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Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation.

Wang Y, Tatham MH, Schmidt-Heck W, Swann C, Singh-Dolt K, Meseguer-Ripolles J, Lucendo-Villarin B, Kunath T, Rudd TR, Smith AJH, Hengstler JG, Godoy P, Hay RT, Hay DC.

iScience. 2019 Jun 28;16:206-217. doi: 10.1016/j.isci.2019.05.028. Epub 2019 May 24.


Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum.

Trivedi DK, Sinclair E, Xu Y, Sarkar D, Walton-Doyle C, Liscio C, Banks P, Milne J, Silverdale M, Kunath T, Goodacre R, Barran P.

ACS Cent Sci. 2019 Apr 24;5(4):599-606. doi: 10.1021/acscentsci.8b00879. Epub 2019 Mar 20.


α-Synuclein-Confocal Nanoscanning (ASYN-CONA), a Bead-Based Assay for Detecting Early-Stage α-Synuclein Aggregation.

Pérez-Pi I, Evans DA, Horrocks MH, Pham NT, Dolt KS, Koszela J, Kunath T, Auer M.

Anal Chem. 2019 May 7;91(9):5582-5590. doi: 10.1021/acs.analchem.8b03842. Epub 2019 Apr 18.


Are PARKIN patients ideal candidates for dopaminergic cell replacement therapies?

Kunath T, Natalwala A, Chan C, Chen Y, Stecher B, Taylor M, Khan S, Muqit MMK.

Eur J Neurosci. 2019 Feb;49(4):453-462. doi: 10.1111/ejn.14314. Epub 2019 Jan 23.


Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene.

Chen Y, Dolt KS, Kriek M, Baker T, Downey P, Drummond NJ, Canham MA, Natalwala A, Rosser S, Kunath T.

Eur J Neurosci. 2019 Feb;49(4):510-524. doi: 10.1111/ejn.14286. Epub 2018 Dec 21.


α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.

Ludtmann MHR, Angelova PR, Horrocks MH, Choi ML, Rodrigues M, Baev AY, Berezhnov AV, Yao Z, Little D, Banushi B, Al-Menhali AS, Ranasinghe RT, Whiten DR, Yapom R, Dolt KS, Devine MJ, Gissen P, Kunath T, Jaganjac M, Pavlov EV, Klenerman D, Abramov AY, Gandhi S.

Nat Commun. 2018 Jun 12;9(1):2293. doi: 10.1038/s41467-018-04422-2.


TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons.

Vogt MA, Ehsaei Z, Knuckles P, Higginbottom A, Helmbrecht MS, Kunath T, Eggan K, Williams LA, Shaw PJ, Wurst W, Floss T, Huber AB, Taylor V.

Sci Rep. 2018 May 25;8(1):8097. doi: 10.1038/s41598-018-26397-2.


Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling.

Collo G, Cavalleri L, Bono F, Mora C, Fedele S, Invernizzi RW, Gennarelli M, Piovani G, Kunath T, Millan MJ, Merlo Pich E, Spano P.

Neural Plast. 2018 Feb 4;2018:4196961. doi: 10.1155/2018/4196961. eCollection 2018.


Producing Stem Cell-Based Transplants for Future Therapeutic Purposes.

Velasco I, Kunath T, Ramos-Mejía V, Velasco-Velázquez MA.

Stem Cells Int. 2017;2017:9592302. doi: 10.1155/2017/9592302. Epub 2017 Dec 11. No abstract available.


Mono-Substituted Hydrocarbon Diastereomer Combinations Reveal Stapled Peptides with High Structural Fidelity.

McWhinnie FS, Sepp K, Wilson C, Kunath T, Hupp TR, Baker TS, Houston DR, Hulme AN.

Chemistry. 2018 Feb 9;24(9):2094-2097. doi: 10.1002/chem.201705983. Epub 2018 Jan 19.


Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling.

Cavalleri L, Merlo Pich E, Millan MJ, Chiamulera C, Kunath T, Spano PF, Collo G.

