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Publishing the best basic and applied pain science: open science and PAIN.

Keefe FJ, Ballantyne J, Blyth F, Coghill RC, Dickenson A, Dionne CE, Eccleston C, Finnerup NB, Kuner R, Seminowicz DA, Sluka K.

Pain. 2018 Mar;159(3):405-406. doi: 10.1097/j.pain.0000000000001166. No abstract available.


The quest for more research on painful diabetic neuropathy.

Nawroth PP, Bendszus M, Pham M, Jende J, Heiland S, Ries S, Schumann C, Schmelz M, Schuh-Hofer S, Treede RD, Kuner R, Oikonomou D, Groener JB, Kopf S.

Neuroscience. 2017 Sep 20. pii: S0306-4522(17)30667-X. doi: 10.1016/j.neuroscience.2017.09.023. [Epub ahead of print]


A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity.

Tan LL, Pelzer P, Heinl C, Tang W, Gangadharan V, Flor H, Sprengel R, Kuner T, Kuner R.

Nat Neurosci. 2017 Nov;20(11):1591-1601. doi: 10.1038/nn.4645. Epub 2017 Sep 18.


Molecular, cellular and circuit basis of cholinergic modulation of pain.

Naser PV, Kuner R.

Neuroscience. 2017 Sep 8. pii: S0306-4522(17)30625-5. doi: 10.1016/j.neuroscience.2017.08.049. [Epub ahead of print]


Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component.

Bali KK, Kuner R.

Pain. 2017 Nov;158(11):2243-2258. doi: 10.1097/j.pain.0000000000001032.


Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain.

Paldy E, Simonetti M, Worzfeld T, Bali KK, Vicuña L, Offermanns S, Kuner R.

Nat Commun. 2017 Aug 2;8(1):176. doi: 10.1038/s41467-017-00341-w.


A mouse model for pain and neuroplastic changes associated with pancreatic ductal adenocarcinoma.

Selvaraj D, Hirth M, Gandla J, Kuner R.

Pain. 2017 Aug;158(8):1609-1621. doi: 10.1097/j.pain.0000000000000956.


Structural plasticity and reorganisation in chronic pain.

Kuner R, Flor H.

Nat Rev Neurosci. 2017 Jan 20;18(2):113. doi: 10.1038/nrn.2017.5. No abstract available.


A checkpoint to pain.

Hirth M, Gandla J, Kuner R.

Nat Neurosci. 2017 Jun 27;20(7):897-899. doi: 10.1038/nn.4586. No abstract available.


miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels.

Gandla J, Lomada SK, Lu J, Kuner R, Bali KK.

Pain. 2017 Sep;158(9):1765-1779. doi: 10.1097/j.pain.0000000000000971.


Structural plasticity and reorganisation in chronic pain.

Kuner R, Flor H.

Nat Rev Neurosci. 2016 Dec 15;18(1):20-30. doi: 10.1038/nrn.2016.162. Review. Erratum in: Nat Rev Neurosci. 2017 Jan 20;18(2):113.


Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.

Wetzel C, Pifferi S, Picci C, Gök C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, Bégay V, Moroni M, Estebanez L, Kühnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Kuner R, Poulet JF, Schmoranzer J, Poole K, Lewin GR.

Nat Neurosci. 2017 Feb;20(2):209-218. doi: 10.1038/nn.4454. Epub 2016 Dec 12.


Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions.

Pitzer C, Kuner R, Tappe-Theodor A.

Pain Rep. 2016 Aug 9;1(1):e564. doi: 10.1097/PR9.0000000000000564. eCollection 2016 Jul.


EXPRESS: Voluntary and evoked behavioral correlates in neuropathic pain states under different housing conditions.

Pitzer C, Kuner R, Tappe-Theodor A.

Mol Pain. 2016 Jun 15;12. pii: 1744806916656635. doi: 10.1177/1744806916656635. Print 2016.


Cross-talk between AMPK and EGFR dependent Signaling in Non-Small Cell Lung Cancer.

Praveen P, Hülsmann H, Sültmann H, Kuner R, Fröhlich H.

Sci Rep. 2016 Jun 9;6:27514. doi: 10.1038/srep27514.


A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons.

Florez-Paz D, Bali KK, Kuner R, Gomis A.

Sci Rep. 2016 May 17;6:25923. doi: 10.1038/srep25923.


Functional characterization of a mouse model for central post-stroke pain.

Gritsch S, Bali KK, Kuner R, Vardeh D.

Mol Pain. 2016 Mar 8;12. pii: 1744806916629049. doi: 10.1177/1744806916629049. Print 2016.


A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.

Eliava M, Melchior M, Knobloch-Bollmann HS, Wahis J, da Silva Gouveia M, Tang Y, Ciobanu AC, Triana Del Rio R, Roth LC, Althammer F, Chavant V, Goumon Y, Gruber T, Petit-Demoulière N, Busnelli M, Chini B, Tan LL, Mitre M, Froemke RC, Chao MV, Giese G, Sprengel R, Kuner R, Poisbeau P, Seeburg PH, Stoop R, Charlet A, Grinevich V.

