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Exportin 1 inhibition induces nerve growth factor receptor expression to inhibit the NF-kB pathway in preclinical models of pediatric high-grade glioma.

DeSisto JA, Flannery P, Lemma R, Pathak A, Mestnik S, Philips N, Bales NJ, Kashyap T, Moroze E, Venkataraman S, Kung AL, Carter BD, Landesman Y, Vibhakar R, Green AL.

Mol Cancer Ther. 2019 Oct 8. pii: molcanther.1319.2018. doi: 10.1158/1535-7163.MCT-18-1319. [Epub ahead of print]


Eye-gaze processing in the broader bipolar phenotype revealed by electrical neuroimaging.

Berchio C, Küng AL, Kumar S, Cordera P, Dayer AG, Aubry JM, Michel CM, Piguet C.

Psychiatry Res Neuroimaging. 2019 Sep 30;291:42-51. doi: 10.1016/j.pscychresns.2019.07.007. Epub 2019 Jul 31.


Development and Validation of a Risk Score to Predict the First Hip Fracture in the Oldest Old: A Retrospective Cohort Study.

Lam MT, Sing CW, Li GHY, Kung AWC, Tan KCB, Cheung CL.

J Gerontol A Biol Sci Med Sci. 2019 Jul 29. pii: glz178. doi: 10.1093/gerona/glz178. [Epub ahead of print]


Adipocytes sensitize melanoma cells to environmental TGF-β cues by repressing the expression of miR-211.

Golan T, Parikh R, Jacob E, Vaknine H, Zemser-Werner V, Hershkovitz D, Malcov H, Leibou S, Reichman H, Sheinboim D, Percik R, Amar S, Brenner R, Greenberger S, Kung A, Khaled M, Levy C.

Sci Signal. 2019 Jul 23;12(591). pii: eaav6847. doi: 10.1126/scisignal.aav6847.


Psychiatric disorders among offspring of patients with Bipolar and Borderline Personality Disorder.

Küng AL, Pham E, Cordera P, Hasler R, Aubry JM, Dayer A, Perroud N, Piguet C.

J Clin Psychol. 2019 Oct;75(10):1810-1819. doi: 10.1002/jclp.22817. Epub 2019 Jun 10.


25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese.

Leung RY, Cheung BM, Tan KC, Kung AW, Cheung CL.

Public Health Nutr. 2019 Jun 6:1-7. doi: 10.1017/S1368980019000582. [Epub ahead of print]


Greater than 50 times compression of 1030 nm Yb:KGW laser pulses to single-cycle duration.

Lu CH, Wu WH, Kuo SH, Guo JY, Chen MC, Yang SD, Kung AH.

Opt Express. 2019 May 27;27(11):15638-15648. doi: 10.1364/OE.27.015638.


Serum metabolomic profiling and its association with 25-hydroxyvitamin D.

Leung RYH, Li GHY, Cheung BMY, Tan KCB, Kung AWC, Cheung CL.

Clin Nutr. 2019 May 11. pii: S0261-5614(19)30211-0. doi: 10.1016/j.clnu.2019.04.035. [Epub ahead of print]


High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma.

Wang S, Hwang EE, Guha R, O'Neill AF, Melong N, Veinotte CJ, Conway Saur A, Wuerthele K, Shen M, McKnight C, Alexe G, Lemieux ME, Wang A, Hughes E, Xu X, Boxer MB, Hall MD, Kung A, Berman JN, Davis MI, Stegmaier K, Crompton BD.

Clin Cancer Res. 2019 Jul 15;25(14):4552-4566. doi: 10.1158/1078-0432.CCR-17-0375. Epub 2019 Apr 12.


Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry.

Hsu YH, Estrada K, Evangelou E, Ackert-Bicknell C, Akesson K, Beck T, Brown SJ, Capellini T, Carbone L, Cauley J, Cheung CL, Cummings SR, Czerwinski S, Demissie S, Econs M, Evans D, Farber C, Gautvik K, Harris T, Kammerer C, Kemp J, Koller DL, Kung A, Lawlor D, Lee M, Lorentzon M, McGuigan F, Medina-Gomez C, Mitchell B, Newman A, Nielson C, Ohlsson C, Peacock M, Reppe S, Richards JB, Robbins J, Sigurdsson G, Spector TD, Stefansson K, Streeten E, Styrkarsdottir U, Tobias J, Trajanoska K, Uitterlinden A, Vandenput L, Wilson SG, Yerges-Armstrong L, Young M, Zillikens MC, Rivadeneira F, Kiel DP, Karasik D.