Mol Psychiatry. 2018 Apr;23(4):812-823. doi: 10.1038/mp.2017.241. Epub 2017 Nov 21.


A synthetic cell permeable antioxidant protects neurons against acute oxidative stress.

Drummond NJ, Davies NO, Lovett JE, Miller MR, Cook G, Becker T, Becker CG, McPhail DB, Kunath T.

Sci Rep. 2017 Sep 19;7(1):11857. doi: 10.1038/s41598-017-12072-5.


Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4.

Azami T, Waku T, Matsumoto K, Jeon H, Muratani M, Kawashima A, Yanagisawa J, Manabe I, Nagai R, Kunath T, Nakamura T, Kurimoto K, Saitou M, Takahashi S, Ema M.

Development. 2017 Oct 15;144(20):3706-3718. doi: 10.1242/dev.150755. Epub 2017 Sep 4.


Expansion of human midbrain floor plate progenitors from induced pluripotent stem cells increases dopaminergic neuron differentiation potential.

Fedele S, Collo G, Behr K, Bischofberger J, Müller S, Kunath T, Christensen K, Gündner AL, Graf M, Jagasia R, Taylor V.

Sci Rep. 2017 Jul 20;7(1):6036. doi: 10.1038/s41598-017-05633-1.


Modeling Parkinson's disease with induced pluripotent stem cells harboring α-synuclein mutations.

Singh Dolt K, Hammachi F, Kunath T.

Brain Pathol. 2017 Jul;27(4):545-551. doi: 10.1111/bpa.12526. Review.


Preparation, characterization, and banking of clinical-grade cells for neural transplantation: Scale up, fingerprinting, and genomic stability of stem cell lines.

Natalwala A, Kunath T.

Prog Brain Res. 2017;230:133-150. doi: 10.1016/bs.pbr.2017.02.007. Epub 2017 Apr 7. Review.


The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.

Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H.

Sci Transl Med. 2017 May 24;9(391). pii: eaaf3962. doi: 10.1126/scitranslmed.aaf3962.


Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology.

Amorim IS, Graham LC, Carter RN, Morton NM, Hammachi F, Kunath T, Pennetta G, Carpanini SM, Manson JC, Lamont DJ, Wishart TM, Gillingwater TH.

J Cell Sci. 2017 Jan 15;130(2):325-331. doi: 10.1242/jcs.194241. Epub 2017 Jan 3.


Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells.

Sotthibundhu A, McDonagh K, von Kriegsheim A, Garcia-Munoz A, Klawiter A, Thompson K, Chauhan KD, Krawczyk J, McInerney V, Dockery P, Devine MJ, Kunath T, Barry F, O'Brien T, Shen S.

Stem Cell Res Ther. 2016 Nov 15;7(1):166.


Derivation of the clinical grade human embryonic stem cell line RCe015-A (RC-11).

De Sousa PA, Tye BJ, Bruce K, Dand P, Russell G, Collins DM, Greenshields A, McDonald K, Bradburn H, Laurie A, Canham M, Kunath T, Downie JM, Bateman M, Courtney A.

Stem Cell Res. 2016 Jul;17(1):42-48. doi: 10.1016/j.scr.2016.04.021. Epub 2016 May 7.


Derivation of the clinical grade human embryonic stem cell line RCe013-A (RC-9).

De Sousa PA, Tye BJ, Bruce K, Dand P, Russell G, Collins DM, Greenshields A, McDonald K, Bradburn H, Canham MA, Kunath T, Downie JM, Bateman M, Courtney A.

Stem Cell Res. 2016 Jul;17(1):36-41. doi: 10.1016/j.scr.2016.04.020. Epub 2016 May 6.


Derivation of the clinical grade human embryonic stem cell line RCe021-A (RC-17).

De Sousa PA, Tye BJ, Bruce K, Dand P, Russell G, Collins DM, Greenshields A, McDonald K, Bradburn H, Allan D, Laurie A, Kunath T, Canham MA, Downie JM, Bateman M, Courtney A.