Neuron. 2016 Mar 16;89(6):1291-1304. doi: 10.1016/j.neuron.2016.01.041. Epub 2016 Mar 3.


Early-onset treadmill training reduces mechanical allodynia and modulates calcitonin gene-related peptide fiber density in lamina III/IV in a mouse model of spinal cord contusion injury.

Nees TA, Tappe-Theodor A, Sliwinski C, Motsch M, Rupp R, Kuner R, Weidner N, Blesch A.

Pain. 2016 Mar;157(3):687-97. doi: 10.1097/j.pain.0000000000000422.


The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons.

Njoo C, Agarwal N, Lutz B, Kuner R.

PLoS Biol. 2015 Oct 23;13(10):e1002286. doi: 10.1371/journal.pbio.1002286. eCollection 2015 Oct.


[Pharmacological aspects of pain research in Germany].

Niederberger E, Kuner R, Geißlinger G.

Schmerz. 2015 Oct;29(5):531-8. doi: 10.1007/s00482-015-0042-0. Review. German.


Unravelling Spinal Circuits of Pain and Mechanical Allodynia.

Gangadharan V, Kuner R.

Neuron. 2015 Aug 19;87(4):673-5. doi: 10.1016/j.neuron.2015.08.013.


A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain.

Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R.

Cancer Cell. 2015 Jun 8;27(6):780-96. doi: 10.1016/j.ccell.2015.04.017. Erratum in: Cancer Cell. 2015 Aug 10;28(2):270.


The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.

Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R.

Nat Med. 2015 May;21(5):518-23. doi: 10.1038/nm.3852. Epub 2015 Apr 27.


A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.

Lu J, Luo C, Bali KK, Xie RG, Mains RE, Eipper BA, Kuner R.

Nat Commun. 2015 Apr 13;6:6820. doi: 10.1038/ncomms7820.


Spinal excitatory mechanisms of pathological pain.

Kuner R.

Pain. 2015 Apr;156 Suppl 1:S11-7. doi: 10.1097/j.pain.0000000000000118. Review.


Molecular players of tumor-nerve interactions.

Selvaraj D, Kuner R.

Pain. 2015 Jan;156(1):6-7. doi: 10.1016/j.pain.0000000000000010. Review. No abstract available.


Meet PAIN pictured.

Kuner R.

Pain. 2015 Jan;156(1):3. doi: 10.1016/j.pain.0000000000000024. No abstract available.


BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence.

Gu L, Frommel SC, Oakes CC, Simon R, Grupp K, Gerig CY, Bär D, Robinson MD, Baer C, Weiss M, Gu Z, Schapira M, Kuner R, Sültmann H, Provenzano M; ICGC Project on Early Onset Prostate Cancer, Yaspo ML, Brors B, Korbel J, Schlomm T, Sauter G, Eils R, Plass C, Santoro R.

Nat Genet. 2015 Jan;47(1):22-30. doi: 10.1038/ng.3165. Epub 2014 Dec 8.


Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice.

Gritsch S, Lu J, Thilemann S, Wörtge S, Möbius W, Bruttger J, Karram K, Ruhwedel T, Blanfeld M, Vardeh D, Waisman A, Nave KA, Kuner R.

Nat Commun. 2014 Dec 1;5:5472. doi: 10.1038/ncomms6472.


Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction.

Chen JT, Guo D, Campanelli D, Frattini F, Mayer F, Zhou L, Kuner R, Heppenstall PA, Knipper M, Hu J.

Nat Commun. 2014 Oct 30;5:5331. doi: 10.1038/ncomms6331.


Activation of AMP-activated protein kinase sensitizes lung cancer cells and H1299 xenografts to erlotinib.

Hülsmann HJ, Rolff J, Bender C, Jarahian M, Korf U, Herwig R, Fröhlich H, Thomas M, Merk J, Fichtner I, Sültmann H, Kuner R.

Lung Cancer. 2014 Nov;86(2):151-7. doi: 10.1016/j.lungcan.2014.09.001. Epub 2014 Sep 10.


Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.

Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R.

Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016/j.neuron.2014.05.037.


Noncoding RNAs: key molecules in understanding and treating pain.

Bali KK, Kuner R.

Trends Mol Med. 2014 Aug;20(8):437-48. doi: 10.1016/j.molmed.2014.05.006. Epub 2014 Jun 28. Review.


Studying ongoing and spontaneous pain in rodents--challenges and opportunities.

Tappe-Theodor A, Kuner R.

Eur J Neurosci. 2014 Jun;39(11):1881-90. doi: 10.1111/ejn.12643. Epub 2014 May 29. Review.


Synaptic plasticity in pathological pain.

Luo C, Kuner T, Kuner R.

Trends Neurosci. 2014 Jun;37(6):343-55. doi: 10.1016/j.tins.2014.04.002. Epub 2014 May 12. Review.


