019 Feb 21.


Observation of chiral surface excitons in a topological insulator Bi2Se3.

Kung HH, Goyal AP, Maslov DL, Wang X, Lee A, Kemper AF, Cheong SW, Blumberg G.

Proc Natl Acad Sci U S A. 2019 Feb 20. pii: 201813514. doi: 10.1073/pnas.1813514116. [Epub ahead of print]


KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis.

Wu MC, Cheng HH, Yeh TS, Li YC, Chen TJ, Sit WY, Chuu CP, Kung HJ, Chien S, Wang WC.

Cell Death Dis. 2019 Jan 25;10(2):68. doi: 10.1038/s41419-019-1305-y.


In Vivo Ester Hydrolysis as a New Approach in Development of Positron Emission Tomography Tracers for Imaging Hypoxia.

Zhang L, Yao X, Cao J, Hong H, Zhang A, Zhao R, Zhang Y, Zha Z, Liu Y, Qiao J, Zhu L, Kung HF.

Mol Pharm. 2019 Mar 4;16(3):1156-1166. doi: 10.1021/acs.molpharmaceut.8b01131. Epub 2019 Feb 20.


Dietary wild bitter gourd displays selective androgen receptor modulator like activity and improves the muscle decline of orchidectomized mice.

Wang CL, Kung HN, Wu CH, Huang CJ.

Food Funct. 2019 Jan 22;10(1):125-139. doi: 10.1039/c8fo01777h.


Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction.

Cheng CT, Qi Y, Wang YC, Chi KK, Chung Y, Ouyang C, Chen YR, Oh ME, Sheng X, Tang Y, Liu YR, Lin HH, Kuo CY, Schones D, Vidal CM, Chu JC, Wang HJ, Chen YH, Miller KM, Chu P, Yen Y, Jiang L, Kung HJ, Ann DK.

Commun Biol. 2018 Oct 26;1:178. doi: 10.1038/s42003-018-0178-4. eCollection 2018.


Estimation of the Fe and Cu Contents of the Surface Water in the Ebinur Lake Basin Based on LIBS and a Machine Learning Algorithm.

Zhang X, Zhang F, Kung HT, Shi P, Yushanjiang A, Zhu S.

Int J Environ Res Public Health. 2018 Oct 28;15(11). pii: E2390. doi: 10.3390/ijerph15112390.


Imaging Brain Metastasis Patients With 18F-(2S,4R)-4-Fluoroglutamine.

Xu X, Zhu H, Liu F, Zhang Y, Yang J, Zhang L, Zhu L, Li N, Kung HF, Yang Z.

Clin Nucl Med. 2018 Nov;43(11):e392-e399. doi: 10.1097/RLU.0000000000002257.


Novel HDAC5-interacting motifs of Tbx3 are essential for the suppression of E-cadherin expression and for the promotion of metastasis in hepatocellular carcinoma.

Dong L, Dong Q, Chen Y, Li Y, Zhang B, Zhou F, Lyu X, Chen GG, Lai P, Kung HF, He ML.

Signal Transduct Target Ther. 2018 Aug 24;3:22. doi: 10.1038/s41392-018-0025-6. eCollection 2018.


Fluorine-18 labeled diphenyl sulfide derivatives for imaging serotonin transporter (SERT) in the brain.

Zhang Y, Liu F, Xiao H, Yao X, Li G, Choi SR, Ploessl K, Zha Z, Zhu L, Kung HF.

Nucl Med Biol. 2018 Nov;66:1-9. doi: 10.1016/j.nucmedbio.2018.06.008. Epub 2018 Jul 4.


KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC.

Wang HJ, Pochampalli M, Wang LY, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Hsieh CL, Sung SY, Li CF, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, Kung HJ.

Oncogene. 2019 Jan;38(1):17-32. doi: 10.1038/s41388-018-0414-x. Epub 2018 Aug 2.


FMNL1 mediates nasopharyngeal carcinoma cell aggressiveness by epigenetically upregulating MTA1.

Chen WH, Cai MY, Zhang JX, Wang FW, Tang LQ, Liao YJ, Jin XH, Wang CY, Guo L, Jiang YG, Ren CP, Mai HQ, Zeng MS, Kung HF, Qian CN, Xie D.

Oncogene. 2018 Nov;37(48):6243-6258. doi: 10.1038/s41388-018-0351-8. Epub 2018 Jul 16.


PET Imaging of 18F-(2 S,4 R)4-Fluoroglutamine Accumulation in Breast Cancer: From Xenografts to Patients.

Liu F, Xu X, Zhu H, Zhang Y, Yang J, Zhang L, Li N, Zhu L, Kung HF, Yang Z.