Stem Cell Res. 2016 Jul;17(1):1-5. doi: 10.1016/j.scr.2016.04.019. Epub 2016 Apr 30.


Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation.

Bergström P, Agholme L, Nazir FH, Satir TM, Toombs J, Wellington H, Strandberg J, Bontell TO, Kvartsberg H, Holmström M, Boreström C, Simonsson S, Kunath T, Lindahl A, Blennow K, Hanse E, Portelius E, Wray S, Zetterberg H.

Sci Rep. 2016 Jul 7;6:29200. doi: 10.1038/srep29200.


The Molecular Karyotype of 25 Clinical-Grade Human Embryonic Stem Cell Lines.

Canham MA, Van Deusen A, Brison DR, De Sousa PA, Downie J, Devito L, Hewitt ZA, Ilic D, Kimber SJ, Moore HD, Murray H, Kunath T.

Sci Rep. 2015 Nov 26;5:17258. doi: 10.1038/srep17258.


Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.

Sposito T, Preza E, Mahoney CJ, Setó-Salvia N, Ryan NS, Morris HR, Arber C, Devine MJ, Houlden H, Warner TT, Bushell TJ, Zagnoni M, Kunath T, Livesey FJ, Fox NC, Rossor MN, Hardy J, Wray S.

Hum Mol Genet. 2015 Sep 15;24(18):5260-9. doi: 10.1093/hmg/ddv246. Epub 2015 Jul 1.


Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors.

Holmqvist S, Brouwer M, Djelloul M, Diaz AG, Devine MJ, Hammarberg A, Fog K, Kunath T, Roybon L.

Stem Cell Res. 2015 Jul;15(1):203-20. doi: 10.1016/j.scr.2015.05.014. Epub 2015 Jun 6.


Conformational dynamics of α-synuclein: insights from mass spectrometry.

Phillips AS, Gomes AF, Kalapothakis JM, Gillam JE, Gasparavicius J, Gozzo FC, Kunath T, MacPhee C, Barran PE.

Analyst. 2015 May 7;140(9):3070-81. doi: 10.1039/c4an02306d. Epub 2015 Mar 10.


Isolation and manipulation of mouse trophoblast stem cells.

Hayakawa K, Himeno E, Tanaka S, Kunath T.

Curr Protoc Stem Cell Biol. 2015 Feb 2;32:1E.4.1-1E.4.32. doi: 10.1002/9780470151808.sc01e04s32.


Developmental differences in the expression of FGF receptors between human and mouse embryos.

Kunath T, Yamanaka Y, Detmar J, MacPhee D, Caniggia I, Rossant J, Jurisicova A.

Placenta. 2014 Dec;35(12):1079-88. doi: 10.1016/j.placenta.2014.09.008. Epub 2014 Sep 23.


A cell culture model for monitoring α-synuclein cell-to-cell transfer.

Reyes JF, Olsson TT, Lamberts JT, Devine MJ, Kunath T, Brundin P.

Neurobiol Dis. 2015 May;77:266-75. doi: 10.1016/j.nbd.2014.07.003. Epub 2014 Jul 16.


Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.

Crompton LA, Byrne ML, Taylor H, Kerrigan TL, Bru-Mercier G, Badger JL, Barbuti PA, Jo J, Tyler SJ, Allen SJ, Kunath T, Cho K, Caldwell MA.

Stem Cell Res. 2013 Nov;11(3):1206-21. doi: 10.1016/j.scr.2013.08.002. Epub 2013 Aug 9.


Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration.

Fukuda S, Nagano M, Yamashita T, Kimura K, Tsuboi I, Salazar G, Ueno S, Kondo M, Kunath T, Oshika T, Ohneda O.

Stem Cells. 2013 Oct;31(10):2149-61. doi: 10.1002/stem.1469.


ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment.

Hamilton WB, Kaji K, Kunath T.

PLoS One. 2013 Apr 16;8(4):e60907. doi: 10.1371/journal.pone.0060907. Print 2013.