Sources of individual variability: miRNAs that predispose to neuropathic pain identified using genome-wide sequencing.

Bali KK, Hackenberg M, Lubin A, Kuner R, Devor M.

Mol Pain. 2014 Mar 19;10:22. doi: 10.1186/1744-8069-10-22.


Genetic dissection of plexin signaling in vivo.

Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9. doi: 10.1073/pnas.1308418111. Epub 2014 Jan 27.


BKCa channels expressed in sensory neurons modulate inflammatory pain in mice.

Lu R, Lukowski R, Sausbier M, Zhang DD, Sisignano M, Schuh CD, Kuner R, Ruth P, Geisslinger G, Schmidtko A.

Pain. 2014 Mar;155(3):556-65. doi: 10.1016/j.pain.2013.12.005. Epub 2013 Dec 11.


Gq rather than G11 preferentially mediates nociceptor sensitization.

Wirotanseng LN, Kuner R, Tappe-Theodor A.

Mol Pain. 2013 Oct 25;9:54. doi: 10.1186/1744-8069-9-54.


microRNAs in nociceptive circuits as predictors of future clinical applications.

Kress M, Hüttenhofer A, Landry M, Kuner R, Favereaux A, Greenberg D, Bednarik J, Heppenstall P, Kronenberg F, Malcangio M, Rittner H, Uçeyler N, Trajanoski Z, Mouritzen P, Birklein F, Sommer C, Soreq H.

Front Mol Neurosci. 2013 Oct 17;6:33. doi: 10.3389/fnmol.2013.00033. Review.


Transcriptional mechanisms underlying sensitization of peripheral sensory neurons by granulocyte-/granulocyte-macrophage colony stimulating factors.

Bali KK, Venkataramani V, Satagopam VP, Gupta P, Schneider R, Kuner R.

Mol Pain. 2013 Sep 25;9:48. doi: 10.1186/1744-8069-9-48.


Genome-wide identification and functional analyses of microRNA signatures associated with cancer pain.

Bali KK, Selvaraj D, Satagopam VP, Lu J, Schneider R, Kuner R.

EMBO Mol Med. 2013 Nov;5(11):1740-58. doi: 10.1002/emmm.201302797. Epub 2013 Oct 18.


A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signalling pathways in sensory nerves in vivo.

Gangadharan V, Selvaraj D, Kurejova M, Njoo C, Gritsch S, Škoricová D, Horstmann H, Offermanns S, Brown AJ, Kuner T, Tappe-Theodor A, Kuner R.

Pain. 2013 Dec;154(12):2801-12. doi: 10.1016/j.pain.2013.08.019. Epub 2013 Aug 22.


Pain hypersensitivity mechanisms at a glance.

Gangadharan V, Kuner R.

Dis Model Mech. 2013 Jul;6(4):889-95. doi: 10.1242/dmm.011502. Review.


Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation.

Gaffal E, Cron M, Glodde N, Bald T, Kuner R, Zimmer A, Lutz B, Tüting T.

J Immunol. 2013 May 15;190(10):4929-36. doi: 10.4049/jimmunol.1201777. Epub 2013 Apr 12.


ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer.

Kacprzyk LA, Laible M, Andrasiuk T, Brase JC, Börno ST, Fälth M, Kuner R, Lehrach H, Schweiger MR, Sültmann H.

PLoS One. 2013;8(3):e59976. doi: 10.1371/journal.pone.0059976. Epub 2013 Mar 29.


Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer.

Weischenfeldt J, Simon R, Feuerbach L, Schlangen K, Weichenhan D, Minner S, Wuttig D, Warnatz HJ, Stehr H, Rausch T, Jäger N, Gu L, Bogatyrova O, Stütz AM, Claus R, Eils J, Eils R, Gerhäuser C, Huang PH, Hutter B, Kabbe R, Lawerenz C, Radomski S, Bartholomae CC, Fälth M, Gade S, Schmidt M, Amschler N, Haß T, Galal R, Gjoni J, Kuner R, Baer C, Masser S, von Kalle C, Zichner T, Benes V, Raeder B, Mader M, Amstislavskiy V, Avci M, Lehrach H, Parkhomchuk D, Sultan M, Burkhardt L, Graefen M, Huland H, Kluth M, Krohn A, Sirma H, Stumm L, Steurer S, Grupp K, Sültmann H, Sauter G, Plass C, Brors B, Yaspo ML, Korbel JO, Schlomm T.

Cancer Cell. 2013 Feb 11;23(2):159-70. doi: 10.1016/j.ccr.2013.01.002.


Serum miR-142-3p is associated with early relapse in operable lung adenocarcinoma patients.

Kaduthanam S, Gade S, Meister M, Brase JC, Johannes M, Dienemann H, Warth A, Schnabel PA, Herth FJ, Sültmann H, Muley T, Kuner R.

Lung Cancer. 2013 May;80(2):223-7. doi: 10.1016/j.lungcan.2013.01.013. Epub 2013 Feb 11.


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