Mol Pharm. 2018 Aug 6;15(8):3448-3455. doi: 10.1021/acs.molpharmaceut.8b00430. Epub 2018 Jul 20.


Discovery of rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer.

Shi X, Li H, Shi A, Yao H, Ke K, Dong C, Zhu Y, Qin Y, Ding Y, He YH, Liu X, Li L, Lei L, Hai Q, Chen W, Leung KS, Wong MH, Kung HF, Lin MC.

Oncol Rep. 2018 Sep;40(3):1592-1600. doi: 10.3892/or.2018.6533. Epub 2018 Jun 27.


Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis.

Lin HH, Chung Y, Cheng CT, Ouyang C, Fu Y, Kuo CY, Chi KK, Sadeghi M, Chu P, Kung HJ, Li CF, Limesand KH, Ann DK.

Autophagy. 2018;14(9):1481-1498. doi: 10.1080/15548627.2018.1450708. Epub 2018 Aug 21.


HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer.

Chang YT, Lin TP, Tang JT, Campbell M, Luo YL, Lu SY, Yang CP, Cheng TY, Chang CH, Liu TT, Lin CH, Kung HJ, Pan CC, Chang PC.

Cancer Lett. 2018 Oct 1;433:43-52. doi: 10.1016/j.canlet.2018.06.029. Epub 2018 Jun 23.


Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance.

Shi Y, Guryanova OA, Zhou W, Liu C, Huang Z, Fang X, Wang X, Chen C, Wu Q, He Z, Wang W, Zhang W, Jiang T, Liu Q, Chen Y, Wang W, Wu J, Kim L, Gimple RC, Feng H, Kung HF, Yu JS, Rich JN, Ping YF, Bian XW, Bao S.

Sci Transl Med. 2018 May 30;10(443). pii: eaah6816. doi: 10.1126/scitranslmed.aah6816.


Microvascular fractal dimension predicts prognosis and response to chemotherapy in glioblastoma: an automatic image analysis study.

Chen C, He ZC, Shi Y, Zhou W, Zhang X, Xiao HL, Wu HB, Yao XH, Luo WC, Cui YH, Bao S, Kung HF, Bian XW, Ping YF.

Lab Invest. 2018 Jul;98(7):924-934. doi: 10.1038/s41374-018-0055-2. Epub 2018 May 15.


Targeting Galectin-1 Impairs Castration-Resistant Prostate Cancer Progression and Invasion.

Shih TC, Liu R, Wu CT, Li X, Xiao W, Deng X, Kiss S, Wang T, Chen XJ, Carney R, Kung HJ, Duan Y, Ghosh PM, Lam KS.

Clin Cancer Res. 2018 Sep 1;24(17):4319-4331. doi: 10.1158/1078-0432.CCR-18-0157. Epub 2018 Apr 17.


Deuterium-substituted 2-(2'-((dimethylamino)methyl)-4'-[18 F](fluoropropoxy)phenylthio)benzenamine as a serotonin transporter imaging agent.

Liu F, Zhu L, Choi SR, Plössl K, Zha Z, Kung HF.

J Labelled Comp Radiopharm. 2018 Jun 30;61(8):576-585. doi: 10.1002/jlcr.3626. Epub 2018 May 16.


Large Intergenic Non-coding RNA-RoR Inhibits Aerobic Glycolysis of Glioblastoma Cells via Akt Pathway.

Li Y, He ZC, Liu Q, Zhou K, Shi Y, Yao XH, Zhang X, Kung HF, Ping YF, Bian XW.

J Cancer. 2018 Feb 23;9(5):880-889. doi: 10.7150/jca.20869. eCollection 2018.


Developing a cassette microdosing approach to enhance the throughput of PET imaging agent screening.

Xiao H, Sun M, Zhao R, Hong H, Zhang A, Zhang S, Liu F, Zhang Y, Liu Y, Zhu L, Kung HF, Qiao J.

J Pharm Biomed Anal. 2018 May 30;154:48-56. doi: 10.1016/j.jpba.2018.02.063. Epub 2018 Mar 3.


Alanine and glycine conjugates of (2S,4R)-4-[18F]fluoroglutamine for tumor imaging.

Zha Z, Ploessl K, Lieberman BP, Wang L, Kung HF.

Nucl Med Biol. 2018 May;60:19-28. doi: 10.1016/j.nucmedbio.2018.02.001. Epub 2018 Feb 13.


Improving nuclear envelope dynamics by EBV BFRF1 facilitates intranuclear component clearance through autophagy.

Liu GT, Kung HN, Chen CK, Huang C, Wang YL, Yu CP, Lee CP.