Extraembryonic endoderm cells as a model of endoderm development.

Moerkamp AT, Paca A, Goumans MJ, Kunath T, Kruithof BP, Kruithof-de Julio M.

Dev Growth Differ. 2013 Apr;55(3):301-8. doi: 10.1111/dgd.12036. Epub 2013 Feb 18. Review.


BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm.

Paca A, Séguin CA, Clements M, Ryczko M, Rossant J, Rodriguez TA, Kunath T.

Dev Biol. 2012 Jan 1;361(1):90-102. doi: 10.1016/j.ydbio.2011.10.013. Epub 2011 Oct 14.


Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.

Devine MJ, Ryten M, Vodicka P, Thomson AJ, Burdon T, Houlden H, Cavaleri F, Nagano M, Drummond NJ, Taanman JW, Schapira AH, Gwinn K, Hardy J, Lewis PA, Kunath T.

Nat Commun. 2011 Aug 23;2:440. doi: 10.1038/ncomms1453.


Primed for pluripotency.

Kunath T.

Cell Stem Cell. 2011 Mar 4;8(3):241-2. doi: 10.1016/j.stem.2011.02.009.


Induced pluripotent stem cell technology and stem cell therapy for diabetes.

Drummond RJ, Kunath T, Mee PJ, Ross JA.

Exp Ther Med. 2011 Jan;2(1):3-7. Epub 2010 Dec 2.


Transgenic RNA interference to investigate gene function in the mouse.

Kunath T.

Methods Mol Biol. 2008;461:165-86. doi: 10.1007/978-1-60327-483-8_11. Review. No abstract available.


Isolation and manipulation of mouse trophoblast stem cells.

Himeno E, Tanaka S, Kunath T.

Curr Protoc Stem Cell Biol. 2008 Oct;Chapter 1:Unit 1E.4. doi: 10.1002/9780470151808.sc01e04s7.


FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment.

Kunath T, Saba-El-Leil MK, Almousailleakh M, Wray J, Meloche S, Smith A.

Development. 2007 Aug;134(16):2895-902.


p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc.

Gladdy RA, Nutter LM, Kunath T, Danska JS, Guidos CJ.

Mol Cancer Res. 2006 May;4(5):311-8.


Mouse trophoblast stem cells.

Quinn J, Kunath T, Rossant J.

Methods Mol Med. 2006;121:125-48.


Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts.

Kunath T, Arnaud D, Uy GD, Okamoto I, Chureau C, Yamanaka Y, Heard E, Gardner RL, Avner P, Rossant J.

Development. 2005 Apr;132(7):1649-61.


Phenotypic analyses of mouse embryos with ubiquitous expression of Oct4: effects on mid-hindbrain patterning and gene expression.

Ramos-Mejía V, Escalante-Alcalde D, Kunath T, Ramírez L, Gertsenstein M, Nagy A, Lomelí H.

Dev Dyn. 2005 Jan;232(1):180-90.


Early trophoblast determination and stem cell maintenance in the mouse--a review.

Kunath T, Strumpf D, Rossant J.

Placenta. 2004 Apr;25 Suppl A:S32-8. Review.


Transcriptome analysis of mouse stem cells and early embryos.

Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T, Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T, Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ, Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A, Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso J, Hide W, Ko MS.

PLoS Biol. 2003 Dec;1(3):E74. Epub 2003 Dec 22.


Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype.

Kunath T, Gish G, Lickert H, Jones N, Pawson T, Rossant J.

Nat Biotechnol. 2003 May;21(5):559-61. Epub 2003 Apr 7.


Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity.

Tanaka TS, Kunath T, Kimber WL, Jaradat SA, Stagg CA, Usuda M, Yokota T, Niwa H, Rossant J, Ko MS.

Genome Res. 2002 Dec;12(12):1921-8.


Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta.

Tremblay GB, Kunath T, Bergeron D, Lapointe L, Champigny C, Bader JA, Rossant J, Giguère V.

Genes Dev. 2001 Apr 1;15(7):833-8.

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