J Bone Miner Res. 2019 Jul;34(7):1284-1296. doi: 10.1002/jbmr.3698. Epub 2019 Mar 19.


Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion-Driven Cancer.

Slotkin EK, Diolaiti D, Shukla NN, Dela Cruz FS, Clark JJ, Gundem G, Yellapantula VD, Levine MF, You D, Ma P, Pachhal S, Ibanez Sanchez G, Benayed R, Jungbluth AA, Smyth LM, Mauguen A, Gushterova I, Ding H, Spraggon L, Darnell R, Califano A, Ladanyi M, Papaemmanuil E, Kung AL, Hyman DM, Roberts SS.

Cancer Discov. 2019 May;9(5):605-616. doi: 10.1158/2159-8290.CD-18-0953. Epub 2019 Mar 15.


Rumination related activity in brain networks mediating attentional switching in euthymic bipolar patients.

Apazoglou K, Küng AL, Cordera P, Aubry JM, Dayer A, Vuilleumier P, Piguet C.

Int J Bipolar Disord. 2019 Jan 12;7(1):3. doi: 10.1186/s40345-018-0137-5.


Agile Co-Creation for Robots and Aging (ACCRA) Project: new technological solutions for older people.

D'Onofrio G, Fiorini L, de Mul M, Fabbricotti I, Okabe Y, Hoshino H, Limosani R, Vitanza A, Greco F, Giuliani F, Guiot D, Senges E, Kung A, Cavallo F, Sancarlo D, Greco A.

Eur Geriatr Med. 2018;9(6):795-800. doi: 10.1007/s41999-018-0106-7. Epub 2018 Sep 6.


A recurrent novel MGA-NUTM1 fusion identifies a new subtype of high-grade spindle cell sarcoma.

Diolaiti D, Dela Cruz FS, Gundem G, Bouvier N, Boulad M, Zhang Y, Chou AJ, Dunkel IJ, Sanghvi R, Shah M, Geiger H, Rahman S, Felice V, Wrzeszczynski KO, Darnell RB, Antonescu CR, French CA, Papaemmanuil E, Kung AL, Shukla N.

Cold Spring Harb Mol Case Stud. 2018 Dec 17;4(6). pii: a003194. doi: 10.1101/mcs.a003194. Print 2018 Dec.


Impulsivity and its association with childhood trauma experiences across bipolar disorder, attention deficit hyperactivity disorder and borderline personality disorder.

Richard-Lepouriel H, Kung AL, Hasler R, Bellivier F, Prada P, Gard S, Ardu S, Kahn JP, Dayer A, Henry C, Aubry JM, Leboyer M, Perroud N, Etain B.

J Affect Disord. 2019 Feb 1;244:33-41. doi: 10.1016/j.jad.2018.07.060. Epub 2018 Aug 6.


BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation.

Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ, Piwnica-Worms H, Zhao JJ, Kung AL, Kaelin WG Jr, Livingston DM.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9600-E9609. doi: 10.1073/pnas.1807112115. Epub 2018 Sep 25.


Reply to: Association Between Alendronate and All-Cause Mortality and Cardiovascular Mortality Among Hip Fracture: An Alternative Explanation.

Sing CW, Wong AY, Kiel DP, Cheung EY, Lam JK, Cheung TT, Chan EW, Kung AW, Wong IC, Cheung CL.

J Bone Miner Res. 2018 Oct;33(10):1908-1909. doi: 10.1002/jbmr.3568. Epub 2018 Sep 6. No abstract available.


Germline SDHA mutations in children and adults with cancer.

Dubard Gault M, Mandelker D, DeLair D, Stewart CR, Kemel Y, Sheehan MR, Siegel B, Kennedy J, Marcell V, Arnold A, Al-Ahmadie H, Modak S, Robson M, Shukla N, Roberts S, Vijai J, Topka S, Kentsis A, Cadoo K, Carlo M, Latham Schwark A, Reznik E, Dinatale R, Hechtman J, Borras Flores E, Jairam S, Yang C, Li Y, Bayraktar EC, Ceyhan-Birsoy O, Zhang L, Kohlman W, Schiffman J, Stadler Z, Birsoy K, Kung A, Offit K, Walsh MF.