FASEB J. 2018 Jul;32(7):3968-3983. doi: 10.1096/fj.201701253R. Epub 2018 Feb 26.


Synthesis and evaluation of a novel urea-based 68Ga-complex for imaging PSMA binding in tumor.

Zha Z, Ploessl K, Choi SR, Wu Z, Zhu L, Kung HF.

Nucl Med Biol. 2018 Apr;59:36-47. doi: 10.1016/j.nucmedbio.2017.12.007. Epub 2017 Dec 27.


In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity.

Yang WS, Campbell M, Kung HJ, Chang PC.

J Vis Exp. 2018 Jan 29;(131). doi: 10.3791/56629.


In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of 18F-(2S,4R)-4-Fluoroglutamine.

Dunphy MPS, Harding JJ, Venneti S, Zhang H, Burnazi EM, Bromberg J, Omuro AM, Hsieh JJ, Mellinghoff IK, Staton K, Pressl C, Beattie BJ, Zanzonico PB, Gerecitano JF, Kelsen DP, Weber W, Lyashchenko SK, Kung HF, Lewis JS.

Radiology. 2018 May;287(2):667-675. doi: 10.1148/radiol.2017162610. Epub 2018 Jan 31.


H1/pHGFK1 nanoparticles exert anti-tumoural and radiosensitising effects by inhibition of MET in glioblastoma.

Zhang W, Duan R, Zhang J, Cheung WKC, Gao X, Zhang R, Zhang Q, Wei M, Wang G, Zhang Q, Mei PJ, Chen HL, Kung H, Lin MC, Shen Z, Zheng J, Zhang L, Yao H.

Br J Cancer. 2018 Feb 20;118(4):522-533. doi: 10.1038/bjc.2017.461. Epub 2018 Jan 18.


Chiral Spin Mode on the Surface of a Topological Insulator.

Kung HH, Maiti S, Wang X, Cheong SW, Maslov DL, Blumberg G.

Phys Rev Lett. 2017 Sep 29;119(13):136802. doi: 10.1103/PhysRevLett.119.136802. Epub 2017 Sep 27.


Deuterated 18F-9-O-hexadeutero-3-fluoropropoxyl-(+)-dihydrotetrabenazine (D6-FP-(+)-DTBZ): A vesicular monoamine transporter 2 (VMAT2) imaging agent.

Liu F, Choi SR, Zha Z, Ploessl K, Zhu L, Kung HF.

Nucl Med Biol. 2018 Feb;57:42-49. doi: 10.1016/j.nucmedbio.2017.11.009. Epub 2017 Dec 6.


Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells.

Dong C, Yang R, Li H, Ke K, Luo C, Yang F, Shi XN, Zhu Y, Liu X, Wong MH, Lin G, Wang X, Leung KS, Kung HF, Chen C, Lin MC.

Sci Rep. 2017 Dec 21;7(1):17987. doi: 10.1038/s41598-017-18178-0.


Does the "freeze-all" policy allow for a better outcome in assisted reproductive techniques than the use of fresh embryo transfers? - A retrospective study on cumulative live birth rates.

Chang JC, Chen MJ, Guu HF, Chen YF, Yi YC, Kung HF, Chen LY, Chou MM.

Taiwan J Obstet Gynecol. 2017 Dec;56(6):775-780. doi: 10.1016/j.tjog.2017.10.013.


Stanniocalcin-1 augments stem-like traits of glioblastoma cells through binding and activating NOTCH1.

Li Y, He ZC, Zhang XN, Liu Q, Chen C, Zhu Z, Chen Q, Shi Y, Yao XH, Cui YH, Zhang X, Wang Y, Kung HF, Ping YF, Bian XW.

Cancer Lett. 2018 Mar 1;416:66-74. doi: 10.1016/j.canlet.2017.11.033. Epub 2017 Nov 28.


A glycolysis-based ten-gene signature correlates with the clinical outcome, molecular subtype and IDH1 mutation in glioblastoma.

Chen C, Shi Y, Li Y, He ZC, Zhou K, Zhang XN, Yang KD, Wu JR, Kung HF, Ping YF, Bian XW.

J Genet Genomics. 2017 Nov 20;44(11):519-530. doi: 10.1016/j.jgg.2017.05.007. Epub 2017 Sep 21.


Old drug, new indication: Olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity.

Niu Y, Li H, Gao L, Lin H, Kung H, Lin MC, Leung KS, Wong MH, Xiong W, Li L.

J Pharmacol Sci. 2017 Nov;135(3):114-120. doi: 10.1016/j.jphs.2017.10.007. Epub 2017 Oct 31.

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