Cold Spring Harb Mol Case Stud. 2018 Aug 1;4(4). pii: a002584. doi: 10.1101/mcs.a002584. Print 2018 Aug.


A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors.

Alvarez MJ, Subramaniam PS, Tang LH, Grunn A, Aburi M, Rieckhof G, Komissarova EV, Hagan EA, Bodei L, Clemons PA, Dela Cruz FS, Dhall D, Diolaiti D, Fraker DA, Ghavami A, Kaemmerer D, Karan C, Kidd M, Kim KM, Kim HC, Kunju LP, Langel Ü, Li Z, Lee J, Li H, LiVolsi V, Pfragner R, Rainey AR, Realubit RB, Remotti H, Regberg J, Roses R, Rustgi A, Sepulveda AR, Serra S, Shi C, Yuan X, Barberis M, Bergamaschi R, Chinnaiyan AM, Detre T, Ezzat S, Frilling A, Hommann M, Jaeger D, Kim MK, Knudsen BS, Kung AL, Leahy E, Metz DC, Milsom JW, Park YS, Reidy-Lagunes D, Schreiber S, Washington K, Wiedenmann B, Modlin I, Califano A.

Nat Genet. 2018 Jul;50(7):979-989. doi: 10.1038/s41588-018-0138-4. Epub 2018 Jun 18.


Serum follicle stimulating hormone is associated with reduced risk of diabetes in postmenopausal women: The Hong Kong osteoporosis study.

Cheung CL, Kung AWC, Tan KCB.

Maturitas. 2018 Aug;114:41-45. doi: 10.1016/j.maturitas.2018.05.011. Epub 2018 Jun 1.


Association of Alendronate and Risk of Cardiovascular Events in Patients With Hip Fracture.

Sing CW, Wong AY, Kiel DP, Cheung EY, Lam JK, Cheung TT, Chan EW, Kung AW, Wong IC, Cheung CL.

J Bone Miner Res. 2018 Aug;33(8):1422-1434. doi: 10.1002/jbmr.3448. Epub 2018 May 9.


Sub-4 fs laser pulses at high average power and high repetition rate from an all-solid-state setup.

Lu CH, Witting T, Husakou A, Vrakking MJJ, Kung AH, Furch FJ.

Opt Express. 2018 Apr 2;26(7):8941-8956. doi: 10.1364/OE.26.008941.


Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.

Wagner FF, Benajiba L, Campbell AJ, Weïwer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ, Stone RM, Kaya T, Shi X, Robers MB, Machleidt T, Wilkinson J, Hermine O, Kung A, Stein AJ, Lakshminarasimhan D, Hemann MT, Scolnick E, Zhang YL, Pan JQ, Stegmaier K, Holson EB.

Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. doi: 10.1126/scitranslmed.aam8460.


BET bromodomain proteins regulate enhancer function during adipogenesis.

Brown JD, Feldman ZB, Doherty SP, Reyes JM, Rahl PB, Lin CY, Sheng Q, Duan Q, Federation AJ, Kung AL, Haldar SM, Young RA, Plutzky J, Bradner JE.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2144-2149. doi: 10.1073/pnas.1711155115. Epub 2018 Feb 14.


Quantification of dsRNA using stable isotope labeling dilution liquid chromatography/mass spectrometry.

Kung AW, Kilby PM, Portwood DE, Dickman MJ.

Rapid Commun Mass Spectrom. 2018 Apr 15;32(7):590-596. doi: 10.1002/rcm.8074.


Precision Medicine in Children and Young Adults with Hematologic Malignancies and Blood Disorders: The Columbia University Experience.

Marks LJ, Oberg JA, Pendrick D, Sireci AN, Glasser C, Coval C, Zylber RJ, Chung WK, Pang J, Turk AT, Hsiao SJ, Mansukhani MM, Glade Bender JL, Kung AL, Sulis ML.

Front Pediatr. 2017 Dec 12;5:265. doi: 10.3389/fped.2017.00265. eCollection 2017.


Leukemia-specific delivery of mutant NOTCH1 targeted therapy.

Roti G, Qi J, Kitara S, Sanchez-Martin M, Saur Conway A, Varca AC, Su A, Wu L, Kung AL, Ferrando AA, Bradner JE, Stegmaier K.

J Exp Med. 2018 Jan 2;215(1):197-216. doi: 10.1084/jem.20151778. Epub 2017 Nov 20.


HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer.

Hideshima T, Mazitschek R, Qi J, Mimura N, Tseng JC, Kung AL, Bradner JE, Anderson KC.

Oncotarget. 2017 Jul 5;8(46):80109-80123. doi: 10.18632/oncotarget.19019. eCollection 2017 Oct 6.


Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy.

Church AJ, Calicchio ML, Nardi V, Skalova A, Pinto A, Dillon DA, Gomez-Fernandez CR, Manoj N, Haimes JD, Stahl JA, Dela Cruz FS, Tannenbaum-Dvir S, Glade-Bender JL, Kung AL, DuBois SG, Kozakewich HP, Janeway KA, Perez-Atayde AR, Harris MH.

Mod Pathol. 2018 Mar;31(3):463-473. doi: 10.1038/modpathol.2017.127. Epub 2017 Nov 3.


Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.

Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A.

Sci Transl Med. 2017 Nov 1;9(414). pii: eaam9078. doi: 10.1126/scitranslmed.aam9078.


Cohort Profile: The Hong Kong Osteoporosis Study and the follow-up study.

Cheung CL, Tan KCB, Kung AWC.

Int J Epidemiol. 2018 Apr 1;47(2):397-398f. doi: 10.1093/ije/dyx172. No abstract available.


Stability of intraoral vertical ramus osteotomies for mandibular setback: a longitudinal study.

Kung AYH, Leung YY.

Int J Oral Maxillofac Surg. 2018 Feb;47(2):152-159. doi: 10.1016/j.ijom.2017.09.004. Epub 2017 Sep 28.


Face and gaze perception in borderline personality disorder: An electrical neuroimaging study.

Berchio C, Piguet C, Gentsch K, Küng AL, Rihs TA, Hasler R, Aubry JM, Dayer A, Michel CM, Perroud N.

Psychiatry Res Neuroimaging. 2017 Nov 30;269:62-72. doi: 10.1016/j.pscychresns.2017.08.011. Epub 2017 Sep 15.


Pediatric Sarcoma Data Forms a Unique Cluster Measured via the Earth Mover's Distance.

Chen Y, Cruz FD, Sandhu R, Kung AL, Mundi P, Deasy JO, Tannenbaum A.

Sci Rep. 2017 Aug 1;7(1):7035. doi: 10.1038/s41598-017-07551-8.


Corrigendum to "New and Emerging Therapies for Osteoporosis".

Lewiecki EM, Diaz Curiel M, Borges JL, Kung A, Brandi ML, Dimai HP.

J Osteoporos. 2017;2017:4175180. doi: 10.1155/2017/4175180. Epub 2017 Jun 28.


PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature.

Efimenko E, Davé UP, Lebedeva IV, Shen Y, Sanchez-Quintero MJ, Diolaiti D, Kung A, Lannutti BJ, Chen J, Realubit R, Niatsetskaya Z, Ten V, Karan C, Chen X, Califano A, Diacovo TG.

Mol Cancer Ther. 2017 Oct;16(10):2069-2082. doi: 10.1158/1535-7163.MCT-17-0141. Epub 2017 Jul 17.


Mentalization in adults with attention deficit hyperactivity disorder: Comparison with controls and patients with borderline personality disorder.

Perroud N, Badoud D, Weibel S, Nicastro R, Hasler R, Küng AL, Luyten P, Fonagy P, Dayer A, Aubry JM, Prada P, Debbané M.

Psychiatry Res. 2017 Oct;256:334-341. doi: 10.1016/j.psychres.2017.06.087. Epub 2017 Jun 30.


Germline BRCA2 mutations detected in pediatric sequencing studies impact parents' evaluation and care.

Walsh MF, Kennedy J, Harlan M, Kentsis A, Shukla N, Musinsky J, Roberts S, Kung AL, Robson M, Kushner BH, Meyers P, Offit K.

Cold Spring Harb Mol Case Stud. 2017 Nov 21;3(6). pii: a001925. doi: 10.1101/mcs.a001925. Print 2017 Nov.


Image-guided transplantation of single cells in the bone marrow of live animals.

Turcotte R, Alt C, Runnels JM, Ito K, Wu JW, Zaher W, Mortensen LJ, Silberstein L, Côté DC, Kung AL, Ito K, Lin CP.

Sci Rep. 2017 Jun 20;7(1):3875. doi: 10.1038/s41598-017-02896-6.


Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma.

Giulino-Roth L, van Besien HJ, Dalton T, Totonchy JE, Rodina A, Taldone T, Bolaender A, Erdjument-Bromage H, Sadek J, Chadburn A, Barth MJ, Dela Cruz FS, Rainey A, Kung AL, Chiosis G, Cesarman E.

Mol Cancer Ther. 2017 Sep;16(9):1779-1790. doi: 10.1158/1535-7163.MCT-16-0848. Epub 2017 Jun 15.


Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases.

Ni F, Kung A, Duan Y, Shah V, Amador CD, Guo M, Fan X, Chen L, Chen Y, McKenna CE, Zhang C.

J Am Chem Soc. 2017 Jun 14;139(23):7701-7704. doi: 10.1021/jacs.7b03266. Epub 2017 Jun 2.


A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases.

Kung A, Schimpl M, Ekanayake A, Chen YC, Overman R, Zhang C.

ACS Chem Biol. 2017 Jun 16;12(6):1499-1503. doi: 10.1021/acschembio.6b01083. Epub 2017 May 8.


A novel, potentially targetable TMEM106B-BRAF fusion in pleomorphic xanthoastrocytoma.

Hsiao SJ, Karajannis MA, Diolaiti D, Mansukhani MM, Bender JG, Kung AL, Garvin JH Jr.

Cold Spring Harb Mol Case Stud. 2017 Mar;3(2):a001396. doi: 10.1101/mcs.a001396.


Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia.

Pikman Y, Alexe G, Roti G, Conway AS, Furman A, Lee ES, Place AE, Kim S, Saran C, Modiste R, Weinstock DM, Harris M, Kung AL, Silverman LB, Stegmaier K.

Clin Cancer Res. 2017 Feb 15;23(4):1012-1024. doi: 10.1158/1078-0432.CCR-15-2869. Epub 2016 Nov 9.


Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial.

Coates A, Kung A, Mounts E, Hesla J, Bankowski B, Barbieri E, Ata B, Cohen J, Munné S.

Fertil Steril. 2017 Mar;107(3):723-730.e3. doi: 10.1016/j.fertnstert.2016.12.022. Epub 2017 Jan 27.


Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese.

Leung RY, Cheung BM, Nguyen US, Kung AW, Tan KC, Cheung CL.

Bone. 2017 Apr;97:293-298. doi: 10.1016/j.bone.2017.01.030. Epub 2017 Jan 24.


Purification and characterisation of dsRNA using ion pair reverse phase chromatography and mass spectrometry.

Nwokeoji AO, Kung AW, Kilby PM, Portwood DE, Dickman MJ.

J Chromatogr A. 2017 Feb 10;1484:14-25. doi: 10.1016/j.chroma.2016.12.062. Epub 2016 Dec 21.


Successful Targeted Therapy of Refractory Pediatric ETV6-NTRK3 Fusion-Positive Secretory Breast Carcinoma.

Shukla N, Roberts SS, Baki MO, Mushtaq Q, Goss PE, Park BH, Gundem G, Tian K, Geiger H, Redfield K, Behr G, Benayed R, Zehir A, Hechtman JF, Darnell RB, Papaemmanuil E, Ladanyi M, Ku N, Kung AL, Baselga J, Drilon A, Hyman DM.

JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.17.00034. Epub 2017 Aug 18. No abstract available.


Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations.

Oberg JA, Glade Bender JL, Sulis ML, Pendrick D, Sireci AN, Hsiao SJ, Turk AT, Dela Cruz FS, Hibshoosh H, Remotti H, Zylber RJ, Pang J, Diolaiti D, Koval C, Andrews SJ, Garvin JH, Yamashiro DJ, Chung WK, Emerson SG, Nagy PL, Mansukhani MM, Kung AL.

Genome Med. 2016 Dec 23;8(1):133. doi: 10.1186/s13073-016-0389-6.


Differences in pregnancy outcomes in donor egg frozen embryo transfer (FET) cycles following preimplantation genetic screening (PGS): a single center retrospective study.

Coates A, Bankowski BJ, Kung A, Griffin DK, Munne S.

J Assist Reprod Genet. 2017 Jan;34(1):71-78. doi: 10.1007/s10815-016-0832-z. Epub 2016 Nov 16.

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